Department of Chemistry

• Department of Chemistry
  • FACULTY
  • ASSOCIATE FACULTY
  • UNDERGRADUATE PROGRAMS
    • Bachelor of Science Program
    • Bachelor of Arts Program
    • Required Science and Math Courses
    • Honors Program
    • Minor
  • GRADUATE PROGRAMS
    • Master of Science Program
    • Doctor of Philosophy Program
  • FACILITIES
  • RESEARCH
  • COLLOQUIA AND SEMINARS
  • UNDERGRADUATE COURSES
  • GRADUATE COURSES
  • BACHELOR OF ARTS DEGREE IN CHEMISTRY
  • BACHELOR OF SCIENCE IN CHEMISTRY DEGREE

Department of Chemistry

Millis Science Center
Phone 368-5914; Fax 368-3006
Anthony Pearson

The Department of Chemistry consists of 22 faculty members, approximately 12 postdoctoral associates, 80 graduate students, and more than 130 undergraduate students majoring in chemistry. Programs in chemistry for the degrees of Bachelor of Arts, Bachelor of Science, Master of Science, and Doctor of Philosophy are offered.

The Department of Chemistry is the largest department and central focus of a wide array of departments representing the chemical sciences at Case Western Reserve University, including chemical engineering, macromolecular science, biochemistry, and pharmacology. Both the undergraduate and graduate student bodies have representatives of all regions of the United States and of numerous foreign countries. The John Schoff Millis Science Center and the Morley Chemical Laboratories house the department's well-equipped offices, classrooms, and instructional and research laboratories. The major chemical stockroom and electronics shop facilities are located in the Millis Science Center. Within short walking distance is the Kelvin Smith Library, which contains a comprehensive collection of books and periodicals in all technical fields. Also available nearby on campus is the outstanding Cleveland Health Sciences Library. Its Health Center Branch, in the new building of the Case Western Reserve University School of Medicine, serves mainly academic interests; the Allen Memorial Branch emphasizes clinical medicine. All departments, research centers, and major facilities related to science, technology, and medicine are conveniently close to one another.

Chemical research is an integral part of the department's activities; more than $3 million of federal and private research support flows into the department each year. The facilities for carrying out first-rate research are outstanding and are available to both graduate and undergraduate students. Undergraduates are encouraged to participate in research projects with individual faculty members as a method of expanding their chemical training. Research programs typically involve interchange and collaboration across all levels of experience from students to faculty. Mutual interests among faculty members also lead frequently to cooperative research efforts.

An important aspect of chemical employment is the broad range of opportunities it offers. Chemists can work for others or by themselves. They can direct their talents to specialized problems of applied research, or they can choose to delve into fundamental investigations. They can cover the spectrum of chemical specialties from microbiochemistry to the study of lunar materials. To satisfy their interests, they can work in fields closely akin to other professions, such as medicine, dentistry, and law. They can transmit their knowledge to others by teaching at a wide variety of levels. They can work for private industry or for the public as government employees.

The American Chemical Society, with its more than 100,000 members, is the major professional society in the United States for practicing chemists. Both undergraduate and graduate students may become affiliated with the society.

FACULTY

Anthony J. Pearson, Ph.D. (University of Aston, Birmingham, England)

Alfred B. Anderson, Ph.D. (Johns Hopkins University)

Mary D. Barkley, Ph.D. (University of California, San Diego)

Robert C. Dunbar, Ph.D. (Stanford University)

Philip P. Garner, Ph.D. (University of Pittsburgh)

Malcolm E. Kenney, Ph.D. (Cornell University)

Stephen J. Klippenstein, Ph.D. (California Institute of Technology)

Gilles Klopman, Ph.D. (University of Brussels, Belgium)

Gheorghe D. Mateescu, Ph.D. (Case Western Reserve University)

Barry Miller, Ph.D. (Massachusetts Institute of Technology)

Ignacio Ocasio, Ph.D. (University of Puerto Rico)

John D. Protasiewicz, Ph.D. (Cornell University)

Robert G. Salomon, Ph.D. (University of Wisconsin, Madison)

Lawrence M. Sayre, Ph.D. (University of California, Berkeley)

Daniel A. Scherson, Ph.D. (University of California, Davis)

M. Cather Simpson, Ph.D. (University of New Mexico)

John E. Stuehr, Ph.D. (Case Western Reserve University)

Chaim N. Sukenik, Ph.D. (California Institute of Technology)

Terrence J. Swift, Ph.D. (University of California, Berkeley)

Fred L. Urbach, Ph.D. (Michigan State University )

Michael G. Zagorski, Ph.D. (Case Western Reserve University)

ASSOCIATE FACULTY

Marc S. Berridge, Ph.D. (Washington University)

Vernon E. Anderson, Ph.D. (University of Wisconsin-Madison)

John J. Mieyal, Ph.D. (Case Western Reserve University)

UNDERGRADUATE PROGRAMS

The Department of Chemistry offers two basic curricula for undergraduate chemistry majors, leading to either a Bachelor of Science degree or a Bachelor of Arts degree.

Bachelor of Science Program

The Bachelor of Science degree program is designed for students who plan professional careers in chemistry and leads to certification by the American Chemical Society. The required science, math and computing courses for the B.S. curriculum are shown on the following page. The B.S. curriculum provides a rigorous background in chemistry yet has considerable flexibility in the senior year in the choice of electives. During the senior year, the B.S. major is expected to go a step beyond basic preparation in an area of chemistry of particular interest. Research is strongly encouraged. As many as nine hours of research (CHEM 397) may be credited toward the degree. B.S. majors who plan to go on to graduate study may elect to take advanced courses in inorganic chemistry (CHEM 412, 413); organic chemistry (CHEM 421, 422, 435); chemical thermodynamics (CHEM 407); quantum mechanics (CHEM 446); instrumental analytical chemistry (CHEM 410), or other graduate offerings. Interdisciplinary strengths can be achieved by selecting technical electives to follow designed "tracks" in biological chemistry, chemical physics, environmental chemistry, material science or polymer science.

Bachelor of Arts Program

The B.A. program is intended for students who plan careers in medicine or other health or science-related fields for which a baccalaureate degree in chemistry provides appropriate pre-professional training. B.A. majors may supplement their chemical training by electing additional chemistry courses or may utilize the curriculum flexibility in the Department of Chemistry to develop an interdisciplinary program of their choice. Many B.A. majors participate in undergraduate research within the Department of Chemistry (CHEM 397) or in other science departments including those in the medical school.

Required Science and Math Courses

1. Chemistry courses

CHEM 105, 106, 113

CHEM 223, 224 (or CHEM 323, 324), 233, 234 (or CHEM 321, 322)

CHEM 301, 302, (or CHEM 335, 336), 304, 305

2. Additional required courses

PHYS 115, 116 (or PHYS 121, 122)

MATH 125, 126 (or MATH 121, 122)

Honors Program

Chemistry majors who have excellent academic records may participate in the Honors in Chemistry Program. To graduate with honors in chemistry, a student must satisfy the following requirements:

1. A combined grade point average of 3.30 in chemistry, physics, and mathematics and an overall grade point average of 3.00
2. A minimum of six semester hours of CHEM 397, or, with departmental approval, chemical research done under another course number
3. A thesis approved by the Undergraduate Committee of the department on the basis of the level of research, the quality of the manuscript, and the chemical content

Minor

Students may complete a minor in chemistry, defined as one year of freshman chemistry (including laboratory); two additional three-hour lecture courses; and two additional laboratory or approved courses. A recommended sequence would include: CHEM 105, 106, Principles of Chemistry I, II (3,3), or CHEM 107, 108, Properties and Structure of Matter I, II (3,3), and CHEM 113, Principles of Chemistry Laboratory (2) CHEM 223, 224, Introductory Organic Chemistry I, II (3,3), or CHEM 323, 324, Organic Chemistry I, II (3,3), and CHEM 233, 234, Introductory Organic Chemistry Laboratory I, II (2,2). Other sequences may be followed after consultation with the Department of Chemistry.

GRADUATE PROGRAMS

Master of Science Program

The Master of Science degree in chemistry may be obtained by completing a program including the preparation of a master's thesis or a program involving only coursework. Both programs require a minimum of 27 semester credit hours, of which up to 6 semester credit hours may be for the master's thesis. Course work may be taken on a part-time basis for the master's degree. Thesis research can be undertaken only by full-time graduate students. Only the master's degree without thesis can be earned entirely on a part-time basis.

Doctor of Philosophy Program

The Doctor of Philosophy degree in chemistry is granted to those students who have shown an extensive knowledge of advanced chemistry and the ability to do original research. The program usually requires four years of full-time study after the bachelor's degree. Besides advanced courses, the program consists of cumulative and oral examinations, seminars and colloquia, and, most importantly, original research. At least twelve months must be spent in residence on campus while fulfilling the Ph.D. thesis research requirement.

Full-time graduate students who maintain satisfactory academic performance while pursuing the Ph.D. degree in chemistry normally receive a stipend for teaching and/or research which includes full tuition and a monthly amount sufficient to cover living expenses.

FACILITIES

Facilities for experimental and theoretical research are modern and extensive. They include diverse major instruments for use by faculty and students, as well as specialized equipment serving individual research groups. Among the former are the instruments of the Major Analytical Instruments Facility. The MAIF was established in the Department of Chemistry through joint funding by the National Science Foundation and local industry. This Facility centers on two Varian XL-200 Fourier transform nuclear magnetic resonance spectrometers, a Varian Gemini 300 MHz FT NMR, a Bruker MSL-400 FT NMR with microimaging, a Varian IEE x-ray photoelectron spectroscopy unit, a Mattson Sirius-100 GC-FTIR with matrix isolation capability, 3M ion scattering and secondary ion mass spectrometers, a Kratos M.S.-25 RFA GC mass spectrometer, and an electron-spin resonance spectrometer.

Other departmental instrumentation includes equipment for ion cyclotron resonance spectrometry, laser Raman spectroscopy, x-ray diffraction, extremely rapid kinetics measurements, spectropolarimetry and circular dichroism, protein structure elucidation, ellipsometry, electrochemical measurements, and low-energy diffraction and Auger studies of surfaces.

Access to very high field NMR instrumentation is available on campus at the Cleveland Center for Structural Biology (CCSB). Many faculty in the Chemistry Department are actively involved with the CCSB, which is equipped with a modern 300 and 500 MHz, plus two 600 MHz, spectrometers.

The Frank Hovorka Information Center stands as the core of the Chemistry Department's computer facility. This center and associated laboratories represents an array of advanced computational and graphics capabilities, including seven Silicon Graphics Indigo computers and two SUN workstations. Many of the department's analytical instruments are networked with these workstations together with computers in individual faculty research areas. The Chemistry Department's computers are part of the campus-wide communications network, CWRUnet. In addition to the full complement of software, Internet, and library database services offered by the University through CWRUnet, connections to off-site databases, such as STN and Ohio Supercomputer Center, are available to departmental users.

A large number of laboratory microcomputers are in operation in the department. For the design, maintenance, and repair of research apparatus, excellent shop facilities and staff personnel are available for glass blowing and electronics work.

RESEARCH

The Department of Chemistry is noted for the diversity of its research efforts. These range from synthetic studies of important bioactive substances, including antibiotics and DNA-binding substances, to a detailed understanding of the surface properties of materials used in batteries and electrolytic cells. Studies are being performed with molecules as simple as oxygen and as complicated as those which describe the active centers of enzymes or the protein core of insoluble aggregates which deposit in neuro-degenerative disease. Multidisciplinary approaches are being applied to understanding energy transfer in proteins. Efforts are being made to understand the basic chemical properties leading to reactive modifiers generated from physiological lipids. Other research is aimed at developing new drugs for photodynamic therapy and at understanding biological activity through artificial intelligence approaches. The influence of metal ions in modifying reactivity is a common interest of several members of the faculty, as is the development of organometallic compounds for synthesis and catalysis.

Experimental and theoretical studies of gas phase molecules are providing a fundamental understanding of unimolecular reaction dynamics and ionization processes important in atmospheric chemistry. Chemical surfaces are being studied. Of particular importance are studies designed to characterize the electrode-electrolyte interfaces important in electrocatalysis and the electrochemical properties of new semiconductors. These efforts are complemented by theoretical studies on the interfacial structure and bonding in composite materials.

The department uses some of the foremost equipment available in high-resolution nuclear magnetic resonance spectroscopy and in tunable laser spectroscopy. Work on various aspects of chemistry as studied by these techniques is recognized throughout the world.

The graduate program The Chemistry of Life Processes offers the student the opportunity of pursuing a course of study that cuts across traditional disciplines. The three traditional areas of chemistry--inorganic, organic, and physical--are all represented in their biological aspects. Through strong ties with the biomedical community within the University surroundings, faculty who carry out research in biochemical areas have coordinated a program of integrated coursework, seminar offerings, and research experience. Although the student receives a Ph.D. degree in chemistry, participants in this program gain a broader, interdisciplinary background which provides distinct advantages when embarking upon a career in teaching/research, industry, or at government laboratories.

Case Western Reserve University ranks among the leading universities internationally in its strengths in electrochemistry and has brought these strengths together under one coordinated structure, The Yeager Center for Electrochemical Studies (YCES). The interdisciplinary nature of electrochemistry requires the interaction of electrochemists in the chemistry and chemical engineering departments with metallurgists, surface physicists, inorganic and organic chemists, polymer membrane chemists, and electrical engineers. Such interactions are lacking on most campuses and are promoted at Case Western Reserve University through YCES. Graduate students in the chemistry department have the opportunity to specialize in the area of electrochemistry with one of the most extensive course and research programs in the United States.

COLLOQUIA AND SEMINARS

The department sponsors a rich program of colloquia and seminars on recent advances in chemical research. Most notable among these is the Frontiers in Chemistry Lecture Series, in which scientists of international distinction lecture on major discoveries and developments in chemistry. In addition, a weekly colloquium series provides lectures by invited speakers in a variety of fields of chemical investigation. Both of these programs are addressed to the general audience of faculty, students, and other chemical scientists in the University and the Cleveland area, and are a vital means to a broad, current knowledge. Numerous other seminars and meetings are held on a more specialized and informal level. Most individual research groups conduct weekly discussions to evaluate their progress.

Chemistry (CHEM)

UNDERGRADUATE COURSES

CHEM 105, Principles of Chemistry I, 3

Atomic structure; thermochemistry; periodicity, bonding and molecular structure; intermolecular forces; properties of solids; liquids, gases and solutions. One year of high school chemistry.

CHEM 106, Principles of Chemistry II, 3

Thermodynamics, chemical equilibrium; acid/base chemistry; oxidation and reduction; kinetics; spectroscopy; introduction to nuclear, organic, and industrial chemistry.

Prerequisite: CHEM 105

CHEM 107, Properties and Structure of Matter I, 3

A first course in university chemistry emphasizing physical chemistry of materials. States of matter, thermodynamics and chemical equilibrium. One year of high school chemistry required.

CHEM 108, Properties and Structure of Matter II, 3

Spectroscopy and the structure of atoms and molecules; rate processes and reaction mechanisms; properties of metals and nonmetals; properties of organic compounds and macromolecules.

Prerequisite: CHEM 107

CHEM 113, Principles of Chemistry Laboratory, 2

A one semester laboratory offering a challenging sequence of experiments designed to teach a creative approach to modern chemistry. Corequisite is CHEM 105, 106 or 107, 108.

CHEM 223, Introductory Organic Chemistry I, 3

Introductory course for Engineering students and B.A. science majors. Develops themes of structure and bonding, reaction mechanism, nuclear magnetic resonance spectroscopy, and synthetic analysis. Uses problem solving strategies to explore fundamental concepts in the discipline. Relates course materials to topics in technology and biological science.

Prerequisite: CHEM 106 or CHEM 108

CHEM 224, Introductory Organic Chemistry II, 3

(Continuation of CHEM 223) Introduces carbonyl and aromatic functional groups. Uses multiple spectroscopic methods for structure identification, and studies biopolymers as integrative examples of complex organic chemistry.

Prerequisite: CHEM 223 or CHEM 323

CHEM 233, Introductory Organic Chemistry Laboratory I, 2

Synthesis and purification of organic compounds, isolation of natural products, and systematic identification of organic compounds by physical and chemical methods.

Prerequisite: CHEM 106 or CHEM 108, and CHEM 113

CHEM 234, Introductory Organic Chemistry Laboratory II, 2

(Continuation of CHEM 233.)

Prerequisite: CHEM 233

CHEM 301, Introductory Physical Chemistry I, 3

First of a two-semester sequence covering principles and applications of physical chemistry, intended for chemistry majors and other students having primary interests in biochemical, biological or life-science areas. States and properties of matter. Thermodynamics and its application to chemical and biochemical systems. Chemical equilibrium. Electrochemistry. Requires one year each of physics and calculus, preferably including partial derivatives.

Prerequisite: CHEM 106 or CHEM 108

CHEM 302, Introductory Physical Chemistry II, 3

(Continuation of CHEM 301) Introductory quantum chemistry. Spectroscopy. Chemical kinetics and catalysis in chemical and enzymatic systems. Statistical mechanics and thermodynamics.

Prerequisite: CHEM 301 or CHEM 335

CHEM 304, Chemical Measurements Laboratory, 3

A one semester laboratory course on techniques for quantitative chemical measurements, error analysis, and advanced concepts in ionic equilibria, including pH. Basic chemical instrumentation.

Prerequisite: CHEM 233 and CHEM 234 or CHEM 321 and CHEM 322. Corequisite: CHEM 301

CHEM 305, Introductory Physical Chemistry Laboratory, 3

A one-semester laboratory course that acquaints the student with the principles and quantitative characterization of chemical and biochemical systems. Experiments such as electrolyte equilibria, viscosity of macromolecules, and kinetics of rapid reactions. Required to have two semesters of physical chemistry (second semester may be taken concurrently).

Prerequisite: CHEM 304

CHEM 311, Inorganic Chemistry I, 3

Fundamentals of inorganic chemistry. Topics include molecular structure, molecular shape and symmetry, structures of solids, d-metal complexes and oxidation and reduction.

Either prerequisite may be taken concurrently.

Prerequisite: CHEM 301 or CHEM 335

CHEM 312, Inorganic Chemistry II, 3

(Continuation of CHEM 311) Fundamentals of inorganic chemistry. Topics include acids and bases, electronic spectra of complexes, structures and properties of solids and descriptive chemistry of representative elements.

Prerequisite: CHEM 311

CHEM 317, Radiochemistry: Radioactivity and its Applications, 3

Application of radiotracers in chemistry, biology, engineering, and medical diagnosis and therapy. Covers radiation safety and basic theory, techniques, and uses of radiochemistry.

Prerequisite: CHEM 106 or CHEM 108

CHEM 320, Advanced Chemical Laboratory Methods, 3

Techniques of chemical synthesis, analysis, and characterization. Corequisite: CHEM 223 or CHEM 323

Prerequisite: CHEM 113, and CHEM 224

CHEM 321, Laboratory Methods and Techniques I, 3

CHEM 321 and 322 are the first two semesters of an integrated laboratory sequence. Experimental approach to chemical problems. Chemical measurements, synthesis, and characterization. Corequisite: CHEM 223 or CHEM 323

Prerequisite: CHEM 113

CHEM 322, Laboratory Methods and Techniques II, 3

(Continuation of CHEM 321)

Prerequisite: CHEM 321

CHEM 323, Organic Chemistry I, 3

Enriched course for sufficiently able and interested student who wishes a deeper and broader appreciation of theory and practice of organic chemistry. Focuses on relationships between molecular structure and chemical reactivity, and stresses the development of sophisticated problem-solving skills in the context of organic reaction mechanisms and multi-step synthesis. Homolytic and heterolytic substitution, elimination, oxidation and reduction reactions, topics in stereochemistry and spectroscopy. Recommended for Chemistry, Biochemistry, and related majors. Consent of instructor required.

Prerequisite: CHEM 106 or CHEM 108

CHEM 324, Organic Chemistry II, 3

(Continuation of CHEM 323) Introduces the chemistry of carbonyl, aromatic and amino functional groups, and develops the concepts of conjugation and resonance, molecular orbital theory and pericyclic reactions. Consent of instructor required.

Prerequisite: CHEM 323

CHEM 325, Physical Methods for Determining Organic Structure, 3

Determination of structure of organic compounds, separation techniques. Application of infrared, ultraviolet, and visible spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry, and modern instrumental techniques. Two semester of organic chemistry required.

CHEM 329, Chemical Aspects of Living Systems, 3

A series of special topics in the chemistry of biological processes at the level of molecular mechanisms. Chemico-biological interactions. Homogeneous catalysis in biochemical and biomimetic systems. Biochemical dynamics. Mitochondrial respiration and photosynthesis. Biological activity and carcinogenesis. Two semesters of organic chemistry and one semester of physical chemistry required.

CHEM 330, Computer Techniques in Chemistry Lab, 2

Computer techniques for chemical research; searching chemical databases; data collection and analysis with computers; computational methods and molecular modeling. Introduction to software packages for computer applications in chemistry. Corequisite: CHEM 301 or 335

Prerequisite: CHEM 322

CHEM 331, Laboratory Methods and Techniques III, 3

Synthesis, separation techniques, physical properties, and analysis. Advanced techniques of chemical synthesis, leading the student to the preparation of interesting inorganic and organometallic compounds.

Prerequisite: CHEM 322

CHEM 332, Laboratory Methods and Techniques IV, 3

Modern techniques of physical measurement, including nuclear magnetic resonance, electronic spin resonance, and electrochemistry.

Prerequisite: CHEM 331

CHEM 335, Physical Chemistry I, 3

First of a two-semester sequence of physical chemistry for chemistry majors and others with career goals in the physical sciences or engineering. States of matter. Kinetic theory of gases. Transport phenomena. Chemical thermodynamics and its application to chemical systems. Equilibrium. Ionic solutions and electrochemistry. Statistical mechanics and thermodynamics. Recommend having calculus including partial derivatives; PHYS 221 may be concurrent.

Prerequisite: CHEM 106 or CHEM 108, and PHYS 221

CHEM 336, Physical Chemistry II, 3

(Continuation of CHEM 335) Chemical quantum mechanics. Spectroscopy (including optical spectroscopies, magnetic resonance, mass spectrometry). Reaction kinetics and catalysis. Further consideration of statistical thermodynamics and chemical equilibrium. Reaction dynamics.

Prerequisite: CHEM 335, PHYS 221

CHEM 337, Quantum Mechanics I, 3

Introduction to quantization, measurement and the Schrodinger equation; angular momentum and states of molecules. Perturbation theory, spectroscopy and chemical bonding. Variational theory and calculations of molecular properties.

Prerequisite: CHEM 336

CHEM 395, Chemistry Colloquium Series, 1

Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.

CHEM 397, Undergraduate Research, 1-9

Independent research project within a research group in the chemistry department; arrangements should be made with the faculty member selected. Open to all chemistry majors and other qualified students; required for honors in chemistry. A written report is required each semester. Consent of department required.

GRADUATE COURSES

CHEM 406, Chemical Kinetics, 3

Theory and characterization of chemical rate processes. Two semesters of undergraduate physical chemistry required.

CHEM 407, Chemical Thermodynamics, 3

Thermodynamics and statistical thermodynamics and their application to chemical problems. Two semesters of undergraduate physical chemistry required.

CHEM 410, Instrumental Analytical Chemistry, 3

Principles and applications of analytical instrumentation including optical spectroscopy, photoelectron and ion bombardment spectrometry, mass spectrometry, NMR and magnetic resonance imaging. Two semesters of undergraduate physical chemistry required.

CHEM 412, Advanced Inorganic Chemistry I, 3

Chemistry of inorganic systems. Spectroscopy, magnetism, and stereochemistry of transition metal compounds. One semester of undergraduate inorganic and two semesters of physical chemistry required.

CHEM 413, Advanced Inorganic Chemistry II, 3

Chemistry of inorganic compounds; mechanisms of reactions. Prerequisite course or its equivalent required.

Prerequisite: CHEM 412

CHEM 414, Organometallic Reactions and Structures, 3

Bonding and structure in organometallic chemistry and the relevance of organometallic species to chemical catalysis. One semester of undergraduate inorganic chemistry required.

CHEM 415, Chemical Applications of Group Theory, 3

Experimental and semi-empirical treatments of structure and bonding in chemical systems based on a presentation of relationships and the theory of point and space groups. Prerequisite course or its equivalent required.

Prerequisite: CHEM 412

CHEM 417, Radiochemistry: Radioactivity and its Applications, 3

Application of radiotracers in chemistry, biology, engineering, and medical diagnosis and therapy. Covers radiation safety and basic theory, techniques, and uses of radiochemistry.

Prerequisite: CHEM 107 or CHEM 108

CHEM 421, Advanced Organic Chemistry I, 3

Elementary general molecular orbital theory. Stereoisomerism. Reaction mechanisms. Pericyclic reactions and orbital symmetry conservation. Organic photochemistry. Free radical, radical ion, carbene, nitrene, aryne intermediates and their reactions. Two semesters of undergraduate organic chemistry required.

CHEM 422, Advanced Organic Chemistry II, 3

Carbocations and carbanions. Nucleophilic and electrophilic aliphatic substitutions. Heterolytic addition and elimination reactions. Electrophilic, nucleophilic, and free radical aromatic substitutions. Carbonyl reactions. Oxidations, reductions, rearrangements. Two semesters of undergraduate organic chemistry required.

CHEM 425, Physical Methods for Determining Organic Structure, 3

Determination of structure of organic compounds; separation techniques. Application of infrared, ultraviolet, and visible spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry, and modern instrumental techniques. Two semesters of undergraduate organic chemistry required.

CHEM 429, Chemical Aspects of Living Systems, 3

A series of special topics in the chemistry of biological processes at the level of molecular mechanisms. Chemicobiological interactions. Homogeneous catalysis in biochemical and biomimetic systems. Biochemical dynamics. Mitochondrial respiration and photosynthesis. Biological activity and carcinogenesis. Two semesters of undergraduate organic and one semester of undergraduate physical chemistry required.

CHEM 435, Synthetic Methods in Organic Chemistry, 3

Systematic consideration of reactions which allow carbon-carbon bond formation or cleavage, as well as the introduction, removal, interconversion, or transposition of functional groups. Two semesters of undergraduate organic chemistry required.

CHEM 436, Complex Molecular Synthesis, 3

The logic which may be applied to designing syntheses of complex molecules in the context of a comparison of in vivo and laboratory syntheses of natural products including acetogenins, alkaloids, aromatic amino acids, fatty acids, macrolides, porphyrins, prostaglandins, steroids, and other terpenoids. Consent of instructor may replace prerequisite course.

Prerequisite: CHEM 435

CHEM 445, Electrochemistry I, 3

Electrochemical properties and processes of electrode/electrolyte interfaces. Fundamental background for work in corrosion, electrodeposition, industrial electrolysis, electro-organic synthesis, batteries, fuel cells, and photoelectrochemical energy conversion. One undergraduate course in physical chemistry and a working knowledge of thermodynamics required.

CHEM 446, Quantum Mechanics I, 3

Introduction of quantization, measurement and the Schršdinger equation; angular momentum and states of molecules. Perturbation theory, spectroscopy and chemical bonding. Variational theory and calculations of molecular properties. Two semesters of undergraduate physical chemistry required.

CHEM 447, Quantum Mechanics II, 3

(Continuation of CHEM 446.) Abinitio and semi-empirical methods, configuration interaction, time dependent phenomena, and principles of group theory.

Prerequisite: CHEM 446

CHEM 448, Statistical Mechanics, 3

A systematic development of equilibrium statistical mechanics; the properties of the gaseous, liquid, and solid states of matter. Introduction to nonequilibrium statistical mechanics. Consent of instructor may replace prerequisite courses.

Prerequisite: CHEM 407 and CHEM 446

CHEM 450, Molecular Spectroscopy, 3

Rotation, vibration, and electronic spectra of simple and complex molecules.

Prerequisite: CHEM 446

CHEM 460, NMR Spectroscopy and Imaging, 3

Fundamental and advanced topics in understanding and application of NMR imaging and spectroscopy. Theoretical description and specific examples of spin Hamiltonians, pulse sequences, and basic instrumentation.

Prerequisite: CHEM 410, PHYS 431 or EBME 410

CHEM 470, Macromolecular Synthesis, 4

Organic chemistry of macromolecules, mechanism of poly reactions, preparation of addition and condensation polymers, and the chemical reactions of polymers.

Prerequisite: CHEM 224 or CHEM 324 and EMAC 270

CHEM 479, X-ray Crystallography, 3

Scattering of x-rays by crystalline and semicrystalline solids including polymers. Technique of structure analysis.

CHEM 502, Special Topics in Inorganic Chemistry, 1-6

(Credit as arranged) Lectures on advanced topics in inorganic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 503, Special Topics in Organic Chemistry, 1-6

(Credit as arranged) Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 504, Special Topics in Organic Chemistry, 1-6

(Credit as arranged) Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 505, Special Topics in Physical Chemistry, 1-6

(Credit as arranged) Lectures on advanced topics in physical chemistry presented by staff or visiting lecturers. Course titles, content, and credit change from year to year.

CHEM 507, Special Readings in Chemistry, 1-6

Detailed study of a special topic in chemistry under the guidance of a faculty member.

CHEM 508, Special Readings in Chemistry, 1-6

Detailed study of a special topic in chemistry under the guidance of a faculty member.

CHEM 511, Electrochemistry II, 3

Electrocatalysis, semiconductor electrochemistry and photoelectrochemistry, and electrochemical impedance methods, as well as battery and fuel cell systems.

CHEM 601, Research, 1-36

(Credit as arranged) Special research in an area of chemistry under the guidance of a faculty member.

CHEM 605, Chemistry Colloquium Series, 1

Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.

CHEM 651, Thesis M.S., 1-36

(Credit as arranged)

CHEM 701, Dissertation Ph.D., 1-36

(Credit as arranged)

BACHELOR OF ARTS DEGREE IN CHEMISTRY

BACHELOR OF SCIENCE IN CHEMISTRY DEGREE (REQUIRED SCIENCE, MATH AND COMPUTING COURSES)

The Bacholor of Science in Chemistry degree requires completion of the Arts and Sciences General Education Requirements and the courses listed in the following table.

Selected students may be invited to take PHYS 123, 124, 223 (Honors).

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