Case Western Reserve University has been accredited since 1913 by the Higher Learning Commission of the North Central Association of Colleges and Schools, one of the six regional agencies that accredit U.S. colleges and universities at the institutional level. Accreditation provides assurance to the public and to prospective students that standards of quality have been met.

A team from the Commission visited Case on April 11-13, 2005 to evaluate whether the university continues to meet the requirements for accreditation. Based on the team's recommendation, the Commission voted in October 2005 to continue Case's accreditation for the next ten years, the maximum period possible. Information on the team's report and subsequent review process is available here.