Scientific Publications that Use HTPF Tissue

Colon Cancer Biomarkers

Luo L, Shen GQ, Stiffler KA, Wang QK, Pretlow TG, Pretlow TP. Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer. Carcinogenesis in press, 2006.

Luo L, Chen W-d, Pretlow TP. CpG island methylation in aberrant crypt foci and cancers from the same patients. Int J Cancer 115:747-751, 2005.

Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature 436:792, 2005.

Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, Van Der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 304:1164-1166, 2004.

Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554, 2004.

Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen W Dong, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36:417-422, 2004.

Li H, Myeroff L, Smiraglia D, Romero, MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JKV, Plass C, Markowitz, SD. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci USA 100:8412-8417, 2003.

Wiesner G., Platzer P, Buxbaum S, Lewis S, MacMillen M, Olechnowicz J, Willis J, Chakravarti A, Elston R, Markowitz S. Testing for colon neoplasia susceptibility variants at the human COX2 locus. J Natl Cancer Inst 93:635-639, 2001.

Breast, Ovarian, Cervical Cancer

Milliken EL, Landis MD, Whitten I, Keri RA. Centrosome amplification in a p53-independent mouse model of hormone-induced mammary cancer. In revision for Carcinogenesis.

Landis MD, Seachrist DD, Abdul-Karim F, Keri RA. Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2/Neu-induced tumors. Oncogene, in press.

Feng YH, Li X, Wang L, Zhou L, Gorodeski GI. A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem 2006 Apr 18.

Mililiken EL, Zhang X, Flask C, Duerk JL, MacDonald PN, Keri, RA. EB1089, a vitamin D receptor agonist, reduces proliferation and decreases tumor growth rate in a mouse model of hormone-induced mammary cancer. Cancer Lett 229:205-215, 2005.

Landis MD, Seachrist DD, Montanez-Wiscovich ME, Danielpour D, Keri RA. Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-b signaling in ErbB2/Neu-induced tumors from transgenic mice. Oncogene 24:5173-5190, 2005.

Wittmann BM, Wang N, Montano MM. Identification of a novel inhibitor of cell growth that is down-regulated by estrogens and decreased in breast tumors. Cancer Res 63:5151-5158, 2003.

Keri RA, Lozada KL, Abdul-Karim FW, Nadeau JH, Nilson JH. Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition. Proc Natl Acad Sci USA 97:383-387, 2000.

Prostate, Testicular Cancer

Shukla S, Gupta S. Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Mol Cancer Ther 5:843-52, 2006 Apr.

Shukla S, Gupta S. Dietary agents in the chemoprevention of prostate cancer. Nutr Cancer 53:18-32, 2005.

Shukla S, MacLennan GT, Fu P, Patel J, Marengo SR, Resnick MI, Gupta S. Nuclear factor-κB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. Neoplasia 6:390-400, 2004.

Lam MY, Youngren KK, Nadeau JH. Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice. Genetics 166:925-933, 2004.

Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O'Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH. Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445-448, 2004.

Lung Cancer

Zhou H, Liu L, Lee K, Qin X, Grasso AW, Kung HJ, Willis JE, Kern J, Wagner T, Gerson SL. Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosoure. Oncogene 21:8732-40, 2002 Dec 12.

Other

Sun D, McCrae KR. Endothelial cell apoptosis induced by cleaved high molecular weight kininogen (HKa) is matrix dependent and requires the generation of reactive oxygen species. Blood 2006 Jan 17.

Haaga JR, Exner AA, Wang Y, Stowe NT, Tarcha PJ. Combined tumor therapy by using radiofrequency ablation and 5-FU-laden polymer implants: Evaluation in Rats and Rabbits. Radiology 237:911-918, 2005.

Exner AA, Weinberg BD, Stowe NT, Gallacher A, Wilson DL, Haaga JR, Gao J. Quatintive computed tomography analysis of local chemotherapy in liver tissue after radiofrequency ablation. Acad Radiol 11:1326-36, 2004.