PSYCHIATRY

George E. Jaskiw, MD

Associate Professor of Psychiatry, CWRU
Director of Psychiatry Research, LSC-VAMC

Office Phone: 440-526-3030 ext 6846
gxj5@case.edu
Office Location: 10000 Brecksville Road | Brecksville, Ohio 44141

Medical School

University of Toronto, Canada

Residency

Massachusetts Mental Health Center, Boston (Adult Psychiatry)

Fellowship

Clinical Brain Disorders Branch, National Institutes of Mental Health, Bethesda, Maryland

Board Certification

Adult Psychiatry and ABPN

Special Interests

Schizophrenia, Psychoses, Dopamine, Prefrontal Cortex, Antipsychotic Drugs, Tyrosine and Phenylalanine

Research Projects

Clozapine - Efficacy and Side Effects during Long-Term Treatment

In vitro Modeling of the Blood Brain Barrier

Tyrosine Availability Influences Mesocortico-Limbic Catecholamines in the Rat

Tyrosine Effects on Brain Indices in Schizophrenia

Association Memberships

Society for Neuroscience
National Association for Veterans Affairs Physicians and Dentists
Ukrainian Medical Association of North America
Advisory Board: National Alliance for the Mentally Ill (Cleveland)
Advisory Board: PLAN of Northeast Ohio

Publications

1. Jaskiw, G.E., Kirkbride, B., Bongiovanni, R. In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels. Psychopharmacol 185:416-422, 2006.

2. Bongiovanni, R., Young, D., Newbould, E., Jaskiw, G.E., Increased striatal dopamine synthesis is associated with decreased tissue levels of tyrosine. Brain Res. 1115:26-36, 2006.

3. Bongiovanni, R., Newbould, E., Jaskiw, G.E., Tyrosine depletion lowers dopamine synthesis and desipramine-induced prefrontal cortex catecholamine levels. Brain Res. 1190:39-48, 2008.

4. Jaskiw, G.E. Newbould, E., Bongiovanni, R., Tyrosine availability modulates potassium-induced striatal catecholamine efflux in vivo. Brain Res. 1209:74-84, 2008

5. Jaskiw, G.E., Konicki, P.E., Fuller,  M.A., Clozapine: Toxicity vs. postmortem redistribution. Schizophr Res. 101:344-5, 2008.

6. Bongiovanni, R., Newbould, E., Jaskiw, G.E., Tyrosine influences on gammabutyrolactone induced changes in dopamine metabolites in prefrontal cortex and striatum. Eur.J.Pharmacol. 589:106-109, 2008.