Rudy-CV

Biographical Sketch

	Affiliation and Title
	Education
	Professional Experience
	Honors
	Visiting Professorships
	NIH Committees
	Other Review Committees
	Nominations for Excellence in Teaching
	Editorial Boards
	Reviewer & Editorial Consultant
	Professional Societies
	Publications in Refereed Journals
	Books and Chapters
	Conference Proceedings & Editorials
	Abstract
	Patents
	Reports in the General Press
	Invited Presentations
	Other Professional Activities
	Post Doctoral Fellows
	Graduate Students
	University & Departmental Activities
	Teaching
	Grants
	Research Activities

Affiliation and Title:

Name	Yoram Rudy
Title	The M. Frank and Margaret C. Rudy Professor of Cardiac Bioelectricity, Professor of Biomedical Engineering, Physiology and Biophysics, and Medicine (Cardiology) Director, Cardiac Bioelectricity Research and Training Center (CBRTC)
Address	Cardiac Bioelectricity Center 509 Wickenden Building Case Western Reserve University Cleveland, Ohio 44106-7207 USA Phone: (216) 368-4051 FAX: (216) 368-8672 Email: yxr@cwru.edu Website: http://www.cwru.edu/med/CBRTC

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Education:

Technion, Haifa, Israel, B.Sc., 1971, Physics

Technion, Haifa, Israel, M.Sc., 1973, Physics

Case Western Reserve University, School of Medicine, 1 year, 1976

Case Western Reserve University, Ph.D., 1978, Biomedical Engineering

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Professional (Research/Teaching) Experience:

1994-	Director, Cardiac Bioelectricity Research and Training Center Case Western Reserve University
1989-	Professor, Department of Biomedical Engineering Case Western Reserve University
1998 -	Professor, Department of Physiology and Biophysics Case Western Reserve University
1991 -	Professor, Combined Program in Biophysics/Bioengineering Case Western Reserve University
1992 -	Professor, Department of Medicine, Division of Cardiology Case Western Reserve University
1986 - 1989	Associate Professor, Department of Biomedical Engineering Case Western Reserve University
1981 - 1986	Assistant Professor, Department of Biomedical Engineering Case Western Reserve University

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Honors:

Member of the National Academy of Engineering (since 2003)
Citation: “For leadership in the engineering sciences of cardiac excitation at the genetic and molecular levels and for introducing new methods in clinical diagnosis and therapy”

NIH MERIT Award, September, 1998

The Biomedical Engineering Society (BMES) 2001 Distinguished Lectureship Award

Fellow of the American Physiological Society
Citation: "For outstanding research contributions in the field of cardiac electrophysiology"

Fellow of the Institute of Electrical and Electronics Engineers (IEEE)
Citation: "For contributions to mathematical descriptions and solutions applicable
to cardiac electrophysiology"

Fellow of the American Institute of Medical and Biological Engineering (AIMBE)
Citation: "In recognition of outstanding contributions to the field of medical and biological engineering"

The Gordon K Moe Professorship Award, Masonic Medical Research Laboratory, 1997.
Citation: “In recognition of outstanding contributions to science and medicine in
the fields of cardiac electrophysiology and arrhythmias”

The A.C. Suhren Jr. Scholar, Tulane University, 1998.

Keynote Address, Biomedical Engineering Day, Washington University in St. Louis,
March, 2001.

The Rijlant Distinguished Lecturer, International Congress on Electrocardiology, Milan,
Italy, 2000.

The Ueda Memorial Lecture Award, The Japanese Society of Electrocardiology and Japan
College of Cardiology, Nagoya, Japan, September 2002.

Sigma Xi

Who's Who in America

Who's Who in Science and Engineering

Who's Who in the World

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Visiting Professorships:

Technion - Israel Institute of Technology, Haifa, Israel, Department of Biomedical Engineering (Dec. 1982 - Mar. 1983).

University of Parma, Italy, Institute of General Physiology (July 1986 and July 1987).

University of Berne, Switzerland, Department of Physiology (May 1990).

University of Utah, Salt Lake City, The Nora Eccles Harrison Cardiovascular Research and Training Institute (October 1990).

Tel-Aviv University, Israel, Department of Physics and Astronomy (June - July, 1991).

Columbia University, College of Physicians and Surgeons, Department of Pharmacology,
New York, August 1994.

Cornell University, Department of Physiology, Ithaca, New York, October 1994.

Masonic Medical Research Laboratory, Utica, New York, December 1995.

Russian Academy of Sciences, St. Petersburg, June 1997.

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NIH Committees:

Member, Cardiovascular and Pulmonary Study Section, July 1, 1984 - June 30, 1988.

Member, National Institutes of Health Reviewers (NRR), July 1, 1988 - June 20, 1992.

Ad Hoc member, Cardiovascular and Pulmonary Study Section, July 1, 1983 - June 30, 1984.

Member, Special Study Section on Dysrhythmias in the Developing and Immature Heart, June 27-29, 1983.

Member, Small Business Innovative Research Review Committee, February 14, 1984.

Member, site visit teams for various Program Project Grant applications.

Task force on developing a long-term plan for imaging research, 1994.

Ad Hoc member of various Study Sections, 1992 -

Panelist, Bioengineering - Building the Future of Biology and Medicine, February 27-28, 1998.

Panelist, Biomedical Imaging - Visualizing the Future of Biology and Medicine, June 25-16, 1999.

Review of Grants for Centers of Excellence in Computational Biology, October 25, 2002.

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Other Review Committees:

The Whitaker Foundation

National Science Foundation

Medical Research Council of Canada

American Heart Association

The Wellcome Trust

Pittsburgh Supercomputing Center (PSC)

Fondues FCAR, Canada

FRSQ, Quebec, Canada

United States-Israel Binational Science Foundation

The Israel Science Foundation

The Israel Academy of Science

The Austrian Science Fund

Review and evaluation of research programs at the Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City (October 18-20, 1990).

Review of the Center for Biomedical Modeling and Simulation, University of Montreal/Ecole Polytechnique, Montreal, Canada (January 8-9, 1991).

Review of the Experimental Cardiology Program, Masonic Medical Research Laboratory, Utica, New York (September 11-12, 1997).

Review and site visit, Whitaker Foundation Leadership Award Application, Johns Hopkins University (September 15-16, 1998).

Review and site visit, The University of Oklahoma Bioengineering Center, (June 2002, June 2003).

NIH Special Emphasis Review Panel, (November 2003).

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Nominations for Excellence in Teaching:

John S. Diekhoff Award for Excellence in Graduate Teaching, 1994.

The Carl F. Wittke Award for Distinguished Undergraduate Teaching, 1999.

Excellence in Mentoring Graduate Students, 1999.

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Editorial Boards:

Cardiovascular Research

Heart Rhythm (Section Editor, “Viewpoints”)

Journal of Cardiovascular Electrophysiology (Section Editor, "Point of View")

Journal of Electrocardiology

Cardiac Electrophysiology Review

Cardiovascular Engineering: An International Journal

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Reviewer and Editorial Consultant:

Nature

Science

Proceedings of the National Academy of Sciences, U.S.A.

Journal of Physiology (London)

Circulation Research

Journal of the American College of Cardiology

Circulation

Biophysical Journal

American Journal of Physiology

Cardiovascular Research

Journal of Cardiovascular Electrophysiology

Journal of Molecular and Cellular Cardiology

IEEE Transactions on Biomedical Engineering

Annals of Biomedical Engineering

Journal of Electrocardiology

Medical and Biological Engineering and Computing

Medical Engineering and Physics

Mathematical Biosciences

Journal of Theoretical Biology

Journal on Inverse Problems

Inverse Problems in Engineering

Heart and Vessels

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Professional Societies:

National Academy of Engineering (NAE)

American Institute of Medical and Biological Engineering (AIMBE)

American Association for the Advancement of Science

IEEE Engineering in Medicine and Biology Society

Basic Science Council of the American Heart Association

Biomedical Engineering Society (BMES)

Cardiac Electrophysiology Society

American Physiological Society

Biophysical Society

New York Academy of Science

International Society for Computerized Electrocardiology

North American Society of Pacing and Electrophysiology (NASPE)

International Society of Electrocardiology

Central Society for Clinical Research

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Publications in Refereed Journals:

Y. Rudy and R.Plonsey, “A note on the Brody-Effect” J Electrocardiology 1978; 11: 87-90.

Y. Rudy and R. Plonsey, "The Eccentric Spheres Model as the Basis for a Study of the Role of Geometry and Inhomogeneities in Electrocardiography” IEEE Trans Biomed Eng BME 1979; 26: 392-399.

Y. Rudy , R. Plonsey, and J. Liebman, "The Effects of Variations in Conductivity and Geometrical Parameters on the Electrocardiogram, Utilizing an Eccentric Spheres Model” Circ Res 1979; 44: 104-111.

R. Plonsey and Y. Rudy , "Electrocardiogram Sources in a 2-Dimensional Anisotropic Activation Model” Medical and Bio Eng and Comp 1980; 18: 87-94.

Y. Rudy and R. Plonsey, "A Comparison of Volume Conductor and Source Geometry Effects on Body Surface and Epicardial Potentials” Circ Res 1980; 46: 283-291.

Y. Rudy and R. Plonsey, "Comments on the Effect of Variations in the Size of the Heart on the Magnitude of ECG Potentials” J Electrocardiology 1980; 13: 79-82.

J. Liebman, C. Thomas, Y. Rudy , and R. Plonsey, "Electrocardiographic Body Surface Potential Maps of the QRS of Normal Children” J Electrocardiology 1981; 14: 249-260.

Y. Rudy , R. Wood, R. Plonsey, and J. Liebman, "The Effect of High Lung Conductivity on ECG Potentials: Results Obtained from Human Subjects Undergoing Bronchopulmonary Lavage” Circulation 1982; 65: 440-445.

P. Diaz, Y. Rudy , and R. Plonsey, "A Model Study of the Effect of the Intercalated Discs on Discontinuous Propagation in Cardiac Muscle” Advances in Experimental Medicine and Biology 1983; 161 ("Myocardial Injury"): 79-90.

P. Diaz, Y. Rudy , and R. Plonsey, "The Intercalated Discs as a Cause for Discontinuous Propagation in Cardiac Muscle: A Theoretical Simulation” Annals of Biomedical Engineering 1983; 11: 177-189.

J. Liebman, Y. Rudy , P. Diaz, C.W. Thomas, and R. Plonsey, "The Spectrum of Right Bundle Branch Block as Manifested in Electrocardiographic Body Surface Potential Maps” J Electrocardiology 1984; 17: 329-346.

B.J. Messinger-Rapport and Y. Rudy , "Effects of the Torso Boundary and Internal Conductivity Interfaces in Electrocardiography: An Evaluation of the "Infinite Medium" Approximation” Bulletin of Mathematical Biology 1985; 47: 685-694.

B.J. Messinger-Rapport and Y. Rudy , "The Inverse Problem in Electrocardiography: A Model Study of the Effects of Geometry and Conductivity Parameters on the Reconstruction of Epicardial Potentials” IEEE Trans Biomed Eng BME 1986; 33: 667-676.

Y. Rudy and W. Quan, "A Model Study of the Effects of the Discrete Cellular Structure on Electrical Propagation in Cardiac Tissue” Circ Res 1987; 61: 815-823.

L. Widman, J. Liebman, C.W. Thomas, R. Fraenkel, and Y. Rudy , "Electrocardiographic Body Surface Potential Maps of the QRS and T of Normal Young Adults - Qualitative Description and Selected Quantifications” J Electrocardiology 1988; 21: 121-136.

J.N. Amoore and Y. Rudy , "The Effect of Variations of Ventricular Volume on the Electrocardiogram. A Comparison of Two Models” J Electrocardiology 1988; 21: 154-160.

B.J. Messinger-Rapport and Y. Rudy , "Regularization of the Inverse Problem in Electrocardiography: A Model Study” Mathematical Biosciences 1988; 89: 79-118.

J.N. Amoore, Y. Rudy , and J. Liebman, "Respiration and the ECG. A Study Using Body Surface Potential Maps” J Electrocardiology 1988; 21: 263-271.

Y. Rudy and B.J. Messinger-Rapport, "The Inverse Problem in Electrocardiography: Solutions in terms of Epicardial Potentials” CRC Critical Reviews in Biomedical Engineering 1988; 16: 215-268.

F. Dexter, G.M. Saidel, M.N. Levy, and Y. Rudy , "Mathematical Model of the Dependence of Heart Rate on the Tissue Concentration of Acetylcholine” Am J Physiol 1989; 256 (Heart Circ Physiol 25): H520-H526.

F. Dexter, Y. Rudy , M.N. Levy, "Muscarinic Autoreceptors do not Modulate Kinetics of Acetylcholine Release in Hearts” Am J Physiol 1989; 256 (Heart Circ Physiol 25): H1073-H1078.

J. Liebman, C.W. Thomas, R. Fraenkel, and Y. Rudy , "Analysis of the Hypoplastic Right Ventricle Utilizing Electrocardiographic Body Surface Potential Mapping” J Electrocardiology 1989; 22: 195-209.

F. Dexter, M.N. Levy, Y. Rudy , "Mathematical Model of the Changes in Heart Rate Elicited by Vagal Stimulation” Circulation Research 1989; 65: 1330-1339.

B.J.Messinger-Rapport and Y. Rudy , "Computational Issues of Importance to the Inverse Recovery of Epicardial Potential in a Realistic Heart-Torso Geometry” Mathematical Biosciences 1989; 97: 85-120.

D. Khoury, H. McAlister, B. Wilkoff, T. Simmons, Y. Rudy , R. McCowan, V. Morant, L. Castle, and J. Maloney, "Continuous Right Ventricular Volume Assessment by Catheter Measurement of Impedance for Antitachycardia System Control” PACE 1989; 12: 1918-1926.

F. Dexter, G.M. Saidel, and Y. Rudy , “Simulation of the diffusion of Acetylcholine in the Neuroeffector Junctions of the Sinus Node” J Theo Boils 1989; 141: 505-514.

W. Quan and Y. Rudy , "Unidirectional Block and Reentry of Cardiac Excitation–A Model Study” Circulation Research 1990; 66: 367-382.

B.J. Messinger-Rapport and Y. Rudy , "Non-Invasive Recovery of Epicardial Potentials in a Realistic Heart-Torso Geometry: Normal Sinus Rhythm” Circulation Research 1990; 66: 1023-1039.

Y. Reich, C.W. Thomas, J. Liebman, Y.H. Pao, and Y. Rudy , "Multi-Category Classification of Body Surface Potential Maps” IEEE Trans Biomed Eng BME 1990; 37: 945-955.

J. Liebman, B. Olshansky, A. Zeno, A. Geha, Y. Rudy , W. Henthorn, M. Cohen, and A.L. Waldo, "Electrocardiographic Body Surface Potential Mapping in the Wolff - Parkinson -White Syndrome: Non-invasive Determination of the Ventricular Insertion Sites of AV Connections” Circulation 1991; 83: 886-901.

F. Dexter, Y. Rudy , M.N. Levy, and E.N. Bruce, "Mathematical Model of Cellular Basis for the Respiratory Sinus Arrhythmia” J Theor Biol 1991; 150: 157-173.

A. Shimizu, A. Nozaki, Y. Rudy and A.L. Waldo, "Onset of Induced Atrial Flutter in the Canine Pericarditis Model” J Amer College Cardiol 1991; 17: 1223-1234.

A. Shimizu, A. Nozaki, Y. Rudy , and A.L. Waldo, "Multiplexing Studies of the Effects of Rapid Atrial Pacing on the Area of Slow Conduction During Atrial Flutter in the Canine Pericarditis Model” Circulation 1991; 83: 983-994.

C. Luo and Y. Rudy , "A Model of the Ventricular Cardiac Action Potential: Depolarization, Repolarization and their Interaction” Circulation Research 1991; 68: 1501-1526.

Y. Rudy and W. Quan, "Propagation Delays Across Gap Junctions and their Reflection in Extracellular Potentials: a Simulation Study” J Cardiovascular Electrophysiology 1991; 2: 299-315.

W. Quan and Y. Rudy , "Termination of Reentrant Propagation by a Single Stimulus - A Model Study” PACE 1991; 14: 1700-1706.

H.S. Oster and Y. Rudy , "The Use of Temporal Information in the Regularization of the Inverse Problem of Electrocardiography” IEEE Trans Biomed Eng 1992; 39: 65-75.

Y. Rudy and H.S. Oster, "The Electrocardiographic Inverse Problem” CRC Critical Reviews in Biomedical Engineering 1992; 20: 25-46.

D. Khoury and Y. Rudy , "A Model Study of Volume Conductor Effects on Endocardial and Intracavitary Potentials” Circulation Research 1992; 71: 511-525.

J. Liebman, C.W. Thomas, and Y. Rudy , "Electrocardiographic Body Surface Potential Mapping Many Years After Successful Surgery for Coarctation of the Aorta” J Electrocardiology 1993; 26: 25-41.

A. Shimizu, A. Nozaki, Y. Rudy , and A.L. Waldo, "Characterization of Double Potentials in a Functionally Determined Reentrant Circuit” J Amer Coll Cardiol 1993; 22: 2022- 2032.

J. Ortiz, M. Igarashi, H.X. Gonzalez, K. Laurita, Y. Rudy , and A.L. Waldo, "Mechanism of Spontaneous Termination of Stable Atrial Flutter in the Canine Sterile Pericarditis Model” Circulation 1993; 88: 1866-1877.

Y. Rudy and C. Luo, "Cellular Responses to Electrical Stimulation–A Study Using a Model of the Ventricular Cardiac Action Potential” Adv Exp Med Biol 1993; 346: 79-90.

F. Dexter, Y. Rudy , and G.M. Saidel, "Mathematical Model of Acetylcholine Kinetics in Neuroeffector Junctions” Am J Physiol 1994; 266 (Heart Circ. Physiol 35): H298- H309.

J .Ortiz, S. Niwano, H. Abe, H.X. Gonzalez, Y. Rudy , N. Johnson and A.L. Waldo, "Mapping the Conversion of Atrial Flutter to Atrial Fibrillation and Atrial Fibrillation to Atrial Flutter - Insights into Mechanism” Circulation Research 1994; 74: 882-894.

C. Luo and Y. Rudy , "A Dynamic Model of the Cardiac Ventricular Action Potential: I. Simulations of Ionic Currents and Concentration Changes” Circulation Research 1994; 74: 1071-1096.

C. Luo and Y. Rudy , "A Dynamic Model of the Cardiac Ventricular Action Potential: II. Afterdepolarizations, Triggered Activity and Potentiation” Circulation Research 1994; 74: 1097-1113.

D.W. Whalley, D.J. Wendt, C.F. Starmer, Y. Rudy , and A.O. Grant, "Voltage- Independent Effects of Extracellular K⁺ on the Na⁺ Current and Phase 0 of the Action Potential in Isolated Cardiac Myocytes” Circulation Research 1994; 75: 491-502.

J. Ortiz, A. Nozaki, A. Shimizu, Y. Rudy , and A.Waldo, "Mechanism of Interruption of Atrial Flutter by Moricizine: Electrophysiological and Multiplexing Studies in the Canine Sterile Pericarditis Model of Atrial Flutter” Circulation 1994; 89: 2860-2869.

S. Niwano, J.Ortiz, H. Abe, X. Gonzalez, Y. Rudy , and A.L. Waldo, "Characterization of the excitable gap in a functionally determined reentrant circuit” Circulation 1994; 90: 1997-2014.

D.S. Khoury, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , "Reconstruction of Endocardial Potentials and Activation Sequences from Intracavitary Probe Measurements: Localization of Pacing Sites and Effects of Myocardial Structure” Circulation 1995; 91: 845-863.

J. Zeng and Y. Rudy , "Early Afterdepolarizations in Cardiac Myocytes: Mechanism and Rate Dependence” Biophys J 1995; 68: 949-964.

R.M. Shaw and Y. Rudy , "The Vulnerable Window for Unidirectional Block in Cardiac Tissue: Characterization and Dependence on Membrane Excitability and Cellular Coupling” J Cardiovascular Electrophysiology 1995; 6: 115-131.

Y. Rudy , "Reentry: Insights from Theoretical Simulations in a Fixed Pathway” J Cardiovascular Electrophysiology 1995; 6: 294-312.

J. Zeng, K. R. Laurita, D. S. Rosenbaum, and Y. Rudy , "Two Components of the Delayed Rectifier K⁺ Current in Ventricular Myocytes of the Guinea Pig Type: Theoretical Formulation and their Role in Repolarization” Circulation Research 1995; 77: 1-13.

Y. Rudy , “Model Studies of Cellular Excitation” Adv Exp Med Biol 1995; 382: 67-77.

H.S. Oster and Y. Rudy , "Regional Regularization of the Electrocardiographic Inverse Problem: A Model Study using Spherical Geometry” IEEE Trans BME 1997; 44: 188-199.

H.S.Oster, B.Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy , "Noninvasive Electrocardiographic Imaging: Reconstruction of Epicardial Potentials, Electrograms and Isochrones, and Localization of Single and Multiple Electrocardiac Events" Circulation 1997; 96: 1012-1024.

R.M. Shaw and Y. Rudy , "Elecrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure" Circ Res 1997 ; 80:124-138.

Z.W. Liu, P.Jia, P.R.Ershler, B.Taccardi, R.L. Lux, D.S. Khoury, Y. Rudy , "Noncontact Endocardial Mapping: Reconstruction of Electrograms and Isochrones from Intracavitary Probe Potentials" J Cardiovasc Electrophys 1997; 8: 415-431.

R.M. Shaw and Y. Rudy , "Electrophysiologic Effects of Acute Myocardial Ischemia: A Theoretical Study of Altered Cell Excitability and Action Potential Duration" Cardiovascular Research 1997; 35: 256-272

K.R. Laurita, S.D. Girouard, Y. Rudy , D.S. Rosenbaum, "Role of Passive Electrical Properties During Action Potential Restitution in the Intact Heart" Am J. Physiol 1997; 273: H1205-H1214.

Y. Rudy and R.M. Shaw, "Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions" Adv Exp Med Biol 1997; 430: 269-280.

R.M. Shaw and Y. Rudy , “Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-Type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling” Circ Res 1997; 81:727-741.

J.E. Burnes, D.C. Kaelber, B. Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy ," A Field- Compatible Method for Interpolating Biopotentials: Development and Evaluation in Electrocardiographic Imaging" Annals of Biomedical Engineering 1998; 26: 37-47.

H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, Y. Rudy , “Electrocardiographic Imaging: Noninvasive Characterization of Intramural Myocardial Activation from Inverse Reconstructed Epicardial Potentials and Electrograms” Circulation 1998; 97:1496-1507.

Y. Rudy , B. Taccardi, “Noninvasive Imaging and Catheter Imaging of Potentials, Electrograms and Isochrones on the Ventricular Surfaces” J Electrocardiology 1998; 30:19-23.

Z.W. Liu, P.Jia, L.A. Biblo, B. Taccardi, Y. Rudy , “Single-Beat Endocardial Mapping from a Noncontact Nonexpandable 9F Catheter: A Feasibility Study” Annals of Biomedical Engineering 1998; 26:994-1009.

Y. Rudy , "Cardiac Conduction: An Interplay Between Membrane and Gap Junction" J Electrocardiology 1999; 31:1-5.

S.G. Priori, J. Barhanin, R.N.W. Hauer, W. Haverkamp, H.J. Jongsma, A.G. Kleber, W.J. McKenna, D.M. Roden, Y. Rudy , K. Schwartz, P.J. Schwartz, J.A. Towbin, A.M. Wilde, "Genetic and Molecular Basis of Cardiac Arrhythmias, Parts I and II" Circulation 1999; 99:518-528. (Also published in Eur Heart J. 1999;20:179-195).

_____ "Genetic and Molecular Basis of Cardiac Arrhythmias, Part III" Circulation 1999; 99:674-681. (Also published in Eur Heart J. 1999; 20:179-195).

P.C. Viswanathan, R.M. Shaw, Y. Rudy , "Effects of Ikr and Iks Heterogeneity on Action Potential Duration and its Rate - Dependence: A Simulation Study" Circulation 1999; 99:2466-2474.

P.C. Viswanathan, Y. Rudy , "Pause Induced Early Afterdepolarizations in the Long QT Syndrome: A Simulation Study" Cardiovascular Research 1999; 42:530-542.

Y. Rudy , J.E. Burnes, "Noninvasive Electrocardiographic Imaging (ECGI)" Annals of Noninvasive lectrocardiology 1999;4:340-359.

C. E. Clancy, Y. Rudy , "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia" Nature 1999;400:566-569.

Y.H.He, R.N. Ghanem, A.L. Waldo, Y. Rudy , “An Interactive Graphical System for Automated Mapping and Display of Cardiac Rhythms” J Electrocardiology 1999;32:225-241.

Y. Rudy , "ECGI: A Noninvasive Imaging Modality for Characterization of Intramural Myocardial Activation" J Electrocardiology 1999;32: 1-6.

P.C. Viswanathan, Y. Rudy , "Cellular Arrhythmogenic Effects of the Congenital and Acquired Long QT Syndrome in the Heterogeneous Myocardium" Circulation 2000;101:1192- 1198.

J.E. Burnes, B. Taccardi, R.S. MacLeod, Y. Rudy , "Noninvasive Electrocardiographic Imaging of Electrophysiologically Abnormal Substrate in Infarcted Hearts: A Model Study" Circulation 2000;101:533-540.

Y. Wang, Y. Rudy , "Action Potential Propagation in Inhomogeneous Cardiac Tissue: Safety Factor Considerations and Ionic Mechanism" Am J Physiol (Heart) 2000;278:H1019- H1029.

G.M. Faber, Y. Rudy , “Action Potential and Contractility Changes in [Na⁺]_i Overloaded Cardiac Myocytes: A Simulation Study” Biophys J 2000; 78:2392-2404.

J. E. Burnes, B. Taccardi, Y. Rudy , “A Noninvasive Imaging Modality for Cardiac Arrhythmias” Circulation 2000; 102:2152-2158.

Y. Rudy , “From Genome to Physiome: Integrative Models of Cardiac Excitation” Annals of Biomedical Engineering 2000; 28:945-950.

T. J. Hund, N.F. Otani, Y. Rudy , “The Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Ionic Mechanisms” Am J Physiol (Heart) 2000; 279:H1869-H1879.

E. Ficker, D. Thomas, P.C. Viswanathan, A. T. Dennis, S. G. Priori, C. Napolitano, M. Memmi, B.A. Wible, E. S. Kaufman, S. Iyengar, P. J. Schwartz, Y. Rudy , A.M. Brown, “Novel Characteristics of a Misprocessed Mutant HERG Channel Linked to Hereditary Long QT Syndrome” Am J Physiol (Heart) 2000; 279:H1748-H1756.

T. J. Hund, Y. Rudy “Determinants of Excitability in Cardiac Myocytes: Mechanistic Investigation of Memory Effect” Biophys J 2000; 79:3095-3104.

P. Jia, B. Punske, B. Taccardi, Y. Rudy , “Electrophysiologic Endocardial Mapping from a Noncontact Nonexpandable Catheter: A Validation Study of a Geometry-Based Concept” J Cardiovasc Electrophysiol 2000; 11:1238-1251.

C. Ramanathan, Y. Rudy , “Electrocardiographic Imaging: I. Effect of Torso Inhomogeneities on Body Surface Electrocardiographic Potentials” J Cardiovasc Electrophysiol 2001; 12:229-240.

C. Ramanathan, Y. Rudy , “Electrocardiographic Imaging:II. Effect of Torso Inhomogeneities on the Noninvasive Reconstruction of Epicardial Potentials, Electrograms and Isochrones” J Cardiovasc Electrophysiol 2001; 12:241-252.

C. E. Clancy, Y. Rudy , “Cellular Consequences of HERG Mutations in the Long QT Syndrome: Precursors to Sudden Cardiac Death” Cardiovascular Research 2001 ;50:301-313.

D. Noble, Y. Rudy , “Models of Cardiac Ventricular Action Potentials: Iterative Interaction Between Experiment and Simulation” Philosophical Transactions Royal Society (London) 2001; 359:1127-1142.

D. Nuyens, M. Stengl, S. Dugarmaa, T. Rossenbacker, V. Compernolle, Y. Rudy , J.F. Smits, W. Flameng, C.E. Clancy, L. Moons, M.A. Vos, M. Dewerchin, K. Benndorf, D. Collen, E. Carmeliet, P. Carmeliet, “Abrupt Rate Accelerations or Premature Beats Cause Life Threatening Arrhythmias in Mice with Long-QT3 Syndrome” Nature Medicine 2001; 7:1021-1027.

J.E. Burnes, R.N. Ghanem, A.L. Waldo, Y. Rudy , “ Imaging Dispersion of Myocardial Repolarization I. Comparison of Body Surface and Epicardial Measures” Circulation 2001;104:1299 – 1305.

R.N. Ghanem, J.E. Burnes A.L. Waldo, Y. Rudy , “ Imaging Dispersion of Myocardial Repolarization II. Noninvasive Reconstruction of Epicardial Measures” Circulation 2001;104:1306 – 1312.

R.N. Ghanem, J.E. Burnes A.L. Waldo, Y. Rudy , “ Electrocardiographic Imaging: Noninvasive Reconstruction of Epicardial Measures of Dispersion of Repolarization” Biomedizinische Technik 2001;46:201-203.

T.J. Hund, J.P. Kucera, N.F. Otani, Y. Rudy , “Ionic Charge Conservation and Long – Term Steady State in the Luo-Rudy Dynamic Cell Model” Biophys J 2001;81:3324-3331.

J. E. Burnes, B. Taccardi, P. Ershler, Y. Rudy , “Noninvasive ECG Imaging of Substrate and Intramural Ventricular Tachycardia in Infarcted Hearts” J Amer College Cardiol (JACC) 2001;38:2071-2078.

J.P. Kucera, Y. Rudy , “Mechanistic Insights into Very Slow Conduction in Branching Cardiac Tissue: A Model Study” Circ Res 2001; 89:799-806.

Y. Rudy together with other 23 members of the Sicilian Gambit on Cardiac Arrhythmia, “New Approaches to Antiarrhythmic Therapy: Emerging Therapeutic Applications of the Cell Biology of Cardiac Arrhythmias”, Part I, Circulation 2001;104:2865-2873. Co-Published in European Heart Journal, and Cardiovascular Research .

------ “New Approaches to Antiarrhythmic Therapy: Emerging Therapeutic Applications of the Cell Biology of Cardiac Arrhythmias”, Part II, Circulation 2001;104:2990-2994. Co-Published in European Heart Journal, and Cardiovascular Research .

Y. Rudy , “The Ionic Mechanism of Conduction in Cardiac Tissue” J Electrocardiology 2001 ; 34:65-68.

C.E. Clancy, Y. Rudy , “A Na⁺ Channel Mutation that Causes Both Brugada and Long QT Syndrome Phenotypes: A Simulation Study of Mechanism” Circulation 2002;105:1208-1213.

K. Gima, Y. Rudy , “ Ionic Current Basis of Electrocardiographic Waveforms: A Model Study “ Circulation Research 2002;90:889-896.

P. Jia, B.Punske, B.Taccardi, Y. Rudy , “Endocardial Mapping of Electrophysiologically Abnormal Substrates and Cardiac Arrhythmias using a Noncontact Nonexpandable Catheter” J Cardiovasc Electrophysiol 2002;13:888-895.

J.P. Kucera, S. Rohr, Y. Rudy , “Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction” Circulation Research 2002; 91:1176-1182.

J. Silva, Y. Rudy , “Pacemaking Activity in Ventricular Myocytes Under Downregulation of Ik1: A Study of Mechanism” Circulation Research 2003; 92:261-263.

S.P. Thomas, J.P. Kucera, L. Bircher-Lehman, Y. Rudy , J.E. Saffitz, A.G. Kleber, “Impulse Propagation in Synthetic Strands of Neonatal Cardiac Myocytes with Genetically Reduced Levels of Connexin43” Circulation Research 2003; 92:1209-1216.

C. Ramanathan, P. Jia, R.N. Ghanem, D. Calvetti, Y. Rudy , “Noninvasive Electrocardiographic Imaging (ECGI): Application of the Generalized Minimal Residual (GMRes) Method” Annals of Biomedical Engineering 2003; 31:981-994.

R.N. Ghanem, C. Ramanathan, P. Jia, Y. Rudy , “Heart-Surface Reconstruction and ECG Electrodes Localization Using Fluoroscopy, Epipolar Geometry and Stereovision: Application to noninvasive imaging of cardiac electrical activity” IEEE Trans on Medical Imaging 2003;22:1307-1318.

A.G. Kleber, Y. Rudy , “Basic Mechanisms of Cardiac Impulse Propagation and Reentrant Arrhythmias” Physiological Reviews 2004; 84:431-488.

C. Ramanathan, R.N. Ghanem, P. Jia, K. Ryu, Y. Rudy , “Electrocardiographic Imaging (ECGI): A Noninvasive Imaging Modality for Cardiac Electrophysiology and Arrhythmia” Nature Medicine 2004; 10:422-428.

Y. Rudy , “Genetic Defects, Ionic Currents and Electrocardiographic Alterations” Annals of Medicine 2004; 36:15-21.

Y. Rudy , “ From Genetics to Cellular Function Using Computational Biology” Annals N.Y. Academy of Science 2004; 1015:261-270.

T.J. Hund, Y. Rudy, "Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model" Circulation 2004 (in press).

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Books and Chapters:

J. Liebman, R. Plonsey and Y. Rudy , (Eds). New Directions In Fundamental And Pediatric Electrocardiography Martinez Nijhoff Publishers, 1987.

Y. Rudy , “Critical Aspects of the Forward and Inverse Problems in Electrocardiography" In: Simulating and Imaging of the Cardiac System Eds.: S. Sideman and R. Beyar. Martinus Nijhoff Publishers, 1985, pp. 279-298.

Y. Rudy , “The Effects of the Thoracic Volume Conductor (Inhomogeneities) on the Electrocardiogram" In: New Directions in Fundamental and Pediatric Electro- cardiography Eds.: J. Liebman, R. Plonsey, and Y. Rudy . Martinus Nijhoff Publishers, 1987, pp. 49-73.

Y. Rudy , “The Inverse Problem in Electrocardiography: Effects of Geometry and Inhomogeneities on the Reconstruction of Epicardial Potentials" In: Simulation and Control of the Cardiac System Vol. III Eds.: S. Sideman and R. Beyar. CRC Press, 1987, pp. 29-42.

Y. Rudy , “The Relationship Between Body Surface and Epicardial Potentials: A Theoretical Model Study" In: Electrocardiographic Body Surface Mapping Eds.: R. Th. van Dam and A. van Oosterom, Martinus Nijhoff Publishers, 1986, pp. 247-258.

Y. Rudy and W. Quan, “Effects of the Discrete Cellular Structure on Electrical Propagation in Cardiac Tissue” In: Activation, Metabolism and Perfusion of the Heart Eds.: S. Sideman and R. Beyar. Martinus Nijhoff Publishers, 1987, pp. 61-76.

J. Liebman, C.W. Thomas, R. Salamone, Y. Rudy , and R. Plonsey. “Electrocardio- graphic Body Surface Potential Maps of the QRS and T of Normal Children – Qualitative Description and Selected Quantitations” In: New Directions in Fundamental and Pediatric Electrocardiography Eds.: J. Liebman, R. Plonsey, and Y. Rudy . Martinus Nijhoff Publishers, 1987, pp. 381-388.

J. Liebman, Y. Rudy , C.W. Thomas, and R. Plonsey, “RVH with Terminal Right Conduction Delay Versus Partial Right Bundle Branch Block (Utilizing Body Surface Potential Maps)” In: New Directions in Fundamental and Pediatric Electrocardiography Eds.: J. Liebman, R. Plonsey, and Y. Rudy . Martinus Nijhoff Publishers, 1987, pp. 389-398.

J. Liebman, C.W. Thomas, and Y. Rudy , “Conduction Abnormalities and Ventricular Hypertrophy" In: Body Surface Electrocardiographic Mapping Ed.: D.M. Mirvis. Kluwer Academic Publishers, 1988, pp. 153-166.

Y. Rudy and W. Quan, “The Effects of the Discrete Cellular Structure on Propagation of Excitation in Cardiac Tissue: A Model Study” In: Cell Interactions and Gap Junctions Eds.: N. Sperelakis and W. Cole. CRC Press, 1989, Vol. II pp. 123-142.

J. Liebman and Y. Rudy , “Electrocardiography in Infants” In: Fetal, Neonatal, and Infant Cardiac Disease Eds.: J. Moller, and W. Neal, Appleton and Lange. 1989, pp. 179-246.

Y. Rudy and B.J Messinger-Rapport, “Inverse Reconstruction of Epicardial Potentials in a Realistic Geometry Heart-Torso System” In: Imaging Analysis and Simulation of the Cardiac System Eds.: S. Sideman and R. Beyar. Freund Publishing House, London, 1990, pp.767-784.

Y. Rudy , “Non-Invasive Reconstruction of Epicardial Potentials: Accuracy and Practical Considerations” In: Imaging, Measurement and Analysis of the Heart Eds.: S. Sideman and R. Beyar. Hemisphere Publishing, 1991 pp. 351-360.

Y. Rudy and W. Quan, “Reentry of Cardiac Excitation: A Simulation Study” In: Cardiac Electrophysiology, Circulation, and Transport Eds.: S. Sideman, R. Beyar and A. Kleber. Kluwer Academic Publishers, 1991, pp. 63-72.

Y. Rudy and H.S. Oster, “The Electrocardiographic Inverse Problem” In: High Performance Computing in Biomedical Research Eds.: T.C. Pilkington, B. Loftis, J.F. Thompson, S.L-Y. Woo, T.C. Palmer, T.F. Budinger. CRC Press, 1993, pp. 135-155.

Y. Rudy , “Models of Continuous and Discontinuous Propagation in Cardiac Tissue” In: Cardiac Electrophysiology: From Cell to Bedside Eds.: D.P. Zipes and J. Jalife. W.B. Saunders Publishers, 1995, pp. 326-334.

Y. Rudy , “The Electrocardiogram and its Relationship to Excitation of the Heart” In: Physiology and Pathophysiology of the Heart Ed.: N. Sperelakis. Kluwer Academic Publishers, 1995, pp. 201-239.

Y. Rudy , “The Role of Cellular Coupling in Propagation of Excitation and Reentry - Theoretical Observations” In: Atrial Arrhythmias - State of the Art Eds.: P. DiMarco and E.N. Prystowsky. American Heart Association Monograph Series, Futura Publishing Co., 1995, pp. 149-154.

Y. Rudy , “Electrocardiographic Imaging - A Functional Imaging Modality for the Reconstruction of Cardiac Electrical Function” A Report on Medical Imaging, The National Academy of Sciences, 1995.

Y. Rudy , “Model Studies of Cellular Excitation” In: Molecular and Subcellular Cardiology Eds.: S. Sideman and R. Beyar. Plenum Press, 1995, pp.67-77.

Y. Rudy , “Reentry of Cardiac Excitation: Insights from Theoretical Studies” In: Atrial Flutter Eds: A.L. Waldo and P. Touboul. Futura Publishing Co., 1996, pp.83-101.

Y. Rudy and R. M. Shaw, “Membrane Factors and Gap-Junction Factors as Determinants of Ventricular Conduction and Reentry” In: Discontinuities in Cardiac Conduction Eds.: P. Spooner, R. W. Joyner and J. Jalife. Futura Publishing Co., 1997, pp.523-546.

Y. Rudy and R.M. Shaw, “Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions” In: Analytical and Quantitative Cardiology: From Genetics to Function Eds.: S. Sideman and R. Beyar. Plenum Press, 1997, pp. 269-280.

R.M. Shaw and Y. Rudy , “Gap Junctions and the Spread of Electrical Excitation” In: Heart Cell Communication in Health and Disease Eds: W. C. De Mello and M. J. Janse. Kluwer Academic Publishers, 1998, pp. 125-147.

Y. Rudy , "Principles of Slow Conduction in Cardiac Tissue" In: Atrial-AV Nodal Electrophysiology; State of the Art at the End of the Century Eds. T. Mazgalev and P. Tchou. Futura Publishing Co., 2000, pp. 61-72.

Y. Rudy , "Ionic Mechanisms of Cardiac Electrical Activity" In: Cardiac Electrophysiology: From Cell to Bedside , 3rd edition, Eds. D.P. Zipes and J. Jalife. W.B. Saunders Publishers, 2001, pp. 257-265.

Y. Rudy and J. Jalife, "Global Behaviors of Cardiac Activation" In: Foundation of Cardiac Arrhythmias Eds. P.M. Spooner and M.R. Rosen. Marcel Dekker Publishers, 2001, pp. 349-392.

Y. Rudy , "The Electrocardiogram and Cardiac Excitation" In: Heart Physiology and Pathophysiology 4th Edition, Eds. N. Sperelakis, Y. Kurachi, A. Terzic and M. Cohen. Academic Press, 2001, pp.133-148.

Y. Rudy , “Noninvasive Electrocardiographic Imaging of Cardiac Excitation and Arrhythmia” In: Computer Simulation and Experimental Assessment of Cardiac Electrophysiology. Eds. N. Virag, O. Blanc, L. Kappenberger. Futura Publishing Co. 2001, pp. 37-46.

Y. Rudy , “The Cardiac Ventricular Action Potential” In: Handbook of Physiology: The Heart, Eds. E. Page, H.A. Fozzard and R.J. Solaro. Oxford University Press, 2001, pp. 531-547.

Y. Rudy and R.N. Ghanem, “ Noninvasive Imaging of Cardiac Repolarization “ In: Einthoven 2002 : 100 Years of Electrocardiography, Eds. M.J. Schalij, M.J. Janse, A. van Oosterom, H.J.J. Wellens and E.E. van der Wall. The Einthoven Foundation, 2002, pp. 303 – 310.

Y. Rudy , "Ionic Mechanisms of Cardiac Electrical Activity" In: Cardiac Electrophysiology: From Cell to Bedside , 4th edition, Eds. D.P. Zipes and J. Jalife. Elsevier Science Publisher, 2003, pp.255-266.

T. Hund and Y. Rudy, "A Role for Calcium/Calmodulin-Dependent Protein Kinase II in Cardiac Disease and Arrhythmia" In: Handbook of Experimental Pharmacology: Basis and Treatment of Cardiac Arrhythmias, Eds. R. Kass and C. E. Clancy. Springer-Verlag 2004 (in press).

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Conference Proceedings and Editorials:

R. Plonsey, W. Ko, J. Liebman, Y. Rudy , C. Thomas, and S. Hunter, “ECG Body Surface Mapping Project at Case Western Reserve University” Zbornik Radova Jurema, 1979, 24: 1-7 . (Proceedings of the Yugoslav Assoc. of Measurement, Control and Automation).

Y. Rudy and R. Plonsey, “Volume Conductor and Geometrical Effects on Body Surface and Epicardial Potentials: I. Theory, II. Applications” Digest of the combined meeting: XII Internat. Conference on Medical and Biological Engineering; V Internat. Conference on Medical Physics, 1979, Part III: 50.1, 50.2.

R. Plonsey and Y. Rudy , “Considerations of Anisotropy in Cardiac Activation” Digest of the combined meeting: XII Internat. Conference on Medical and Biological Engineering; V Internat. Conference on Medical Physics,1979, Part III: 56.1.

P. Diaz, Y. Rudy , and R. Plonsey, “A Cardiac Propagation Model with Intercalated Discs” Proceedings of the 34th ACEMB, 1981, 217.

Y. Rudy , “Inverse Computation of Cardiac Potentials: An Ill-Posed Problem” Proceedings of the 34th ACEMB, 1981, 123, (invited paper).

Y. Rudy , P, Diaz, and R. Plonsey, “Discontinuous Propagation of Excitation in Cardiac Muscle: A Theoretical Study” Proceedings of the 10th International Congress on Electrocardiology, Bratislava, Czechoslovakia, (1983).

J. Liebman, C.W. Thomas, R. Salamone, Y. Rudy , and R. Plonsey, “Quantification of Electrocardiographic Body Surface Potential Maps of the QRS and T of Normal Children” Japanese Heart Journal 1982; 23: 409.

J. Liebman, Y. Rudy , P. Diaz, C.W. Thomas, and R. Plonsey, “Electrocardiographic Body Surface Maps in Advanced Right Bundle Branch Block” In: Advances in Body Surface Potential Mapping Eds.: K. Yamada, K. Harumi and T. Musha. The University of Nagoya Press, 1983, pp. 217-226.

R. Plonsey, W. Ko, J. Liebman, Y. Rudy , and C.W. Thomas, “Body Surface Potential Mapping Project at Case Western Reserve University” In: Advances in Body Surface Potential Mapping Eds.: K. Yamada, K. Harumi, and T. Musha. The University of Nagoya Press, 1983, pp. 77-84.

J. Liebman, C.W. Thomas, Y. Rudy , P.J. Diaz, R. Plonsey, and W. Ko, “Clinical Data with a Color Display 180 Electrode ECG-BSPM System” Proceedings-Fifth Annual Conference of IEEE/EMBS,1983, pp. 32-37.

B.J. Messinger-Rapport and Y. Rudy . “The Torso-Air and Internal Conductivity Interfaces in Electrocardiography” Proceedings, IEEE 1985 Frontiers of Engineering and Computing in Health Care. Chicago, IL, September 27-30, 1985, pp. 759-761.

B.J. Messinger-Rapport and Y. Rudy . “The Inverse Problem in Electrocardiography: A Model Study” Proceedings, IEEE 1985 Frontiers of Engineering and Computing in Health Care. Chicago, IL, September 27-30, 1985.

Y. Rudy , and B. J. Messinger-Rapport, “Volume Conductor Effects and the Use of Regularization Techniques in the Inverse Recovery of Epicardial Potentials” Proceedings, IEEE 1986 Frontiers of Engineering and Computing in Health Care. Dallas - Fort Worth, November 7-10, 1986 (invited paper).

Y. Rudy and W. Quan, “Model Studies of Discontinuous Propagation in Cardiac Muscle” 40th ACEMB, The Canada - U.S. Symposium on Electrophysiology. Niagara Falls, NY, September 1987 (invited paper).

W. Quan and Y. Rudy , “Induced Unidirectional Block and Reentry of Cardiac Excitation” Proceedings, IEEE Frontiers of Engineering and Computing in Health Care. Boston, MA, Nov. 1987, pp. 210-211.

B.J. Messinger-Rapport, and Y. Rudy , “Recovery of Epicardial Potentials from Body Surface Data in a Realistic Geometry Torso" Proceedings, World Congress on Medical Physics and Biomedical Engineering. San Antonio, TX, Sept., 1988 (invited paper).

Y. Rudy and W. Quan, “The Role of Cellular Discontinuities in Reentry of Cardiac Excitation” Proceedings, IEEE Frontiers of Engineering and Computing in Health Care. New-Orleans, LA, Nov. 1988, pp. 946-947 (invited paper).

G. Sun, C.W. Thomas, J. Liebman, Y. Rudy , D. Stilli, and E. Macchi, “Classification of Normal and Ischemia from BSPM by Neural Network Approach” Proceedings, IEEE Frontiers of Engineering and Computing in Health Care, New-Orleans, LA, Nov. 1988, pp. 1504-1505.

G. Sun, C.W., Thomas, J. Liebman, and Y. Rudy , “Automatic QRS Offset Detection of Body Surface Potential Maps by Spatial and Temporal Approach” Proceedings, 15th International Congress on Electrocardiology. Wiesbaden, Germany, Sept. 1988, pp. 373-376 (Published 1989).

G. Sun, C.W., Thomas, J. Liebman, Y. Rudy , D. Stilli, E. Macchi, and E. Musso, “A Trajectory Study of Normal and Abnormal Body Surface Potential Maps in the First and Second Spatial Eigenvector Space” Proceedings, 15th International Congress on Electrocardiology. Wiesbaden, Germany, Sept. 1988, pp. 235-238 (Published 1989).

D. Khoury, J. Maloney, H. McAlister, T. Simmons, B. Wilkoff, and Y. Rudy , “The Impedance Catheter: Potential for Differentiation between Hemodynamically Stable and Unstable Arrhythmias” Proceedings, 15th Annual Northeast Bioengineering Conference. Boston, MA, March 1989.

Y. Rudy , and B.J. Messinger-Rapport, “Non-Invasive Reconstruction of Epicardial Potentials from Body Surface Potential Data” NIH Conference on Cardiovascular Science and Technology. Louisville, KY, Dec. 2-4, 1989 (invited paper).

Y. Rudy , F. Dexter, and M.N. Levy, “Changes in Heart Rate Elicited by Vagal Activity: A Model Study” Computers in Cardiology. Jerusalem, Israel, September 19-22, 1989 (Published 1990).

Y. Rudy , and W. Quan, “Mathematical Model of Reentry of Cardiac Excitation” Computers in Cardiology. Jerusalem, Israel, September 19-22, 1989. (Published 1990).

H. Oster and Y. Rudy , “The Use of Temporal Information in the Regularization of the Inverse Problem of Electrocardiography” IEEE/Engineering in Medicine and Biology Society 12th Annual Conference. Philadelphia, PA, Nov. 1-4, 1990.

H. Oster and Y. Rudy , “The Use of Temporal Information in the Reconstruction of Epicardial Potentials from Body Surface Potential Data” NIH Conference on Cardiovascular Science and Technology. Louisville, KY, Dec. 1990 (invited paper).

R.W. Henthorn, Y. Rudy , and A.L. Waldo, “Evolving Concepts Regarding the Role of Tissue Structure in Arrhythmogenesis in the Infarcted Human Heart” J Amer. Coll Cardiol 15: 1608-1609, 1990 (Editorial).

J. Liebman, C.W. Thomas, Y. Rudy , and R. Saltzberg, “The Initial QRS in Severe Aortic Stenosis - A Body Surface Potential Mapping Study” 19th International Congress on Electrocardiology. Lisbon, Portugal, June, 1992.

D.S. Khoury and Y. Rudy , “Reconstruction of Endocardial Potentials from Intracavitary Probe Potentials” Computers in Cardiology. Durham, NC, October, 1992. IEEE Computer Society Press, pp. 9-12.

Y. Rudy , H.S. Oster, D.S. Khoury, “Inverse Reconstruction of Epicardial and Endocardial Potentials: The Use of Temporal Information” IEEE/EMBS 14th Annual Conference, Paris, France, Oct. 29 - Nov. 1, 1992 (invited paper).

Y. Rudy , "Model Studies of Cardiac Arrhythmias: Reentry and Arrhythmogenic Activity of the Single Cell” IEEE/EMBS 14th Annual Conference, Paris, France, Oct. 29 - Nov. 1, 1992 (invited paper).

Y. Rudy , “The Role of Cellular Coupling in Propagation of Excitation and Reentry - Theoretical Observations” American Heart Association State-of-the-Art Conference on Atrial Arrhythmias. October 4-5, 1993, Dallas, TX (invited paper).

R.M. Shaw and Y. Rudy , “Electrophysiological Changes of Ventricular Tissue under Ischemic Conditions: A Simulation Study” Computers in Cardiology. Bethesda, MD, Sept. 25-28, 1994.

H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Electrocardiographic Imaging: Evaluating its Ability to Locate and Resolve Pacing Sites Noninvasively” IEEE/EMBS 16th Annual Conference. Baltimore, MD, Nov. 3-6, 1994. 16 (1): 151-152.

D. Kaelber, J. Haaga, and Y. Rudy , “Non-Invasive in vivo Determination of Body Surface and Epicardial Geometries for Electrocardiographic Imaging” IEEE/EMBS 16th Annual Conference. Baltimore, MD, Nov. 3-6, 1994. 16 (1): 153-154.

Y. Rudy , “Modeling Cardiac Ventricular Cells” IEEE/EMBS 17th Annual Conference, Montreal, Canada, Sept. 20-23, 1995 (invited paper).

P.C. Viswanathan, R.M. Shaw and Y. Rudy , “Pause-Induced Early Afterdepolarization in Ventricular Myocytes: Mechanism and Dependence on Cell Type” 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

R.M. Shaw and Y. Rudy , “Supernormal and Subnormal Conduction Velocity Caused by Ischemic Elevation of Extracellular Potassium: A Model Study” 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

D. Kaelber, J. Burnes, S. Platt, J. Haaga, A. Waldo, and Y. Rudy , “Design and Development of Tools for Clinical Electrocardiographic Imaging (ECGI)” 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Noninvasive Electrocardiographic Imaging for Reconstructing Epicardial Electrograms, Isochrones and Potential Distributions” 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

Z.W. Liu, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Inverse Reconstruction of Endocardial Electrograms and Activation Sequences from Intracavitary Multielectrode Probe Potentials Measurements” 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

J.E. Burnes, B.Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Interpolation Methods for Body Surface Potential Maps and Their Use in the Inverse Reconstruction of Epicardial Potentials” 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

Y. Rudy and B.Taccardi, “Noninvasive Imaging of Potentials, Electrograms and Isochrones on the Ventricular Surfaces” 22nd Annual Conference of the International Society for Computerized Electrocardiology (ISCE). Palm Coast, Florida, April 26 - May 1, 1997. J Electrocardiology 1998; 30:19-23.

J.E. Burnes, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , "Electrocardiographic Imaging: Non-Invasive Identification of Functionally Abnormal Electrophysiologic Substrate" Computers in Cardiology. Cleveland, OH, September 1998. IEEE Computer Society Press.

Y. Rudy , “Electrocardiographic Imaging: On the Road to its Development as a Clinical Tool” (The Rijlant Lecture). XXVII International Congress on Electrocardiology. Milan, Italy, June 2000.

Y. Rudy , “Non-Invasive Electrocardiographic Imaging of Cardiac Excitation and Arrhythmia” Second International Workshop on Computer Simulation and Experimental Assessment of Electrical Cardiac Function. Lausanne, Switzerland, December 2000.

Y. Rudy , “Computational Biology (A White Paper)” The Whitaker Foundation Biomedical Engineering Education Summit. Lansdowne, Virginia, December 7-10, 2000.

Y. Rudy , “Multiple Interactions Determine cellular Electrical Processes in the Multicellular Tissue” Cardiovasc Res 2001; 51:1-3 (Editorial).

Y. Rudy , “Abnormal Repolarization: Simulation of Mechanism and Noninvasive Electrocardiographic Imaging “ International J Bioelectromagnetism 2002; 4:79-81. (International Congress on Electrocardiology, Montreal, July, 2002).

Ghanem RN, Ramanathan C, Jia P, Rudy Y. “Fluoroscopy Based Method to Determine Heart Geometry for Functional Imaging of Cardiac Electrical Activity” Proc. of SPIE 2003; 5031: 63-68. (SPIE Medical Imaging, Physiology and Function: Methods, Systems and Applications, San Diego, California February 2003).

Y. Rudy , “ Inverse Computation of Epicardial Potentials” International J Bioelectromagnetism 2003; 5: 218-220. (International Congress on Electrocardiology, Helsinki, June, 2003).

Y. Rudy , “ Ionic Basis of Repolarization and ECG Waveforms” International J Bioelectromagnetism 2003; 5: 302-303. (International Congress on Electrocardiology, Helsinki, June, 2003).

A. Kleber, Y. Rudy, J. Jalife, “ The Third International Workshop on Computer Simulation and Experimental Assessment of Cardiac Cardiac Electrical Function” J Cardiovasc Electrophysiol 2003;14 No.10 (supplement):S118-S120 (Editorial)

Y. Rudy, "Conductive Bridges in Cardiac Tissue: A Beneficial Role or an Arrhythmogenic Substrate" Circ Res 2004; 94:709-711. (Editorial).

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Abstracts:

Y. Rudy , R. Plonsey, and J. Liebman, “The Effects of Inhomogeneities and Geometry on the Electrocardiogram” Circulation 1977; Vol. 56, no. 4: 17.

Y. Rudy and R. Plonsey, “A Comparison of Volume Conductor Effects on Epicardial and Body Surface Potentials” Federation Proceedings 1979; 38: 1153.

Y. Rudy and R. Plonsey, “The Effects of Inhomogeneities and Geometry on Body Surface and Epicardial Potentials” Circulation 1979; Vol. 60, No. 4: 11.

R. Grossman and Y. Rudy , “An Integral Operator Approach to the Inverse Problem in Electrocardiography” International Symposium on Ill-Posed Problems. University of Delaware, 1979.

J. Liebman, C. Thomas, Y. Rudy , and R. Plonsey, “Variation of Body Surface Potential Maps (QRS) in Normal Children” Circulation 1980; Vol. 62, No. 4: 271.

P. Diaz, Y. Rudy , and R. Plonsey, “The Effects of the Intercalated Discs on the Propaga- tion of Electrical Activity in Cardiac Muscle” Fed Proceedings 1981; 40: 393.

P. Diaz, Y. Rudy , and R. Plonsey, “The Intercalated Discs as a Cause for Discontinuous Propagation in Cardiac Muscle: A Theoretical Simulation” Fed Proceedings 1982; 41 No. 3: XII.

J. Liebman, Y. Rudy , P. Diaz, C.W. Thomas, and R. Plonsey, “ECG-BSPM Partial RBBB Versus RVH with Terminal Right Conduction Delay” IEEE Trans Biomed Eng BME 1983; 30: 498.

Y. Rudy , “The Relationship between Body Surface and Epicardial Potentials” 3rd Interna- tional Symposium on Body Surface Mapping. Nijmegen, The Netherlands, June, 1985 (invited).

B.J. Messinger-Rapport and Y. Rudy , "The Inverse Problem in Electrocardiography: A Model Study” Circulation October 1985; 72 Supp III: 160. (American Heart Association 58th Scientific Sessions).

D. Lee, C.W. Thomas, Y. Rudy , and J. Liebman, “A Knowledge-Based Approach in Design of an Automated Body Surface Potential Mapping (BSPM) Processing System” 13th International Congress on Electrocardiology. Washington, D.C. September 10-12, 1986.

W.P. Huebner, C.W. Thomas. Rudy, and J. Liebman, “An Improved Pseudocolor Scale for the Display of Body Surface Potential Maps” 13th International Congress on Electrocardiology. Washington, D.C., September 10-12, 1986.

L.E. Widman, J. Liebman, C.W. Thomas, R. Fraenkel, and Y. Rudy , “Quantification of Electrocardiographic Body Surface Potential Maps (BSPM) of the QRS and T of Normal Young Adult Males” 13th International Congress on Electrocardiology. Washington, D.C., September 10-12, 1986.

J. Liebman, C.W. Thomas, R. Fraenkel, Y. Rudy , and G. Ben-Shachar, “Preliminary Observations of the RVH in Body Surface Potential Mapping (BSPM) of Pulmonic Stenosis (PS) and Atrial Septal Defect (ASD)” 13th International Congress on Electrocardiology. Washington, D.C., September 10-12, 1986.

B.J. Messinger-Rapport and Y. Rudy , “Regularization of the Inverse Problem in Electrocardiography” 40th ACEMB. Niagara Falls, NY, Sept. 1987.

F. Dexter, M.N. Levy, G. Saidel, and Y. Rudy , “Model of Chronotropic Response to Phasic Vagal Stimuli” 40th ACEMB. Niagara Falls, NY, Sept. 1987.

Y. Rudy and W. Quan, “Structural Effects on Propagation of Excitation in Cardiac Muscle” APS Fall Meeting. San Diego, CA, Oct. 1987 (invited).

W. Quan and Y. Rudy , “Induced Unidirectional Block and Reentry of Cardiac Excitation - A Model Study” IEEE/Engineering in Medicine and Biology Society 9th Annual Conference. Boston, MA, Nov. 1987.

Y. Rudy , “The Role of Cellular Discontinuities in Reentry of Cardiac Excitation” IEEE/Engineering in Medicine and Biology Society 10th Annual Conference. New Orleans, LA, Nov. 1988 (invited).

B.J. Messinger-Rapport and Y. Rudy , “Recovery of Epicardial Potentials from Body Surface Data in a Realistic Geometry Torso” World Congress on Medical Physics and Biomedical Engineering. San Antonio, TX, Aug. 1988 (invited).

W. Quan and Y. Rudy , “Unidirectional Block and Reentry of Cardiac Excitation: Effects of Myocardial Structure” American Heart Association 61st Scientific Sessions. Washington, D.C., Circulation , Nov. 1988; 78 No. 4: II-413.

J. Liebman, B. Olshansky, M. Cohen, A. Geha, Y. Rudy , R. Fraenkel, R.W. Henthorn, and A. Waldo, “WPW Syndrome-Correlations of Body Surface Potential Mapping with Electrophysiologic Study and Surgical Mapping” American Heart Association 61st Scientific Sessions. Washington, D.C., Circulation Nov 1988; 78 No. 4: II-137.

Y. Rudy , F. Dexter, and M.N. Levy, “Mathematical Model of Vagal Induced Changes in Heart Rate” Computers in Cardiology. Jerusalem, Israel, September 19-22, 1989 (invited).

Y. Rudy , and W. Quan, “Mathematical Model of Reentry of Cardiac Excitation” Computers in Cardiology. Jerusalem, Israel, September 19-22, 1989 (invited).

A. Shimizu, A. Nozaki, C.W. Thomas, Y. Rudy , and A. Waldo, “Multiplexing Study of the Onset of Atrial Flutter in a Canine Model” American Heart Association 62nd Scientific Sessions. New Orleans, LA, Circulation Nov. 1989; 80 No. 4: II-95.

A. Shimizu, A. Nozaki, C.W. Thomas, Y. Rudy , and A. Waldo, “Multiplexing Study of Interruption of Atrial Flutter by Rapid Pacing” American Heart Association 62nd Scientific Sessions. New Orleans, LA, Circulation Nov. 1989; 80 No. 4: II-95.

A. Nozaki, A. Shimizu, C.W. Thomas, Y. Rudy , and A. Waldo, “Multiplexing Study of Termination of Atrial Flutter By Moricizine” American Heart Association 62nd Scientific Sessions. New Orleans, LA, Circulation Nov. 1989; 80 No. 4 II-135.

A. Shimizu, A. Nozaki, C.W. Thomas, Y. Rudy , and A. Waldo, “Multiplexing Study of the Onset of Atrial Flutter in a Canine Pericarditis Model - Insights into Double Potentials and Fractionated Signals” PACE 1990; 13: 513.

A. Shimizu, A. Nozaki, C.W. Thomas, Y. Rudy , and A. Waldo, “Multiplexing Studies During Entrainment and Interruption of Atrial Flutter to Characterize Double Potentials” American College of Cardiology. New Orleans, LA, March 18-22, 1990. Journal of the American College of Cardiology 1990; 15: 123A.

J. Liebman, J. Zeno, B. Olshansky, M. Cohen, A. Geha, Y. Rudy , R. Fraenkel, R. Henthorn, and A.L. Waldo, “WPW Syndrome: Correlations of Body Surface Potential Mapping with Electrophysiologic Study and Surgical Mapping” J Electrocardiology 1990; 23 No. 3: 280.

J. Liebman, C.W. Thomas, R. Fraenkel, Ben-Shachar, and Y. Rudy , “Body Surface Potential Mapping Many Years after Successful Surgery for Coarctation of the Aorta” 17th International Congress on Electrocardiology. Florence, Italy, September 26-29, 1990.

Y. Rudy , W. Quan, and C. Luo, “Model Studies of Reentrant Propagation and of Rate Dependent Excitation in the Single Cell” 17th International Congress on Electrocardiology. Florence, Italy, September 26-29, 1990 (invited).

J. Liebman, C.W. Thomas, R. Fraenkel, G. Ben-Shachar, and Y. Rudy , “Right Ventricular Hypertrophy Many Years after Surgery for Coarctation of the Aorta, Diagnosed with Electrocardiographic Body Surface Potential Mapping” American Academy of Pediatrics, Section on Cardiology, Boston, MA, October 5-7, 1990. (Published in the American Journal of Cardiology, August, 1990).

Y. Rudy , “Modeling in Cardiac Electrophysiology: Basic Mechanisms and Clinical Applications” IEEE/Engineering in Medicine and Biology Society 12th Annual Conference. Philadelphia, PA November 1-4, 1990 (invited).

A. Shimizu, M. Igarashi, Y. Rudy , and A.L. Waldo, “Insights into Atrial Flutter from Experimental Models” PACE 1991; 14: 627.

M. Igarashi, A. Shimizu, Y. Rudy , and A.L. Waldo, “Surprising Effects of N-Acetylprocainamide on Atrial Flutter in the Canine Pericarditis Model” PACE 1991; 14: 723.

J. Ortiz, M. Igarashi, X. Gonzalez, K. Laurita, Y. Rudy , and A.L. Waldo, “Mechanism of Spontaneous Termination of Atrial Flutter in the Canine Pericarditis Model” PACE 1991; 14: 627.

W. Quan and Y. Rudy , “Initiation and Termination of Reentrant Propagation by a Single Stimulus: A Model Study” PACE 1991; 14: 626.

D. Khoury and Y. Rudy , “Effects of Geometry and Conductivity Parameters on Intra- Cavitary, Endocardial, and Epicardial Potentials: A Model Study” PACE 1991; 14: 714.

Y. Rudy , W. Quan and C. Luo, “Model Studies of Reentry and of Arrhythmogenic Activity of the Single Cell” Proceedings of the JAPAN-USA Symposium on Cardiac Excitation and Conduction. Palm Desert, CA Nov. 14-17, 1991 (invited).

Y. Rudy , “The Electrocardiographic Inverse Problem: Stability, Regularization and a priori Information” The Canadian Association for the Advancement of Science 60th Congress, Montreal, Canada, May 11 - May 15, 1992 (invited).

W. Quan and Y. Rudy , “Electric Field Stimulation of a Single Spheroidal Cardiac Cell - A Model Study” NASPE 13th Annual Scientific Session. Chicago, IL, May 14-16, 1992. PACE 1992; 15: 521.

Y. Rudy , “Model Simulations of the Action Potential and Electrical Activity of the Mammalian Cardiac Cell” International Society for Computerized Electrocardiology. Keystone, CO, May, 1992. J Electrocardiol. 1992; 25: 68 (invited).

J. Ortiz, M. Igarashi, X. Gonzalez, K. Laurita, Y. Rudy , and A. Waldo, “Mechanism of Spontaneous Termination of Atrial Flutter in the Canine Pericarditis Model” XIV Inter American Congress of Cardiology. Orlando, FL, May 23-27, 1992.

D.S. Khoury and Y. Rudy , “Reconstruction of Endocardial Potentials from Intracavitary Probe Potentials” Computers in Cardiology. Durham, NC, October, 1992.

C.H. Luo and Y. Rudy , “A Dynamic Model of the Cardiac Ventricular Action Potential: Ionic Currents and Concentration Changes” American Heart Association 65th Scientific Sessions. New Orleans, LA, Nov. 16-19, 1992. Circulation 1992; 86: I-563.

Y. Rudy , “Electrocardiographic Imaging: Noninvasive Reconstruction of Cardiac Electrical Activity” International Symposium on Biomedical Optics. Los Angeles, CA, January, 1993 (invited).

Y. Rudy , “Advances in Noninvasive Electrocardiographic Imaging” AAMI and NIH (NHLBI) Cardiovascular Science and Technology Conference. Washington, D.C., December 10-12, 1993 (invited).

J. Zeng and Y. Rudy , “Simulation Studies of the Mechanism of Arrhythmogenic Early Afterdepolarizations in Cardiac Myocytes” Biophys J 1994; 66:A322.

Y. Rudy , “Model Studies of Arrhythmogenic Activity of the Single Cardiac Cell” Symposium on Modeling and Control in Biomedical Systems. Galveston, TX, March 27-30, 1994 (invited).

J. Zeng and Y. Rudy , “Simulation Studies of the Rate Dependence Mechanism of Early and Delayed Afterdepolarizations” Experimental Biology 94. Anaheim CA, April 24-28, 1994. The FASEB Journal 1994; 8:A77.

D.S. Khoury, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Reconstruction of Endocardial Potentials and Activation Sequences from Intracavitary Probe Measurements” NASPE. Nashville, TN, May 11-14, 1994. PACE 1994; 17:825.

R.M. Shaw and Y. Rudy , “Electrophysiological Changes of Ventricular Tissue under Ischemic Conditions: A Simulation Study” Computers in Cardiology. Bethesda, MD, Sept. 25-28, 1994.

K.R. Laurita, S.D. Girouard, Y. Rudy , and D.S. Rosenbaum, “Influence of Electrotonus on Repolarization during Premature Stimulation” American Heart Association 67th Scientific Sessions. Dallas, TX, Nov. 14-17, 1994. Circulation 1994; 90 No. 4: I-413.

H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Electrocardiographic Imaging: Noninvasive Localization of Pacing Sites, Simulating Ectopic Foci” American Heart Association 67th Scientific Sessions. Dallas, TX, Nov. 14-17, 1994. Circulation 1994; 90 No. 4: I - 437.

J. Zeng and Y. Rudy , “Two Components of the Delayed Rectifier K⁺ Current in Ventricular Myocytes: Theoretical Formulation and Their Role In Repolarization” Biophysical Society 39th Annual Meeting. San Francisco, CA, Feb. 1995. Biophys J 1995; 68 No. 2: A252.

Y. Rudy , “Vulnerability for Unidirectional Block and Reentry” Eur J C P E Vol.6, No. 1 June 1996.

H.S. Oster, B. Taccardi, R.L. Lux, P.R. Ershler, and Y. Rudy , “Noninvasive Electrocardiographic Imaging for Reconstructing Epicardial Electrograms, Isochrones and Potential Distributions" 23rd International Congress on Electrocardiology. Cleveland, OH, July 31-August 4, 1996.

R.M. Shaw and Y. Rudy , “Modeling The Electrophysiological Effects of Acute Ischemia” Biomedical Engineering Society 1996 Annual Fall Meeting. Penn State University, Oct. 3-6, 1996. Annals of Biomedical Engineering 1996; 24 (1): S-58.

Y. Rudy , J. Zeng, R.M. Shaw, and P. C. Viswanathan, “Modeling Cardiac Ventricular Cells” Biomedical Engineering Society 1996 Annual Fall Meeting. Penn State University, Oct. 3-6, 1996. Annals of Biomedical Engineering 1996; 24 (1): S-58.

Y. Rudy , H.S. Oster, B. Taccardi, RL Lux, and P.R. Ershler, “Noninvasive Electrocardiographic Imaging for Reconstructing Epicardial Electrograms, Isochrones and Potential Distribution” Biomedical Engineering Society 1996 Annual Fall Meeting. Penn State University, Oct. 3-6, 1996. Annals of Biomedical Engineering 1996; 24 (1): S-58.

R.M. Shaw and Y. Rudy , “The Ionic Mechanisms of Depressed Ischemic Conduction and Conduction Block” American Heart Association 69th Scientific Sessions. New Orleans, LA, Nov. 10-13, 1996. Circulation 1996 ; 94 No.8: I-306.

P. C. Viswanathan, R. M. Shaw, and Y. Rudy , “Effect of Gap Junction Coupling on Early Afterdepolarizations in the Heterogeneous Myocardium” American Heart Association 69th Scientific Sessions. New Orleans, LA, Nov. 10-13, 1996. Circulation 1996 ; 94 No.8: I-527.

P. C. Viswanathan, R. M. Shaw, and Y. Rudy , “Transmural Heterogeneity of Ventricular Action Potentials: Mechanism and Rate Dependence” American Heart Association 69th Scientific Session. New Orleans, LA, Nov. 10-13, 1996. Circulation 1996; 94 No.8: I-712.

P.C. Viswanathan and Y. Rudy , “Differential Sensitivity of Ventricular Cell Types to Class III Antiarrhythmic Agents” Biophysical Society 41st Annual Meeting. New Orleans, LA, March 2-6, 1997. Biophys J 1997; 72 No.2 : A48.

R.M. Shaw and Y. Rudy , “Effects of Acute Myocardial Ischemia on Excitability and Action Potential Duration: Ionic Mechanisms” Biophysical Society 41st Annual Meeting. New Orleans, LA, March 2-6, 1997. Biophys J 1997;72 No.2: A47.

Y. Rudy and R.M. Shaw, “Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of Sodium and L-type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling” Biophysical Society 41st Annual Meeting. New Orleans, LA, March 2-6, 1997. Biophys J 1997; 72 No.2: A110.

Y. Rudy , “Interactive Membrane Processes and Gap Junction Properties During Cardiac Action Potential Propagation” XXXIII International Congress on Physiological Sciences, St. Petersburg, Russia, June 1997.

Y. Rudy , "Cardiac Conduction: An Interplay Between Membrane and Gap Junction" 23rd Annual Conference of the International Society for Computerized Electrocardiology (ISCE), Keystone, Colorado, April 18-23, 1998.

Y. Rudy , "Electrocardiographic Imaging (ECGI)" Biomedical Engineering Society 1998 Annual Meeting. Cleveland, OH, October 1998. Annals of Biomedical Engineering 1998; 26(1): S -18.

Y. Rudy , "Cardiac Conduction: An Interplay Between Membrane and Gap Junction" Biomedical Engineering Society 1998 Annual Meeting. Cleveland, OH, October 1998. Annals of Biomedical Engineering 1998; 26(1): S-17.

J.E. Burnes, P.R. Ershler, R.L. Lux, B. Taccardi, and Y. Rudy , "Electrocardiographic Imaging: Non-Invasive Reconstruction of Reentrant Activation during VT" American Heart Association 71st Scientific Sessions. Dallas, TX, November 1998. Circulation 1998; 98 No.7: I25.

C.E. Clancy and Y. Rudy , "The Cellular Electrophysiological Consequences of the ∆KPQ Sodium Channel Mutation in the Long - QT Syndrome" Biophysical Society 43rd Annual Meeting, Baltimore, Feb. 1999. Biophys J 1999; 76 No. 1:A267.

G.M. Faber and Y. Rudy , "Action Potential and Contractility Change due to Elevated [Na⁺]_i: Role of I_Na_Ca and I_NaK" Biophysical Society 43rd Annual Meeting, Baltimore, Feb. 1999. Biophys J 1999; 76 No.1:A369.

T. Hund and Y. Rudy , "Restitution of Excitability and Action Potential Duration in Cardiac Myocytes: Mechanistic Investigation of Memory Effect" Biophysical Society 43rd Annual Meeting, Baltimore, Feb. 1999. Biophys J 1999; 76 No.1:A369.

Y. Wang and Y. Rudy , "Effects of Structural and Membrane Inhomogeneities on Action Potential Propagation in Cardiac Tissue: Conduction Safety and Ionic Mechanisms" Biophysical Society 43rd Annual Meeting, Baltimore, Feb. 1999. Biophys J 1999;76 No.1:A88.

D.C. Kaelber, L.A. Biblo, S.B. Platt, J.E. Burnes, J.R. Haaga, A.L. Waldo, Y. Rudy , "Noninvasive Electrocardiographic Imaging: Initial Evaluation in Humans During Ventricular Pacing" NASPE 20th Scientific Sessions, Toronto, Canada, May 1999. PACE 1999; 22 No. 4: p. 887.

Y. Rudy , “Identifying the Ionic Mechanisms of Cardiac Arrhythmias Using Computer Modeling” Physiome Symposium on Integrated Biology of the Heart, Seattle, September 1999.

J. Wei, I. C-H. Yang, A. R. Tapper, K.T. Murray, P.C. Viswanathan, Y. Rudy , P.B. Bennett, K. Norris, J.R. Balser, D. M.Roden, A.L. George, Jr., “KCNE1 Polymorphism Confers Risk of Drug-Induced Long QT Syndrome by Altering Kinetic Properties of Iks Potassium Channels” American Heart Association 72nd Scientific Sessions, November 1999. Circulation 1999; 100, No. 18: I-495.

Y. Rudy , “Integrative Models of Cardiac Excitation and Arrhythmia” Biophysical Society 44th Annual Meeting, New Orleans, Feb. 2000. Biophys J 2000; 78 No.1: 27A.

E.K. Ficker, D. Thomas, P. Viswanathan, Y. Rudy , A.M. Brown, “Rescue of a Misprocessed Mutant HERG Channel Linked to Hereditary Long QT Syndrome” Biophysical Society 44th Annual Meeting, New Orleans, Feb. 2000. Biophys J 2000; 78 No.1:342A.

C.E. Clancy, Y. Rudy , “Theoretical Investigation of the Effects of LQT2 Mutations on the Cardiac Ventricular Action Potential” Biophysical Society 44th Annual Meeting, New Orleans, Feb. 2000. Biophys J 2000; 78 No.1: 454A.

T.J. Hund, N.F. Otani, Y. Rudy , “Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Theoretical Study of Ionic Mechanisms” Biophysical Society 44th Annual Meeting, New Orleans, Feb. 2000. Biophys J 2000; 78 No.1:454A.

Y. Rudy , “Noninvasive Electrocardiographic Imaging (ECGI): The Road to its Development as a Clinical Tool” International Congress on Electrocardiology, Milan, Italy, June 2000.

Y. Rudy , “From Genome to Physiome: Integrative Models of Cardiac Excitation” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

C.E. Clancy, Y. Rudy , “A Single Channel Model of Cardiac Ikr and its Role in Action Potential Repolarization” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

G. M. Faber, Y. Rudy , “Efficacy of Na⁺-Ca²⁺ Exchange Blockade and Sarcolemmal Ca²⁺ Pump Enhancement in Prevention of [Ca²⁺]_i – Overload: A Simulation Study” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

K. Gima, Y. Rudy , “The Ionic Channel Basis of Electrocardiographic Waveforms: A Simulation Study” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

J. E. Burnes, R. N. Ghanem, Y. Rudy , “Electrocardiographic Imaging: Reflection of Myocardial Repolarization Heterogeneities in Body Surface Indices of Dispersion” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

C. Ramanathan, Y. Rudy , “Electrocardiographic Imaging: Effect of Torso Inhomogeneities on Body Surface Electrocardiographic Potentials” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

C. Ramanathan, Y. Rudy , “Electrocardiographic Imaging: Effect of Torso Inhomogeneities on the Noninvasive Reconstruction of Epicardial Potentials, Electrograms and Isochrones” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

P. Jia, B.B. Punske, B. Taccardi, Y. Rudy , “Electrophysiological Endocardial Imaging Using a Noncontact Nonexpandable Geometry-Based Catheter” World Congress on Medical Physics and Biomedical Engineering, Chicago, July 2000.

C. E. Clancy, Y. Rudy , “A Single Mutation in the Cardiac Sodium Channel is Sufficient to Cause Both the Brugada and Long QT Syndrome Phenotypes” American Heart Association Scientific Sessions 2000. New Orleans, LA, Nov. 12-15, 2000. Circulation 2000;102 No. 8:II-355.

Y. Rudy , “From Genome to Physiome: Integrative Models of Cardiac Excitation and Arrhythmia” Workshop on Mapping and Control of Complex Arrhythmias. University of Montreal, Canada, October 29 – November 1, 2000.

Y. Rudy , “The Ionic Mechanisms of Conduction in Cardiac Tissue” International Society For Computerized Electrocardiology. Hutchinson Island, Florida, April 2001.

Y. Rudy , “From Genetics to Function: Computational Models of Cardiac Arrhythmia” Frontiers in Mathematical and Computational Biology, University of Texas, Dallas, June 2001.

Y. Rudy , “Mechanistic Insights from Quantitative Models of Genetically Inherited Cardiac Arrhythmias” International Congress on Electrocardiology, Sao Paulo, Brazil, June 2001.

Y. Rudy , “Ventricular Cell Electrophysiology: From Mutations to Cell Function” Satellite Meeting of the 34th World Congress of the international Union of Physiological Sciences, Queenstown, New Zealand, August 2001.

Y. Rudy , “Genetically Inherited Cardiac Arrhythmias: Mechanistic Insights from Theoretical Simulations” 34th International Congress of Physiological Sciences, Christchurch New Zealand, August 2001.

R. N. Ghanem, J.E. Burnes, A.L. Waldo, Y. Rudy , “Electrocardiographic Imaging: Noninvasive Reconstruction of Epicardial Measures of Dispersion of Repolarization” 3rd International Symposium on Noninvasive Functional Source Imaging, Austrian Society of Biomedical Engineering, Innsbruck Austria, September 2001

C.E. Clancy, Y. Rudy , “From Genetic Defect to Cell Dynamics” SIAM Life Sciences 2001 Conference, Boston, September 2001.

T.J. Hund, J.P. Kucera, N.F. Otani, Y. Rudy , “Charge Conservation and Steady State in the Luo-Rudy Dynamic Model of the Cardiac Cell” Biomedical Engineering Society Annual Meeting, Durham, North Carolina, October 2001. Annals of Biomed Eng 2001; Vol 29, Supp 1.

C. Ramanathan, P. Jia, R.N. Ghanem, D. Calvetti, Y. Rudy , “Noninvasive Electrocardiographic Imaging (ECGI) Using the Generalized Minimal Residual Method (GMRes)” Biomedical Engineering Society Annual Meeting, Durham, North Carolina, October 2001. Annals of Biomed Eng 2001; Vol 29, Supp 1.

C.E. Clancy, Y. Rudy,“1795insD in Cardiac I_Na Leads to Brugada and Long-QT Syndromes: Theoretical Exploration of Kinetics” Biomedical Engineering Society Annual Meeting, Durham, North Carolina, October 2001. Annals of Biomed Eng 2001; Vol 29, Supp 1.

P. Jia, B. Punske, B. Taccardi, Y. Rudy , “Electrophysiologic Endocardial Mapping of Abnormal Arrhythmogenic Substrates Using a Noncontact Nonexpandable Catheter” Asian-Pacific Symposium on Cardiac Pacing and Electrophysiology, Beijing China, October 2001.

Y. Rudy , “Abnormal Repolarization: Simulation of Mechanism and Noninvasive Electrocardiographic Imaging“ International Congress on Electrocardiology, Montreal, July, 2002.

Y. Rudy , “From Genome to Physiome: Integrative Models of Cardiac Arrhythmia” Japan – Canada Conference on Cardiac Arrhythmias, Montreal, Canada, July 2002.

Y. Rudy , “Cardiac Arrhythmias: Computational Models of Mechanisms and Electrocardiographic Imaging (ECGI)” Japanese J. Electrocardiology 2002; 22:357

J.P. Kucera, S. Rohr, Y. Rudy , “ Localization of Sodium Channels in Intercalated Discs Modulates Cardiac Conduction” American Heart Association Scientific Sessions 2002. Chicago, November 17- 20, 2002. Circulation 2002;106 No. 19:II-88.

T.J. Hund, Y. Rudy , “ Ca²⁺ /Calmodulin-dependent Protein Kinase Underlies Rate Dependence of Ca²⁺ Transient in a Dynamic Model of the Ventricular Action Potential” American Heart Association Scientific Sessions 2002. Chicago, November 17- 20, 2002. Circulation 2002;106 No. 19:II-227.

J. Silva, Y. Rudy , “Open-State IKS Block Causes Rate-Independent Action Potential Prolongation” North American Society of Pacing and Electrophysiology (NASPE), 24th Annual Scientific Sessions, Washington DC, May 14-17, 2003. PACE 2003;26 No. 4:II-977.

C. Ramanathan, P. Jia, R. Ghanem, K. Ryu, Y. Rudy “Noninvasive Electrocardiographic Imaging (ECGI) of Normal Activation and Repolarization of the Human Heart” North American Society of Pacing and Electrophysiology (NASPE), 24th Annual Scientific Sessions, Washington DC, May 14-17, 2003. PACE 2003; 26 No. 4: II-995.

G. M. Faber, Y. Rudy , “A Single Channel Markov Model of the Cardiac L-Type Ca²⁺ Channel: Simulation Studies in the Luo-Rudy Model of the Guinea Pig Ventricular Myocyte” North American Society of Pacing and Electrophysiology (NASPE), 24th Annual Scientific Sessions, Washington DC, May 14-17, 2003. PACE 2003; 26 No. 4: II-1022.

R. N. Ghanem, C. Ramanathan, P. Jia, Y. Rudy “ Noninvasive Electrocardiographic Imaging (ECGI) of Cardiac Arrhythmias” Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Colby-Sawyer College, New London, New Hampshire, August 10-15, 2003.

T. J. Hund, Y. Rudy , “Regulation of Electrophysiology and Calcium Handling in a Model of the Canine Ventricular Myocyte” Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Colby-Sawyer College, New London, New Hampshire, August 10-15, 2003.

G. M. Faber, Y. Rudy , “A Single Channel Model of the Cardiac L-type Ca²⁺ Channel: Simulation Studies in the Luo-Rudy Model of the Guinea Pig Ventricular Myocyte” Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Colby-Sawyer College, New London, New Hampshire, August 10-15, 2003.

J. R. Silva, Y. Rudy , “Open-State Iks Block Causes Rate-Independent Action Potential Prolongation” Gordon Research Conference on Cardiac Arrhythmia Mechanisms Colby-Sawyer College, New London, New Hampshire, August 10-15, 2003.

T. J. Hund, Y. Rudy , “Calcium Regulation and Cellular Electrophysiology” 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, September 17-21, 2003.

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Patents:

U.S. patent number 6772004 "System and Method for Non-invasive Eletrocardiographic Imaging".

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Reports in the General Press:

New York Times, April 22, 2004, “Beyond the EKG, to a Hypersensitive Heart Monitor”, reported by Anne Eisenberg.

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Invited Presentations:

Duke University, Department of Biomedical Engineering, March, 1981.

34th Annual Conference on Engineering in Medicine and Biology, Houston, TX, September, 1981.

Ohio State University, Department of Biomedical Engineering, Columbus, OH, November,1982.

Technion - Israel Institute of Technology, Department of Biomedical Engineering, Haifa, Israel, January, 1983.

Tel-Hashomer Heart Institute, Tel-Aviv, Israel, February, 1983.

The fifth Annual Conference of the IEEE/Engineering in Medicine and Biology Society, Columbus, OH, September, 1983.

University of Montreal, Department of Biomedical Engineering, Montreal, Canada, April, 1984.

The First Henry Goldberg Workshop on 3-D Simulation and Imaging of the Cardiac System. Department of Biomedical Engineering, Technion, Haifa, Israel, March, 1984.

The Second Henry Goldberg Workshop on Simulation and Control of the Cardiac System. Department of Biomedical Engineering, Technion, Haifa, Israel, March, 1985.

3rd International Symposium on Body Surface Mapping, Nijmegen. The Netherlands, June, 1985.

University of Akron, Department of Biomedical Engineering, Akron, OH, March, 1986.

The 3rd Henry Goldberg Workshop on Simulation and Modeling of the Cardiac System. Department of Biomedical Engineering, Rutgers University, New Brunswick, NJ, April 1986.

University of Parma, Institute of General Physiology, Parma, Italy, July 1986.

University of Pavia, Institute of Numerical Analysis, Pavia, Italy, July 1986.

Technion-Israel Institute of Technology, Department of Biomedical Engineering, Haifa, Israel, August 1986.

13th International Congress on Electrocardiology, Washington, D.C., September 1986. (Opening talk of the conference).

College of Physicians and Surgeons of Columbia University, Department of Pharmacology, NY, October, 1986.

Eight Annual Conference, IEEE/Engineering in Medicine and Biology Society, Dallas -Fort Worth, TX, November 1986.

University of Utah, Cardiology Division, Salt Lake City, UT, March 1987.

University of Utah, The Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, UT, March 1987.

University of Parma, Institute of General Physiology, Parma Italy, July 1987.

Technion - Israel Institute of Technology, Department of Biomedical Engineering, August 1987.

The Canada - U.S. Symposium on Electrophysiology. Niagara Falls, NY, Sept. 1987.

The American Physiological Society Fall Meeting. San Diego, CA, Oct. 1987.

Workshop on Analysis and Simulation of the Cardiac System. Cambridge University, England, April 1988.

Summer Conference on Electrophysiological Mechanisms of Propagation in, and Activation of Cardiac and Smooth Muscle. Federation of American Societies for Experimental Biology. Saxtons River, VT Aug. 1988.

10th Annual Conference, IEEE/Engineering in Medicine and Biology Society. New Orleans, LA, Nov. 1988.

University of Utah, The Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, UT, October 1988.

Johns Hopkins University, Department of Biomedical Engineering, Baltimore, MD, October 1988.

Indiana University School of Medicine, Department of Pharmacology and Toxicology, Indianapolis, IN, May 1989.

Mayo Clinic, Department of Physiology and the Biodynamics Research Unit, Rochester MN, May 1989.

Computers in Cardiology. Jerusalem, Israel, September 1989. (A Tutorial on the Inverse Problem in Electrocardiography).

State University of New York, Department of Physiology and Biophysics. Stony Brook NY, October 1989.

The 6th Henry Goldberg Workshop on Imaging, Measurement and Analysis of the Heart. Eilat, Israel, December 1989.

The 7th Henry Goldberg Workshop on Micro Phenomena in the Cardiac Muscle: Activation. Circulation and Transport. Berne Switzerland, May 1990.

University of Berne, Department of Physiology, Berne, Switzerland, May 1990.

Columbia University, College of Physicians and Surgeons, Department of Pharmacology, New York, August 1990.

17th International Congress on Electrocardiology. Florence, Italy, September 1990.

University of Utah, The Nora Eccles Harrison Cardiovascular Research and Training Institute. Salt Lake City, UT, October 1990.

Cardiac Electrophysiology Society. Dallas, TX, November 1990.

American Heart Association 63 Scientific Sessions. Dallas, TX, November 1990.

12th Annual Conference, IEEE/Engineering in Medicine and Biology Society, Philadelphia, PA, November 1990.

Washington University, Department of Medicine, St. Louis, MO April 1991.

Conference on Chaos and Sudden Death. The Johns Hopkins University, Baltimore, MD, May 1991.

Tel-Aviv University, Department of Physics and Astronomy, Tel-Aviv, Israel, June, 1991.

Meir Hospital, Kefar-Saba, Israel, July 1991.

JAPAN-USA. Symposium on Cardiac