Robert Friedland, professor of neurology at Case Western Reserve University School of Medicine, is seeking to learn why African Americans suffer from higher rates of Alzheimer's disease and strokes than the rest of the population. He is looking for genetic and non-genetic clues that can shed light on the reasons behind the differences.

His work is part of the Multi-institutional Research in Alzheimer's Genetic Epidemiology Study, or MIRAGE. The study, funded by National Institutes of Health, involves the University Memory and Aging Center at CWRU and University Hospitals of Cleveland, plus 12 other medical centers in the United States, Germany and Canada.

The study aims to evaluate the association between genetic and non-genetic risk factors for Alzheimer's disease (AD). It also hopes to educate the public with a comprehensive program aiming to raise awareness of the importance of various risk factors for AD and stroke.

Friedland and colleagues are conducting research that compares genetic and non-genetic factors across cultures.

"Working in Africa, it has been found that Alzheimer's disease and stroke are much less prevalent than in the United States; however, both diseases more frequently affect African Americans than Caucasians," Friedland said. "Our research is now studying the similarities and differences between genetic risks found among African-American and Caucasian families. In addition, we are researching the genes and environmental factors that are cause for the higher risk of these diseases among African Americans."

MIRAGE is hoping to recruit African Americans in an effort to conduct this research. Volunteers should have memory difficulties. Participants may suffer from mild memory complaints or mild to severe dementia. Other qualifications may vary by study.

"Volunteers will help future generations by assisting researchers in learning more about these diseases," Friedland said.

Other benefits to volunteers include memory and neurological assessments; feedback to their family physicians (if desired); the opportunity to work with caring and highly qualified medical, nursing and social work professionals; and access to up-to-date information.

Participants are reminded that all research activities are voluntary, confidential and free of charge. Information gained from the MIRAGE study will lead to advances in the development of new diagnostic techniques and treatments for Alzheimer's disease. For more information, contact Kathy Shaw, community relations manager, at 216-844-6400, toll free at 1-800-252-5048 or visit the web at http://www.ohioalzcenter.org/.