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The overall goal of my research is to elucidate
the molecular intricacies of
enzyme mechanism and receptor activation. Our
projects range from guanylyl cyclases (blood pressure, vision, and bone
growth) to beta-lactamases (responsible for the current epidemic
antibiotic resistance). Our lab employs state of the art
multi-disciplinary biophysical, biochemical, crystallographic, molecular
biology, and cell biology techniques.
(van den Akker lab is funded by NIH R01, R21, R56, AHA SDG, and Steris Foundation) |
