From the University of Minnesota, Department of Medicine, Hypertension Section

1. Ernsberger, P., Azar, S., Livingston, S., and Halberg, F.: Strain difference in mesor of circadian rhythmic urinary kallikrein excretion and in adjustment to dietary salt loading of Dahl rats. Chronobiologia, 6: 338-339, 1979.

2. Powell, E.W., Halberg, F., Pasley, J., Lubanovic, W., Ernsberger, P., and Scheving, L.: The suprachiasmatic nucleus and circadian rhythm in rat core temperature. Journal of Thermal Biology, 5: 189-194, 1980.

3. Azar, S., Ernsberger, P., Livingston, S., Azar, P., and Iwai, J.: Paraventricular-suprachiasmatic lesions prevent Dahl hypertension. Clinical Science, 61: 49s-51s, 1981.

4. Ernsberger, P., Azar, S., and Tarbell, M.: Effects of preoptic-suprachiasmatic lesions on renal excretion of electrolytes. Life Sciences, 28: 1387-1390, 1981.

5. Ernsberger, P., Azar, S., and Iwai, J.: Open field behavior in two models of genetic hypertension and the behavioral effects of salt excess. Behavioral and Neural Biology, 37: 10-25, 1983.

6. Ernsberger, P., Azar, S., and Azar, P.: The role of the anteromedial hypothalamus in Dahl hypertension. Brain Research Bulletin, 15: 651-656, 1985.

From Northwestern University, Department of Pharmacology

7. Ernsberger, P., and U'Prichard, D.C.: Para-azidoclonidine: a novel photoaffinity ligand for the 2-receptor. Life Sciences, 38: 1557-1563, 1986.

8. Ernsberger, P., and U'Prichard, D.C.: Modulation of agonist and antagonist interactions at kidney 1 adrenoceptors by nucleotides and metal ions. European Journal of Pharmacology, 133: 165-176, 1987.

9. Ernsberger, P.: Neural mediation of genetic and nutritional effects on blood pressure: role of adrenergic receptor regulation in kidney, brain, and heart. Doctoral Dissertation; University Microfilms, Ann Arbor, MI, 1985.

From Northwestern University, Department of Physiology

10. Ernsberger, P., and Nelson, D.O.: Refeeding hypertension in dietary obesity. American Journal of Physiology: Regulatory and Integrative Physiology, 254: R47-R55, 1988.

11. Ernsberger, P., and Nelson, D.O.: The effects of fasting and refeeding on blood pressure are determined by nutritional state, not by body weight change. American Journal of Hypertension, 1: 153S-157S, 1988.



From Cornell University, Department of Neurology, Division of Neurobiology

12. Meeley, M.P., Ernsberger, P., Granata, A.R., and Reis, D.J.: An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla. Life Sciences, 38: 1119-1126, 1986.

13. Ernsberger, P., Meeley, M.P., and Reis, D.J.: Clonidine-displacing substance binds preferentially to imidazole binding sites in the ventrolateral medulla labeled by 3H-para-aminoclonidine. Journal of Hypertension, 4(Supplement 5): S109-S111, 1986.

14. Meeley, M.P., Ernsberger, P., and Reis, D.J.: An endogenous substance with clonidine-like receptor binding selectivity: the brain's own clonidine? Journal of Hypertension, 4(Supplement 6): S257-S259, 1986.

15. Ernsberger, P., Meeley, M.P., Mann, J.J., and Reis, D.J.: Clonidine binds to imidazole binding sites as well as 2-adrenoceptors in the ventrolateral medulla. European Journal of Pharmacology, 134: 1-13, 1987.

16. Granata, A.R., Ernsberger, P., and Reis, D.J.: Hypotension and bradycardia elicited by histamine into the C1 area of the rostral ventrolateral medulla. European Journal of Pharmacology, 136: 157-162, 1987. (see also Erratum: 142: 494, 1987)

17. Felsen, D., Ernsberger, P., Meeley, M.P., and Reis, D.J.: Clonidine-displacing substance is biologically active on smooth muscle. European Journal of Pharmacology, 142: 453-455, 1987.

18. Meeley, M.P., Towle, A.C., Ernsberger, P., and Reis, D.J.: A specific antiserum recognizes clonidine-displacing substance: Implications for the structure of the brain's own clonidine. Neuroscience Letters, 84: 84-90, 1988.

19. Ernsberger, P., Meeley, M.P., and Reis, D.J.: An endogenous substance with clonidine-like properties: Selective binding to imidazole sites in the ventrolateral medulla. Brain Research, 441: 309-318, 1988.

20. Ernsberger, P., Arango, V., and Reis, D.J.: A high density of muscarinic receptors in the ventrolateral medulla of the rat is revealed by correction for autoradiographic efficiency. Neuroscience Letters, 85: 179-186, 1988.

21. Ernsberger, P., Arneric, S.P., Arango, V., and Reis, D.J.: Quantitative distribution of muscarinic receptors and choline acetyltransferase in rat medulla: Examination of transmitter-receptor mismatch. Brain Research, 452: 336-344, 1988.

22. Meeley, M.P., Ernsberger, P., McCauley, P.M., and Reis, D.J.: Clonidine-specific antibodies as models for imidazole and 2-adrenergic receptor binding sites: Implications for the structure of clonidine-displacing substance. Journal of Hypertension, 6 (Supplement 4): S490-S493, 1988.

23. Ernsberger, P., Giuliano, R., Willette, R.N., Granata, A.R., and Reis, D.J.: Hypotensive action of clonidine analogs correlates with binding affinity at imidazole and not 2-adrenergic receptors in the rostral ventrolateral medulla. Journal of Hypertension, 6 (Supplement 4): S554-S557, 1988.

24. Giuliano, R., Ruggiero, D., Morrison, S., Ernsberger, P., and Reis, D.J.: Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla. Journal of Neuroscience, 9: 923-942, 1989.

25. Meeley, M.P., Towle, A.C., Ernsberger, P., Char, L.K., McCauley, P.M., Callaway, J.L., and Reis, D.J.: Clonidine-specific antisera recognize an endogenous clonidine-displacing substance in brain. Hypertension, 13: 341-351, 1989.

26. Hensley, M.L., Meeley, M.P., McCauley, P.M., Ernsberger, P., and Reis, D.J.: Clonidine-displacing substance is present in peripheral tissues of the rat. American Journal of Hypertension, 2: 917-919, 1989.

27. Morrison, S.F., Ernsberger, P., Milner, T.A., Callaway, J., Gong, A., and Reis, D.J.: A glutamate mechanism in the intermediolateral nucleus mediates sympathoexcitatory responses to stimulation of the rostral ventrolateral medulla. Progress in Brain Research, 81: 159-179, 1989.

28. Ernsberger, P., Meeley, M.P., and Reis, D.J.: Neuroblastoma-glioma hybrid cells contain clonidine-displacing substance. European Journal of Pharmacology, 174: 135-138, 1989.

29. Ernsberger, P., Feinland, G., Meeley, M.P., and Reis, D.J.: Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidine-displacing substance. American Journal of Hypertension, 3: 90-97, 1990.

30. Arneric, S.P., Giuliano, R., Ernsberger, P., Underwood, M.D., and Reis, D.J.: Synthesis, release and receptor binding of acetylcholine in the C1 area of the rostral ventrolateral medulla: Contributions in regulating arterial pressure. Brain Research, 511: 98-112, 1990.

31. Ernsberger, P., Giuliano, R., Willette, R.N., and Reis, D.J.: Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. Journal of Pharmacology and Experimental Therapeutics, 253: 408-418, 1990.

32. Arango, V., Ernsberger, P., Reis, D.J., and Mann, J.J.: Demonstration of high- and low-affinity -adrenergic receptors in slide-mounted sections of rat and human brain. Brain Research, 516: 113-121, 1990.

33. Ernsberger, P., Iacovitti, L., and Reis, D.J.: Glia cultured from specific brain regions differ in their expression of adrenergic binding sites. Brain Research, 517: 202-208, 1990.

34. Arango, V., Ernsberger, P., Marzuk, P., Chen, J.-S., Tierney, H., Stanley, M., Reis, D.J. and Mann, J.J.: Autoradiographic demonstration of increased 5-HT2 and -adrenergic receptors in the brains of suicide victims. Archives of General Psychiatry, 47: 1038-1047, 1990.

35. Gomez, R., Ernsberger, P., Feinland, G., and Reis, D.J.: Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. European Journal of Pharmacology, 195: 181-191, 1991.

36. Meeley, M.P., Hensley, M.L., Ernsberger, P., Felsen, D., and Reis, D.J.: Evidence for a bioactive clonidine displacing substance in peripheral tissues and serum. Biochemical Pharmacology, 44: 733-740, 1992.



From Case Western Reserve University School of Medicine

37. Kou, Y.R., Ernsberger, P., Cragg, P.A., Cherniack, N.S. and Prabhakar, N.R.: Role of 2-adrenergic receptors in the carotid body response to isocapnic hypoxia. Respiratory Physiology, 83: 353-364, 1991.

38. Ernsberger, P., Zhou, J., Damon, T., and Douglas, J.G.: Angiotensin II receptor subtypes in cultured rat renal mesangial cells. American Journal of Physiology: Renal, Fluid and Electrolyte Physiology, 263: F411-F416, 1992.

39. Ernsberger, P., Westbrooks, K.L., Schäfer, S.G. and Christen, M.O.: A second generation of centrally-acting antihypertensives acts on putative I1-imidazoline receptors. Journal of Cardiovascular Pharmacology, 20 (Supplement 4): S1-S10, 1992.

40. Haxhiu, M.A., Dreshaj, I., Erokwu, B., Schäfer, S.G., Christen, M.O., and Ernsberger, P.: Vasodepression elicited in hypertensive rats by the selective I1-imidazoline agonist moxonidine administered into the rostral ventrolateral medulla. Journal of Cardiovascular Pharmacology, 20 (Supplement 4): S11-S15, 1992.

41. Ernsberger, P., Damon, T.H., Graff, L.M., Schäfer, S.E., Christen, M.O.: Moxonidine, a centrally-acting antihypertensive agent, is a selective ligand for I1-imidazoline sites. Journal of Pharmacology and Experimental Therapeutics, 264: 172-182, 1993.

42. Liedtke, C.M., Furin, J., and Ernsberger, P.: 2-Adrenergic, but not imidazole, agonists activate NaCl cotransport in rabbit tracheal cells. American Journal of Physiology: Cellular Physiology, 264: C568-C576, 1993.

43. Madhun, Z.T., Ernsberger, P., Ke, F.-C., Zhou, J., Hopfer, U., and Douglas, J.G.: Signal transduction mediated by angiotensin II receptor subtypes expressed in rat renal mesangial cells. Regulatory Peptides, 44: 149-157, 1993.

44. Zhou, J., Ernsberger, P., and Douglas, J.G.: Proposed AT1A and AT1B angiotensin receptor subtypes in rat mesangial cells: Coupling to adenylyl cyclase. Hypertension, 21: 1035-1038, 1993.

45. Ernsberger, P., Koletsky, R.J., Collins, L.A., and Douglas, J.G.: Autoradiographic visualization of renal angi otensin II receptors in obese SHR with glomerulopathy. Hypertension, 21: 1039-1045, 1993.

46. Haxhiu-Poskurica, B., Ernsberger, P., Haxhiu, M.A., Miller, M.J., Cattarossi, L., and Martin, R.J.: Development of cholinergic innervation and muscarinic receptor subtypes in piglet trachea. American Journal of Physiology: Lung Cellular and Molecular Physiology, 264: L606-L614, 1993.

47. Mitra, J, Dev, N.B., Trivedi, R., Amini, S., Ernsberger, P., and Cherniack, N.S.: Intramedullary sodium cyanide injection on respiratory and vasomotor responses in cats. Respiration Physiology, 93: 71-82, 1993.

48. Birnkrant, D.J., Davis, P.B., and Ernsberger, P.: Visualization of high and low-affinity -adrenergic receptors in rat lung: Up-regulation by chronic hypoxia. American Journal of Physiology: Lung Cellular and Molecular Physiology, 265: L389-L394, 1993.

49. Arango, V., Ernsberger, P., Sved, A.F., and Mann, J.J.: Quantitative autoradiography of 1- and 2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Research, 630: 271-282, 1993.

50. Felsen, D., Ernsberger, P., Sutaria, P.M., Nejat, R.J., Nguyen, P., May, M., Breslin, D.S., Broder, S., Marion, D.V., and Vaughan, E.D., Jr.: Identification, localization and functional analysis of prostatic imidazoline and-adrenergic receptors. Journal of Pharmacology and Experimental Therapeutics, 268: 1063-1071, 1994.

51. Evinger, M.J., Ernsberger, P., Regunathan S., Joh, T.H., and Reis, D.J.: A single transmitter regulates gene expression through two separate mechanisms: Cholinergic regulation of PNMT mRNA via nicotinic and muscarinic pathways. Journal of Neuroscience, 14: 2106-2116, 1994.

52. Ernsberger, P., Haxhiu, M.A., Graff, L.M., Collins, L.A., Dreshaj, I., Grove, D.L., Graves, M.E., Schäfer, S.G., and Christen, M.O.: A novel mechanism of action for hypertension control: Moxonidine as a selective I1 imidazoline agonist. Cardiovascular Drugs and Therapy, 8: 27-41, 1994.

53. Haxhiu, M.A., Dreshaj, I., Schäfer, S.G., and Ernsberger, P.: Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla. Journal of Cardiovascular Pharmacology, 24 (Supplement 1): S1-S8, 1994.

54. Dulin, N.O., Ernsberger, P., Suciu, D.J., and Douglas, J.G.: Rabbit renal epithelial angiotensin II receptors. American Journal of Physiology: Renal, Fluid and Electrolyte Physiology, 267: F776-F782, 1994.

55. Ernsberger, P., Koletsky, R.J., Baskin, J.Z., and Foley, M.: Refeeding hypertension in obese SHR. Hypertension, 24: 699-705, 1994.

56. Zheng, L., Berridge, M.S., Ernsberger, P.: Synthesis, binding properties and 18F-labeling of fluorocarazolol, a high-affinity ß-adrenergic receptor antagonist. Journal of Medicinal Chemistry, 37: 3219-3230, 1994.

57. Piletz, J.E., Chikkala, D.N., and Ernsberger, P.: Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and 2-adrenergic receptors. Journal of Pharmacology and Experimental Therapeutics, 272: 581-587, 1995.

58. Buccafusco, J.J., Lapp, C.A., Westbrooks, K.L., and Ernsberger, P.: Role of medullary I1-imidazoline and 2 adrenergic receptors in the antihypertensive response evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats. Journal of Pharmacology and Experimental Therapeutics, 273: 1162-1171, 1995.

59. Yohannan, M.D., and Ernsberger, P.: Heterogeneity of neurokinin1 binding sites in porcine respiratory tract. Peptides, 16: 873-882, 1995.

60. Evinger, M.J., Ernsberger, P., Regunathan, S., and Reis, D.J.: Regulation of PNMT gene expression in adrenal chromaffin cells by imidazoline receptors. Journal of Neurochemistry, 65:988-997, 1995.

Dr. Paul Ernsberger's Publications/Cont'd