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Allison Kraus, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineEmail: alk127@case.edu
I research self-propagating misfolded proteins of neurodegenerative diseases, including Alzheimer’s, chronic traumatic encephalopathy, Parkinson’s, and prion diseases. I also focus on the analysis of what makes a misfolded protein transmissible, and what makes a transmissible protein seed pathogenic to the host.
Thomas LaFramboise, PhD
ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineMemberCancer Genomics and Epigenomics ProgramCase Comprehensive Cancer CenterEmail: thomas.laframboise@case.edu
Phone: 216.368.0150
We develop and apply computational tools to identify molecular variants that contribute to cancer and related diseases in humans.
Justin D. Lathia, PhD
ProfessorDepartment of Molecular MedicineSchool of MedicineCo-LeaderMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: lathiaj@ccf.org
Phone: 216.445.7475
We use in vivo imaging models to interrogate the tumor microenvironment, examining communication mechanisms in cancer stem cells, currently focused on malignant brain tumors.
John J. Letterio, MD
ProfessorDepartment of PediatricsSchool of MedicineCo-LeaderDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: john.letterio@UHhospitals.org
Phone: 216.844.3345
I focus on TGF-ß in immune cell development and function, as well as tumor suppressor functions of TGF-b.
Alan Levine, PhD
ProfessorDepartment of Molecular Biology and MicrobiologySchool of MedicineProfessorDepartment of PharmacologyProfessorDepartment of MedicineSchool of MedicineProfessorDepartment of PathologySchool of MedicineProfessorDepartment of PediatricsSchool of MedicineEmail: alan.levine@case.edu
Phone: 216.368.0342
My research includes intestinal host defense: immune tolerance and immune protection in inflammatory bowel disease, HIV or SARS-CoV-2 infection, and opioid use disorder.
Gina Lewin, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineMemberCenter for Global Health and DiseasesSchool of MedicineEmail: grl48@case.edu
Phone: 216.368.1650
Our human microbiota consists of complex communities where microbial interactions modulate bacterial behavior and influence human health. The Lewin lab is interested in understanding the role of microbial interactions in polymicrobial sites, especially the oral microbiome. We use cutting-edge computational techniques and wet-lab approaches to study these interactions in the context microbial diversity and the dynamic infection environment.
Yan Li, PhD
Associate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: yan.li17@case.edu
Phone: 216.368.0305
I investigate single cell genomics in diabetes research, non-coding cis-regulatory elements in development and complex diseases, and functional characterization of non-coding GWAS SNPs in diabetic conditions.
Xiaoxia Li , PhD
ProfessorDepartment of Molecular MedicineSchool of MedicineProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: lix@ccf.org
Phone: 216.445.8706
My research includes signal transduction in innate and adaptive immunity.
Xiao Li, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCenter for RNA Science and TherapeuticsSchool of MedicineAssistant ProfessorDepartment of Biomedical EngineeringCase School of EngineeringEmail: xiao.li9@case.edu
Phone: 216-368-0258
I study RNA systems biology in precision medicine.
Xin Liu, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineEmail: xxl1436@case.edu
Phone: 216-368-2433
My lab is interested in understanding how the immune system responds to a variety of insults (e.g. bacteria, viruses, tumors) to control human diseases (e.g. infectious diseases and cancer). Increasing evidence has implicated that metabolism plays a crucial role in shaping immune cell phenotype and function. Our studies aim to investigate the interactions between metabolism and innate immune response in the settings of lung infection and cancer.