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Research:
My project involves delineating the biochemical mechanism(s) by which P-TEFb is mobilized from the 7SK snRNP nuclear complex upon T cell receptor activation of CD4+ T lymphocytes. I'm also interested in understanding how, after its mobilization, P-TEFb becomes recruited to the HIV LTR to facilitate processive transcription of the latent provirus.
Select Publications:
Mbonye UR, Song I. Posttranscriptional and posttranslational determinants of cyclooxygenase expression. BMB Rep. 2009 Sep 30;42(9):552-60. [PubMed]
Mbonye UR, Yuan C, Harris CE, Sidhu RS, Song I, Arakawa T, Smith WL. Two distinct pathways for cyclooxygenase-2 protein degradation. J Biol Chem. 2008 Mar 28;283(13):8611-23. Epub 2008 Jan 18. [PubMed]
Kang YJ, Mbonye UR, DeLong CJ, Wada M, Smith WL. Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation. Prog Lipid Res. 2007 Mar;46(2):108-25. Epub 2007 Jan 18. [PubMed]
Mbonye UR, Wada M, Rieke CJ, Tang HY, Dewitt DL, Smith WL: The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system. J Biol Chem. 2006 Nov 24;281(47):35770-8. Epub 2006 Sep 25. [PubMed]
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