Related Publications


Single Cell Studies 

 

From Genetics to Cellular Function Using Computational Biology
by Yoram Rudy Annals N.Y. Academy of Science  2003 (in press)  

A Na+ channel mutation that causes both Brugada and Long QT Syndrome phenotypes: A simulation study of mechanism.
by Colleen Clancy and Yoram Rudy  Circulation 2002;105:1208-1213

Charge Conservation and Long-term Steady-state in the Luo-Rudy Dynamic Cell Model
by Thomas J. Hund, Jan P. Kucera, Neils F. Otani, and Yoram Rudy  Biophys J 2001;81:3324-3331

Cellular Consequences of HERG Mutations in the Long QT Syndrome: Precursors to Sudden Cardiac Death
by Colleen Clancy and Yoram Rudy  Cardivas Res 2001;50:301-313

Determinants of Excitability in Cardiac Myocytes: Mechanistic Investigation of Memory Effect
by Thomas J. Hund and Yoram Rudy  Biophys J 2000;79:3095-3104

Action Potential and Contractility Changes in [Na+]i Overloaded Cardiac Myocytes: A Simulation Study
by Gregory M. Faber and Yoram Rudy  Biophys J 2000;78:2392-2404

Cellular Arrhythmogenic Effects of Congenital and Acquired Long-QT Syndrome in the Heterogeneous Myocardium
by Prakash Viswanathan and Yoram Rudy  Circulation 2000;101:1192-1198

Bridging the Gap Between a Genetic Defect and its Cellular Phenotype in a Cardiac Arrhythmia
by Colleen Clancy and Yoram Rudy Nature 1999;400:566-569

Pause Induced Early Afterdepolarizations in the Long QT Syndrome: A Simulation Study
by Prakash Viswanathan and Yoram Rudy  Cardiovas Res 1999;42:530-542

Effects of Ikr and Iks Heterogeneity on Action Potential Duration and its Rate - Dependence: A Simulation Study
by Prakash Viswanathan, Robin Shaw, and Yoram Rudy  Circulation 1999;99:2466-2474

Electrophysiologic Effects of Acute Myocardial Ischemia: A Theoretical Study of Altered Cell Excitability and Action Potential Duration
by Robin Shaw and Yoram Rudy  Cardiovasc Res_1997;35:256-272

Early Afterdepolarizations in Cardiac Myocytes: Mechanism and Rate Dependence
by Jinglin Zeng and Yoram Rudy  Biophys J 1995;68:949-964

Two Components of the Delayed Rectifier K+ Current in Ventricular Myocytes of the Guinea Pig Type : Theoretical Formulation and Their Role in Repolarization
by Jinglin Zeng, Kenneth R. Laurita, David S. Rosenbaum, and Yoram Rudy  Circ Res 1995;77:140-152

A Dynamic Model of the Cardiac Ventricular Action Potential. II. Afterdepolarizations, Triggered Activity, and Potentiation
by Ching-Hsing Luo and Yoram Rudy  Circ Res 1994;74:1097-1113

A Dynamic Model of the Cardiac Ventricular Action Potential. I. Simulations of Ionic Currents and Concentration Changes
by Ching-Hsing Luo and Yoram Rudy  Circ Res_1994;74:1071-1096

A Model of the Ventricular Cardiac Action Potential. Depolarization, Repolarization, and Their Interaction
by Ching-Hsing Luo and Yoram Rudy  Circ Res_1991;68:1501-1526



Multicellular Propagation Studies 

 

Genetic Defects, Ionic Currents and Electrocardiographic Alterations  
by Yoram Rudy  Annals  of  Medicine  2003 (in press) 

Ionic Current Basis of Electrocardiographic Waveforms: A Model Study
by Kazutaka Gima and Yoram Rudy  Circulation Research 2002;90:889-896

Mechanistic Insights Into Very Slow Conduction in Branching Cardiac Tissue: A Model Study
by Jan Kucera and Yoram Rudy  Circ Res 2001;89:799-806

The Dynamics of Action Potential Head-Tail Interaction During Reentry in Cardiac Tissue: Ionic Mechanisms
by Thomas J. Hund, Neils F. Otani, and Yoram Rudy  Am J Physiol 2000;279:H1869-H1879

Action Potential Propagation in Inhomogeneous Cardiac Tissue: Safety Factor Considerations and Ionic Mechanism
by Yan Wang and Yoram Rudy  Am J Physiol 2000;278:H1019-H1029

Ionic Mechanisms of Propagation in Cardiac Tissue: Roles of the Sodium and L-Type Calcium Currents During Reduced Excitability and Decreased Gap-Junction Coupling
by Robin Shaw and Yoram Rudy  Circ Res 1997;81:727-741

Elecrophysiologic Effects of Acute Myocardial Ischemia: A Mechanistic Investigation of Action Potential Conduction and Conduction Failure
by Robin Shaw and Yoram Rudy  Circ Res 1997; 80:124-138

The Vulnerable Window for Unidirectional Block in Cardiac Tissue: Characterization and Dependence on Membrane Excitability and Cellular Coupling
by Robin Shaw and Yoram Rudy  J Cardiovasc Electrophysiol 1995;6:115-131
 
 

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