Current Students
G. Thomas Brown
Advisor: Dr. Thomas McIntyre
Research Interests: To elucidate the molecular mechanisms of LPS-induced activation of human platelets. While the TLR4 signaling pathway has been well-studied in nucleated cells, this has not been the case with platelets.
Kan Chen.
Advisor: Dr Roy Silverstein.
Research Interests: Defining the mechanisms of CD36 function in platelets. CD36 was functionally identified as a class B scavenger receptor that recognizes a large variety of ligands, including oxidized low density lipoprotein (oxLDL), advanced glycated end products (AGE), and apoptotic cells. These ligands form in the setting of chronic diseases, such as hyperlipidemia, atherosclerosis, diabetes, inflammation, and cancer, all of which are associated with a prothrombotic state. Mechanism of platelet regulation by these pathological ligands for CD36 and the mechanisms by which CD36 may contribute to pathological thrombosis.
Ling-Yun Chu.
Advisor: Dr. Roy Silverstein.
Research Interests: CD36 is required for Thrombospondin-1(TSP-1)
mediated anti-angiogenesis. The binding of TSP-1 to CD36 can be
blocked by the phosphorylation of T92 on CD36. The
regulation of CD36 T92 phosphorylation by CD36 ligands in macrophages
and endothelial cells.
- Oral presentation at Experimental Biology 2008 (San Diego, CA)
- Title: "TSP-1 Binds Thr92 Phosphorylated CD36 in a Calcium Dependent Manner and the Ligans of CD36 Regulate the Phosphorylation of Thr92 in Mouse Macrophages."
Amanda Finan.
Advisor: Dr. Marc Penn.
Research Interests: The identification of the transcription factors
involved in the differentiation of embryonic stem cells to cardiac
myocytes. The goal is to then deliver these transcription factors to
embryonic stem cells by cell penetrating peptides to increase the yield
of differentiated cardiac myocytes.
Young-mi Park.
Advisor: Dr. Roy Silverstein.
Research Interests: Macrophage cytoskeletal signaling that is modulated by the transmembrane glycoprotein receptor CD36. CD36 functions as a scavenger receptor for oxidized LDL and CD36 deficiency protects against atherosclerosis. Mechanism of how CD36 mediated signaling influences cell migration and contributes to atherosclerosis.
- Poster presentation
- Junior Investigator Award for Women Finalist, presented by the American Heart Association Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
at the Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) Annual Conference 2007 (April 2007, Chicago, Illinois)
- Oral presentation at Vascular Biology 2008
- Junior Investigator Award Finalist, presented by the North American Vascular Biology Organization (NAVBO)
Experimental Biology 2008 (Annual Conference of the Federation of American Societies for Experimental Biology
at (FASEB), April 2008, San Diego, California)
- Poster presentation
- Honorable Mention (Prize from the Graduate Student Poster Contest)
at Research Show CASE (April 2008, Case Western Reserve Unversity)
Nikolai Sopko.
Advisor: Dr. Marc Penn
Research Interests: The effects of aging on stem cell mediated repair of the heart in pressure overload heart failure.
Arundhati Undurti.
Advisor: Dr. Stanley Hazen.
Research Interests: Project uses a variety of approaches including proteomics to understand the structural interactions between apolipoprotein A1 (the major protein in HDL) and it's receptor scavenger receptor B1 (SR-B1). Interested in how these interactions influence both the efflux and anti-apoptotic functions of HDL.
Recent
graduates
Maria
Bamberger
(2002) "Identification of a Cell Surface Receptor Complex for Fibrillar
beta-Amyloid the Mediates Microglial Activation" (G. Landreth laboratory)
Currently at University of New Hampshire (Durham, NH)
Emil
Chuck
(1998) "The Development of the His-Purkinje System: Electrophysiological
and Anatomical Correlations in the Embryonic Heart" (M. Watanabe
laboratory)
Currently at George Mason University (Washington, D.C.)
Mark
Frey
(2001) "Interaction of snRNA Genes with Cajal Bodies" (G. Matera laboratory)
Currently at Vanderbilt University (Nashville, TN)
Lynn
Horton (1996) "Studies on Cyclin Structure and Rb Phosphorylation in Cell
Cycle Control" (D. Templeton laboratory)
Currently at Hawken School (Cleveland, OH)
Malathy
Mahalingham
(1996) "Mechanisms of S6 Kinase Signaling" (D. Templeton laboratory)
Currently at Hutchinson Cancer Research Institute (Seattle, WA)
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