Department of Anatomy
School of Medicine
Phone 368-3430
The Department of Anatomy focuses on contemporary and emerging biological and medical problems from structural or morphogenetic perspectives. Programs are offered leading to a Doctor of Philosophy or a combined Doctor of Medicine-Doctor of Philosophy degrees. The emphasis of the doctoral programs is in preparation for careers in teaching and research in anatomical sciences with full regard for modern interdisciplinary approaches and linkages. Work can be at a variety of biological levels of organization, ranging from molecular biology through cell biology to macroscopic structural issues as they relate to evolution and development. The programs are tailor-made for the students specific interests with emphasis on close personal contact.
The research of the faculty in cell and molecular biology involves modern structural biology. The structural studies extend from the ultrastructure of the visual nervous system, primate placenta and secretory glands to the development of new contrast agents in magnetic resonance imaging. Transgenic mice are also used to study the metabolic interaction of growth hormone and insulin on receptor phosphorylation, signal transduction, and glucose uptake. Other studies include the regulation of gene expression in skeletal muscle development, cell-cell interactions contributing to this process and the alterations in proteoglycans of arthritic individuals. Joint ventures of the group expand the research base to studies on insulin resistance in neonates and during pregnancy, cancer of the vascular system, atherosclerosis, the development of blood vessels and cartilage alterations in arthritis.
Joseph LaManna, Ph. D. (Duke University)
Professor and Acting Chairman
J. Douglas Caston, Ph.D. (Brown University)
Professor
Amos L. Hopkins, Ph.D. (Washington University)
Associate Professor
Ita R. Kaiserman Abramof, Ph.D. (Federal University of Minas Gerais, Brazil)
Associate Professor
Charles E. Maier, Ph.D. (Case Western Reserve University)
Assistant Professor
Raphael L. Poritsky, Ph.D. (Case Western Reserve University)
Associate Professor
Ronald J. Przybylski, Ph.D. (University of Chicago)
Associate Professor
Thomas Hering, Ph.D. (Case Western Reserve University)
Adjunct Assistant Professor
Judith Ilan, Ph.D. (The Hebrew University of Jerusalem, Israel)
Professor
Thomas Johnson, Ph.D. (Case Western Reserve University)
Adjunct Instructor
Hue-Lee C. Kaung, Ph.D. (University of Iowa)
Assistant Professor
Charles J. Malemud, Ph.D. (George Washington University)
Professor
Peter V. Scoles, M.D. (Thomas Jefferson University)
Associate Professor
Bruce Latimer, Ph.D. (Kent State University)
Adjunct Assistant Professor
Anatomy (ANAT)
ANAT 399. Independent Study in Anatomy (credit as arranged).
Prerequisite: Limited to undergraduates. Students must obtain approval of a supervising professor before registration and list the professor's name on the schedule card.
ANAT 411. Gross Anatomy (1-4).
Dissection of the adult human cadaver. Prerequisite: Consent of instructor.
ANAT 412. Histology and Ultrastructure (3).
General histology and ultrastructure, with histophysiological correlations. Prerequisite: Consent of instructor.
ANAT 413. Laboratory in General Histology (2).
Microscopic structure of tissues and organs. Prerequisite: Consent of instructor.
ANAT 431. Statistical Methods I (3)
ANAT 448. The Molecular Biology of Reproductive Hormone Action on Developmental Systems (3).
(See RBI0 448.)
ANAT 459. Advanced Cellular Physiology (3)
ANAT 462. Advanced Principles of Developmental Biology (3).
ANAT 464. Problems of Mammalian Reproduction (3).
(See BIOL 464.)
ANAT 495. Optical Methods in Biology (4).
(Also listed as BIOL 495.) Laboratory experience in the techniques commonly employed in a variety of optical approaches to biological systems, including light, phase, interference contrast fluorescence, and electron microscopy. Prerequisite: Consent of instructor.
ANAT 501. Genome Expression: Determination and Differentiation (3).
(Also listed as BIOL 501.) Comparison of determination in several phyla, determination and transdetermination in insects, induction and competence, differentiation and modulation illustrated by specific examples and by genetic variants, embryonic fields and gradients, influence of hormones and other factors in development, regeneration, and cell death. Prerequisite: BIOL 362, its equivalent, or consent of instructor.
ANAT 503. Readings and Discussion in Anatomy (credit as arranged).
In-depth consideration of special selected topics through critical evaluation of the literature. Prerequisite: Consent of instructor.
ANAT 514. Normal and Abnormal Mammalian Development (3).
Lectures and readings on the developing mammal (including the human) from gamete to fetus. Discussions based on original article dealing with descriptive, genetic, and experimental analyses of normal and pathological development. Prerequisite: BIOL 362 or consent of instructor.
ANAT 515. Seminar: Special Problems in Mammalian Reproduction (2).
(See RBI0 515.)
ANAT 518. Cell Surfaces and Matrices (3)
ANAT 519. Seminar in Cell Biology of Muscle Development (1).
In-depth analysis of papers dealing with various aspects of cell biology with emphasis on correlating structure and function. Prerequisite: Basic knowledge in cell and developmental biology and consent of instructor.
ANAT 522. Proposition (3).
Design of research proposal. Prerequisite: Consent of Graduate committee.
ANAT 550. Seminar in Experimental Biology (credit as arranged).
(See BIOL 550.)
ANAT 552. Seminar in Developmental Biology (credit as arranged).
(See BIOL 552.)
ANAT 569. Advanced Seminar in Developmental Biology (credit as arranged).
Participants prepare and present seminar on subjects of interest and importance in contemporary biology.
ANAT 570. Gene Expression and Development (3).
Studies on cloned genes that are known to affect development. Osteogenesis imperfecta and the expression of collagen a 2(1) collagen gene in man; transgenic experiments in mice and partial corrections of hereditary disorders; the globin-gene family and human thalassemias; histone gene expression during development of cellular oncogenes and development, the translational regulation during development; genes controlling embryonic segmentation; mRNA splicing and development; and other topics related to gene activity and developmental disorders. Prerequisite: CB10 455 and consent of instructor.
ANAT 601. Research in Anatomy (credit as arranged).
ANAT 701. Dissertation (Ph.D.) (credit as arranged).
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