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James M. Anderson, M.D., Ph.D.Professor of Pathology, Macromolecular Science, and Biomedical EngineeringMailing Address: fax: (216) 368-0494 email: James.Anderson@Case.edu |
Biography
Dr. James Anderson received his Ph.D. at Oregon State University in 1967. In 1976, he graduated from
the Case Western Reserve University School of Medicine with an M.D. degree and finished his Anatomic
Pathology residency at the Institute of Pathology of University Hospitals of Cleveland in 1979.
Following the completion of his residency, Dr. Anderson joined the faculty of the Institute of
Pathology at Case Western Reserve University. Dr. Anderson has worked in the area of biomaterials,
medical devices, and prostheses for the past 35 years and his current activities range from the
clinical pathology evaluation of retrieved implants from humans to fundamental studies of
cellular interactions with biomaterials. Dr. Anderson is the recipient of a NIH MERIT (Method to
Extend Research In Time) Award (1993 to 2003). He is a founding member of the Society for Biomaterials
and the Controlled Release Society and serves as a consultant to the National Institutes of Health
Artificial Heart Program, the Food and Drug Administration, and the International Standards Organization
where he is the Co-Chair of Working Group 1 for the development of the ISO Standard on Biological
Evaluation of Medical Devices, ISO 10993. He is the Editor-in-Chief of the Journal of Biomedical
Materials Research. In 2003, he was elected to the Institute of Medicine of the National Academies of
Science. In 2005, Dr. Anderson received the Elsevier Biomaterials Gold Medal Award given to the
individual who has made the most significant contributions to biomaterials science over the 25 year
period from 1980 to 2005. He received this award at the Tissue Engineering Science International
Conference held in Shanghai, China, in October of 2005. Dr. Anderson is the recipient of the 2006
Chugai Mentoring Award given by the American Society for Investigative Pathology to senior investigators
who have distinguished their careers with a dedication to mentoring and education. In 2008, Dr. Anderson
was elected to the American Association of Physicians.
Research
Our research efforts are centered around the development of a better understanding of blood
and tissue/material interactions as they relate to implantable devices and biomaterials. The overall
focus of our efforts is on the cellular and humoral responses to implanted materials. Studies
currently ongoing include an analysis of the wound healing response to vascular graft materials, in
vivo biocompatibility testing with the focus on macrophage and foreign body giant cell adhesion
and activation, and a determination of those factors which lead to the biodegradation of biomaterials.
In addition, we are investigating human blood/material interactions using an in vitro system and
interrelating variations in protein adsorption, cellular components, coagulation parameters,
platelet activation and release, and complement activation.
Publications
Refereed Journals
Patel, JD, M. Ebert, R. Ward, and J.M. Anderson, S. epidermidis biofilm formation: Effects of
biomaterial surface chemistry and serum proteins. J. Biomed. Mater. Res., 2007;80A(#3):742-751.
McNally, A.K., S.R. MacEwan, and J.M. Anderson, Alpha subunit partners to Beta1 and Beta2 integrins during IL-4-induced foreign body giant cell formation. J. Biomed. Mater. Res., 2007;82A:568-574.
Anderson, J.M. and J.A. Jones, Phenotypic dichotomies in the foreign body reaction. Biomaterials 28 (2007) 5114-5120.
Jones, J.A., D.T. Chang, H. Meyerson, E. Colton, I.K. Kwon, T. Matsuda, and J.M. Anderson, Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface- adherent macrophages and foreign body giant cells. J. Biomed. Mater. Res., 2007;83A:585-596.
Anderson, James, Elizabeth M. Christenson, and Anne Hiltner, Biodegradation mechanisms of polyurethane elastomers. Corrosion Engineering Science and Technology, 2007;42(4):312-323.
Jones, J.A., A. McNally, D.T. Chang, L.A. Qin, H. Meyerson, E. Colton, I.K. Kwon, T. Matsuda, and J.M. Anderson, Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials. J. Biomed. Mater. Res. 2008;84A(1):158-166.
McNally, Amy K., Jacqueline A. Jones, Sarah R. MacEwan, Erica Colton, and James M. Anderson, Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation. J. Biomed. Mater. Res. 2008;86A(2):535-543.
Anderson, James M., Analiz Rodriguez, and David T. Chang, Foreign body reaction to biomaterials. Seminars in Immunology, 2008;20(2):86-100.
Brodbeck, William G. and James M. Anderson, Giant cell formation and function. Curr. Opin. In Hematology, 2009, 16:53-57.
Chang, David T., Erica Colton, and James M. Anderson, Paracrine and juxtacrine lymphocyte enhancement of adherent macrophage and foreign body giant cell activation. J. Biomed. Mater. Res. 2009;89A(2):490-498.
Rodriguez, Analiz, Sarah R. MacEwan, Howard Meyerson, James T. Kirk, and James M. Anderson, The foreign body reaction in T cell deficient mice. J. Biomed. Mater. Res. 2009;90A:106-113.
Book Chapters
Anderson, James M., Inflammation and the Role of Macrophages in the Foreign Body Reaction, in
Joint Replacement and Bone Resorption, Arun Shanbhag, Harry E. Rubash, Joshua J. Jacobs, Eds.,
Taylor & Francis, New York, 2006, pp. 255-280.
Anderson, James M., Biocompatibility and Bioresponse to Biomaterials, in Principles of Regenerative Medicine, A. Atala, R. Lanza, J.A. Thomson, R.M. Nerem, Eds., Elsevier/Academic Press, 2008, pp. 704-723.
Anderson, James M., In Vitro and In Vivo Monocyte, Macrophage, Foreign Body Giant Cell and Lymphocyte Interactions with Biomaterials, in Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses, R. Bizios and D. Puleo, Eds., Springer, New York, 2009, in press.