Cell Biology Program
Pathology 115
Phone 368-5544
e-mail: amt10@po.cwru.edu
The Cell Biology Program provides educational and research opportunities through its journal clubs and colloquia and through graduate training toward the Ph.D. degree. The research environment includes all the basic science departments of the School of Medicine, the Department of Biology, and a number of laboratories at University Hospitals of Cleveland and at the Cleveland Clinic Foundation. These departments collectively cover a diverse set of areas of contemporary interest in the cell biology of higher animals, plants, yeast, and other microorganisms. These include the extracellular matrix, secretion and endocytosis, cell adhesion, the cytoskeleton, the nuclear envelope, etc. Many of these areas interface with local research in biochemistry, genetics, immunology, molecular biology, neuroscience, pharmacological sciences, and physiology and biophysics.
First-year graduate students follow the Correlated Curriculum in Cell and Molecular Biology (CB10 453-456, 12 credit hours) along with students from all graduate departments. They also complete three laboratory rotations (starting July 1) among the laboratories of training faculty of the Cell Biology Program, which span the entire campus. In addition, they participate actively in the weekly Cell Biology Journal Club and attend the cell biology colloquia. The goal of the rotations is to guarantee that the student has sufficient breadth of familiarity with cell biology faculty to allow him or her to make the best choice of a permanent research laboratory. In all cases, this selection must be made, with the consent of the sponsor and his/her department, before nine months have elapsed.
During the following years, the student devotes most of his or her time to laboratory research, while attending courses, seminars and journal clubs. The courses may be given by any department or program on campus. Students must take a total of 36 credit hours of courses and maintain a B average.
Preparation for the qualifying exam and the writing of research proposals and the dissertation match the norm of the department in which the student elects to do his thesis work; however, the content of the exams and proposal(s) have a clear emphasis on cell biology itself.
All efforts should be made to complete the Ph.D. within four years. It is expected that the student will be the first author on at least two articles accepted for publication in highly-regarded scientific journals.
Melvin Berger, Susann Brady-Kalnay, Cathleen Carlin, Lloyd A. Culp, Piet de Boer, Clark W. Distelhorst, Richard L. Eckert, Thomas Egelhoff, Susan Eshler, Edward Greenfield, Alison C. Hall, Clifford Harding, David Katz, Hsing-Jlen Kung, Lynn Landmesser, Thomas Large, Sandra Lemmon, Vance Lemmon, Sanford Markowitz, Gregory Matera, Robert H.Miller, George Perry, Sanjay Pimplikar, Kurt W. Lunge, Urs Rutishauser, Ruth E. Siegel, Neena Singh, Martin Snider, Himan Sternlicht, Alan M. Tartakoff, Dennis Templeton, Christopher D. Town, Mark L. Tykocinski, Mitchiko Watanabe, Joanne Wise, and Richard Zigmond.
Required (first year)
CBIO 453-456. Correlated Curriculum
in Cell and Molecular Biology (12 credits)
BIOC 408 Enzymes and their Regulation (3)
PHRM 413 Molecular Pharmacology (4)
CLBY/PATH 416. Fundamental Immunology (3)
CLBY/NEUR/BIOL 427. Developmental Neurobiology (3)
CLBY/MBIO 436 Advanced Molecular Biology of Eukaryotic Cells (3)
PATH 444 Neurodegenerative Diseases: A Cellular and Molecular Perspective (3)
PHOL 464 Cell Physiology (6)
MBIO 465 Virology (3)
CLBY/PATH 467 Advanced Molecular Immunology (3)
CLBY/BIOC 473 Protein Biosynthesis (3)
NEUR 473 Introduction to Neurobiology (3)
PATH 477 Cellular and Molecular Basis of Immune Dysfunction (3)
PATH 481 Immunology of Infectious Diseases (2)
CLBY/PATH 487 Cell Biology of the Nucleus (3)
CLBY/PATH488/MBIO 451C. Yeast Cell Biology (3)
GENE 500 Advanced Eukaryotic Genetics (3)
CLBY/GENE/BIOL 501 Genetic Control of Development (3)
CLBY/PHRM 505 Neuropharmacology (3)
GENE 510 Human Genetics (3)
GENE 511 Topics in Human Genetics (3)
CLBY/NEUR 512 Synaptic Physiology and Plasticity
CLBY/GENE/MBIO 518 Cell Surfaces and Matrices (3)
GENE 520 Gene Expression in Replication and Differentiation (3)
CLBY/PATH 527 Mechanisms of Cell Growth Control (3)
CLBY 610 Research (credit as arranged).
CLBY 701 Dissertation (credit as arranged)
Cellular and Molecular Biology (CBIO)
CBIO 453, Cell Biology I, 3
Structure and function of subcellular organelles in cells of higher eucaryotes. Vesicular transport. Protein sorting. Cytoskeleton. Growth control. Extracellular matrix.
Prerequisite: BIOC 307 or BIOC 407
CBIO 454, Cell Biology II, 3
Cell-cell communication via nerves and hormones. Intracellular signaling. Introduction to Immunology.
Prerequisite: CBIO 453 or CBIO 455
CBIO 455, Molecular Biology I, 3
Genetic analysis of regulatory mechanisms involved in the synthesis of DNA, RNA, and proteins. Drosophilia and mouse molecular genetics.
Prerequisite: BIOC 307 or BIOC 407
CBIO 456, Molecular Biology II, 3
Eucaryotic molecular biology. Gene organization and regulation of gene expression in eucaryotes. Cell cycle. Cancer.
Prerequisite: CBIO 453 and CBIO 455
Cell Biology (CLBY)
CLBY 416, Fundamental Immunology, 3
(See PATH 416)
CLBY 427, Developmental Neurobiology, 3
(See NEUR 427)
CLBY 467, Advanced Molecular immunology, 3
(See PATH 467)
CLBY 473, Protein Biosynthesis, 3
(See BIOC 473)
Prerequisite: BIOC 307
CLBY 487, Cell Biology of the Nucleus, 3
(See PATH 487)
Prerequisite: CBIO 453 and CBIO 456
CLBY 488, Yeast Genetics/Cell Biology, 3
(See MBIO 488, GENE 488, PATH 488)
CLBY 501, Genetic Control of Development, 3
(See GENE 501)
CLBY 515, Endocrine Pharmacology, 3
(See PHRM 515)
CLBY 518, Cell Surfaces & Matrices, 3
(See GENE 518)
CLBY 527, Mechanisms of Cell Growth Control, 3
(See PATH 527)
Prerequisite: CBIO 453, CBIO 454, CBIO 455, and CBIO 456
CLBY 601, Special Problems, 1-36
This is the listing for independent research. Students should enroll in this course once they have selected their laboratory for Ph.D. research. The number of credit hours depends on how many didactic courses they are following at the same time. Once they have passed their qualifying examination they should register for CLBY 701.
CLBY 701, Dissertation Ph.D., 1-36
This is the listing for independent research toward the Ph.D. The number of credit hours depends on how many didactic courses students are following at the same time. Students may register for this course only once they have passed their qualifying examination.
CWRU Provost's Office --
About this server
-- Copyright 1996 CWRU
-- Unauthorized use prohibited
|