Case Western Reserve University

The Biochemistry faculty has a wide range of research interests from cell biology to molecular biophysics. Primary faculty have their main affiliation with the Department of Biochemistry and are based within the department. Secondary faculty have their main affiliation with other departments or centers, including the RNA center. Students can thus work in virtually any field in current biomedical research.

Primary Faculty
Barbara Bedogni	Melanoma development and progression.
Paul Carey	Protein-ligand interaction and Raman spectroscopy.
Richard W. Hanson	Hormonal control of gene expression.
Michael Harris	Structure and function of large ribozymes (RNA enzymes) including ribonuclease P RNA. Mechanisms of catalysis by ribozymes
Nikki Harter	Molecular mechanisms of adult stem cells and the transformation of melanocytes.
Hung-Ying Kao	Signaling pathways controlled by transcription corepressors and histone deacetylases.
William C. Merrick	Mechanism and regulation of eukaryotic protein bioshynthesis.
Nelson F. B. Phillips	Biochemical mechanisms of tissue-specific transcription factors.
Marianne Pusztai-Carey	Structure and function of the insecticidal proteins expressed by the Bacillus thuringiensis family.
Amy Ruschak	Molecular basis of caspase activation in cell death and immune response pathways.
David Samols	The mammalian response to inflammation; function and regulation of the acute phase reactant, C-reactive protein.
Menachem Shoham	Drug discovery against infectious diseases, heart disease and cancer.
Martin Snider	Intracellular movement of cell-surface receptors during endocytosis.
Saba Valadkhan	Role of the mammalian long non-coding RNAs in neurogenesis and cancer.
Focco van den Akker	Multi-facetted structural approach to understanding the molecular signal transduction events of membrane receptors.
Zhuli Wan	X-ray crystallography.
Michael Weiss	Structural mechanisms of human diseases, transcriptional deregulation, and protein misfolding with applications to diabetes and disorders of sexual development.
Jonathan Whittaker	Structure and function of the insulin receptor family.
Yanwu Yang	Protein-protein interaction, multidimensional NMR spectroscopy.
Yu-Chung Yang	Cytokine signal transduction, transcription factors, hematopoiesis, and cancer.
Vivien C. Yee	Structure-function studies of enzymes and prion proteins using X-ray crystallography.

RNA Center Faculty
Kristian Baker	Mechanisms of the nonsense-mediated mRNA decay.
James P. Bruzik	Regulation of alternative pre-mRNA splicing.
Jeffery Coller	Translational control and mRNA decay.
Pieter deHaseth	Mechanism of RNA polymerase-DNA interactions.
Jonatha Gott	Mechanistic studies of RNA editing in Physarum mitochondria.
Eckhard Jankowsky	Molecular Mechanisms of RNA Helicases
Ahmad Khalil	Epigenetic Regulation of the Genome, Histone Modifications and Non-coding RNA.
Donny Licatalosi	Gene expression, alternative RNA regulation, protein-RNA interactions, mammalian germ cell biology.
Timothy Nilsen	Mechanisms of post transcriptional gene regulation.

Secondary Faculty
Dr. Nathan Berger	PolyADP-ribose metabolism in DNA repair and replication.
Dr. Henri Brunengraber	Nutritional Biochemistry.
Dr. Thomas Gerken	Biosynthesis of O-Linked Glycans.
Dr. Vincent Hascall	Structure, function and metabolism of proteoglycans and hyaluronan in connective tissues.
Dr. Douglas Kerr	Metabolic disorders in infants.
Dr. Donal Luse	Eukaryotic gene transcription and RNA polymerase.
Dr. Vincent Monnier	Biochemistry of aging.
Dr. Nancy Oleinick	Control of cell death and sensitivity of tumor cells to photodynamic therapy.
Dr. Jun Qin	Biomolecular NMR spectroscopy, signal transduction.
Dr. David Sedwick	Genetic approaches to drug mechanism and development.
Dr. Ganes Sen	Mammalian gene expression anantiotensin-converting enzyme and interferon.
Marion J. Skalweit	Mechanisms of antimicrobial resistance.
Dr. Jonathan Stamler	Redox-based cellular regulation and signal transduction, and in particular the role of protein S-nitrosylation.
Dr. John Stuehr	Dynamics of metal complexation reactions and elementary steps in enzymes.
Dr. Martina Veigl	Calmodulin regulation in differentiation of blood cells and DNA repair.
Dr. James Zull	Human learning.

Other Biochemistry Trainers
Dr. Scott Welford	The impact of hypoxia (low oxygen) on tumor initiation and resistance to therapy.