Key Factors that Stimulate Brain Tumor Cells to Spread are Identified by the Lab of Susann Brady-Kalnay
A new paper published by the lab of Susann Brady-Kalnay and collaborators, which was funded by the National Institutes of Health, have found that the activity of a protein tyrosine phosphatase fragment in brain cells helps stimulate the spread of an aggressive brain tumor called glioblastoma multiforme (GBM). This group showed that a small designer peptide can block this phosphatase activity and reduce the spreading of GBM cells grown in the laboratory.
The findings are the result of a research project by graduate student Adam Burgoyne and have been published in Cancer Research [Full Article] subscription may be required. Additional collaborators include Case Western Reserve faculty and neurosurgeons Shenandoah Robinson, M.D. and Andrew E. Sloan, M.D., and Robert H Miller, Ph.D., an expert on glial cell development.
Full text of the announcement by the National Institute of Health may be found HERE.
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