Biochemistry Department - Primary Faculty
Primary Faculty
Zhuli Wan, Ph.D.
Instructor
Education
- Ph.D.: The Structural Biology, Institute of Biophysics of Chinese Academy of Sciences
- Postdoc: The Structural Biology Laboratory, The University of York, UK.
Research Interests
My research interests concern structure-function relationships in proteins. The protein structures determined and analysed by X-ray crystallographic methods.
Selected References
- Wan ZL, Huang K, Hu SQ, Whittaker J & Weiss MA
“The Structure of a Mutant Insulin Uncouples Receptor Binding from Protein Allostery. an electrosratic block to the TR transition ”
J. Biol. Chem 283(30),21198-21210 (2008). - Wan ZL,Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG & Weiss MA
“Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama”
Biochemistry 44(13),5000-5016 (2005). - Wan ZL, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis
PG & Weiss MA
“Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.”
Biochemistry 43(51),16119-16133 (2004) - Bayrer J, Wan ZL, Li B & Weiss MA
“Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex ”
Acta Crystallogr D Biol Crystallogr 60,1328-1330.Epub (2004). - Wan ZL, Xu B, Chu YC, Katsoyannis PG & Weiss MA
“Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding ”
Biochemistry 42(44),12770-83 (2003).
