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Research
Cell Transport: Cell transport is important in several physiological and pathological processes such as inflammation, embryogenesis, cancer metastasis and wound healing. Several mechanisms of cell transport have been identified: passive transport through random diffusion and active transport via convection and mechanisms such as chemotaxis, chemokinesis, and haptotaxis. The main goal of this research is to understand various mechanisms of cell transport and to modulate the growth of cell monolayers.
Selected PublicationsR. Toy, E. Hayden, C. Shoup, H. Baskaran, S. Karathanasis. “In Vitro Evaluation of the Effect of Microcirculation on Nanoparticle Distribution for Effective Tumor Targetting”, Nanotechnology, 22, February 2011, doi:10.1088/0957-4484/22/11/115101. M. Breckenridge, T. Egelhoff, and H. Baskaran. “A Microfluidic Imaging Chamber for the Direct Observation of Chemotactic Transmigration”, Biomedical Microdevices, 12(3):543-53, June 2010. W. H. Liang, B. L. Kienitz, J. F. Welter, K. Penick, T.A. Zawodzinski, and H. Baskaran. “Optimizing collagen-GAG scaffolds for Tissue Engineering Applications”, Journal of Biomedical Materials Research Part A, 94(4):1050-60, September 2010. J. Mazzoccoli, D. Feke, H. Baskaran, and P. Pintauro. “Mechanical and Cell Viability Properties of Crosslinked Low- and High-Molecular Weight Poly(ethylene glycol) Diacrylate Blends”. Journal of Biomedical Material Research Part A, 93(2):558-66, May 2010. J. Mazzoccoli, D. Feke, H. Baskaran, and P. Pintauro. “Development of Multilayered Cell-hydrogel Composites Using an Acoustic Focusing Technique”. Biotechnology Progress, 26(2):600-5, March 2010. S. Sarkar, T. Egelhoff, and H. Baskaran. “Insights into the Roles of Non-Muscle Myosin IIA in Human Keratinocyte Migration", Cellular and Molecular Bioengineering, 2(4):486-494, November 2009. V. Janakiraman, D. Englert, A. Jayaraman, and H. Baskaran. “Modeling Growth and Quorum Sensing in Biofilms Grown in Microfluidic Chambers”, Annals of Biomedical Engineering, 37(6), 1206-16, June, 2009. V. Janakiraman, S. Sastry, J. Kadambi, and H. Baskaran. “Experimental Characterization and Computational Modeling of Hydrodynamics in Bifurcating Microchannel Networks”, Biomedical Microdevices, 10(3), 355-65, June 2008. V. Janakiraman, B. Kienitz, and H. Baskaran. “Lithography Techniques for Topographical Micropatterning of Collagen-Glycosaminoglycan Membranes for Tissue Engineering Applications” Journal of Medical Devices, 1(3), 233-237, September, 2007. V. Janakiraman, K. Mathur, and H. Baskaran. “Optimal Planar Capillary Network Designs for Tissue Engineered Constructs with Built-in Microvasculature”, 35(3), 337-347, Annals of Biomedical Engineering, March 2007 |
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Microvascular Tissue Engineering: Tissue engineering has the potential to revolutionize healthcare. A significant challenge in tissue engineering is to overcome substrate mass transfer limitations, which if ignored can result in a product that will not function adequately. The main goal of this research is to design and build microvascular flow analogs that can be used to overcome nutrient limitations in tissue-engineered products.