Welcome to the van den Akker Lab!
Structural Biology on Drug Target Proteins
The overall goal of my research is to elucidate the molecular intricacies of enzyme mechanism and receptor activation. Our projects range from guanylyl cyclases (blood pressure, vision, and bone growth) to beta-lactamases (responsible for the current epidemic antibiotic resistance). Our lab employs state of the art multi-disciplinary biophysical, biochemical, crystallographic, molecular biology, computational, and cell biology techniques.