|
Kingman P. Strohl, M.D.
Center for Sleep Disorders Research
This center
interacts with a wide variety of programs
involved in the pathogenesis and management of
sleep apnea, a disorder involving the physiology
of breathing and sleep. Sleep apnea is a common
condition, occurring in some 2 - 4% of the
population. There is little recognition of its
role in producing illness in the community:
however, in its extreme form, those with
multiple apneas (upper airway occlusion) during
sleep present in middle-age suffering from the
complications of sleep interruption (sleepiness)
and intermittent asphyxia (hypoxia and
hypercapnia). How does this illness develop?
What are the mechanisms for symptom expression?
Can we create animal models of sleep apnea or
its componenets- obesity, blunting of
respiratory drive, craniofacial features, upper
airway function etc.?
Our concept is
breathing and breathing during sleep should be
considered as a behavior, in part genetically
determined but to a large degree modified by
growth and experience. The domains of interest
are respiratory and sleep neurobiology. An
emerging area of our interest is in the genetic
dissection of respiratory traits of ventilatory
control and factors that intiate and maintain
sleep. Funded projects involve animal models of
obesity, ventilatory control, and sleep, as well
as human studies of upper airway fucntion and
disease expression.
Selected References:
Strohl KP,
Thomas AJ, Schlenker EH, Koletsky RJ, St. Jean
P, Schork NJ. Ventilation and metabolism among
rat strains. J Appl Physiol 82(1):317-323, 1997.
Redline S,
Tishler PV, Hans MG, Tosteson TD, Spry K, Strohl
KP. Sleep-disordered breathing in
african-americans and caucasions: Racial
differences in age of onset and underlying risk
factors. Am J Respir Crit Care Med 155:186-192,
1997.
Strohl KP,
Strobel RJ, Parisi R. Obesity and Pulmonary
Function. In: Handbook of Obesity. Eds.,
Bray GA, Bouchard C, James, WPT, Marcel Dekker,
Inc., New York, 725-739, 1997.
Strohl KP,
Beall C. Ventilatory responses to experimental
hypoxia in adult male and female natives of the
Tibetan and Andean plateaus. In:
Hypoxia Women at Altitude, Ed. Charles S.
Houston, Queen City Printer, Inc., Burlington,
Vermont, 154-165, 1997.
Strohl KP,
Thomas AS. Neonatal conditioning for adult
respiratory behavior. Respiratory Physiology
110:269-275, 1997.
Dick TE,
Haxhiu MA, Strohl KP. Respiratory control. In:
Comprehensive Textbook of Pulmonary Medicine,
Mosby-Year Book, Inc., St. Louis, Missouri,
Chapter 4:1-17, 1997.
Strohl KP,
Thomas AS. Neonatal conditioning for adult
respiratory behavior. Respiratory Physiology
110:269-275, 1997. |
