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Department of Chemistry
1045 Millis Science Center
Phone 368-3622; Fax 368-3006
Gilles Klopman
The Department of Chemistry consists of 22 faculty members, approximately 12 postdoctoral associates, 80 graduate students, and more than 120 undergraduate students majoring in chemistry. Programs in chemistry for the degrees of Bachelor of Arts, Bachelor of Science, Master of Science, and Doctor of Philosophy are offered through the College of Arts and Sciences. The Department of Chemistry is the largest department and central focus of a wide array of departments representing the chemical sciences at Case Western Reserve University, including chemical engineering, macromolecular science, biochemistry, and pharmacology. Both the undergraduate and graduate student bodies have representatives of all regions of the United States and of numerous foreign countries. The John Schoff Millis Science Center and the Morley Chemical Laboratories house the department's well-equipped offices, classrooms, and instructional and research laboratories. The major chemical stockroom and electronics shop facilities are located in the Millis Science Center. Within short walking distance is Sears Library, which contains a comprehensive collection of books and periodicals in all technical fields. Also available nearby on campus is the outstanding Cleveland Health Sciences Library. Its Health Center Branch, in the new building of the Case Western Reserve University School of Medicine, serves mainly academic interests; the Allen Memorial Branch emphasizes clinical medicine. All departments, research centers, and major facilities related to science, technology, and medicine are conveniently close to one another.
Chemical research is an integral part of the department's activities; more than $3 million of federal and private research support flows into the department each year. The facilities for carrying out first-rate research are outstanding and are available to both graduate and undergraduate students. Undergraduates are encouraged to participate in research projects with individual faculty members as a method of expanding their chemical training. Research programs typically involve interchange and collaboration across all levels of experience from students to faculty. Mutual interests among faculty members also lead frequently to cooperative research efforts.
An important aspect of chemical employment is the wide array of opportunities it offers. Chemists can work for others or by themselves. They can direct their talents to specialized problems of applied research, or they can choose to delve into fundamental investigations. They can cover the spectrum of chemical specialties from microbiochemistry to the study of lunar materials. To satisfy their interests, they can work in fields closely akin to other professions, such as medicine, dentistry, and law. They can transmit their knowledge to others by teaching at a wide variety of levels. They can work for private industry or for the public as government employees.
The American Chemical Society, with its more than 100,000 members, is the major professional society in the United States for practicing chemists. Both undergraduate and graduate students may become affiliated with the society.
Gilles Klopman, Ph.D. (University of Brussels, Belgium)
Charles F. Mabery Professor of Research in Chemistry and Chairman of the Department of Chemistry
Theoretical chemistry; interpretation and prediction of selectivity and reactivity in reactions: chemotherapy and carcinogenicity.
Alfred B. Anderson, Ph.D. (Johns Hopkins University)
Professor
Pure and applied theoretical chemistry: surface science, inorganic chemistry and properties of materials
Douglas F. Dedolph, Ph.D. (Iowa State University)
Instructor
Organic chemistry
Robert C. Dunbar, Ph.D. (Stanford University)
Professor
Gas phase ions and ion-neutral interactions: ionmolecular reaction kinetics
Philip P. Garner, Ph.D. (University of Pittsburgh)
Associate Professor
Synthetic organic chemistry
Malcolm E. Kenney, Ph.D. (Cornell University)
Hurlbut Professor of Chemistry
Porphyrin-like compounds; organosilicon compounds: inorganic polymers
Stephen J. Klippenstein, Ph.D. (California Institute of Technology)
Assistant Professor
Theoretical chemistry; chemical reaction dynamics
Gheorghe D. Mateescu, Ph.D. (Case Western Reserve University)
Professor and Director of the Major Analytical Instruments Facility
Analytical and physical chemistry; photoelectron spectroscopy; visual pigments, water and related systems; nuclear magnetic resonance; ion bombardment spectroscopy
Barry Miller, Ph.D. (Massachusetts Institute of Technology)
Hovorka Professor of Chemistry
Analytical chemistry; electrochemistry
Garnett R. McMillan, Ph.D. (University of Rochester)
Professor
Photochemistry; kinetics and mechanisms of free radical reactions
Ignacio Ocasio, Ph.D. (University of Puerto Rico)
Assistant Professor
Physical chemistry
Anthony J. Pearson, Ph.D. (University of Aston, Birmingham, England)
Rudolph and Susan Rense Professor of Chemistry
Natural products, organometallics
John D. Protasiewicz, Ph.D. (Cornell University)
Assistant Professor
Inorganic chemistry; organometallic reaction mechanisms; catalyzed oxidations
William M. Ritchey, Ph.D. (Ohio State University)
Professor of Chemistry and Macromolecular Science
Nuclear magnetic resonance spectroscopy
Robert G. Salomon, Ph.D. (University of Wisconsin, Madison)
Professor
Organic chemistry; synthesis; biosynthesis; homogeneous catalysis
Lawrence M. Sayre, Ph.D. (University of California, Berkeley)
Professor
Physical organic chemistry; biomimetic reaction mechanisms; drug-receptor interactions; neurotoxicology
Daniel A. Scherson, Ph.D. (University of California, Davis)
Associate Professor
Electrochemistry; electrode kinetics electrocatalysis;
in-situ spectroscopic methods in electrochemistry
John E. Stuehr, Ph.D. (Case Western Reserve University)
Professor of Chemistry and Biochemistry; Associate Chairman, Chemistry Department
Rapid reactions in solution; metal complexing kinetics; proton transfer kinetics; protein and enzymatic dynamics
Chaim N. Sukenik, Ph.D. (California Institute of Technology)
Professor
Physical organic chemistry; photochemistry; reactions in micelles and oriented media
Terrence J. Swift, Ph.D. (University of California, Berkeley)
Professor of Chemistry and Biochemistry
Rapid solution reactions; magnetic resonance
Fred L. Urbach, Ph.D. (Michigan State University )
Professor
Coordination chemistry of multidentate chelates and biological models; redox behavior of metal complexes
Michael G. Zagorski, Ph.D. (Case Western Reserve University)
Assistant Professor
Organic chemistry; nuclear magnetic resonance; structure of
peptides
Marc S. Berridge, Ph.D. (Washington University)
Associate Professor of Radiology and Chemistry
Nuclear and radiochemistry
Gregory C. Hurst, Ph.D. (University of Rochester)
Assistant Professor of Radiology and Chemistry
NMR imaging and spectroscopy
John J. Mieyal, Ph.D. (Case Western Reserve University)
Associate Professor of Pharmacology and Chemistry
Hemoprotein chemistry, oxygen transport and activation; drug metabolism and related activity of cytochrome
There are two basic curricula for undergraduate chemistry majors, the professional program and the academic program.
The professional major's curriculum, which is taken by all chemistry majors pursuing a Bachelor of Science degree and may be elected by chemistry majors pursuing a Bachelor of Arts degree, is designed for students who plan professional careers in chemistry and leads to certification by the American Chemical Society. The complete professional major's curricula-for B.S. and B.A. students-are shown on the following pages. The professional curriculum provides a rigorous background in chemistry yet has considerable flexibility in the senior year in the choice of electives. During the senior year, the professional major is expected to go a step beyond basic preparation in an area of chemistry of particular interest to him or her. Research is strongly encouraged. As many as nine hours of research (CHEM 397) may be credited toward the degree. Professional majors who plan to go on to graduate study may elect to take advanced courses in inorganic chemistry (CHEM 412, 413); organic chemistry (CHEM 421, 422, 435); chemical thermodynamics (CHEM 407); instrumental analytical chemistry (CHEM 410), or other graduate offerings. Interdisciplinary strengths can be achieved by taking technical electives in such fields as biochemistry, biology, earth sciences, macromolecular science, mathematics, and physics.
The academic program, shown on a following page, is intended for students who plan careers in medicine or other health or science-related fields for which a baccalaureate degree in chemistry provides appropriate pre-professional training. Upon completion of this program, students receive the B.A. degree. Academic majors may supplement their chemical training by electing additional chemistry courses or may develop an interdisciplinary program of their choice. Curriculum flexibility in the Department of Chemistry makes it convenient to switch from the academic to the professional program as late as the beginning of the junior year. Many academic majors participate in research within the Department of Chemistry (CHEM 397) or in other departments.
Chemistry majors who have excellent academic records may participate in the Honors in Chemistry program. To graduate with honors in chemistry, a student must satisfy the following requirements:
- A combined grade point average of 3.3 in chemistry, physics, and mathematics and an overall grade point average of 3.0.
- A minimum of six semester hours of CHEM 397, or, with approval, chemical research done under another course number.
- A thesis approved by the Undergraduate Committee of the department on the basis of the level of research, the quality of the manuscript, and the chemical content.
Students may complete a minor in chemistry, defined as one year of freshman chemistry (including laboratory); two additional three hour lecture courses; and two additional laboratory or approved courses. A recommended sequence would include:
The following chemistry courses may be used to satisfy the Western Reserve Core science requirement: CHEM 105, 106 or 107, 108.
Bachelor of Arts Degree
FRESHMAN
Fall Semester
CHEM 105, Principles of Chemistry I (3) or
CHEM 107, Properties and Structure of Matter I (3)
MATH 125, Mathematics I (4), or
MATH 121, Calculus for Science and Engineering I (4)
ENGL 150, Expository Writing (3)
Core Sequence II, III or IV (6)
PHED 101, Physical Education Activities (0)
Spring Semester
CHEM 106, Principles of Chemistry II (3) or
CHEM 108, Properties and Structure of Matter II (3)
MATH 126, Mathematics II (4), or
MATH 122, Calculus for Science and Engineering II (4)
CHEM 113, Principles of Chemistry Laboratory (2)
Core Sequence II, III or IV (6)
PHED 102, Physical Education Activities (0)
SOPHOMORE
Fall Semester
CHEM 223, Introductory Organic Chemistry I (3) or
CHEM 323, Organic Chemistry I (3)
CHEM 233, Organic Chemistry Laboratory (2) or
CHEM 321, Laboratory Methods and Techniques I (3)
PHYS 115, Introductory Physics I (4) or
PHYS 120, General Physics I (4)*
Course in selected minor field (3)
Core Sequence II, III or IV (3)
Spring Semester
CHEM 224, Introductory Organic Chemistry II (3) or
CHEM 324, Organic Chemistry II (3)
CHEM 234, Organic Chemistry Laboratory (2) or
CHEM 322, Laboratory Methods and Techniques II (3)
PHYS 116, Introductory Physics II (4) or
PHYS 219, General Physics II (4)*.
Course in selected minor field (3)
Core Sequence II, III or IV (3)
JUNIOR
Fall Semester
CHEM 301, Introductory Physical Chemistry I (3) or
CHEM 335, Physical Chemistry I (3)**
CHEM 304, Chemical Measurements Laboratory (2)**
Course in selected minor field (3)
Electives (6)
Spring Semester
CHEM 302, Introductory Physical Chemistry II (3) or
CHEM 336, Physical Chemistry II (3)**
CHEM 305, Introductory Physical Chemistry Laboratory (3)
Course in selected minor field (3)
Electives (6)
SENIOR
Fall Semester
Course in selected minor field (3)
Electives (12)
Spring Semester
Course in selected minor field (3)
Electives (12)
*May be taken in the junior year.
**Taken in the senior year if physics is taken in the junior year.
Bachelor of Arts Degree
FRESHMAN
Fall Semester
CHEM 105, Principles of Chemistry I (3) or
CHEM 107, Properties and Structure of Matter I (3)
MATH 121, Calculus for Science and Engineering I (4)
ENGL 150, Expository Writing (3)
Core Sequence II, III or IV (6)
PHED 101, Physical Education Activities (0)
Spring Semester
CHEM 106, Principles of Chemistry II (3) or
CHEM 108, Properties and Structure of Matter II (3)
MATH 122, Calculus for Science and Engineering II (4)
CHEM 113, Principles of Chemistry Laboratory (2)
PHYS 120, General Physics I (4) or
PHYS 115, Introductory Physics I (4)
Core Sequence II, III or IV (3)
PHED 102, Physical Education Activities (0)
SOPHOMORE
Fall Semester
CHEM 323, Organic Chemistry I (3) or
CHEM 223, Introductory Organic Chemistry I (3)
CHEM 321, Laboratory Methods and Techniques I (3) or
CHEM 233, Organic Chemistry Laboratory I (2)*
MATH 223, Calculus for Science and Engineering III (3)
PHYS 205, General Physics Laboratory (2)
PHYS 219, General Physics II (4) or
PHYS 116, Introductory Physics II (4)
Spring Semester
CHEM 324, Organic Chemistry II (3) or
CHEM 224, Introductory Organic Chemistry II (3)
CHEM 322, Laboratory Methods and Techniques II (3) or
CHEM 234, Organic Chemistry Laboratory II (2)*
MATH 224, Elementary Differential Equations (3)
PHYS 220, General Physics III (3)
Core Sequence II, III or IV (3)
JUNIOR
Fall Semester
CHEM 335, Physical Chemistry I (3)
CHEM 331, Laboratory Methods and Techniques III (3)
CHEM 311, Inorganic Chemistry I (3)
GERM 101, Beginning German (or approved equivalent) (4)
Core Sequence II, III or IV (3)
Spring Semester
CHEM 336, Physical Chemistry II (3)
CHEM 332, Laboratory Methods and Techniques IV (3)
CHEM 312, Inorganic Chemistry II (3) or
approved CHEM elective** (3)
GERM 112, Beginning German for Science Students (4) or
approved equivalent (3)***
Core Sequence II, III or IV (3)
SENIOR
Fall Semester
CHEM 337, Physical Chemistry III (3)
Courses in minor field or electives (12)
Leads to a Bachelor of Arts Degree in chemistry. Requirements
for certification by the American Chemical Society are met
provided that a minimum of two credits of CHEM 397 or an
additional laboratory course in the chemical sciences is taken.
Spring Semester
CHEM or approved elective** (3)
Courses in minor field or electives (12)
- CHEM 105, 106 or 107, 108; CHEM 113
- Six hours of lecture courses in CHEM.
- Two additional laboratory or approved courses.
*CHEM 321, 322 is recommended. If CHEM 233, 234 sequence is followed, CHEM 304 must also be taken.
**This elective must be a lecture course.
***Students with specified strong backgrounds in French, German, or Russian may satisfy this requirement by certification and replace GERM 101-112 with 8 hours of electives. Consult the Undergraduate Committee of the Chemistry Department for further details.
Bachelor of Science in Chemistry Degree
FRESHMAN
Fall Semester
Open elective or humanities/social science (3-0-3) a,b
CHEM 105, Principles of Chemistry I (3-0-3) or
CHEM 107, Properties and Structure of Matter I (3-0-3)
CMPS 131, Elementary Computer Programming (2-2-3)
MATH 121, Calculus for Science and Engineering I (4-0-4)
ENGL 150, Expository Writing (3-0-3)
PHED 101, Physical Education Activities (0-3-0)
Total (15-5-16)
Spring Semester
Humanities/social science or open elective (3-0-3)a,b
CHEM 106, Principles of Chemistry II (3-0-3) or
CHEM 108, Properties and Structure of Matter II (3-0-3)
CHEM 113, Principles of Chemistry Laboratory (1-3-2)
MATH 122, Calculus for Science and Engineering II (4-0-4)
PHYS 120, General Physics I (4-0-4)b
PHED 102, Physical Education Activities (0-3-0)
Total (15-6-16)
SOPHOMORE
Fall Semester
Humanities or Social Science Sequence I (3-0-3)
CHEM 323, Organic Chemistry I (3-0-3) or
CHEM 223, Introduction to Organic Chemistry I (3-0-3)
CHEM 321, Laboratory Methods and Techniques I (1-6-3)
MATH 223, Calculus for Science and Engineering III (3-0-3)
PHYS 205, General Physics Laboratory (0-4-2)
PHYS 219, General Physics II (4-0-4)
Total (14-10-18)
Spring Semester
Class/Lab/Credit Hours
Humanities or Social Science Sequence II (3-0-3)
CHEM 324, Organic Chemistry II (3-0-3) or
CHEM 224, Introduction to Organic Chemistry II (3-0-3)
CHEM 322, Laboratory Methods and Techniques II (1-6-3)
MATH 224, Elementary Differential Equations (3-0-3)
PHYS 220, General Physics III (3-0-3)
Total (13-6-15)
JUNIOR
Fall Semester
Humanities or Social Science Sequence III (3-0-3)
CHEM 335, Physical Chemistry I (3-0-3)
CHEM 331, Laboratory Methods and Techniques III (1-6-3)
CHEM 311, Inorganic Chemistry I (3-0-3)
GERM 101, Beginning German (4-0-4)d
Total (14-6-16)
Spring Semester
Humanities or Social Science Sequence IV (3-0-3)
CHEM 336, Physical Chemistry II (3-0-3)
CHEM 332, Laboratory Methods and Techniques IV (1-6-3)
CHEM 312, Inorganic Chemistry II (3-0-3)c
GERM 112, Beginning German for Science Students (4-0-4)d
Total (14-6-16)
SENIOR
Fall Semester
Humanities or social science course (3-0-3)
CHEM 337, Physical Chemistry III (3-0-3)
Technical elective (3-0-3)e
PHYS 249, Mathematical Physics and Computing, or ECMP 251, Numerical Methods (3-0-3)
Technical elective (3-0-3)
Open elective (3-0-3)
Total (18-0-18)
Spring Semester
Humanities or social science elective (3-0-3)
Chemistry or approved elective (3-0-3)
Technical elective (3-0-3)
Open elective (3-0-3)
Open elective (3-0-3)
Open elective (3-0-3)
Total (18-0-18)
Hours required for graduation: 131. Requirements for certification by the American Chemical Society are met provided that a minimum of two credits of CHEM 397 or an additional laboratory course in the chemical sciences is taken.
a One of these courses must be a humanities/social science course.
b Selected students may be invited to take PHYS 125, 126, Physics & Fronties I, II, in place of an open elective and PHYS 120.
c CHEM 312 is a recommended chemistry elective.
d Students with specified strong backgrounds in French, German, or Russian may satisfy this requirement by certification and replace GERM 101-112 with 8 hours of electives. Consult the Undergraduate Committee of the Chemistry Department for further details.
e A maximum of nine credit hours may be taken in research as chemistry, technical, or open electives.
The Master of Science degree in chemistry may be obtained by completing a program including the preparation of a master's thesis or a program involving only course work. Both programs require a minimum of 27 semester credit hours, of which up to 6 semester credit hours may be for the master's thesis. Course work may be taken on a part-time basis for the master's degree. Thesis research can be undertaken only by full-time graduate students. Only the master's degree without thesis can be earned entirely on a part-time basis.
The Doctor of Philosophy degree in chemistry is granted only to those students who have shown an extensive knowledge of advanced chemistry and the ability to do original research. The program usually requires three to four years of full-time study after the bachelor's degree. Besides advanced courses, the program consists of cumulative and oral examinations, seminars and colloquia, and, most importantly, original research. At least twelve months must be spent in residence on campus while fulfilling the Ph.D. thesis research requirement.
Full-time graduate students who maintain satisfactory academic performance while pursuing the Ph.D. degree in chemistry normally receive a stipend for teaching and/or research which includes full tuition and a monthly amount sufficient to cover living expenses.
Facilities for experimental and theoretical research are modern and extensive. They include diverse major instruments for use by faculty and students, as well as specialized equipment serving individual research groups. Among the former are the instruments of the Major Analytical Instru-ments Facility. The MAIF was established in the Department of Chemistry through joint funding by the National Science Foundation and local industry. This Facility centers on two Varian XL-200 Fourier transform nuclear magnetic resonance spectrometers, a Varian Gemini 300 Mhz FT NMR, a Bruker MSL-400 FT NMR with microimaging, a Varian IEE x-ray photo-electron spectroscopy unit, a Mattson Sirius-100 GC-FTIR with matrix isolation capability, 3M ionscattering and secondary ion mass spectrometers, a Kratos MS-25 RFA GC mass spectrometer, and an electron-spin resonance spectrometer.
Other Departmental instrumentation includes equipment for ion cyclotron resonance spectrometry, laser Raman spectros-copy, x-ray diffraction, extremely rapid kinetics measure-ments, spectropolarimetry and cicular dichroism, protein structure elucidation, ellipsometry, electrochemical measurements, and low-energy diffraction and Auger studies of surfaces. A departmental computer facility based on a Digital Equipment VAX 11/785 computer serves the computational needs of the department. This computer can be accessed from remote stations in research and instructional laboratories and is used in on-line control of experiments and data acquisition. A large number of laboratory microcomputers are in operation in the department. For the design, maintenance, and repair of research apparatus, excellent shop facilities and staff personnel are available for glass blowing and electronics work.
The Department of Chemistry is noted for the diversity of its research efforts. These range from synthetic studies of important hormonal species, such as those involved in digestive intestinal juices, to a detailed understanding of the surface properties of materials used in batteries and electrolytic cells. Studies are being performed with molecules as simple as oxygen and as complicated as those which describe the active centers in metalloproteins. Efforts are being made to understand the basic chemical properties which lead to rearrangements of organic molecules including the isolation and characterization of reactive species. The influence of metal ions in modifying reactivity is the specific interest of several members of the faculty. Gas phase studies of molecules are providing a fundamental understanding of the way in which new compounds are formed. This work has a direct bearing on atmospheric environmental problems.
Chemical surfaces are being studied. Of particular importance are studies designed to reduce the energy losses associated with electrochemical processes. The X-ray photo- electron spectrometer and the ion bombardment spectrometers associated with the Major Analytical Instruments Facility provide tools to explore both the molecular structure of organometallic and carbocation species and the chemical properties of various types of surfaces. This work helps in understanding heterogeneous catalysis and other processes occurring at the solid-gas interface.
The Department uses some of the foremost equipment available in high-resolution nuclear magnetic resonance spectroscopy. Work on various aspects of chemistry as studied by this technique is recognized throughout the world.
The graduate program "The Chemistry of Life Processes" offers the student the opportunity of pursuing a course of study that cuts across traditional disciplines. The three traditional areas of chemistry-inorganic, organic, and physical-are all represented in their biological aspects. A number of faculty who carry out research in biochemical areas are involved in this educational and training program, which leads to the Ph.D. degree in chemistry. The program has several purposes. First, it provides the Ph.D. student research experience and course work required for careers in teaching, industry, government laboratories, or other postgraduate professions. Second, many students who take graduate work in chemistry have interests that overlap with the biological sciences. The program provides a means of satisfying these interests. Third, a graduate student who participates in such an interdisciplinary program will achieve a broader background. This will be distinctly advantageous when embarking upon a career.
Case Western Reserve University ranks among the leading universities internationally in its strengths in electrochemistry and has brought these strengths together under one coordinated structure, The Case Center for Electrochemical Studies (CCES). The interdisciplinary nature of electrochemistry requires the interaction of electrochemists in the chemistry and chemical engineering departments with metallurgists, surface physicists, inorganic and organic chemists, polymermembrane chemists, and electrical engineers. Such interactions are lacking on most campuses and are promoted at Case Western Reserve University through CCES. Graduate students in the chemistry department have the opportunity to specialize in the area of electrochemistry with one of the most extensive course and research programs in the United States.
The department sponsors a rich program of colloquia and seminars on recent advances in chemical research. Most notable among these is the Frontiers in Chemistry Lecture Series, in which scientists of international distinction lecture on major discoveries and developments in chemistry. In addition, a weekly colloquium series provides lectures by invited speakers in a variety of fields of chemical investigation. Both of these programs are addressed to the general audience of faculty, students, and other chemical scientists in the University and the Cleveland area, and are a vital means to a broad, current knowledge. Numerous other seminars and meetings are held on a more specialized and informal level. Most individual research groups conduct weekly discussions to evaluate their progress.
Chemistry (CHEM)
CHEM 105. Principles of Chemistry I (3).
Atomic structure, thermochemistry. periodicity, bonding and molecular structure, intermolecular forces, properties of solids, liquids and gases. Prerequisite: One year of high school chemistry or consent of instructor.
CHEM 106. Principles of Chemistry II (3).
Thermodynamics, chemical equilibrium, acid/base chemistry, oxidation and reduction, kinetics, spectroscopy; introduction to nuclear, organic, and industrial chemistry. Prerequisite: CHEM 105 or consent of instructor.
CHEM 107. Properties and Structure of Matter I (3).
A first course in University chemistry emphasizing physical chemistry of materials. States of matter, thermodynamics and chemical equilibria. Prerequisite: One year of high school chemistry or consent of instructor.
CHEM 108. Properties and Structure of Matter II (3).
Spectroscopy and the structure of atoms and molecules, rate processes and reaction mechanism, properties of metals and non-metals, properties of organic compounds and macromolecules. Prerequisite: CHEM 107 or consent of instructor.
CHEM 113. Principles of Chemistry Laboratory (2).
A one-semester laboratory offering a challenging sequence of experiments designed to teach a creative approach to modern chemistry. Corequisite CHEM 105,106, or 107,108.
CHEM 223. Introductory Organic Chemistry I (3).
Organic chemistry as applied to synthesis, characterization, and reaction mechanisms; biological aspects. For science majors, including premedical students, predental students, and chemical engineers. Prerequisite CHEM 106 or 108.
CHEM 224. Introductory Organic Chemistry II (3).
(Continuation of CHEM 223.) Prerequisites: CHEM 223 or 323.
CHEM 233. Introductory Organic Chemistry Laboratory I (2).
Synthesis and purification of organic compounds, isolation of natural products, and systematic identification of organic compounds by physical and chemical methods. Prerequisite: CHEM 106 or 108. Corequisite: CHEM 223 or 323.
CHEM 234. Introductory Organic Chemistry Laboratory II (2).
(Continuation of CHEM 233.) Prerequisite: CHEM 233.
CHEM 301. Introductory Physical Chemistry I (3).
Application of physical concepts and methods to problems of chemical and biochemical importance. Application of thermodynamics and kinetic theory to states of matter, solutions, chemical equilibria, and electrochemistry. Prerequisites: CHEM 106 or 108, one year each of physics and calculus, preferably including partial derivatives.
CHEM 302. Introductory Physical Chemistry II (3).
(Continuation of CHEM 301.) Introductory quantum chemistry and spectroscopy. Statistical thermodynamics. Prerequisite: CHEM 301 or 335.
CHEM 304. Chemical Measurements Laboratory (2).
A one semester laboratory course on techniques for quantitative chemical measurements, error analysis, and advanced concepts in ionic equilibria, including pH. Basic chemical instrumentation. Prerequisite: CHEM 233, 234 or 321, and 322. Corequisite: CHEM 301.
CHEM 305. Introductory Physical Chemistry Laboratory (3).
A one semester laboratory course that acquaints the student with the principles and quantitative characterization of chemical and biochemical systems. Such experiments as electrolyte equilibria, properties of macromolecules, and kinetics of reactions. Prerequisites: CHEM 304 and two semesters of physical chemistry (second semester may be taken concurrently).
CHEM 311. Inorganic Chemistry I (3).
Reactions and properties of the elements and their compounds, with particular emphasis on relationships to bonding and structure. Prerequisite: Two semesters of physical chemistry. (Physical chemistry may be taken concurrently.)
CHEM 312. Inorganic Chemistry II (3).
Reactions and properties of the elements and their compounds, with particular emphasis on relationships to bonding and structure. Prerequisite: Two semesters of physical chemistry. (Physical chemistry may be taken concurrently )
CHEM 317. Nuclear and Radiochemistry (3).
Radioactivity and its applications, beginning with basic theory and techniques and extending through applications in chemistry, biology, engineering, and medicine.
CHEM 320. Advanced Chemical Laboratory Methods (3).
Techniques of chemical synthesis, analysis, and characterization. Uses students' backgrounds in organic and physical chemistry. Prerequisites: CHEM 301 and 302.
CHEM 321. Laboratory Methods and Techniques I (3).
CHEM 321 and 322 are the first two semesters of an integrated laboratory course. Experimental approach to chemical problems. Chemical measurements, synthesis, and characterization. Prerequisite or corequisite: CHEM 223 or 323, or consent of instructor.
CHEM 322. Laboratory Methods and Techniques II (3).
(Continuation of CHEM 321.) Prerequisite CHEM 321 or consent of instructor.
CHEM 323. Organic Chemistry I (3).
Structure, synthesis, and reaction mechanisms of organic compounds; physical principles. Prerequisites: CHEM 106 or 108, and consent of instructor.
CHEM 324. Organic Chemistry II (3).
(Continuation of CHEM 323.) Prerequisite: CHEM 323.
CHEM 325. Physical Methods for Determining Organic Structure (3).
Lectures on determination of structure of organic compounds involving separation techniques and the application of infrared, ultraviolet, and visible spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry, and other modern instrumental techniques.
CHEM 329. Chemical Aspects of Living Systems (3).
A series of special topics in chemistry of biological processes at the level of molecular mechanisms. Chemico-biological interactions. Homogeneous catalysis in biochemical and biomimetic systems. Biochemical dynamics. Mitochondrial respiration and photosynthesis. Biological activity and carcinogenesis. Prerequisites: Two semesters of organic chemistry and one semester of physical chemistry.
CHEM 331. Laboratory Methods and Techniques III (3).
Synthetics, separation techniques, physical properties, and analysis. Advanced techniques of chemical synthesis, leading the student to the preparation of interesting inorganic and organometallic compounds. Prerequisites: CHEM 321 and 322.
CHEM 332. Laboratory Methods and Techniques IV (3).
(Continuation of CHEM 331.) Modern techniques of physical measurement, including nuclear magnetic resonance, electronic spin resonance, and electrochemistry. Prerequisite: CHEM 331 or consent of instructor.
CHEM 335. Physical Chemistry I (3).
First of a three semester sequence directed to the professional chemistry major. Chemical thermodynamics: the three laws of thermodynamics and their application to chemical systems, Introductory statistical thermodynamics, introductory quantum mechanics. Chemical kinetics. Properties of gases, liquids, and solids. Special topics. Prerequisites: CHEM 106, or 108 and calculus (including partial derivatives), and one year of physics.
CHEM 336. Physical Chemistry II (3).
(Continuation of CHEM 335.) Prerequisite: CHEM 335 or consent of instructor.
CHEM 337. Physical Chemistry III (3).
(Continuation of CHEM 335 and 336.) Prerequisite: CHEM 336.
CHEM 395. Chemistry Colloquium Series (1).
Course content provided by Thursday Chemistry Department colloquia (or Frontiers in Chemistry lectures).
Discussion sessions review previous lectures and lay foundation for forthcoming lectures. Prerequisite: consent of instructor.
CHEM 397. Undergraduate Research (1-9).
Independent research for candidates for honors in chemistry and other qualified students. Not open to graduate students. Prerequisite: consent of department.
CHEM 406. Chemical Kinetics (3).
Theory and characterization of chemical rate processes. Prerequisite: consent of instructor.
CHEM 407. Chemical Thermodynamics (3).
Thermodynamics and statistical thermodynamics and their application to chemical problems.
CHEM 410. Instrumental Analytical Chemistry (3).
Principles and applications of analytical instrumentation including optical spectroscopy, photoelectron and ion bombardment spectrometry, mass spectrometry, NMR and magnetic resonance imaging. Prerequisites: Two semesters of undergraduate physical chemistry and consent of instructor.
CHEM 412. Advanced Inorganic Chemistry I (3).
Chemistry of inorganic systems. Spectroscopy, magnetism, and stereochemistry of transition metal compounds. Prerequisite: consent of instructor.
CHEM 413. Advanced Inorganic Chemistry II (3).
Chemistry of inorganic compounds; mechanisms of reactions.
CHEM 414. Organometallic Reactions and Structures (3).
Developments in the understanding of bonding and structure in organometallic chemistry and the relevance of organometallic species to chemical catalysis.
CHEM 415. Chemical Applications of Group Theory (3).
Experimental and semiempirical treatments of structure and bonding in chemical systems based on a presentation of symmetry relationships and the theory of point and space groups. Prerequisite: CHEM 412 or consent of instructor.
CHEM 417. Nuclear and Radiochemistry (3).
Radioactivity and its applications, beginning with basic theory and techniques and extending through applications in chemistry, biology, engineering, and medicine.
CHEM 421. Advanced Organic Chemistry I (3).
Elementary general molecular orbital theory. Stereo isomerism. Reaction mechanisms. Pericyclic reactions and orbital symmetry conservation. Organic photo-chemistry. Free radical, radicalion, carbene, nitrene, aryne intermediates and their reactions. Prerequisite: consent of instructor.
CHEM 422. Advanced Organic Chemistry II (3).
Carbocations and carbanions. Nucleophilic and electrophilic aliphatic substitutions. Heterolytic addition and elimination reactions. Electrophilic, nucleophilic, and free radical aromatic substitutions. Carbonyl reactions. Oxidations, reductions, rearrangements. Prerequisite: CHEM 421 or consent of instructor.
CHEM 425. Physical Methods for Determining Organic Structure (3).
Lectures on determination of structure of organic compounds involving separation technique and the application of infrared, ultraviolet, and visible spectroscopy, nuclear magnetic resonance spectroscopy, mass spectrometry, and other modern instrumental techniques. Prerequisite: CHEM 410.
CHEM 429. Chemical Aspects of Living Systems (3).
A series of special topics in the chemistry of biological processes at the level of molecular mechanisms. Chemico-biological interactions. Homogeneous catalysis in biochemical and biomimetic systems. Biochemical dynamics. Mitochondrial respiration and photosynthesis. Biological activity and carcinogenesis. Prerequisites: Two semesters of organic chemistry and one semester of physical chemistry.
CHEM 435. Synthetic Methods in Organic Chemistry (3).
Systematic consideration of reactions which allow carbon-carbon bond formation or cleavage, as well as the introduction, removal, interconversion, or transposition of functional groups.
CHEM 436. Complex Molecular Synthesis (3).
The logic which may be applied to designing syntheses of complex molecules in the context of a comparison of in-vivo and laboratory syntheses of natural products including acetogenins, alkaloids, aromatic amino acids, fatty acids, macrolides, porphyrins, prostaglandins, steroids, and other terpenoids.
CHEM 445. Electrochemistry I (3).
Electrochemical properties of electrode-electrolyte interfaces and processes occurring thereat. Fundamental background for work in corrosion, electrodeposition, industrial electrolysis, electro-organic synthesis, batteries, fuel cells, and photoelectrochemical energy conversion. Prerequisites: One undergraduate course in physical chemistry and a working knowledge of thermodynamics.
CHEM 446. Quantum Mechanics I (3).
Physical and mathematical foundations of quantum mechanics, including approximation methods and Hartree-Fock theory, presented and applied to problems in atomic and molecular structure and spectroscopy.
CHEM 447. Quantum Mechanics II (3).
(Continuation of CHEM 446.) Ab initio and semi-empirical methods, configuration interaction, time-dependent phenomena, and principles of group theory. Prerequisite: CHEM 446 or consent of instructor.
CHEM 448. Statistical Mechanics (3).
A systematic development of equilibrium statistical mechanics; the properties of the gaseous, liquid, and solid states of matter. Introduction to non-equilibrium statistical mechanics. Prerequisite: CHEM 407 and 446, or consent of instructor.
CHEM 450. Molecular Spectroscopy (3).
Rotation, vibration, and electronic spectra of simple and complex molecules. Prerequisite: CHEM 446.
CHEM 460. Engineering and Chemical Aspects of NMR Spectroscopy and Imagng (3).
Fundamental and advanced topics in understanding and practice of NMR imaging and spectroscopy. Theoretical description is accompanied by specific examples of spin Hamiltonians, pulse sequences, and basic instrumentation.
CHEM 470. Polymer Synthesis (4).
Organic chemistry of macromolecules, mechanism of polyreactions, preparation of addition and condensation polymers, and the chemical reactions of polymers. Prerequisites: CHEM 224 or 324, and EMAC 270, or consent of instructor.
CHEM 479. X-Ray Crystallography (3).
Scattering of X-rays by crystalline and semi-crystalline solids including polymers. Technique of structure analysis.
CHEM 502. Special Topics in Inorganic Chemistry (credit as arranged).
Lectures on advanced topics in inorganic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.
CHEM 503. Special Topics in Organic Chemistry (credit as arranged).
Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.
CHEM 504. Special Topics in Organic Chemistry (credit as arranged).
Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.
CHEM 505. Special Topics in Physical Chemistry (credit as arranged).
Lectures on advanced topics in physical chemistry presented by staff or visiting lecturers. Course titles, content, and credit change from year to year.
CHEM 506. Special Topics in Physical Chemistry (credit as arranged).
Lectures on advanced topics in physical chemistry presented by staff or visiting lecturers. Course titles, content, and credit change from year to year.
CHEM 507. Special Readings in Chemistry (1-6).
Detailed study of a special topic in chemistry under the guidance of a faculty member. Prerequisite: consent of faculty member.
CHEM 508. Special Reading in Chemistry (1-6).
Detailed study of a special topic in chemistry under the guidance of a faculty member. Prerequisite: consent of faculty member.
CHEM 511. Electrochemistry II (3).
Electrocatalysis, semi-conductor electrochemistry and photoelectrochemistry, and electrochemical impedance methods, as well as battery and fuel cell systems.
CHEM 601. Research (credit as arranged).
Special research in an area of chemistry under the guidance of a faculty member.
CHEM 605. Chemistry Colloquium Series (1).
Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.
CHEM 651. Thesis (M.S.) (credit as arranged).
CHEM 701. Dissertation (Ph.D.) (credit as arranged).
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