Gregory MacLennan, M.D. Professor Mailing Address: 11100 Euclid Ave. Cleveland, OH 44106 phone: (216) 844-7452 email: Gregory.MacLennan@UHhospitals.org

Biography
Dr. Gregory MacLennan earned his M.D. degree from the University of Manitoba, Canada, in 1971. He spent six years training in General Surgery and Urology at Manitoba Affiliated Teaching Hospitals, and followed this with a fellowship in Urodynamics at St. Peter's Hospitals, London, England. From 1978 until 1989, Dr. MacLennan practiced Urology in Grand Forks, N.D. and progressed from Clinical Instructor to Associate Professor of Surgery at the University of North Dakota School of Medicine. In 1989, he returned to Manitoba Affiliated Teaching Hospitals and spent 5 years in Residency and fellowship training in Anatomic Pathology and Cytopathology. In 1994 he began a Fellowship in Surgical and Genitourinary Pathology at Mayo Clinic, Rochester, MN. Following his Fellowship, he joined the staff of the Department of Pathology at CWRU in 1995. Dr. MacLennan is Board certified in both Urology and Anatomic Pathology in both Canada and the United States. Additionally, he is Board certified in Cytopathology. Dr. MacLennan is Professor of Pathology at Case Western Reserve School of Medicine, with secondary appointments in Urology and Oncology. He is the Division Chief of Anatomic Pathology, the Director of the Human Tissue Procurement Facility at University Hospitals of Cleveland, and Director of the Tissue Procurement and Histology Core Facility of the Seidman Cancer Center.

Research
Dr. MacLennan has a particular interest in genitourinary pathology. Much of his time is committed to diagnostic surgical pathology and cytopathology. His research has been predominantly clinically oriented, in collaboration with urologists, oncologists and other pathologists, but has also involved collaborations with basic scientists.

Recent Publications: Peer-Reviewed Articles
Xiao X, Miravalle L, Yuan J, McGeehan J, Dong Z, Wyza R, MacLennan GT, Golichowski AM, Kneale G, King N, Kong Q, Spina S, Vidal R, Ghetti B, Roos K, Gambetti P, Zou WQ. Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease. Am J Pathol 174:1602-1608, 2009.

Wang X, Wang M, MacLennan GT, Abdul-Karim FW, Eble JN, Jones TD, Olobatuyi F, Eisenberg R, Cummings OW, Zhang S, Lopez-Beltran A, Montironi R, Zheng S, Lin H, Davidson DD, Cheng L: Evidence for common clonal origin of multifocal lung cancers. J Natl Cancer Inst 101: 560-570, 2009.

Shukla S, Shukla M, MacLennan GT, Fu P, Gupta S. Deregulation of FOXO3A During Prostate Cancer Progression. Int J Oncol 34:1613-1620, 2009.

Li X, Qi X, Zhou L, Fu W, Abdul-Karim FW, MacLennan GT, Gorodeski GI. P2X(7) receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin. Purinergic Signal 5:351-368, 2009.

Vykhovanets EV, Shukla S, MacLennan GT, Vykhovanets OV, Bodner DR, Gupta S. Il-1 beta-induced post-transition effect of NF-kappaB provides time-dependent wave of signals for initial phase of intrapostatic inflammation. Prostate 69:633-643, 2009.

Sanborn S, MacLennan GT, Cooney M, Zhou M, Ponsky L. High grade transitional cell carcinoma and melanosis of the urinary bladder: case report and review of the literature. Urology, 2009 Apr;73(4):928.e13-5. Epub 2008 Dec 4.

Salem N, Kuang Y, Wang F, MacLennan GT, Lee Z. PET imaging of hepatocellular carcinoma with 2-deoxy-2 (18F) fluoro-D-glucose, 6-deoxy-6 (18F) fluoroD-glucose, (1-11C)-acetate and (N-methyl-11C)-choline. QJ Nucl Med 53:144-156, 2009.

Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, Paner GP, Stovsky M, Young AN, Srigley JR, Cheville JC . Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol 33:384-392, 2009.

Loberant N, Bhatt S, MacLennan GT, Dogra VS. Striated appearance of the testis. Ultrasound Q. 26: 37-44, 2010.

Joshi N, Bissada NF, Bodner D, MacLennan GT, Narendran S, Jurevic R, Skillicorn R. Association between periodontal disease and prostate specific antigen levels in chronic prostatitis patients. J Periodontology 81: 864-869, 2010.

Halat S, Eble JN, Grignon DG, Lopez-Beltran A, Montironi R, Tan PH, Wang M, Zhang S, MacLennan GT, Cheng L: Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma. Mod Pathol 23: 931-936, 2010.

Wang H, Kang W, Zhu H, MacLennan GT, Rollins AM. Three-dimensional imaging of ureter with endoscopic optical coherence tomography. Urology (in press).

Phitayakorn R, MacLennan GT, Sadow P, Wilhelm S. Adrenal adenomatoid tumor in a patient with human immunodeficiency virus. Rare Tumors 2011;3:e21

Zechel JL, MacLennan GT, Heaney JD, Nadeau JH. Spontaneous metastasis in mouse models of testicular germ-cell tumors. Int J Androl. 2011 Jun 9. doi: 10.1111/j.1365-2605.2011.01160.x. [Epub ahead of print]

Recent Publications: Book Chapters
MacLennan GT and Cheng L. Neoplasms of the Kidney. In: Bostwick DG and Cheng L, eds. Urologic Surgical Pathology, 2nd Edition. Edinburgh: Mosby Elsevier. 2008.

Cheng L, Lopez-Beltran A, MacLennan GT, Montironi R, Bostwick DG. Neoplasms of the Urinary Bladder. In: Bostwick DG and Cheng L, eds. Urologic Surgical Pathology, 2nd Edition. Edinburgh: Mosby Elsevier. 2008.

Williamson SR, Lopez-Beltran A, Zhang S, MacLennan GT, Montironi R, Cheng L: Immunological & Molecular Studies in Kidney Tumors. In Albitar MX (ed): Immunological & Molecular Diagnosis of Cancer. Nova Science Publishers, Hauppauge , NY , 2010.

MacLennan GT, Cheng L. Tumors of the kidney. In: Cheng L and Bostwick DG, eds. Essentials of Anatomic Pathology (3rd edition). New York: Springer Science+Business Media. 2011.

Recent Publications: Books
MacLennan GT, Cheng L. Atlas of Genitourinary Pathology. Springer-Verlag London Limited . 2011.