Director : Yoram Rudy, Ph.D.
Lee A. Biblo, M.D. (Case Western Reserve University, 1981); Associate Professor of Medicine (Cardiology), Chief of Cardiology at MetroHealth Medical Center
Research Interests: Left ventricular hypertrophy and arrhythmias, repolarization abnormalities
Clinical Activities: Catheter ablation of cardiac arrhythmias, atrial fibrillation
lbiblo@metrohealth.orgMeredith Bond, Ph.D. (University of Pennsylvania, 1984); Associate Professor of Physiology and Biophysics; Associate Staff, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation
Research Interests: Calcium regulation of cardiac contractility; Regulation of beta adrenergic signaling pathways in cardiac hypertrophy and cardiac failure; Role of A-kinase anchoring proteins in the heart
bondm@cesmtp.ccf.orgArthur M. Brown, M.D. (University of Manitoba, 1956);Ph.D. (University of London, 1964); Professor of Physiology and Biophysics; Vice President for Research, MetroHealth Medical Center
Research Interests: Structure and function of ion channels; Molecular Cardiology; Molecular Neurology
abrown@metrohealth.orgFrank V. Brozovich, M.D. (University of Washington, 1986); Ph.D. (University of Washington, 1986); Associate Professor of Medicine (Cardiology) and Biophysics
Research Interests: Vascular biology; Biophysics of muscle contraction; Regulation of muscle contraction
fxb9@po.cwru.eduMark D. Carlson. M.D. (University of Kansas, 1980): Associate Professor of Medicine (Cardiology)
Research Interests: Autonomic control of heart rhythm; Vagal control of the sinoatrial and atrioventricular nodes
Clinical Activities: Director, Cardiac Electrophysiology Laboratory at University Hospitals; Anti-arrhythmic drug therapy; Implantable cardioverters defibrillators; Radiofrequency catheter ablation; Catheter and surgical mapping
mdc2@po.cwru.eduOtto Constantini, M.D. (New York University, 1989); Assistant Professor of Medicine (Cardiology), MetroHealth Medical Center
Research Interests: Clinical epidemiology; Risk stratification for sudden death
Clinical Activities: Pacing and implantable defibrillators; Arrhythmias in congestive heart failure; Anti-arrhythmic drug therapy
ocostantini@metrohealth.orgJianmin Cui, Ph.D. (State University of New York at Stony Brook, 1992); Assistant Professor of Biomedical Engineering
Research Interests: Molecular and biophysical mechanisms of ion channel function and modulation; The role of ion channels in cardiac excitation and arrhythmias
cui@heart.cwru.eduMark Dibner-Dunlap, M.D. (University of Tennessee, 1092); Associate Professor of Medicine (Cardiology) and Physiology and Biophysics
Research Interests: Mechanisms of sympathoexcitation in heart failure; Autonmi8c control of the circulation; Cholinergic mechanisms in health and disease; Spectral analysis of heart rate
med3@po.cwru.eduDonald G. Ferguson, Ph.D. (University of Alberta, Edmonton, 1983); Assistant Professor of Anatomy
Research Interests: Immunolocalization techniques to study the disposition of calcium pumps and channels in muscle cells; Localization of DHP and ryanodine receptors in developing mammalian cardiac muscle cells; Calcium imaging to examine calcium release during excitation contraction coupling in a cultured cardiac myocyte model
dgf4@po.cwru.eduMiklos Gratzl, Ph.D. (Technical University of Budapest and Hungarian Academy of Sciences, 1986); Associate Professor of Biomedical Engineering
Research Interests:Technologies for clinical diagnostics of ions, gases and biomolecules; Chemical microsensors; Assessment of ion and drug fluxes in single cells; Electroanalytical sensors including ion-selective electrodes, air-gap probes and voltammetric microelectrodes
mxg13@po.cwru.eduRobert Harvey, Ph.D. (Northwestern University, Chicago, 1987); Assistant Professor of Physiology and Biophysics
Research Interests: Cellular cardiac electrophysiology; Regulation of ion channel function; Molecular basis of ion channel structure-function
rdh3@po.cwru.eduNancy J. Johnson, M.D. (University of Oregon, 1980); Assistant Professor of Medicine (Cardiology), MetroHealth Medical Center
Research Interests: Triggered cardiac arrhythmias; Novel pacing systems
Clinical Activities: Director, Pacemaker Services, MetroHealth Medical Center
njj2@concentric.netElizabeth S. Kaufman, M.D. (Harvard Medical School, 1985); Assistant Professor of Medicine (Cardiology), MetroHealth Medical Center
Research Interests: Long QT syndrome; Cardiac repolarization
Clinical Activities: Director, Electrophysiology Services, MetroHealth Medical Center
ekaufman@metrohealth.orgGlenn E.Kirsh, Ph.D. (Purdue University, 1976); Associate Professor of Physiology and Biophysics, MetroHealth Medical Center
Research Interests: Structure, function and modulation of cardiac ion channels
gkirsch@metrohealth.orgAntonio E. Lacerda, Ph.D. (University of Connecticut 1984); Assistant Professor of Physiology and Biophysics, MetroHealth Medical Center
Research Interests: Calcium ion channels in cardiac myocytes; Regulatory mechanisms modulating single calcium channel function; Calcium entry through ion channels; Molecular structures within the channel protein that affect calcium entry.
alacerda@metrohealth.orgKenneth R. Laurita, Ph.D. (Case Western Reserve University, 1996); Instructor of Medicine and Biomedical Engineering, MetroHealth Medical Center
Research Interests: Cellular mechanisms of cardiac arrhythmias using fluorescent imaging of transmembrane potential and intracellular calcium in the intact heart; Cardiac repolarization kinetics and its influence on arrhythmia vulnerability; Intracellular calcium homeostatis and its role in arrhythmogenesis; Instrumentation and software design for imaging the electrical activity of the heart; Real time digital signal processing techniques for automated analysis of cardiac biopotentials.
klaurita@metrohealth.orgMatthew N. Levy, M.D. (Case Western Reserve University, 1945); Professor Emeritus of Physiology and Biophysics and of Biomedical Engineering; Chief, Investigative Medicine, Mt. Sinai Medical Center
Research Interests: Autonomic neural control of the heart; Role of neuropeptides in cardiac control; Endocrine regulation of the coronary circulation.
mnl@po.cwru.eduWilliam R. Lewis, M.D. (Ohio State University, 1986); Assistant Professor of Medicine (Cardiology), MetroHealth Medical Center
Research Interests: Cardiac arrhythmias ablation techniques; Autonomic function
Clinical Activities: Director, Electrophysiology Laboratory, MetroHealth Medical Center
wlewis@metrohealth.orgJerome Liebman, M.D. (Harvard Medical School, 1955); Professor of Pediatrics and of Biomedical Engineering
Research Interests: Development of optimal lead systems for clinical electrocardiography; Electrocardiographic body surface potential mapping; Hypertrophy and conduction abnormalities in children with congenital heart disease; Methods for locating accessory connections in the Wolfe-Parkinson-White Syndrome.
Clinical Activities: Director, Clinical Electrocardiology Laboratory in the Division of Pediatric Cardiology; Diagnostic electrocardiography in hypertrophy and in the presence of conduction defects.
jxl5@po.cwru.eduJudith A. Mackall, M.D. (Wright State University, 1987); Assistant Professor of Medicine (Cardiology)
Research Interests: Autonomic mediation of electrical alternans; Pacemakers
Clinical Activities: Permanent transvenous pacemakers; Evaluation of new pacing leads; Radiofrequency catheter ablation.
jxm77@po.cwru.eduNiels F. Otani, Ph.D. (University of California, Berkeley, 1986); Associate Professor of Biomedical Engineering
Research Interests: Computer models of cardiac action potential wave propagation; Nonlinear dynamical properties of excitable tissues; Spiral waves of excitation.
nfo@po.cwru.eduKara J. Quan, M.D. (Northeast Ohio University College of Medicine, 1990); Assistant Professor of Medicine (Cardiology), MetroHealth Medical Center
Research Interests: Autonomic function; Cardiac rhythm devices
Clinical Activities: Director, Telemetry Unit
kquan@metrohealth.orgDavid S. Rosenbaum, M.D. (University of Illinois, Chicago, 1983); Associate Professor of Medicine (Cardiology) and of Biomedical Engineering, MetroHealth Medical Center
Research Interests: Basic mechanisms of cardiac repolarization and arrhythmias using high-resolution optical mapping with voltage-sensitive dyes; Digital signal processing of ECG; Electrical alterations of cardiac activity
Clinical Activities: Chief, Cardiac Electrophysiology Service, VA Medical Center; Implantable devices; Prediction of sudden cardiac death from surface ECG; Cardiac electrophysiological studies
drosenbaum@metrohealth.orgYoram Rudy, Ph.D. (Case Western Reserve University,1978); Professor of Biomedical Engineering, Physiology and Biophysics, and Medicine (Cardiology); Director, Cardiac Bioelectricity Research and Training Center
Research Interests: Bioelectric phenomena; Mathematical modeling and computer simulations of cardiac excitation and arrhythmias at the cellular, tissue and whole-heart levels; Models of cardiac ion channels; Electric fields generated by the heart and Electrocardiographic Imaging; Mapping approaches to the study and diagnosis of cardiac electrical function
yxr@po.cwru.eduAlbert L. Waldo, M.D. (State University of New York, College of Medicine, New York City, 1962); The Walter H. Pritchard Professor of Cardiology, Professor of Medicine and Professor of Biomedical Engineering
Research Interests: Mechanisms of cardiac arrhythmias and emphasis on reentry; Atrial flutter and atrial fibrillation in a canine model; Studies of mechanisms of arrhythmias in patients; Simultaneous multisite mapping of cardiac arrhythmias; Mechanism of action of anti-arrhythmic drugs
Clinical Activities: Diagnosis, treatment and prevention of disorders of cardiac rhythm and conduction; Atrial fibrillation and flutter; AV reentrant tachycardias and ventricular tachycardias; Studies of the role of drugs and devices in the treatment and prevention of cardiac arrhythmias
alw2@po.cwru.eduMichiko Watanabe, Ph.D. (Wesleyan University, 1981); Associate Professor of Pediatrics
Research Interests: Role of adhesion molecules in cardiogenesis; Form and function of the developing cardiac conduction system; Apoptosis in outflow tract development; The role of adhesion molecules in regulating adult circadian rhythms
mxw13@po.cwru.eduDavid L. Wilson, Ph.D. ( Rice University, Houston, Texas, 1985); Associate Professor of Biomedical Engineering
Research Interests: Biomedical imaging of the heart and vasculature; Cardiac MRI; Intracoronary ultrasound; Interventional X-ray fluoroscopy
dlw@po.cwru.eduMartin N. Wiseman, M.D. (University of London, 1979); Assistant Professor of Medicine (Cardiology)
Research Interests: New atrial and ventricular implantable cardioverters defibrillators; Pacemaker laser lead extraction
Clinical Activities: Pacemaker implantation and therapy; Implantable cardioverters; Radiofrequency catheter ablation of cardiac arrhythmias
mnw@po.cwru.edu
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