Trainers Directory

My research is in cellular and molecular biology of myelination, demyelination, and remyelination with a focus on multiple Sclerosis. 

Bruce D. Trapp's Biography 

I study the role of long non-coding RNAs (lncRNAs) in human and mouse, including high throughput studies of cellular gene expression pattern (bulk and single-cell RNA-seq, ChIP-seq, etc). 

Saba Valadkhan's Biography 

I research cellular and humoral alloimmune responses to solid organ transplants. 

Anna Valujskikh's Biography

I focus on structural biology, infectious diseases/antibiotic resistance, cardiovascular diseases, small-molecule therapeutics design, and cell signaling. 

Focco van den Akker's Biography 

Our laboratory studies the role of carotenoids and their retinoid metabolites in vision. Specically, we analyze how these lipids are absorbed, distributed in the body, and metabolized to biologically active metabolites, including the visual chrmophore. We use mouse modles with mutation in these genes to establish treatments of associated blining diseases.

Johannes von Lintig's Biography 

My area of investigation includes cellular therapies for cancer, cancer drug development, and genetic and molecular analyses of leukemia. 

David Wald's Biography 

We interrogate crosstalks between cancer cells and the microenvironment in metastatic colorectal and pancreatic cancers. For example, the surrounding liver mcrienvironment secretes soluble factors to activate HER3 and other survival pathways in cancer liver metastases. By identifying key survival pathways (such as HER3) ivolved in the crosstalk, we aim to develop therapeutic strategies of disrupting the crosstalk (e.g. block secreted factors, or block HER3 in cancer cells) to inhibit metastatic tumor outgrowth and, and also sensitize cancer cells to standard-of-care treatments for combination therapies.

Rui Wang's Biography

I focus on the molecular mechanisms governing cell migration and proliferation, and experimental therapy of cancer metastasis using tumor-targeting peptides.

Bingcheng Wang's Biography

The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and Case Western Reserve University. Immune-checkpoint blockade therapies have revolutionized the field of Cancer Immunotherapy. The Wang laboratory is among the first groups to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer Immunotherapy. Current projects are multi-disciplinary and involve elucidating the epigenetic and metabolic regulations by novel inhibitory receptors on tumor-associated cytotoxic T cells and tumor-associated macrophages or myeloid derived suppressor cells. We are also investigating the mechanisms of resistance following chimeric antigen receptor (CAR) T cell-based therapies in lymphoma patients.  

Li Lily Wang's Biography

We are interested in statistical method development in data integration and causal inference and collaborative work in biomedical and human health research. We develop computational methods for analyzing and identifying biomarkers from high-dimensional genomic/genetic/imaging data. Also, we work on electronic health record data and other big data in cancer, cardiovascular, kidney and neurodegenerative diseases for decision making and value-based care research.

Ming Wang's Biography