From: Case Western Reserve University School of Medicine, Cont'd.

61. Dreshaj, I.A., Miller, M.J., Ernsberger, P., Haxhiu-Poskurica, B., Martin, R.J., and Haxhiu, M.A.: Central effects of endothelin on respiratory output during development. Journal of Applied Physiology, 79: 420-427, 1995.

62. Koletsky, R.J., Boccia, J., and Ernsberger, P.: Acceleration of renal disease in obese SHR by exacerbation of hypertension. Clinical and Experimental Pharmacology and Physiology, 22:S254-S256, 1995.


63. Huang, S.S., Khosrof, S.A., Koletsky, R.J., and Ernsberger, P.: Characterization of retinal vascular abnormalities in lean and obese SHR. Clinical and Experimental Pharmacology and Physiology, 22:S129-S131, 1995.

64. Ernsberger, P., Koletsky, R.J., Collins, L.A., and Bedol, D.: Sympathetic nervous system in salt-sensitive and obese hypertension: Amelioration of multiple abnormalities by a central sympatholytic agent. Cardiovascular Drugs and Therapy, 10:275-282, 1996.

65. Ernsberger, P., Koletsky, R.J., Baskin, J.Z., and Collins, L.A.: Consequences of weight cycling in obese SHR. American Journal of Physiology: Regulatory and Integrative Physiology, 270: R864-R872, 1996.

66. Separovic, D., Kester, M., and Ernsberger, P.: Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells. Molecular Pharmacology, 49: 668-675, 1996.

67. Ziegler, D., Haxhiu, M.A., Kaan, E.C., Papp, J.G., and Ernsberger, P.: Pharmacology of moxonidine, an I1-imidazoline agonist. Journal of Cardiovascular Pharmacology, 27(Suppl. 3): S26-S37, 1996.

68. Koletsky, R.J., and Ernsberger, P.: Phenotypic characterization of a genetically obese and hypertensive rat strain: SHROB/Kol. Rat Genome, 2:10-22, 1996.

69. Haxhiu, M.A., McFadden,C.B., Ernsberger, P., Kaan, E.C., Erokwu, B., and Dreshaj, I.A.: Activation of I1 imidazoline receptors inhibits reflexly induced tracheal smooth muscle contraction. Atemwegs- und Lungenkrankheiten, 22: 370-373, 1996.

70. Ernsberger, P., and Shen, I.-H.: Plasma membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites. Neurochemistry International, 30: 17-23, 1997.

71. Separovic, D., Kester, M., Haxhiu, M.A., and Ernsberger, P.: Activation of phosphatidylcholine-selective phospholipase C by I1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla. Brain Research, 749: 335-339, 1997.

72. Ernsberger, P., Friedman, J.E., and Koletsky, R.J.: The I1-imidazoline receptor: From binding site to therapeutic target in cardiovascular disease. Journal of Hypertension, 5 (Supplement 1): S9-S23, 1997.

73. Friedman, J.E., Ishizuka, T., Liu, S., Bedol, D., Koletsky, R.J., and Ernsberger, P.: Metabolic consequences of a nonsesnse mutation in the leptin receptor gene (fak ) in the obese spontaneously hypertensive Koletsky rat (SHROB). Experimental and Clinical Endocrinology and Diabetes, 105 (Supplement 3): 82-84, 1997.

74. Jakupaj, M., Martin, R.J., Dreshaj, I.A., Potter, C.F., Haxhiu, M.A., and Ernsberger, P.: Role of endogenous nitric oxide in modulating airway contraction mediated by muscarinic receptors during development. American Journal of Physiology: Lung Cellular and Molecular Physiology, 273: in press.

75. Mandal, A., Wang, Y., Ernsberger, P., and Kester, M.: Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes: Implications for growth senesence. Journal of Biological Chemistry, 272: 20,306-20,311, 1997.

76. Friedman, J.E., Ishizuka, T., Liu, S., Farrell, C.J., Bedol, D., Koletsky, R.J., and Ernsberger, P.: Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat. American Journal of Physiology: Endocrine and Metabolic Physiology, 273: E1014-E1023, 1997.

77. Coles SK, Ernsberger P., Dick TE. Post-hypoxic frequency decline does not depend on alpha2-adrenergic receptors in the adult rat. Brain Res. 1998 Jun 1;794(2):267-73.

78. Coles SK, Ernsberger P., Dick TE. A role for NMDA receptors in posthypoxic frequency decline in the rat. Am J Physiol. 1998 Jun;274(6 Pt 2):R1546-55.

79. Ernsberger P., Kou YR, Prabhakar NR. Carotid body I1-imidazoline receptors: binding, visualization and modulatory function. Respir Physiol. 1998 Jun;112(3):239-51.

80. Haxhiu MA, Dreshaj IA, McFadden CB, Erokwu BO, Ernsberger P. I1-imidazoline receptors and cholinergic outflow to the airways. J Auton Nerv Syst. 1998 Jul 15;71(2-3):167-74.

81. Ernsberger P., Arachidonic acid release from PC12 pheochromocytoma cells is regulated by I1-imidazoline receptors. J Auton Nerv Syst. 1998 Oct 15;72(2-3):147-54.

82. Chelala JL, Kilani A, Miller MJ, Martin RJ, Ernsberger P. Muscarinic receptor binding sites of the M4 subtype in porcine lung parenchyma. Pharmacol Toxicol. 1998 Nov;83(5):200-7.

83. Ishizuka T, Ernsberger P., Liu S, Bedol D, Lehman TM, Koletsky RJ, Friedman JE.Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB). J Nutr. 1998 Dec;128(12):2299-306.

84. Ernsberger P., Ishizuka T, Liu S, Farrell CJ, Bedol D, Koletsky RJ, Friedman JE. Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB). J Pharmacol Exp Ther. 1999 Jan;288(1):139-47.

85. Piletz JE, Jones JC, Zhu H, Bishara O, Ernsberger P. Imidazoline receptor antisera-selected cDNA clone and mRNA distribution. Ann N Y Acad Sci. 1999 Jun 21;881:1-7.

86. Ernsberger P. The I1-imidazoline receptor and its cellular signaling pathways. Ann N Y Acad Sci. 1999 Jun 21; 881:35-53. Review.

87. Haxhiu MA, Dreshaj IA, McFadden CB, Erokwu BO, Ernsberger P. Moxonidine acting centrally inhibits airway reflex responses. Ann N Y Acad Sci. 1999 Jun 21;881:372-82.

88. Yohannan MD, Marti RJ, Dreshaj I, Haxhiu MA, Ernsberger P. Ontogeny of neurokinin-1 receptors in the porcine respiratory system. Peptides. 1999 Nov;20(11):1353-60.

89. Ernsberger P., Koletsky RJ, Kline DD, Bedol DM, Friedman JE. The SHROB model of syndrome X: effects of excess dietary sucrose. Ann N Y Acad Sci. 1999 Nov 18;892:315-8. No abstract available

90. Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides. 1999 Dec;20(12):1449-53.

91. Thomas AJ, Erokwu BO, Yamamoto BK, Ernsberger P., Bishara O, Strohl KP. Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period. Brain Res Dev Brain Res. 2000 Apr 14;120(2):181-189.[Record as supplied by publisher]

92. Tolentino-Silva FP, Haxhiu MA, Waldbaum S, Dreshaj IA, Ernsberger P. alpha(2)-adrenergic receptors are not required for central anti-hypertensive action of moxonidine in mice. Brain Res. 2000 Apr17; 862(1-2):26-35.

93. Piletz JE, Ivanov TR, Sharp JD, Ernsberger P., Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ.Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. DNA Cell Biol. 2000 Jun;19(6):319-29.

94. Tolentino-Silva FP, Haxhiu MA, Ernsberger P., Waldbaum S, Dreshaj IA.Differential cardiorespiratory control elicited by activation of ventral medullary sites in mice.J Appl Physiol. 2000 Aug;89(2):437-44.

Reviews  |  Journals  |  Articles

1. Ernsberger, P., and Haskew, P.: Health implications of obesity: An alternative view. Journal of Obesity and Weight Regulation, 6: 55-137, 1987. (Published separately as a book entitled Rethinking Obesity: An Alternative View of its Health Implications by Human Sciences Press, New York, 1988).

2. Michel, M.C. and Ernsberger, P.: Keep an eye on the I site: Imidazoline-preferring receptors. Trends in Pharmacological Sciences, 13: 369-370, 1992.

3. Ernsberger, P., Elliott, H.L., Weimann, H.-J., Raap, A., Haxhiu, M.A., Hofferber, E., Löw-Kröger, A., Reid, J.L., Mest, H.-J.: Moxonidine: A second-generation central antihypertensive agent. Cardiovascular Drug Reviews, 11: 411-431, 1993.

4. Piletz, J.E., Ernsberger, P., and Halaris, A.: Psychopharmacology of imidazoline and 2-adrenergic receptors: Implications for depression. Critical Reviews in Neurobiology, 9:29-66, 1995.

5. Ernsberger, P., and Douglas, J.D.: Renal angiotensin receptor subtypes: Therapeutic implications. Postgraduate Medicine, November 1995 Special Supplement, pp. 22-27.

6. Ernsberger, P., and Haxhiu, M.A.: The I1-imidazoline binding site is a functional receptor mediating vaso depression via the ventral medulla. American Journal of Physiology: Regulatory and Integrative Physiology, 273: R1572-R1579, 1997.

7.  Ernsberger, P.: The I1-imidazoline receptor agonist moxonidine: Molecular, cellular and organismic actions. Reviews in Contemporary Pharmacotherapy, in press.

8.  Ernsberger, P., Koletsky, R.J., and Friedman, J.E.: Contribution of sympathetic nervous system overactivity to cardiovascular and metabolic disease. Reviews in Contemporary Pharmacotherapy, in press.

Book Chapters and Invited Reviews

1. Halberg, F., Powell, E.W., Lubanovic, W., Scheving, L.E., Pasley, J.N., Ernsberger, P., Sothern, R.B., and Brockway, B.: Chronopharmacologic approach to vigilance: Models and methods for anti-circadian dyschronic drug tests based on different kinds of murine thermodyschronism following unilateral or bilateral suprachiasmatic lesions. In: Pharmacology of the States of Alertness, P. Passouant and I. Oswald, Eds., Pergamon Press, New York, 1979, pp. 39-48.

2. Ernsberger, P.: Does obesity kill? No. Physician's Weekly, 3 (37): 1 (10/6/86).

3. Reis, D. J., Ernsberger, P., and Meeley, M. P.: Clonidine acts on imidazole receptors in brain which bind an endogenous clonidine-displacing substance. In: Pharmacology, M.J. Rand and C. Raper, Eds., Elsevier, Amsterdam, 1987, pp. 41-45. (Excerpta Medica 750: 41-45, 1987)

4. Ernsberger, P.: Obesity is hazardous to your health: Negative. In: Debates in Medicine Volume 2, H.V. Barnes, Ed., Yearbook Medical Publishers, New York, 1989, pp. 113-123. (Debates in Medicine, 2: 113-123, 1989).

5. Ernsberger, P.: Rebuttal: negative. ibid, pp. 129-135. (Debates in Medicine, 2: 129-135, 1989).

6. Ruggiero, D.A., Ernsberger, P., Morrison, S.F., and Reis, D.J.: Regulation of arterial blood pressure by the rostral ventrolateral medulla. In: Foundations of Behavioral Medicine: Cardiovascular Disease, New Hempstead, L.I.: Lawrence Erlbaum Assoc., 1991.

7. Reis, D.J., Ernsberger, P.R., and Meeley, M.P.: Imidazole receptors and their endogenous ligand in the ventrolateral medulla: Relationship to the action of clonidine on arterial pressure. In: Central Neural Mechanisms in Cardiovascular Regulation, G. Kunos and J. Ciriello, Eds., Cambridge, MA: Birkhauser Boston, 1991, pp. 55-68.

8. Mann, J.J., Arango, V., Marzuk, P., Tierney, H., Ernsberger, P., and Reis, D.J.: Postmortem studies of receptors in brains of suicides. In: Neurochemical Correlates of Affective Disorders and Their Treatment, S. Karger, Basel, 1991.

9. Ernsberger, P., Zhou, J., and Douglas, J.G.: Renal angiotensin receptor subtypes. American Heart Association Council on the Kidney in Cardiovascular Disease Newsletter, Fall 1991, pp. 1-5.

10. Koletsky, R.J., and Ernsberger, P.: Obese SHR (Koletsky Rat): A model for the interactions between hypertension and obesity. In: Genetic Hypertension, J. Sassard, Ed., John Libby Ltd., London, 1992, pp. 373-375. (Colloque INSERM 218: 373-375, 1992).

11. Cherniack, N.S., Ernsberger, P., Mitra, J., and Haxhiu, M.A.: The role of ventral medulla in hypoxic respiratory depression and sympathetic excitation. In: Ventral Brainstem Mechanisms and Control Functions, O. Trouth, R. Millis, H. Kiwell-Schone and M. Schläfke, Eds., Marcel Decker, New York, pp. 103-130, 1995. (Lung Biology in Health and Disease, 82: 103-130, 1995; Series Editor: C. Lenfant)

12. Ernsberger, P., Collins, L.A., Graves, M.E., Dreshaj, I.A., and Haxhiu, M.A.: Imidazoline I1 receptors in the ventro-lateral medulla and their role in cardiorespiratory control. In: Ventral Brainstem Mechanisms and Control Functions, O. Trouth, R. Millis, H. Kiwell-Schone and M. Schläfke, Eds., Marcel Decker, New York, pp. 319-358, 1995. (Lung Biology in Health and Disease, 82: 319-358, 1995; Series Editor: C. Lenfant).

13. Ernsberger, P., Graves, M.E., Graff, L.M., Zakieh, N., Nguyen, P., Collins, L.A., Westbrooks, K.L., and Johnson, G.G.: I1-Imidazoline receptors: Definition, characterization, distribution and transmembrane signalling. Annals of the New York Academy of Science, 763:22-42, 1995.

14. Ernsberger, P., Li, P., and Smyth, D.D.: 2,6-Dimethylclonidine: 2-Adrenoceptor or I1-imidazoline receptor agonist? Annals of the New York Academy of Science, 763: 96-99, 1995.

15. Ernsberger, P., Piletz, J.E., Graff, L.M., and Graves, M.E.: Optimization of radioligand binding assays for I1 imidazoline sites. Annals of the New York Academy of Science, 763: 163-168, 1995.

16. Lei, L., Slavica, M., Ernsberger, P., Graves, M.E., Patil, P., Miller, D., and Feller, D.: Calcium channel dependent and I1-imidazoline receptor binding properties of 2-(4'-isothiocyanatobenzyl)-imidazoline analogs. Annals of the New York Academy of Science, 763: 283-286, 1995.

17. Liedtke, C.M., and Ernsberger, P.: Regulation of electrolyte transport in rabbit tracheal epithelial cells by the I1-imidazoline agonist moxonidine. Annals of the New York Academy of Science, 763: 401-404, 1995.

18. Haxhiu, M.A., Dreshaj, I.A., Erokwu, B., Collins, L.A., and Ernsberger, P.: Effect of I1-imidazoline receptor activation on responses of hypoglossal and phrenic nerve to chemical stimulation. Annals of the New York Academy of Science, 763: 445-462, 1995.

Published Correspondence and Editorials

1.  Ernsberger, P., and Haskew, P.: News about obesity. New England Journal of Medicine, 315: 130-131, 1986.

2.  Ernsberger, P.: Body weight and longevity. Journal of the American Medical Association, 257: 1895-1896, 1987.

3.  Ernsberger, P.: Complications of the surgical treatment of obesity. American Journal of Psychiatry, 144: 833-834, 1987.

4.  Ernsberger, P.: NIH consensus conference on obesity: By whom and for what? Journal of Nutrition, 117: 1164-1165, 1987.

5.  Ernsberger, P.: Surgery risks outweigh its benefits. Obesity & Health, March/April 1991, pp.24-25.

6. Schäfer, S.G., Christen, M.O., and Ernsberger, P.: The second generation of centrally acting drugs: Introduction. Journal of Cardiovascular Pharmacology, 20 (Supplement 4): vii-viii, 1992.

7.  Ernsberger, P., and Koletsky, R.J.: Weight cycling and mortality: Support from animal studies. Journal of the American Medical Association, 269: 1116, 1993.

8. Ernsberger, P., and Koletsky, R.J.: Weight cycling. Journal of the American Medical Association, 273: 998-999, 1995.

9. Ernsberger, P.: Adverse reactions to dexfenfluramine. Healthy Weight Journal, 11: 6-9, 1997.