Dr. Hanson and Dr. Kalhan (as part of the Perinatal Research Center of CWRU) are studying the regulation of metabolic processes in the fetus and the mother during the immediate perinatal period.
Drs Hoppel, Stanley and Brunengraber have collaborated on the potential of anaplerotic medium-odd-chain fatty acids for the treatment of cardiac reperfusion injury.
Drs Weiss and Whittaker collaborate on studies of the molecular mechanisms underlying interactions of the insulin-IGF family of peptides and their cognate receptors.
Drs Hatzoglou and Snider work on the regulation of expression of the cat1 gene which encodes a plasma membrane transporter for the cationic amino acids, arginine and lysine.
One of our former trainees, Dr Colleen Croniger (Associate Professor in the Department of Nutrition of CWRU) continues to collaborate with Dr Satish Kalhan, studying the development of carbohydrate metabolism. The above mentioned collaborations are just some of the several active participations between MTP trainers and past trainees.
PRE-DOCTORAL TRAINING: Academic Curriculum for Graduate Students in the Program ? The Metabolism Training Program is part of the interdepartmental Biomedical Scientist Training Program (BSTP) at CWRU (see web site http://www.cwru.edu/med/BSTP/index.html). All graduate students are formally enrolled in the BSTP and can receive a PhD degree from a variety of participating graduate education programs. Therefore, our trainees are not restricted to only one or two departments of the Medical School.
Graduate students are invited to begin their education early in the summer before the school year officially begins in order to become acquainted with the research activities of our faculty. Many of the new students work on research projects in the laboratories of the Training Faculty and have an early exposure to the metabolic research available to them during their thesis years.
Curriculum in Metabolism and Nutrition at CWRU leading to a PhD Degree:
A PhD program, linking nutrition and metabolic biochemistry with molecular biology and genetics, is offered to all trainees in the Metabolism Training Program. This educational component of the Program builds on core courses in the Departments of Nutrition, Biochemistry, Genetics, Molecular Biology, Pharmacology, Physiology, and Biomedical Engineering.
POST-DOCTORAL TRAINING: Postdoctoral scholars are admitted into the Program uncommitted to an individual investigator and are provided support for the full 3 years of training. The Program welcomes both PhD and MD scholars for training and has been successful over the years in attracting and supporting MD scholars for a career in academic medicine in areas related to metabolic research. The career progress of postdoctoral scholars supported by the Program is reviewed regularly by the Steering Committee to insure that the trainees are achieving their research goals. Postdoctoral scholars planning a traditional academic career in a university setting are provided an opportunity to teach a metabolic elective in an advanced seminar course taught to undergraduates in the Dept of Biochemistry.
Metabolic Regulation Journal Club: The Program organizes and sponsors a Metabolic Regulation Journal Club devoted to topics in metabolic research. The Journal Club is attended by a broad cross section of faculty and students both in an out of the Program. The Journal Club was organized in 1978 by the Program leadership as a vehicle for maintaining an interest in metabolism and has been expanded in its emphasis to include areas of molecular and cellular biology and biochemistry as they relate to the interests of the participants. The Journal Club may often present material outside the normal field of interest of a trainee, and thus serve as a means of broadening the education of our students, scholars and faculty. In making Journal Club presentations, the trainees practice the preparation and delivery of a scientific lecture.
Departmental Seminars, a Metabolism Interest Discussion Group, Metabolism-specific Seminar Program, and Memorial Lectures are organized and offered every semesters.
The CWRU School of Medicine is currently ranked 15th in NIH funding. This level of support and the generous investment of the University and members of the Cleveland community, has allowed us to build an excellent, modern research environment to support the work of our Training Faculty. This environment is available to the trainees of the Program.
During the past 10 years, there have been several important developments in the research environment at CWRU that impacted significantly on the Metabolism Training Program. These include the establishment of Biomedical Research Cleveland, an organization consisting of Case Western Reserve University, The Cleveland Clinic Research Foundation, Cleveland State University, MetroHealth Center and University Hospitals of Cleveland.
Case School of Medicine is home to close to 30 Centers and Institutes. As a result, medical students are able to pursue areas of interest in great depth. Read more...
Have a question? From deadlines to requirements, please email Dr. Henri Brunengraber (Program Director) at: hxb8@case.edu
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