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Case Western Reserve University Tuberculosis Research Unit
  Integrating research to combat the global TB epidemic
 
 

TBRU Cumulative Publications


ATTENTION TBRU INVESTIGATORS!

Remember to cite the TBRU contract, per required contract wording on all new manuscripts/publications:

"This project has been funded in whole or in part by the Tuberculosis Research Unit (TBRU), established with Federal funds from the United States National Institutes of Allergy and Infectious Diseases & the United States National Institutes of Health and Human Services, under Contract No. HHSN266200700022C / NO1-AI-70022"

(note to investigators - this contract number is for work as of May 1, 2007; please add the prior TBRU contract number for publications that have overlap from the prior period - thus state "Contract Nos. NO1-AI-95383 and HHSN266200700022C / NO1-AI-70022")


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Publications

Year

Publication

Areas of Interest

2014

Johnson JL, Geldenhuys H, Thiel BA, Toefy A, Suliman S, Pienaar B, Chheng P, Scriba T, Boom WH, Hanekom W, Hatherill M. Effect of isoniazid therapy for latent tuberculosis infection on QuantiFERON-TB Gold In-tube responses in tuberculin skin test positive adults in a high tuberculosis incidence area: A controlled study. Chest 2014; 145:612-617. PMCID: PMC3941252.
Abstract (PubMed)

Clinical TB, Immunology

2014

Sutherland JS, Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, Walzl G, Kaufmann SH, Ottenhoff TH; the GCGH Biomarkers for TB consortium. Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity. Clin Microbiol Infect. 2014; 20:O230-O238. doi: 10.1111/1469-0691.12383. [Epub ahead of print]

Abstract (PubMed)

Immunology

2013

Wampande EM, Mupere E, Debanne SM, Asiimwe BB, Nsereko M, Mayanja H, Eisenach K, Kaplan G, Boom HW, Joloba ML. Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease. BMC Infect Dis. 2013; 13:484.
Abstract (PubMed)

Clinical Mycobacteriology, Genetics

2013

Jaganath D, Zalwango S, Okware B, Nsereko M, Kisingo H, Malone L, Lancioni C, Okwera A, Joloba M, Mayanja-Kizza H, Boom WH, Stein C, Mupere E; for the Tuberculosis Research Unit (2013).Contact Investigation for Active Tuberculosis Among Child Contacts in Uganda. Clin Infect Dis. 2013; 57:1685-1692. PMCID:PMC3840405.
Abstract (PubMed)

Clinical TB, Epidemiology

2013

Stein CM, Hall NB, Malone LL, Mupere E. The household contact study design for genetic epidemiological studies of infectious diseases." Front Genet 2013; 4:61. PMCID: PMC3639375.
Abstract (PubMed)

Genetics, Epidemiology

2013

Sutherland JS, Lalor MK, Black GF,Ambrose LR, Loxton AG, Chegou NN, Kassa D, Mihret A, Howe R, Mayanja-Kizza H, Gomez MP, Donkor S, Franken K, Hanekom W, Klein MR, Parida SK, Boom WH, Thiel BA, Crampin AC, Ota M, Walzl G, Ottenhoff TH, Dockrell HM, Kaufmann SH, GCGH Biomarkers for TB consortium. Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa. PLoS One 2013; 8: e74080. PMCID: PMC3769366.
Abstract (PubMed)

Immunology, Clinical Mycobacteriology

2013

Bark CM, Gitta P, Ogwang S, Nsereko M, Thiel BA, Boom WH, Eisenach KD, Joloba ML, Johnson JL. Comparison of time to positive and colony counting in an early bactericidal activity study of anti-tuberculosis treatment. Int J Tuberc Lung Dis. 2013; 17:1448-1451.
Abstract (PubMed)

Clinical Mycobacteriology, Clinical TB

2013

Gomes T, Vinhas SA, Reis-Santos B, Palaci M, Peres RL, Aguiar PP, Ribeiro FK, Marques HS, Dettoni Vdo V, Johnson JL, Riley LW, Maciel EL. Extrapulmonary Tuberculosis: Mycobacterium tuberculosis Strains and Host Risk Factors in a Large Urban Setting in Brazil. PLoS One. 2013; 8:e74517. PMCID:PMC3788772.
Abstract (PubMed)

Clinical Mycobacteriology, Clinical TB

2013

Luzze H, Johnson DF, Dickman K, Mayanja-Kizza H, Okwera A, Eisenach K, Cave MD, Whalen CC, Johnson JL, Boom WH, Joloba M; Tuberculosis Research Unit. Relapse more common than reinfection in recurrent tuberculosis 1-2 years post treatment in urban Uganda. Int J Tuberc Lung Dis. 2013; 17:361-367.
Abstract (PubMed)

Clinical TB, Clinical Mycobacteriology

2013

Toossi Z, Funderburg NT, Sirdeshmuk S, Whalen CC, Nanteza MW, Johnson DF, Mayanja-Kizza H, Hirsch CS. Systemic Immune Activation and Microbial Translocation in Dual HIV/Tuberculosis-Infected Subjects. J Infect Dis. 2013; 207(12):1841-1849. PMCID: PMC3654743.
Abstract (PubMed)

Immunology

2013

Tao L, Zalwango S, Chervenak K, Thiel B, Malone LL, Qiu F, Mayanja-Kizza H, Boom WH, Stein CM (2013).  Genetic and shared environmental influences on interferon-γ production in response to Mycobacterium tuberculosis antigens in a Ugandan population.  Am J Trop Med Hyg. 2013 Apr 29. [Epub ahead of print]
Abstract (PubMed)

Genetics; Immunology

2013

Soares AP, Kwong Chung CK, Choice T, Hughes EJ, Jacobs G, van Rensburg EJ, Khomba G, de Kock M, Lerumo L, Makhethe L, Maneli MH, Pienaar B, Smit E, Tena-Coki NG, van Wyk L, Boom WH, Kaplan G, Scriba TJ, Hanekom WA.  Longitudinal changes in CD4+ T cell memory responses induced by bacilli calmette Guerin vaccination of newborns. J Infect Dis 2013; 207:1084-94 PMCID: PMC3583271.
Abstract (PubMed)

Immunology

2013

Maciel EL, Brioschi AP, Peres RL, Guidoni LM, Ribeiro FK, Hadad DJ, Vinhas SA, Zandonade E, Palaci M, Dietze R, Johnson JL. Smoking and 2-month culture conversion during anti-tuberculosis treatment. Int J Tuberc Lung Dis. 2013; 17:225-228
Abstract (PubMed)

Mycobacteriology

2012

Johnson JL, Thiel BA. Time until relapse in tuberculosis treatment trials: implication for phase 3 trial design. Am J Respir Crit Care Med. 2012; 186:464. PMCID: PMC3443806.
Abstract (PubMed)

Clinical TB

2012

Baker AR, Qiu F, Randhawa AK, Horne DJ, Adams MD, Shey M, Barnholtz-Sloan J, Mayanja-Kizza H, Kaplan G, Hanekom WA, Boom WH, Hawn TR, Stein CM; Tuberculosis Research Unit (TBRU) and South African Tuberculosis Vaccine Initiative Team (SATVI). Genetic Variation in TLR Genes in Ugandan and South African Populations and Comparison with HapMap Data. PLoS One. 2012; 7:e47597. PMCID: PMC3480404.
Abstract (PubMed)

Genetics; Epidemiology

2012

Wu M, Aung H, Hirsch CS, Toossi Z. Inhibition of Mycobacterium tuberculosis-induced signalling by transforming growth factor-Jl in human mononuclear phagocytes. Scand J Immunol. 2012; 75:301-304. PMCID: PMC3279592.
Abstract (PubMed)

Immunology

2012

Toossi Z, Wu M, Rojas R, KalsdorfB, Aung H, Hirsch CS, Walrath J, Wolbink A, van Ham M, Silver RF. Induction of serine protease inhibitor 9 by Mycobacterium tuberculosis inhibits apoptosis and promotes survival of infected macrophages.   J Infect Dis. 2012; 205:144-151 PMCID: PMC3242743.
Abstract (PubMed)

Immunology

2012

Toossi Z, Wu M, Hirsch CS, Mayanja-Kizza H, Baseke J, Aung H, Canaday DH, Fujinaga K. Activation of P- TEFb at sites of dual HIVITB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime. AIDS Res Hum Retroviruses. 2012; 28:182-1827. PMCID: PMC3275925.
Abstract (PubMed)

Immunology

2012

Mupere E,  Malone L, Zalwango S, Chiunda A, Okwera A, Parraga I, Stein CM, Tisch DJ, Mugerwa R, Boom WH, Mayanja HK, Whalen CC.  Impact of Lean Tissue Mass Wasting and Gender on Survival among Patients with Pulmonary Tuberculosis in Urban Uganda. Ann Epidemiol. 2012; 22:466-473. PMCID: PMC3377556.
Abstract (PubMed)

Epidemiology; Clinical TB

2012

Mahan C, Zalwango S, Thiel B, Malone L, Chervenak K, Baseke J, Dobbs D, Stein, C, Mayanja-Kizza, H, Joloba M, Whalen CC, Boom WH.  Innate and Adaptive Immune Responses during acute M. tuberculosis Infection in Adult Household Contacts in Kampala, Uganda. Am J Trop Med Hyg. 2012; 86:690-697. PMCID: PMC3403758.
Abstract (PubMed)

Immunology; Epidemiology

2012

Mahapatra S, Woolhiser LK, Lenaerts AJ, Johnson JL, Eisenach KD, Joloba ML, Boom WH, Belisle JT. A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct. Antimicrob Agents Chemother. 2012; 56:28-35. PMCID: PMC3256082.
Abstract (PubMed)

Immunology

2012

Bark CM, Furin J, Johnson JL. Approaches to clinical trials of new anti-TB drugs.  Clin Invest 2012; 2:359:370.
Abstract (PubMed)

Clinical TB

2012

Bark CM, Thiel BA, Johnson JL. Pretreatment time to detection of Mycobacterium tuberculosis in liquid culture is associated with relapse after therapy. J Clin Microbiol. 2012; 50:538. PMCID: PMC3264180.
Abstract (PubMed)

Mycobacteriology; Clinical TB

2012

Lancioni C, Nyendak M, Kiguli S, Zalwango S, Mori T, Mayanja-Kizza H, Balyejusa S, Null M, Baseke J, Mulindwa D, Byrd L, Swarbrick G, Scott C, Johnson DF, Malone L, Mudido-Musoke P, Boom WH, Lewinsohn DM, Lewinsohn DA; for the Tuberculosis Research Unit. CD8+ T Cells Provide an Immunologic Signature of Tuberculosis in Young Children. Am J Respir Crit Care Med. 2012; 185:206-212. PMCID: PMC3297089.
Abstract (PubMed)

Immunology

2012

Brites D, Gagneux S. Old and new selective pressures on Mycobacterium tuberculosis. Infect Genet Evol. 2012; 12:678-685. PMCID: PMC3253320.
Abstract (PubMed)

Genetics; Epidemiology

2012

Shey MS, Hughes EJ, de Kock M, Barnard C, Stone L, Kollmann TR, Hanekom WA, Scriba TJ.
Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria. J Immunol Methods. 2012; 376:79-88. PMCID: PMC3273614.
Abstract (PubMed)

Immunology

2011

EI Fenniri L, Toossi Z, Aung H, EI Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, EI Aouad R, Canaday DH.  Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB. Tuberculosis (Edinb). 2011; 91:224-30. PMCID: PMC3306579.
Abstract (PubMed)

Immunology

2011

Toossi Z, Hirsch CS, Wu M, Mayanja-Kizza H, Baseke J, Thiel B. Distinct cytokine and regulatory T cell profile at pleural sites of dual HIY/tuberculosis infection compared to that in the systemic circulation. Clin Exp Immunol. 2011; 163:333-338. PMCID: PMC3048616.
Abstract (PubMed)

Immunology

2011

Comas I, Gagneux S. A role for systems epidemiology in tuberculosis research. Trends Microbiol. 2011; 19:492-500. PMCID: PMC3184389.
Abstract (PubMed)

Epidemiology

2011

Kato-Maeda M, Gagneux S, Flores LL, Kim EY, Small PM, Desmond EP, Hopewell PC. Strain classification of Mycobacterium tuberculosis: congruence between large sequence polymorphisms and spoligotypes.  Int J Tuberc Lung Dis. 201; 15:131-313.
Abstract (PubMed)

Genetics; Epidemiology

2011

Randhawa AK, Shey MS, Keyser A, Peixoto B, Wells RD, de Kock M, Lerumo L, Hughes J, Hussey G, Hawkridge A, Kaplan G, Hanekom WA, Hawn TR; South African Tuberculosis Vaccine Initiative Team. Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. PLoS Pathog. 2011 Aug;7(8):e1002174. PMCID: PMC3154845.
Abstract (PubMed)

Immunology

2011

Nahid P, Saukkonen J, Mac Kenzie W,  Johnson JL, Phillips PN, Anderson J, Bliven E, Belisle J, Boom W, Luetkemeyer A, Campbell T, Eisenach K, Hafner R, Lennox J, Makhene M, Swindells S, Villarino E, Weiner M, Benson C, Burman W, NIH, CDC. Tuberculosis biomarker and surrogate endpoint research roadmap. Am J Respir Crit Care Med 2011; 184:972-979. PMCID: PMC3208659.
Abstract (PubMed)

Clinical TB, Mycobacteriology, Immunology

2011

Nanteza MW, Mayanja-Kizza H, Charlebois E, Srikantiah P, Lin R, Mupere E, Mugyenyi P, Boom WH, Mugerwa RD, Havlir DA, Whalen CC.  A Randomized Clinical Trial of a 6-Month Punctuated Course of Antiretorviral Therapy In Ugandan HIV Seropositive Adults with Pulmonary Tuberculosis and CD4+ T Cell Count > 350 cells/mL.  J Inf Dis, 204:884-92, 2011. PMCID: PMC3156928.
Abstract (PubMed)

Clinical TB/HIV

2011

Bark CM, Dietze R, Okwera A, Quelapio MI, Thiel BA, Johnson JL. Clinical symptoms and microbiological outcomes in tuberculosis treatment trials. Tuberculosis (Edinb). 2011;91:601-604. PMCID: PMC3215825.
Abstract (PubMed)

Clinical TB, Mycobacteriology

2011

Stein CM.  Genetic epidemiology of tuberculosis susceptibility: impact of study design. PLoS Pathog 2011; 7:e1001189. PMCID: PMC3024264.
Abstract (PubMed)

Genetics, Epidemiology

2011

Stein CM, Baker AR. Tuberculosis as a complex trait: impact of genetic epidemiological study design. Mamm Genome, 2011; 22:91-99. PMCID: PMC3043369.
Abstract (PubMed)

Genetics, Epidemiology

2011

Nqoko B, Day CL, Mansoor N, Kock MD, Hughes EJ, Hawkridge T, Kaplan G, Boom WH, Hussey GD, Hanekom WA.  HIV-Specific Gag Responses in Early Infancy Correlate with Clinical Outcome and Inversely with Viral Load. AIDS Res Hum Retroviruses, 2011; 27:1311-1316. PMCID: PMC3227240.
Abstract (PubMed)

Clinical TB/HIV, Immunology

2011

Bark CM, Okwera A, Joloba ML, Thiel BA, Nakibali JG, Debanne SM, Boom WH, Eisenach KD, Johnson JL. Time to detection of Mycobacterium tuberculosis as an alternative to quantitative cultures. Tuberculosis (Edinb). 2011; 91:257-259.
Abstract (PubMed)

Mycobacteriology, Clinical TB

2011

Lancioni CL, Mahan CS, Johnson DF, Walusimbi M, Chervenak KA, Nalukwago S, Charlebois E, Havlir D, Mayanja-Kizza H, Whalen CC, Boom WH. Effects of antiretroviral therapy on immune function of HIV-infected adults with pulmonary tuberculosis and CD4+ >350 cells/mm3. J Infect Dis., 2011; 203:992-1001. PMCID: PMC3068037.
Abstract (PubMed)

Clinical TB/HIV

2011

Baker AR, Zalwango S, Malone LL, Igo Jr RP, Qiu F, Nsereko M, Adams MD, Supelak P, Mayanja-Kizza H, Boom WH, Stein CM (2011).  Genetic susceptibility to tuberculosis associated with CTSZ haplotype in Ugandan household contact study. Hum Immunol, 2011; 72:426-430. PMCID: PMC3078986.
Abstract (PubMed)

Genetics, Epidemiology

2011

Whalen CC, Zalwango S, Chiunda A, Malone LL,, Eisenach, K, Joloba M, Boom WH, Mugerwa RD.  Secondary attack rate of tuberculosis in urban households in Kampala, Uganda.  Plos One, 2011; 6:E16137. PMCID: PMC3038854.
Abstract (PubMed)

Epidemiology

2011

Mahan CS, Johnson DF, Curley C, van der Kuyp F. Concordance of a positive tuberculin skin test and an interferon gamma release assay in bacille Calmette-Guérin vaccinated persons Int J Tuberc Lung Dis 2011; 15:174-178.
Abstract (PubMed)

Clinical TB, Immunology

2011

Lancioni CL, Li Q, Thomas JJ, Ding X, Thiel B, Drage MG, Pecora ND, Ziady AG, Shank S, Harding CV, Boom WH, Rojas RE. Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4+ T cell activation via TLR2/1. Infect Immun. 2011; 79:663-673. PMCID: PMC3028837.
Abstract (PubMed)

Immunology

2010

Harding CV, Boom WH.  Regulation of class II MHC antigen processing by Mycobacterium tuberculosis: a role for Toll-like receptors.  Nature Rev. Microbiology 2010; 8:296-307.  PMCID: PMC3037727.
Abstract (PubMed)

Immunology

2010

Kateete DP, Okee M, Katabazi FA, Okeng A, Asiimwe J, Boom HW, Eisenach KD, Joloba ML. Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis.
BMC Microbiol. 2010; 10:272. PMCID: PMC2989971.
Abstract (PubMed)

Mycobacteriology

2010

De Jong BC, Antonio M, Gagneux S. Mycobacterium africanum - Review of an Important Cause of Human Tuberculosis in West Africa. PLoS Negl Trop Dis. 2010; 4:e744. PMCID: PMC2946903.
Abstract (PubMed)

Clinial TB

2010

Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst JD, Gagneux S . Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet. 2010; 42:498-503. Epub 2010 May 23. PMCID: PMC2883744.
Abstract (PubMed)

Immunology

2010

Shey MS, Randhawa AK, Bowmaker M, Smith E, Scriba TJ, de Kock M, Mahomed H, Hussey G, Hawn TR, Hanekom WA. Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion. Genes Immun. 2010; 11:561-572.
Abstract (PubMed)

Immunology

2010

Maciel ELN, Guidoni LM, Brioschi AP, do Prado TN, Fregona G, Hadad DJ, Molino L, Palaci M, Johnson JL, Dietze R. Household members and health care workers as supervisors of tuberculosis treatment. Rev Saúde Pública 2010; 44:339-343.
Abstract (PubMed)

Clinial TB

2010

Maciel ELN, Guidoni LM, Favero LP, Hadad DJ, Molino LP, Johnson JL, Dietze R. Efeitos adversos causados pelo novo esquema de tratamento da tuberculose preconzido pelo Ministério da Saúde do Brasil. [Adverse effects of the new tuberculosis treatment regimen recommended by the Brazilian Ministry of Health]. J Bras Pneumol 2010; 36:232-238.
Abstract (PubMed)

Clinial TB

2010

Mupere E, Zalwango S, Chiunda A, Okwera A, Mugerwa R, Whalen C.  Body composition among HIV-seropositive and HIV-seronegative adult patients with pulmonary tuberculosis in Uganda.  Ann Epidemiol. 2010; 20:210-6.
Abstract (PubMed)

Clinial TB, Epidemiology

2010

Mahan CS, Walusimbi M, Johnson DF, Lancioni C, Charlebois E, Baseke J, Chervenak KA, Mugerwa RW, Havlir DV, Mayanja-Kizza H, Whalen CC, Boom WH, for the Uganda-Case Western Research Collaboration. Tuberculosis treatment in HIV infected ugandans with CD4 counts .350 cells/mm3 reduces immune activation with no effect on HIV load or CD4 count. PLoS ONE. 2010; 5:e9138. PMCID: PMC2825253.
Abstract (PubMed)

Clinical TB/HIV, Immunology

2010

Leidl L, Mayanja-Kizza H, Sotgiu G, Baseke J, Ernst M, Hirsch C, Goletti D, Toossi Z, Lange C. Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T -cells in HIV infection. Eur Respir J. 2010; 35:619-626.
Abstract (PubMed)

Immunology

2010

Li L, Mahan CS, Palaci M, Horter L, Loeffelholz L, Johnson JL, Dietze R, Debanne SM, Joloba ML, Okwera A, Boom WH, Eisenach KD.  Sputum Mycobacterium tuberculosis mRNA as a marker of bacteriologic clearance in response to anti-tuberculosis therapy.  J Clin Microbiol, 2010; 48:46-51. PMCID: PMC2812283.
Abstract (PubMed)

Clinical TB

2009

Borrell S, Gagneux S. Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis. Int J Tuberc Lung Dis. 2009; 13:1456-1466.
Abstract (PubMed)

Mycobacteriology

2009

Comas I, Homolka S, Niemann S, Gagneux S. Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies. PLoS One. 2009; 4:e7815. PMCID: PMC2772813
Abstract (PubMed)

Mycobacteriology

2009

Comas I, Gagneux S. The past and future of tuberculosis research. PLoS Pathog. 2009; 5:e1000600. Epub 2009 Oct 26. PMCID: PMC2745564.
Abstract (PubMed)

Epidemiology, Mycobacteriology

2009

Niemann S, Köser CU, Gagneux S, Plinke C, Homolka S, Bignell H, Carter RJ, Cheetham RK, Cox A, Gormley NA, Kokko-Gonzales P, Murray LJ, Rigatti R, Smith VP, Arends FP, Cox HS, Smith G, Archer JA. Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints. PLoS One. 2009 Oct 12;4(10):e7407.b. PMCID: PMC2756628.
Abstract (PubMed)

Mycobacteriology

2009

Peres RL, Maciel EL, Morais CG, Ribeiro FC, Vinhas SA, Pinheiro C, Dietze R, Johnson JL, Eisenach K, Palaci M. Comparison of two concentrations of NALC-NaOH for decontamination of sputum for mycobacterial culture. Int J Tuberc Lung Dis. 2009; 13:1572-1575.
Abstract (PubMed)

Mycobacteriology

2009

Black GF, Thiel BA, Ota MO, Parida SK, Adegbola R, Boom WH, Dockrell HM, Franken KL, Friggen AH, Hill PC, Klein MR, Lalor MK, Mayanja H, Schoolnik G, Stanley K, Weldingh K, Kaufmann SH, Walzl G, Ottenhoff TH; GCGH Biomarkers for TB Consortium. Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa. Clin Vaccine Immunol. 2009; 16:1203-1212. PMCID: PMC2725533.
Abstract (PubMed)

Clinical TB, Immunology

2009

Ribeiro FK, Lemos EM, Hadad DJ, Leão SC, Viana-Niero C, Dietze R, Johnson JL, Eisenach KD, Palaci M. Evaluation of low-colony-number counts of Mycobacterium tuberculosis on solid media as a microbiological marker of cross-contamination. J Clin Microbiol. 2009; 47:1950-1952. PMCID: PMC2691123.
Abstract (PubMed)

Mycobacteriology, Clinial TB

2009

McGee B, Dietze R, Hadad DJ, Molino LP, Maciel EL, Boom WH, Palaci M, Johnson JL, Peloquin CA. Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis. Antimicrob Agents Chemother. 2009; 53:3981-3984. PMCID: PMC2737850.
Abstract (PubMed)

Mycobacteriology, Clinial TB, Pharmacology

2009

Maciel EL, Prado TN, Peres RL, Palaci M, Johnson JL, Dietze R. Guided sputum sample collection and culture contamination rates in the diagnosis of pulmonary TB. J Bras Pneumol. 2009; 35:460-463.
Abstract (PubMed)

Mycobacteriology, Clinial TB

2009

Johnson JL, Hadad DJ, Dietze R, Noia Maciel EL, Sewali B, Gitta P, Okwera A, Mugerwa RD, Alcaneses MR, Quelapio MI, Tupasi TE, Horter L, Debanne SM, Eisenach KD, Boom WH. Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion. Am J Respir Crit Care Med.; 180:558-563. PMCID: PMC2742745.
Abstract (PubMed)

Clinical TB

2009

Mahon RN, Rojas RE, Fulton SA, Franko J, Harding CV, Boom WH. Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling. Infect Immun, 2009; 77:4574-4583. PMCID: PMC2747961
Abstract (PubMed)

Immunology

2009

Mayanja-Kizza H, Wu M, Aung H, Liu S, Luzze H, Hirsch C, Toossi Z. The interaction of monocyte chemoattractant protein-1 and tumour necrosis factor-alpha in Mycobacterium tuberculosis-induced HIV-1 replication at sites of active tuberculosis. Scand J Immunol. 2009; 69:516-520.
Abstract (PubMed)

Immunology

2009

Canaday DH, Wu M, Lu S, Aung H, Peters P, Baseke J, Mackay W, Mayanja-Kizza H, Toossi Z. Induction of HIV type 1 expression correlates with T cell responsiveness to mycobacteria in patients coinfected with HIV type 1 and Mycobacterium tuberculosis. AIDS Res Hum Retroviruses. 2009; 25:213-216.
Abstract (PubMed)

Immunology

2009

Mansoor N, Abel B, Scriba TJ, Hughes J, de Kock M, Tameris M, Mlenjeni S, Denation L, Little F, Gelderbloem S, Hawkridge A, Boom WH, Kaplan G, Hussey GD, Hanekom WA. Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life. Clin Immunol. 2009; 130:280-289. PMCID: PMC2722743.
Abstract (PubMed)

Immunology, Pediatrics,
Clinical TB

2009

Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH*, Harding CV*. TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol, 2009; 258:29-37. PMCID: PMC2730726. (*Joint Senior Authorship)
Abstract (PubMed)

Immunology

2009

Mahan CS, Thomas JJ, Boom WH, Rojas RR.  CD4+CD25highFoxp3+ regulatory T cells down-regulate Vδ2+ T lymphocyte responses triggered by anti-CD3 or phosphoantigen.  Clin Immunol. 2009; 127:398-407. PMCID: PMC2712108.
Abstract (PubMed)

Immunology

2009

Mansoor N, Scriba TJ, de Kock M, Tameris M, Abel B, Keyser A, Little F, Soares A, Gelderbloem S, Mlenjeni S, Denation L, Hawkridge A, Boom WH, Kaplan G, Hussey GD, Hanekom WA.  HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine. J Infect Dis. 2009; 199:982-990. PMCID: PMC2815505.
Abstract (PubMed)

Immunology, Pediatrics,
Clinical TB

2008

Stein CM, Zalwango S, Malone LL, Won S, Mayanja-Kizza H, Mugerwa RD, Leontiev DV, Thompson CL, Cartier KC, Elston RC, Iyengar SK, Boom WH, Whalen CC.Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS ONE. 2008; 3:e4094. PMCID: PMC2605555.
Abstract (PubMed)

Genetics,
Clinical TB, Epidemiology

2008

Hershberg R, Lipatov M, Small PM, Sheffer H, Niemann S, Homolka S, Roach JC, Kremer K, Petrov DA, Feldman M, Gagneux S.  High functional dersity in M. tuberculosis driven by genetic drift and human demography. PLoS Biol. 2008; 6:e311. PMCID: PMC2602723.
Abstract (PubMed)

Genetics, Mycobacteriology

2008

Goletti D, Carrara S, Mayanja-Kizza H, Baseke J, Mugerwa M, Girardi E, and Toossi Z. Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study. BMC Infect Dis. 2008; 28:8:11. PMCID: PMC2267196.
Abstract (PubMed)

Immunology

2008

Srikantiah P, Wong JK, Liegler T, Walusimbi M, Mayanja-Kizza H, Kayanja HK, Mugerwa RD, Charlebois ED, Boom WH, Whalen CC, Havlir DV. Unexpected low-level viremia among HIV-infected Ugandan adults with untreated active tuberculosis. J Acquir Immune Defic Syndr, 2008; 49:458-460.
Abstract (PubMed)

Clinical TB

2008

Lewinsohn DA, Zalwango S, Stein CM, Mayanja-Kizza H, Okwera A, Boom WH, Mugerwa RD, Whalen CC. Whole blood interferon-gamma responses to mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda. PLoS ONE. 2008; 3:e3407. PMCID: PMC2560997.
Abstract (PubMed)

Immunology, Pediatrics, Clinical TB

2008

Dietze R, Hadad DJ, McGee B, Molino LP, Maciel EL, Peloquin CA, Johnson DF, Debanne SM, Eisenach K, Boom WH, Palaci M, Johnson JL. Early and extended early bactericidal activity of linezolid in pulmonary tuberculosis. Am J. Respir Crit Care Med 2008; 178:1180-1185. PMCID: PMC2588492.
Abstract (PubMed)

Genetics, Mycobacteriology

2008

Ramachandra L, Boom WH, Harding CV. Class II MHC antigen processing in phagosomes. Methods Mol Biol. 2008; 445:353-377.
Abstract (PubMed)

Immunology

2008

Peloquin CA, Hadad DJ, Molino LP, Palaci M, Boom WH, Dietze R, Johnson JL. Population pharmacokinetics of levofloxacin, gatifloxacin, and moxifloxacin in adults with pulmonary tuberculosis. Antimicrob Agents Chemother. 2008; 52:852-857. PMCID: PMC2258503.
Abstract (PubMed)

Clinical TB, Pharmacokinetics, Mycobacteriology

2008

Anis MM, Fulton SA, Reba SM, Liu Y, Harding CV, Boom WH. Modulation of pulmonary dendritic cell function during mycobacterial infection. Infect Immun. 2008; 76:671-677. PMCID: PMC2223454.
Abstract (PubMed)

Immunology

2007

Toossi Z, Mayanja-Kizza H, Lawn SO, Hirsch CS, Lupo LD, Butera ST. Dynamic variation in the cellular origin of HIV type 1 during treatment oftuberculosis in dually infected subjects.  AIDS Res Hum Retroviruses. 2007; 23:93-100. PMCID: PMC2631233.
Abstract (PubMed)

Immunology

2007

Pennini ME, Liu Y, Yang J, Croniger CM, Boom WH, Harding CV. CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosis 19-kDa lipoprotein. J Immunol. 2007; 179:6910-6918. PMCID: PMC2631233.
Abstract (PubMed)

Immunology

2007

Palaci M, Dietze R, Hadad DJ, Ribeiro FK, Peres RL, Vinhas SA, Maciel EL, do Valle Dettoni V, Horter L, Boom WH, Johnson JL, Eisenach KD. Cavitary disease and quantitative sputum bacillary load in cases of pulmonary tuberculosis. J Clin Microbiol. 2007; 45:4064-4066. PMCID: PMC2168542.
Abstract (PubMed)

Clinical TB, Mycobacteriology

2007

Srikantiah P, Walusimbi MN, Kayanja HK, Mayanja-Kizza H, Mugerwa RD, Lin R, Charlebois ED, Boom WH, Whalen CC, Havlir DV. Early virological response of zidovudine/lamivudine/abacavir for patients co-infected with HIV and tuberculosis in Uganda. AIDS. 2007; 21:1972-1974.
Abstract (PubMed)

Clinical TB/HIV, Virology

2007

Boom WH. New TB vaccines: is there a requirement for CD8 T cells? J Clin Invest. 2007; 117:2092-2094. PMCID: PMC1934597.
Abstract (PubMed)

Clinical TB, Immunology

2007

Stein CM, Zalwango S, Chiunda AB, Millard C, Leontiev DV, Horvath AL, Cartier KC, Chervenak K, Boom WH, Elston RC, Mugerwa RD, Whalen CC, Iyengar SK. Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Hum Genet. 2007; 121:663-673.
Abstract (PubMed)

Genetics, Immunology, Epidemiology

2007

Anis MM, Fulton SA, Reba SM, Harding CV, Boom WH. Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection. Infect Immun. 2007; 75:2260-2268. PMCID: PMC1865791.
Abstract (PubMed)

Immunology

2007

Resende Co T, Hirsch CS, Toossi Z, Dietze R, and Ribeiro-Rodrigues R. . Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy. Clin Exp Immunol. 2007; 147:45-52. PMCID: PMC1810442.
Abstract (PubMed)

Immunology

2007

Srikantiah P, Lin R, Walusimbi M, Okwera A, Luzze H, Whalen CC, Boom WH, Havlir DV, Charlebois ED. Elevated HIV seroprevalence and risk behavior among Ugandan TB suspects: implications for HIV testing and prevention. Int J Tuberc Lung Dis. 2007; 11:168-174.
Abstract (PubMed)

Clinical TB/HIV, Epidemiology

2006

Ribeiro-Rodrigues R, Resende Co T, Maciel E, Dietze R, Boom WH, Hirsch C. A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis. Clin Exp Immunol. 2006; 144:25-34.
Abstract (PubMed)

Immunology, Clinical TB

2006

Johnson JL, Hadad DJ, Boom WH, Daley CL, Peloquin CA, Eisenach KD, Jankus DD, Debanne SM, Charlebois ED, Maciel E, Palaci M, Dietze R. Early and extended early bactericidal activity of levofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. Int J Tuberc Lung Dis 2006; 10:605-612.
Abstract (PubMed)

Clinical TB, Mycobacteriology

2006

Jones-Lopez EC, Okwera A, Mayanja-Kizza H, Ellner JJ, Mugerwa RD, Whalen CC. Delayed-type hypersensitivity skin test reactivity and survival in HIV-infected patients in Uganda: should anergy be a criterion to start antiretroviral therapy in low-income countries? Am J Trop Med Hyg. 2006;74:154-161.
Abstract (PubMed)

Cllinical TB

2006

Muhumuza J, Asiimwe BB, Kayes S, Mugyenyi R, Whalen C, Mugerwa RD, Boom H, Eisenach KD, Joloba ML. Introduction of an in-house PCR for routine identification of M. tuberculosis in a low-income country. Int J Tuberc Lung Dis. 2006;10:1262-1267.
Abstract (PubMed)

Mycobacteriology, Clinical TB

2006

Pennini ME, Pai RK, Schultz DC, Boom WH, Harding CV. Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling. J Immunol. 2006 Apr 1;176(7):4323-30.
Abstract (PubMed)

Immunology

2006

Donald PR. The early bactericidal activity of anti-tuberculosis agents. Int J Tuberc Lung Dis. 2006; 10:591.
Abstract (PubMed)

Clinical TB, Mycobacteriology

2006

Pecora ND, Ghering A, Canaday D, Belisle J, Boom WH, Harding CV.  Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and antigen presenting cell function.  J Immunol 2006; 177:422-429.
Abstract (PubMed)

Immunology

2006

Whalen CC, Chiunda A, Zalwango S, Nshuti L, Jones-Lopez E, Okwera A, Hirsch C, Peters P, Boom WH, Mugerwa RD.;Immune correlates of acute Mycobacterium tuberculosis infection in household contacts in Kampala, Uganda. Am J Trop Med Hyg. 2006; 75:55-61.
Abstract (PubMed)

Immunology, Epidemiology, Clinical TB

2006

Rojas RE, Thomas J, Gehring AJ, Hill P, Belisle J, Harding CV**, Boom WH**.  Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds a5b1 integrin (VLA-5) on CD4+ T Cells and Induces Adhesion to Fibronectin   J. of Immunol. 2006; 177:2959-2968. (**Joint Senior Authorship)
Abstract (PubMed)

Immunology

2006

Theus SA, Cave MD, Eisenach KD, Walrath J, Lee H, Mackay W, Whalen C, Silver RF. 2006. Differences in the growth of paired Ugandan isolates of Mycobacterium tuberculosis within human mononuclear phagocytes correlate with epidemiological evidence of strain virulence. Infect. Immun. 2006; 74:6865-6876.
Abstract (PubMed)

Mycobacteriology, Epidemiology

2006

Torres M, Ramachandra L, Rojas RE, Bobadilla K, Thomas J, Canaday DH, Harding CV**, Boom WH**.  Role of phagosomes and MIIC in MHC-II antigen processing of MTB in human macrophages.  Infect. Immun. 2006, 74:1621-1630. (**Joint Senior Authorship)
Abstract (PubMed)

Immunology

2005

Wallis RS, Johnson JL.  The role of surrogate markers in the clinical evaluation of anti-tuberculous chemotherapy. Curr Med Chem Anti-infective Agents 2005; 4:287-294.

Clinical TB

2005

Stein CM, Nshuti L, Chiunda AB, Boom WH, Elston RC, Mugerwa RD, Iyengar SK, Whalen CC. Evidence for a major gene influence on tumor necrosis factor-α expression in tuberculosis: path and segregation analysis.  Hum Hered 2005; 60:109-118.
Abstract (PubMed)

Genetics, Immunology, Epidemiology

2005

Wiles S, Ferguson K, Stefanidou M, Young DB, Robertson BD. Alternative luciferase for monitoring bacterial cells under adverse conditions.  Appl Environ Microbiol. 2005; 71:3427-3432.
Abstract (PubMed)

Immunology, Mycobacteriology

2005

Toossi Z, Mayanja-Kizza H, Baseke J, Peters P, Wu M, Abraha A, Aung H, Okwera A, Hirsch C, Arts E. Inhibition of human immunodeficiency virus-1 (HIV-1) by beta-chemokine analogues in mononuclear cells from HIV-1-infected patients with active tuberculosis. Clin Exp Immunol. 2005; 142:327-332.
Abstract (PubMed)

Immunology

2005

Kizza H, Rodriguez B, Quinones-Mateu M, Mirza M, Aung H, Yen-Liberman B, Starkey C, Horter L, Peters P, Baseke J, Johnson JL, Toossi Z. Persistent replication of human immunodeficiency virus type 1 despite treatment of pulmonary tuberculosis in dually infected subjects. Clin Diagn Lab Immunol 2005;12:1298-1304.
Abstract (PubMed)

Clinical TB, Immunology

2005

Furin JJ, Johnson JL. (2005) Recent advances in the diagnosis and management of tuberculosis. Curr Opin Pulm Med 11(3):189-94.
Abstract (PubMed)

Clinical TB

2005

Aung H, Wu M, Johnson JL, Hirsch CS and Toossi Z. Bioactivation of latent transforming growth factor beta1 by Mycobacterium tuberculosis in human mononuclear phagocytes. Scand J Immunol. 2005; 61:558-65.
Abstract (PubMed)

Immunology

2005

Hirsch CS, Johnson JL, Okwera A, Kanost RA, Wu M, Peters P, Muhumuza M, McHugh M, Mayanja-Kizza H, Mugerwa RD, Mugyenyi P, Ellner JJ, Toossi Z. (2005) Mechanisms of apoptosis of T-cells in human tuberculosis. J Clin Immunol. 2005; 25:353-364.
Abstract (PubMed)

Immunology

2005

Katamba A, Neuhauser D, Smyth K, Adatu FÝ, Katabira E, Whalen CC. Patients perceived stigma associated with community-based directly observed therapy of tuberculosis in Uganda. East Afr Med J. 2005; 82:337-342.
Abstract (PubMed)

Epidemiology, Clinical TB

2005

Blokpoel M, Murphy H, O Toole R, Wiles S, Runn E, Stewart G, Young D, Robertson B. Tetracycline-inducible gene regulation in mycobacteria. Nucleic Acids Research. 2005; 33:e22.
Abstract (PubMed)

Immunology

2005

Rojas RE, Chervenak KA, Thomas J, Morrow J, Nshuti L, Zalwango S, Thiele BA, Whalen CC, Boom WH (2005).  Vdelta2+ gammadelta T cell function in Mycobacterium tuberculosis- and HIV-1-positive patients in the United States and Uganda: application of a whole-blood assay. J Inf Dis 2005; 192:1806-1814.
Abstract (PubMed)

Immunology

2004

Fulton SA, Reba SM, Pai RK, Pennini M, Torres M, Harding CV, Boom WH. Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein. Infect Immun. 2004; 72:2101-2110.
Abstract (PubMed)

Immunology

2004

Wallis RS, Kyambadde P, Johnson JL, Horter L, Kittle R, Pohle M, Ducar C, Millard M, Mayanja-Kizza H, Whalen C and Okwera A. A study of the safety, immunology, virology, and microbiology of adjunctive etanercept in HIV-1-associated tuberculosis. AIDS 2004; 18:257-264.
Abstract (PubMed)

Clinical TB/HIV

2004

Elliott AM, Luzze H, Quigley MA, Nakiyingi J, Kyaligonza S, Namujju PB, Ducar C, Ellner JJ, Whitworth JAG, Mugerwa R, Johnson JL, Okwera A. A randomised, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1 associated pleural tuberculosis. J Infect Dis. 2004; 190:869-878.
Abstract (PubMed)

Clinical TB/HIV, Immunology

2004

Gehring AJ, Dobos KM, Belisle KM, Harding CV**, Boom WH**. Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage MHC-II antigen processing. J Immunol. 2004; 173:2660-2668.
Abstract (PubMed)

Immunology

2004

Islam N, Kanost RA, Teixeira-Johnson L, Hejal R, Aung H, Wilkinson RJ, Hirsch CS, and Toossi Z. The role of cellular activation and tumor necrosis factor (TNF ) in the early expression of Mycobacterium tuberculosis 85B mRNA in human alveolar macrophages. .J Infect Dis. 2004; 190:341-351.
Abstract (PubMed)

Mycobacteriology, Immunology

2004

Johnson JL, Nunn AJ, Fourie PB, Ormerod LP, Mugerwa RD, Chintu C, Mwinga A, Ngwira B, Onyebujoh P, Zumla A. Effect of Mycobacterium vaccae (SRL172) immunotherapy on radiographic healing in tuberculosis. Int J Tuberc Lung Dis. 2004; 11:1348-1354.
Abstract (PubMed)

Clinical TB, Immunology

2004

Pai RK, Pennini ME, Tobian AAR, Canaday DH, Boom WH, Harding CV. Prolonged toll-like receptor signalling by M. tuberculosis and its 19 kDa lipoprotein inhibits IFN-induced regulation of selected genes in macrophages. Infect Immun. 2004; 11:6603-6614.
Abstract (PubMed)

Immunology

2004

Toossi Z, Mayanja-Kizza H, Kanost A, Edmonds K, McHugh M, and Hirsch C. Protective responses in Tuberculosis: Induction of genes for interferon gamma and cytotoxicity by Mycobacterium tuberculosis and during human tuberculosis. Scand J Immunol. 2004; 60:299-306.
Abstract (PubMed)

Immunology

2004

Hanekom WA, Hughes J, Mavinkurve M, Mendillo M, Gelderbloem SJ, Watkins M, Gamieldien H, Sidibana M, Davids V, Mansoor N, Hawkridge A, Haslett PAJ, Ress S, Hussey GD, Kaplan G. Novel application of a whole blood intracellular cytokine detection assay for evaluating specific T cell frequency and function in field studies. J of Immuno Methods 2004; 291:185-95.
Abstract (PubMed)

Immunology

2003

Boom WH, Canaday DH, Fulton SA, Gehring AJ, Rojas RJ, Torres M. Human Immunity to M. tuberculosis: T cell subsets and antigen processing. Tuberculosis 2003; 83:98-106.
Abstract (PubMed)

Immunology

2003 Hesseling AC, Schaaf HS, Hanekom WA, Beyers N, Cotton MF, Gie RP, Marais BJ, Van Helden P, Warren RM. Danish BCG vaccine-induced disease in HIV-infected children. Clinical Infectious Diseases 2003; 37:1226-33.

Abstract (PubMed)

Clinical TB

2003

Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. J Immunol Methods 2003; 281:129-142.
Abstract (PubMed)

Immunology

2003

Gehring A, Rojas RE, Canaday DH, Lakey D, Harding CV, Boom WH. The Mycobacterium tuberculosis 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Regulated HLA-DR and Fc R1 on Human Macrophages through Toll-Like Receptor 2. Infect Immun 2003; 71:4487-4497. PMCID: PMC166015.
Abstract (PubMed)

Immunology

2003

Guwatudde D, Nakakeeto M, Jones-Lopez EC, Maganda A, Chiunda A, Mugerwa RD, Ellner JJ, Bukenya G, Whalen CC. Tuberculosis in Household Contacts of Infectious Cases in Kampala, Uganda. Am J Epidemiol 2003; 158:887-898. PMCID: PMC2869090.
Abstract (PubMed)

Epidemiology, Clinical TB

2003

Johnson JL, Ssekasanvu E, Okwera A, Mayanja H, Hirsch CS, Nakibali J, Drzayich Jankus D, Eisenach KD, Boom WH, Ellner JJ, Mugerwa RD for the Uganda-Case Western Reserve University Research Collaboration. Randomized trial of adjunctive interleukin-2 in adults with pulmonary tuberculosis. Am J Respir Crit Care Med 2003; 168:185-191.
Abstract (PubMed)

Clinical TB, Immunology

2003

Pai RK, Convery M, Hamilton TA, Boom WH and Harding CV. Inhibition of IFN- -Induced Class II Transactivator Expression by a 19-kDa Lipoprotein from Mycobacterium tuberculosis: A Potential Mechanism for Immune Evasion. J Immunol 2003; 171:175-184.
Abstract (PubMed)

Immunology

2003

Barnes PF.  Immunotherapy for tuberculosis: Wave of the future or tilting at windmills?  Am J Respir Crit Care Med 2003:168:142-143.
Abstract (PubMed)

Immunology

2003

Stein CM, Guwatudde D, Nakakeeto M, Peters P, Elston RC, Tiwari HK, Mugerwa R, Whalen CC. Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis 2003; 187:1679-1685.
Abstract (PubMed)

Epidemiology, Genetics, Immunology

2003

Tobian AAR, Potter NS, Ramachandra L, Pai RK, Convery M, Boom WH and Harding CV. Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharide. J Immunol 2003; 171:1413-1422.
Abstract (PubMed)

Immunology

2003

Wallis RS, Vinhas SA, Johnson JL, Ribeiro FC, Palaci M, Peres RL, Sá RT, Dietze R, Chiunda A, Eisenach K, Ellner JJ. Whole blood bactericidal activity during treatment of pulmonary tuberculosis. J Infect Dis 2003; 187:270-278.
Abstract (PubMed)

Mycobacteriology

2002

Canaday DH, Beigi R, Silver RF, Harding CV, Boom WH, Dubyak GR. ATP and control of intracellular growth of mycobacteria by T cells. Infect Immun 2002;70:6456-6459.
Abstract (PubMed)

Immunology

2002

Collins KR, Quinones-Mateu ME, Wu M, Luzze H, Johnson JL, Hirsch C, Toossi Z, Arts EJ. Human immunodeficiency virus type 1 (HIV-1) quasispecies at the sites of Mycobacterium tuberculosis infection contribute to systemic HIV-1 heterogeneity. J Virol 2002; 76:1697-1706.
Abstract (PubMed)

Immunology, Virology

2002

Fulton SA, Reba SM, Martin TD, Boom WH. Neutrophil mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect Immun 2002; 70:5322-5327.
Abstract (PubMed)

Immunology

2002

Fourie PB, Ellner JJ, Johnson JL. Wither Mycobacterium vaccae encore. Lancet 2002; 360:1032-1033
Abstract (PubMed)

Clinical TB, Immunology
2002

Nieman S, Rusch-Gerdes S, Joloba ML, Whalen CC, Guwatudde D, Ellner JJ, Eisenach K, Fomukong N, Johnson JL, Mugerwa RD, Okwera A, Schwander SK. Mycobacterium africanum subtype II is associated with two distinct genotypes and is a major cause of human tuberculosis in Kampala, Uganda. J Clin Microbiol 2002; 40:3398-3405.
Abstract (PubMed)

Mycobacteriology, Clinical TB

2002

Pai RK, Askew D, Boom WH, Harding CV. Regulation of class I MHC expression in APCs: roles of types I, II, and IV class II transactivator. J Immunol 2002; 169:1326-1333.
Abstract (PubMed)

Immunology

2002

Ribeiro-Rodrigues R, Resende Co T, Johnson JL, Ribeiro F, Palaci M, Sá RT, Maciel EL, Lima FEP, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, Hirsch CS. Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance. Clin Diagn Lab Immunol 2002; 9:818-823. PMCID: PMC120011.
Abstract (PubMed)

Mycobacteriology

2002

Rojas RE, Torres M, Fournie JJ, Harding CV, Boom WH. Phosphoantigen presenation by macrophages to mycobacterium tuberculosis - reactive Vgamma9Vdelta2 + T cells: modulation by Chloroquine. Infect Immun 2002; 70:4019-4027.
Abstract (PubMed)

Immunology

2002

Tristao-Sa R, Ribeiro-Rodrigues R, Teixeira L, Pereira FEL, Dietze R. Intestinal nematodes and pulmonary tuberculosis. Revista da Sociedade Brasileira de Medicina Tropical 2002; 35:533-535.

Clinical TB

2002

Cheon SH, Kampmann B, Hise AG, Phillips M, Song HY, Landen K, Li Q, Larkin R, Ellner JJ, Silver RF, Hoft DF and Wallis RS. Whole blood bactericidal activity as a potential surrogate marker of immunity after vaccination against tuberculosis. Clin Diagn Lab Immunol 2002; 9:901-907.
Abstract (PubMed)

Immunology

2002

Flyer DC, Ramakrishna V, Miller C, Myers H, McDaniel M, Root K, Flournoy C, Engelhard VH, Canaday DH, Marto JA, Ross MM, Hunt DF, Shabanowitz J, White FM. Identification by Mass Spectrometry of CD8+-T-Cell Mycobacterium tuberculosis Epitopes within the RV0341 Gene Product. Infect Immun 2002; 70:2923-2932.
Abstract (PubMed)

Immunology

2002

Hoft DF, Worku S, Kampmann B, Whalen CS, Ellner JJ, Hirsch CS, Brown RB, Larkin R, Li Q, Hyun J and Silver RF. Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective TB immunity. J Infect Dis 2002; 186:1448-1457.
Abstract (PubMed)

Immunology

2001

Brill K, Li Q, Scaccia R, Canaday DH, Boom WH, Silver RF. Human natural killer cells mediate killing of intracellular M. tuberculosis H37Rv via perforin-independent mechanisms. Infection and Immunity, 2001; 69:1755-1765.
Abstract (PubMed)

Immunology

2001

Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH. CD4+ and CD8+ T cells kill intracellular M. tuberculosis by a perforin and FAS/FASL independent mechanism. J. Immunology, 2001; 167:2734-2742.
Abstract (PubMed)

Immunology

2001

DesJardin LE, Hayes LG, Wayne LG, Sohaskey CD, Eisenach KD. Microaerophilic induction of the alpha crystallin chaperone protein homologue (hspX) mRNA of Mycobacterium tuberculosis. J Bacteriol 2001; 183:5311-5316.
Abstract (PubMed)

Mycobacteriology

2001

Dietze R, Teixeira L, Canedo Rocha LM, Palaci M, Johnson JL, Wells C, Rose L, Eisenach K, Ellner JJ. Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis. Antimicrob Agents Chemother 2001; 45:1972-1976. PMCID: PMC90587.
Abstract (PubMed)

Clinical TB, Mycobacteriology

2001

Diniz LM, Zandonade E, Dietze R, Pereira FE, Ribeiro-Rodrigues R. Do intestinal nematodes increase the risk for multibacillary leprosy? Am J Trop Med Hyg 2001; 65:852-854.
Abstract (PubMed)

Immunology

2001

Ehrt, S., D. Schnappinger, S. Bekiranov, J. Drenkow, S. Shi, T. Gingeras, T. Gaasterland, G.K. Schoolnik, and C. Nathan. Extensive remodeling of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 2001; 194:1123-1139.
Abstract (PubMed)

Mycobacteriology, Immunology

2001

Hirsch CS, Johnson JL. Treatment of latent tuberculosis: New U.S. guidelines. Infect Dis Clin Pract 2001; 10(2):93-100.

Clinical TB

2001

Hirsch CS, Toossi Z, Johnson JL, Luzze H, Ntambi L, Peters P, McHugh M, Okwera A, Joloba M, Mugyenyi P, Mugerwa RD, Terubuh P, Ellner JJ. Augmentation of Apoptosis and Interferon-g Production at Sites of Active Mycobacterium tuberculosis Infection in Human Tuberculosis. J Infect Dis 2001; 183:779-788.
Abstract (PubMed)

Immunology

2001

Joloba ML, Johnson JL, Namale A, Morrissey A, Assegghai AE, Rüsch-Gerdes S, Mugerwa RD, Ellner JJ, Eisenach KD. Quantitative bacillary response to treatment in Mycobacterium tuberculosis (MTB) and M. africanum infected adults with pulmonary tuberculosis. Int J Tuberc Lung Dis 2001; 5:579-582.
Abstract (PubMed)

Mycobacteriology

2001

Kato-Maeda, M., Rhee, J.T., Gingeras, T., Salamon, H., Drenkow, J., Smittipat, N., and Small, P.M. Comparing genomes within the species Mycobacterium tuberculosis. Genome Res. 2001; 4:547-554.
Abstract (PubMed)

Genetics, Mycobacteriology

2001

Kato-Maeda, M., Bifani, P.J., Kreiswirth, B., and Small, P.M. The nature and consequences of genetic variability within Mycobacterium tuberculosis. J. Clin. Invest. 2001; 107:533-537, 2001.
Abstract (PubMed)

Genetics, Mycobacteriology

2001

Lawn SD, Pisell T, Hirsch CS, Wu, M, Butera ST, Toossi Z. Anatomically Compartmentalized HIV Replication in HLA-DR+ Cells and CD14+ Macrophages at the Site of Pleural Tuberculosis Co-infection. J Inf Dis, 2001; 184:1127-1133.
Abstract (PubMed)

Immunology

2001

Luzze H, Elliott AM, Joloba ML, Odida ML, Oweka-Onyee J, Nakiyingi J, Quigley M, Hirsch C, Mugerwa RD, Okwera A, Johnson JL. Evaluation of suspected tuberculous pleurisy: Clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. Int J Tuberc Lung Dis 2001; 5:746-753.
Abstract (PubMed)

Clinical TB/HIV

2001

Manganelli, R. M.I. Voskuil, G.K. Schoolnik and I. Smith. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 2001; 41:423-437.
Abstract (PubMed)

Genetics, Mycobacteriology

2001

Mayanja-Kizza H, Waija A, Wu M, Ssengoba A, Peters P, Nalugwa G, Mubiru F, Nassali A, Aung H, Herthoge T, Vanham G, Hirsch CS, Whalen CW, Ellner JJ, and Toossi Z. Activation of Beta-chemokines and CCR-5 and enhanced HIV-1 activity in HIV-infected patients with tuberculosis. J Inf Dis, 2001; 183:1801-1804.
Abstract (PubMed)

Immunology

2001

Mayanja-Kizza H, Johnson JL, Hirsch CS, Peters P, Surewicz K, Wu M, Nalugwa G, Mubiru F, Luzze H, Waija A, Aung H, Ellner JJ, Whalen CW, and Toossi Z. Macrophage activating cytokines in HIV-1 infected and uninfected subjects with pulmonary tuberculosis. J Inf Dis, 2001; 183:1805-1809.
Abstract (PubMed)

Immunology

2001

Noss EH, Sellati TJ, Radolf JD, Belisle J, Golenbock DT, Boom WH**, Harding CV**. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19 kD lipoprotein of M. tuberculosis. J of Immunology, 2001; 167:910-918. (**Joint Senior Authorship)
Abstract (PubMed)

Immunology

2001

Neufert C, Pai RK, Noss EH, Berger M, Boom WH, Harding CV. Mycobacterium tuberculosis 19 kDa lipoprotein promotes neutrophil activation. J. Immunology, 2001; 167:1542-1549.
Abstract (PubMed)

Immunology

2001

Ramachandra L, Noss EN, Boom WH, Harding CV. Processing of M. tuberculosis antigen 85B involves intra-phagosomal formation of peptide:MHC-II complexes and is inhibited by live bacilli that decrease phagosome maturation. J. Exp. Med., 2001; 194:1421-1432.
Abstract (PubMed)

Immunology

2001

Sherman, D.R., M.I. Voskuil, R. Liao, M.I. Harrell and G.K. Schoolnik. Regulation of the Mycobacterium tuberculosis hypoxic gene encoding alpha-crystallin. Proc. Natl. Acad. Sci (USA) 2001; 98:7534-7539.
Abstract (PubMed)

Genetics, Mycobacteriology

2001

Wallis RS, Johnson JL. Adult tuberculosis in the 21st century: pathogenesis, clinical features, and management. Curr Opin Pulm Med 2001;7:124-32 (invited review).

Clinical TB

2001 Wallis RS, Palaci M, Vinhas S, Hise AG, Ribeiro FC, Landen K, Cheon SH, Song HY, Phillips M, Dietze R and Ellner JJ. A whole blood bactericidal assay for tuberculosis. J Infect Dis 2001;183 (8):1300-1303.

Abstract (PubMed)

Immunology, Mycobacteriology

2001

Teixeira L, Perkins MD, Johnson JL, Keller RP, Palaci M, Dettoni V, Rocha L, Talbot E, Dietze R. Infection and disease among household contacts of patients with multi-drug resistant tuberculosis. Int J Tuberc Lung Dis 2001; 5:321-328.
Abstract (PubMed)

Clinical TB, Epidemiology

2001 Hodsdon WS, Luzze H, Hurst TJ, Quigley MA, Kyosiimire J, Namujju PB, Johnson JL, Kaleebu P, Okwera A, Elliott AM. HIV-1-related pleural tuberculosis: elevated production of IFN-g, but failure of immunity to M. tuberculosis. AIDS 2001;15:467-475.

Abstract (PubMed)

Immunology

2001

Toossi Z, Johnson JL, Kanost AR, Wu M, Luzze H, Peters P, Okwera A, Joloba M, Mugyenyi P, Mugerwa RD, Aung H, Ellner JJ, Hirsch CS. Increased replication of Human Immunodeficiency virus-1 (HIV-1) at sites of active M. tuberculosis infection: Potential mechanisms of viral activation. J AIDS 2001; 28:1-8.
Abstract (PubMed)

Immunology, Virology

2001

Toossi Z, Mayanja-Kizza H, Hirsch CS, Edmonds KL, Spahlinger T, Hom DL, Aung H, Mugyenyi P, Ellner JJ, and Whalen CW. Impact of tuberculosis on Human Immunodeficiency Virus-1 (HIV-1) activity in dually infected patients. Clin Exper Immunol, 2001; 123:233-238.
Abstract (PubMed)

Immunology, Clinical TB/HIV

2001

Wallis RS, Phillips M, Johnson JL, Teixeira L, Canedo Rocha L, Maciel E, Rose L, Wells C, Palaci M, Dietze R, Eisenach K, and Ellner JJ. Inhibition of Isoniazid-Induced Expression of Mycobacterium tuberculosis Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials. Antimicrob Agents Chemother 2001; 45:1302-1304. PMCID: PMC90462.
Abstract (PubMed)

Immunology, Mycobacteriology

2001

Wilkinson RJ, DesJardin LE, Islam M, Gibson BM, Kanost RA, Wilkinson KA, Poelman D, Eisenach KD, Toossi Z. An increase in expression of a Mycobacterium tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes. Mol Microbiol 2001; 39:813-821.
Abstract (PubMed)

Mycobacteriology

2001

Wilson, M.A., M. Voskuil, D. Schnappinger and G.K. Schoolnik. Microarray gene response profiling of Mycobacterium tuberculosis. Methods Mol. Biol. 2001; 54:335-358.

Genetics, Mycobacteriology

2000

Hertoghe T, Wajja A, Ntambi L, Okwera A, Aziz MA, Hirsch C, Johnson J, Toossi Z, Mugerwa R, Mugyenyi P, Colebunders R, Ellner J, Vanham G. T cell activation, apoptosis and regulatory cytokine production in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB). Clin Exp Immunol 2000; 122:350-357. (Joint project between TBRU and the Institute of Tropical Medicine - Antwerp, Belgium)
Abstract (PubMed)

Immunology

2000 Piatek AS, Telenti A, Murray MR, El-Haji H, Jacobs WR Jr., Kramer FR, Alland D. Genotypic Analysis of Mycobacterium tuberculosis in Two Distinct Populations Using Molecular Beacons: Implications for Rapid Susceptibility Testing. Antimicrob Agents Chemother 2000; 44: 103-110.

Abstract (PubMed)

Clinical TB, Mycobacteriology

2000 Hondalus MK, Bardarov S, Russell R, Chan J, Jacobs WR Jr. and Bloom B. Attenuation of and Protection Induced by a Leucine Auxotroph of Mycobacterium tuberculosis. Infect Immun 2000; 68:2888-2898.

Abstract (PubMed)

Immunology

2000

Ellner JJk, Hirsch CS, Whalan CC. Correlates of protective immunity to mycobacterium tuberculosis in humans. Clin Inf Dis 2000; 30:s279-282.
Abstract (PubMed)

Immunology

2000

Hirsch CS, Johnson, JL. Rifapentine in the treatment and prevention of tuberculosis. Current Treatment Options in Infect Dis 2000; 2:121-124.

Clinical TB

2000 Alland D, Steyn AJ, Weisbrod T, Aldrich K, Jacobs Jr. WR. Characterization of the Mycobacterium tuberculosis iniBAC Promoter, a Promoter That Responds to Cell Wall Biosynthesis Inhibition. J Bacteriol 2000; 182:1802-1811.

Abstract (PubMed)

Mycobacteriology

2000

Noss EH, Harding CV and Boom WH. Mycobacterium tuberculosis inhibits MHC class II antigen processing in murine bone marrow macrophages. Cellular Immunology 2000; 201:63-74.
Abstract (PubMed)

Immunology

2000

Johnson JL, Ellner JJ. Adult tuberculosis overview: African vs. Western perspectives. Curr Opin Pulm Med 2000; 6:180-186.
Abstract (PubMed)

Clinical TB

2000

Johnson JL, Kamya RM, Okwera A, Loughlin AM, Nyole S, Hom D, Wallis RS, Hirsch CM, Wolski KW, Foulds J, Mugerwa RD, Ellner JJ for the Uganda-Case Western Reserve Research Collaboration. Randomized controlled trial of Mycobacterim vaccae immunotherapy in non-Human Immunodeficiency Virus-infected Ugandan adults with newly diagnosed pulmonary tuberculosis. J Infect Dis 2000; 181:1304-1312.
Abstract (PubMed)

Clinical TB, Immunology

2000

Joloba ML, Johnson JL, Namale A, Morrissey A, Assegghai AE, Mugerwa RD, Ellner JJ, Eisenach KD. Quantitative sputum bacillary load during rifampicin containing short course chemotherapy in human immunodeficiency virus- infected and non-infected adults with pulmonary tuberculosis. Int J Tuberc Lung Dis 2000; 4:526-528.
Abstract (PubMed)

Mycobacteriology
2000

Joloba ML, Whalen CC, Cave DM, Eisenach KD, Johnson JL, Okwera A, Morrissey A, Bajaksouzian S, Feagin J, Mugerwa RD, Ellner JJ, Jacobs MR. Determination of drug susceptibility and DNA fingerprint patterns of clinical isolates of Mycobacterium tuberculosis from Kampala, Uganda. East Afr Med J 2000; 77:111-115.
Abstract (PubMed)

Mycobacteriology

2000

Raychaudhuri, S., Stuart, J.M., Liu, X., Small, P.M., and Altman, R. Pattern recognition of genomic features with microarrays: site typing of Mycobacterium tuberculosis strains. Proc. Int. Conf. Intell. Syst. Mol. Biol. 2000; 8:286-95.
Abstract (PubMed)

Myobacteriology, Genetics

2000

Salamon, H., Kato-Maeda, M., Small, P.M., and Gingeras, T. Detection of deleted genomic DNA using a semiautomated computational analysis of GeneChip data. Genome Res. 2000; 10:2044-2054.
Abstract (PubMed)

Genetics

2000

Wallis RS, Perkins MD, Phillips M, Joloba M, Namale A, Johnson JL, Whalen CC, Teixeira L, Dietze R, Mugerwa R, Eisenach K, Ellner JJ. Predicting the outcome of therapy for pulmonary tuberculosis. Am J Respir Crit Care 2000; 161:1076-1080.
Abstract (PubMed)

Clinical TB, Mycobacteriology

1999

Brooks JV, Furney SK Orme IM. Metronidazole therapy in mice infected with tuberculosis. Antimicrob Agents Chemother. 1999; 43:1285-1288.
Abstract (PubMed)

Immunology, Clinical TB

1999

DesJardin L, Perkins M, Wolski K, Haun S, Teixeira L, Chen Y, Johnson JL, Ellner JJ, Dietze R, Bates J, Cave MD, Eisenach K. Measurement of sputum Mycobacterium tuberculosis messenger RNA as a surrogate for response to chemotherapy. Am J Respir Crit Care Med 1999; 160:203-210.
Abstract (PubMed)

Mycobacteriology

1999 Pavelka MS, Jacobs WR Jr. Comparison of the Construction of Unmarked Deletion Mutations in Mycobacterium smegmatis, Mycobacterium bovis Bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange. J. Bacteriol 1999; 181:4780-4789.

Abstract (PubMed)

Mycobacteriology

1999

Hellyer T, DesJardin LE, Hehman GL, Cave MD, Eisenach KD. Quantitative analysis of mRNA as a marker for viability of Mycobacterium tuberculosis. J Clin Micro 1999; 37:290-295.
Abstract (PubMed)

Mycobacteriology

1999

Hellyer T, DesJardin LE, Teixeira L, Perkins MD, Cave MD and Eisenach KD. Detection of viable Mycobacterium tuberculosis by reverse transcription-strand displacement amplification of mRNA. J Clin Micro 1999; 37:518-523.
Abstract (PubMed)

Mycobacteriology

1999

Hirsch CS, Toossi Z, Othieno C, Johnson JL, Schwander SK, Robertson S, Wallis RS, Edmonds K, Okwera A, Mugerwa R, Peters P, Ellner JJ. Depressed T-cell interferon-g responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J Infect Dis 1999; 180:2069-2073.
Abstract (PubMed)

Immunology

1999

Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Okwera A, Mugerwa R, Mugyenyi P, Ellner JJ. Apoptosis and T-cell hyporesponsiveness in pulmonary tuberculosis. J Infect Dis 1999; 179:945-953.
Abstract (PubMed)

Immunology

1999

Musoke Mudido P, Guwatudde D, Nakakeeto MK, Bukenya GC, Nsamba D, Johnson JL, Mugerwa RD, Ellner JJ, Whalen CC. The effect of bacille Calmette-Guerin vaccination at birth on tuberculin skin test reactivity in Ugandan children. Int J Tuberc Lung Dis 1999; 3:891-895.
Abstract (PubMed)

Clinical TB, Pediatrics

1999

Othieno C, Hirsch CS, Hamilton BD, Wilkinson K, Ellner JJ, Toossi, Z. Interaction of Mycobacterium tuberculosis-induced transforming growth factor b1 and interleukin-10. Infect & Immunity 1999; 67:5730-5735.
Abstract (PubMed)

Immunology

1999

Riska P, Su Y, Bardarov S, Freundlich L, Sarkis G, Hatfull G, Carriere C, Kumar V, Chan J, Jacobs WR Jr. Rapid film-based determination of antibiotic susceptibilities of Mycobacterium tuberculosis strains by using a luciferase reporter phage and the Bronx Box. J. Clinical Microbiol. 1999; 37:1144-1149.
Abstract (PubMed)

Mycobacteriology

1999

Wallis RS, Patil S, Cheon SH, Edmonds K, Phillips M, Perkins MD, Joloba M, Namale A, Johnson JL, Teixeira L, Dietze R, Siddiqi S, Mugerwa RD, Eisenach K, Ellner JJ. Drug tolerance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 1999; 43:2600-2606.
Abstract (PubMed)

Clinical TB

1999

Canaday DH, Ziebold C, Noss E, Chervenak K, Harding CV and Boom WH. Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway. J Immunol; 1999; 162: 372-379.
Abstract (PubMed)

Immunology

1998

Alland D, Kramnik I, Weisbrod TR, Otsubo L, Miller LP, Jacobs Jr. WR, Bloom BR. Identification of Differentially Expressed mRNA in Prokaryotic Organisms by Customized Amplification Libraries (DECAL): The Effect of Isoniazid on Gene Expression in Mycobacterium tuberculosis. Proc. Nat. Acad. Sci. U.S.A. 1998; 22:13227-13232.
Abstract (PubMed)

Mycobacteriology

1998

Brooks JV, Orme IM. Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model. Antimicrob Agents Chemother. 1998; 42:3047-3048.
Abstract (PubMed)

Immunology

1998

DesJardin LE, Chen Y, Perkins MD, Teixeira L, Cave MD and Eisenach KD. Comparative use of competitive PCR and the ABI 7700 for monitoring microbial load in tuberculosis patients during chemotherapy. J. Clin Micro 1998; 36:1964-1968.
Abstract (PubMed)

Mycobacteriology

1998

Piatek AS, Tyagi S, Pol AC, Telenti A, Miller LP, Kramer FR, Alland D. Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis. Nature Biotech. 1998; 16:359-363.
Abstract (PubMed)

Mycobacteriology

1998

Ssali FN, Kamya MR, Wabwire-Mangen F, Kasasa S, Joloba M, Williams D, Mugerwa RD, Ellner JJ, Johnson JL. A prospective study of community acquired bloodstream infections among febrile adults admitted to Mulago Hospital in Kampala, Uganda. J Acquir Immune Defic Syndr Hum Retrovirol 1998;19: 484-9.
Abstract (PubMed)

Clinical TB/HIV

1998

Wallis RS, Perkins M, Phillips M, Joloba M, Demchuk B, Namale A, Johnson JL, Williams D, Wolski K, Teixeira L, Dietze R, Mugerwa RD, Eisenach K, Ellner JJ. Induction of the antigen 85 complex of M. tuberculosis in sputum: a determinant of outcome in pulmonary tuberculosis. J Infect Dis 1998; 178:1115-1121.
Abstract (PubMed)

Immunology

1997

Carriere C, Riska PF, Zimhonv O, Kriakov J, Bardarov S, Burns J, Chan J, Jacobs Jr., WR. Conditionally replicating luciferase reporter phages: Improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis. J Clin Microbiol. 1997; 35 3232-3239.
Abstract (PubMed)

Mycobacteriology

1997

Bardarov S, Kriakov J, Carriere C, Yu S, Vaamonde C, McAdam RA, Bloom BR, Hatfull GF, Jacobs Jr. W. Conditionally replicating mycobacteriophages: A system for transposon delivery to Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1997; 94:10961-10966.
Abstract (PubMed)

Mycobacteriology

1997

Cooper AM, Callahan JE, and Orme IM. The expression of memory immunity in the lung following secondary exposure to Mycobacterium tuberculosis. Tubercle Lung Dis. 1997; 78:67-73.
Abstract (PubMed)

Immunology

1997

Jacobs GG, Johnson JL, Boom WH, Wallis RS, Whalen CC, Ginsberg AM. Tuberculosis vaccines: How close to human testing? Tuberc Lung Dis 1997; 78:159-169.
Abstract (PubMed)

Clinical TB, Immunology

1997

Riska PR, Jacobs Jr. WR, Bloom BR, McKitrick, Chan J. Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: Use of p-Nitro-a-Acetylamino-b-Hydroxy Propiophenone. J Clin Microbiol. 1997; 35:3225-3231.
Abstract (PubMed)

Mycobacteriology

1996

Balasubramanian V, Pavelka Jr. MS, Bardarov SS, Martin J, Weisbrod TR, McAdam RA, Bloom BR, Jacobs Jr. WR. Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. J Bact. 1996; 178:273-279.
Abstract (PubMed)

Mycobacteriology

1996

DesJardin LE, Perkins MD, Teixeira L, Cave MD, Eisenach KD. Alkaline decontamination of sputum specimens adversely affects stability of mycobacterial mRNA. J Clin Microbiol 1996; 34:2435-2439. PMCID: PMC229288.
Abstract (PubMed)

Mycobacteriology

1996

Guleria I, Teitelbaum R, McAdam R, Kalpana G, Jacobs Jr. WR, Bloom BR. Auxotrophic vaccines for tuberculosis. Nature Med. 1996; 2:1-5.
Abstract (PubMed)

Mycobacteriology

1996

Hellyer TJ, DesJardin LE, Assaf MK, Bates JH, Cave MD, Eisenach KD. Specificity of IS6110-based amplification assays for Mycobacterium tuberculosis complex. J. Clin. Micro. 1996; 34:2843-2846.
Abstract (PubMed)

Mycobacteriology

1996

Tyagi JS, Das TK, Kinger AK. A M.tuberculosis DNA fragment contains genes encoding cell division proteins ftsX and ftsE, a basic protein and homologues of PemK and Small Protein B. Gene. 1996.
Abstract (PubMed)

Mycobacteriology

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Presentations and Abstracts

Year

Publication

Areas of Interest

Francis Mumbowa delivered a talk on using the E-test method for routine rifampicin susceptibility at the Arua scientific conference.

Mycobacteriology

2006

Francis Mumbowa presented a poster, “Comparison of Four Rapid Methods for Screening Sputum Specimens for Rifampicin-resistant Tuberculosis” at the 37th Union World Conference on Lung Health in Paris on 4 November 2006.

Mycobacteriology

Sam Ogwang spoke on MDR prevalence, Patrick Orikiriza presented RFLP data, and Francis Mumbowa delivered intriguing data on direct susceptibility testing and the nitrate reductase assay at the annual Wellcome Trust meeting.

Mycobacteriology

2006

Dr. Moses Joloba presented the lab’s cost and performance data for its rapid rifampicin-resistance detection studies at a special session of the Stop TB Working Group on New Diagnostics, 1 November 2006, during the 37th Union World Conference on Lung Health in Paris.  His manuscript entitled “Introduction of PCR for Identification of MTB complex in Routine Practice” was published in the November issue of the International Journal of Tuberculosis and Lung Disease.

Mycobacteriology

2006

Dr. Hirsch presented data on "Immune responses in the lung during human tuberculosis: IFN-g, chemokines and excess apoptosis" at a NIH sponsored work-shop on “Regulatory T-cells and  HIV/AIDS” in Cincinnati September 7-8 2006.

Immunology

2006

Gler MTS, Maramba EKS, Quelapio MID, Johnson J, Boom H, Tupasi TE.  Prediction model of bacillary disease among smear-negative PTB cases in a high TB, low HIV prevalence country.  Submitted for presentation at the 37th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union). Paris, France, October 31-November 4, 2006.

Clinical TB

2006

Chiunda A “Tuberculous infection in Uganda households”,  Poster presented at:  American Thoraic Society Annual Meeting May 19-24, 2006; San Diego, CA.

Epidemiology, Clinical TB

2006

Stein CM , Elston RC, Whalen CC (2006). Genetic models for tuberculosis susceptibility.  Presented at the Roadmap MCRCD K12 Annual Meeting, May 4-5, Silver Spring, MD.

Genetics, Epidemiology, Immunology

 

Sam Ogwang  et al. presented a poster “Comparison of rapid tests for screening sputum specimens for rifampicin-resistant tuberculosis” at the annual Burroughs Wellcome Trust Fund annual meeting, South Africa.

Mycobacteriology

Ogwang Sam et a.l presented a poster “Rapid screening of TB cultures for Resistance to rifampicin and Streptomycin using Bacteriophage D29” at the annual Burroughs Wellcome Trust Fund annual meeting, South Africa.

Mycobacteriology

Kayes Susan et al. presented a poster “Resistance to Anti-tuberculosis Drugs in Patients Attending Mulago Hospital, Kampala” at the annual Burroughs Wellcome Trust Fund annual meeting, South Africa.

Mycobacteriology

2005

Julius Muhumuza presented a poster “ Introduction of Rapid Identification of Mycobacterium tuberculosis complex in Bactec 12B vials by PCR into routine practice” at the Union World Conference on Lung Health to be held in Paris, October, 2005.

Mycobacteriology

2005

Ogwang Sam presented a poster  “Comparison of Bactec 12B and 7H10 Media as Markers for Response to Therapy”, at the Union World Conference on Lung Health to be held in Paris, October, 2005.

Mycobacteriology

2005

Luzze H, Okwera A, Ssekasanvu E, Johnson JL, Mayanja H, Whalen CC, Mugerwa RD. Prevalence of smear-negative pulmonary tuberculosis in Kampala, Uganda.  Poster presentation at the 36th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union). Paris, France, October 18-22, 2005.  Int J Tuberc Lung Dis 2005;9(11, Suppl 1):S97-98.

Clinical TB, Epidemiology

2005

Gler MT, Asonio C, Alcaneses MR, Orillaza RB, Macalintal LE, Raymond L, Quelapio MI, Tupasi T.  Cavitary and drug resistant TB in new cases of pulmonary tuberculosis seen at Makati Medical Center.  (submitted for presentation at the 36th World Congress of the IUATLD, October 21-24, 2005, Paris, France)

Clinical TB

2005

S Theus S, Cave D, Eisenach K, Walrath J, Mackay W, Whalen C, and Silver R.  Differences in the growth of paired clinical isolates of Mycobacterium tuberculosis within human mononuclear phagoyctes correlate with epidemiological evidence of strain virulence”,(abstract) presented at the 2005 Keystone Conference “Tuberculosis: Integrated Host and Pathogen Biology”, April 2005.

Mycobacteriology, Epidemiology

2004

Ribeiro-Rodrigues R, Resende Co T, Maciel EL, Dietze R, Boom WH and Hirsch CS. A Role for CD25+CD4+ regulatory cells in the Immune Response during Human Tuberculosis. Presented (oral presentation), ALA/ATS International Conference, Orlando, FL, May 2004.

Immunology

2004

Hirsch C, Rodrigues R, Resende Co T, Detttoni V, Boom WH, Dietze R, Toossi Z. Immune responses in the lung during human tuberculosis: IFN- , chemokines and excess apoptosis. Presented at the 100th International Conference of the American Thoracic Society, Orlando, Florida, May 21-26, 2004, session B84, abstract A462.

Immunology

2004

Hirsch CS. Tuberculosis and HIV: Pathogenesis, Host Immune Response and Prospects for an Effective TB Vaccine in HIV-Infected Persons. Presented (oral presentation) as part of Symposium A07: "Issues of Global Importance in Tuberculosis." ALA/ATS International Conference, Orlando, FL, May 2004.

Immunology

2004

Kucharski LM, Wyza M, Drzayich Jankus D, Foulds J, Whalen CC, Boom WH. Consent and confidentiality: Responsible specimen distribution. International Society for Biological and Environmental Repositories Annual Meeting, 2004.

Epidemiology

2004

Kucharski LM, Drzayich Jankus D, Foulds J, Whalen CC, Boom WH. Data management of a multi-site international specimen repository. International Society for Biological and Environmental Repositories Annual Meeting, 2004.

Epidemiology

2002

Elliott AM, Luzze H, Quigley MA, Nakiyingi J, Whitworth JAG, Mugerwa R, Ellner JJ, Johnson JL, Okwera A. A randomised, double-blind, placebo controlled trial of the use of prednisolone as an adjunct to anti-tuberculous therapy in HIV-associated pleural tuberculosis in Uganda. Oral presentation at the Global Congress on Lung Health - 33rd World Conference of the International Union Against Tuberculosis and Lung Disease. Montreal, Canada, October 6-10, 2002. Int J Tuberc Lung Dis 2002; 6(10, Suppl 1):S89.

Clinical TB/HIV

2002

Ssekasanvu E, Johnson JL, Okwera A, Mayanja H, Hirsch CS, Eisenach KD, Boom WH, Ellner JJ, Mugerwa RD. Adjunctive interleukin 2 in the treatment of HIV-non-infected adults with pulmonary tuberculosis. Poster presentation at the 14th Conference of the International Union Against Tuberculosis and Lung Disease (IUATLD) African Region. Durban, South Africa, June 11-14, 2002.

Clinical TB

2002

Gehring A, Rojas R, Canaday D, Noss E, Lakey D, Harding C, Boom WH. Inhibition of human MHC-II antigen processing by 19 kD lipoprotein of M. tuberculosis. Poster presentation at the World Congress on Tuberculosis, Washington, D.C., June 3-5, 2002.

Immunology

2002

Canaday D, Beigi R, Silver RF, Harding CV, Boom WH, Dubyak GR. Role of ATP in T cell killing of M. tuberculosis growth. Poster presentation at the World Congress on Tuberculosis, Washington, D.C., June 3-5, 2002.

Immunology

2002

Boom WH. Human Immune Response to M. Tuberculosis. Oral presentation at the 4th World Congress on TB, Washington, D.C., June 3-5, 2002, p. 10.

Immunology

2002

Johnson JL, Okwera A, Ssekasanvu E, Mayanja H, Hirsch CS, Eisenach KD, Boom WH, Ellner JJ, Mugerwa RD. Adjunctive interleukin 2 in the treatment of HIV-non-infected adults with pulmonary tuberculosis. Poster presentation at the 98th International Conference of the American Thoracic Society. Atlanta, Georgia, May 17-22, 2002. Am J Respir Crit Care Med 2002;165(8):B36.

Clinical TB

2002

Wallis, RS, Palaci M, Vinhas S, Ribiero R, Johnson J, Hirsch C, Boom WH, Ellner JJ. A whole blood bactericidal assay for tuberculosis. Submitted for presentation at the Meeting of the American Society for Microbiology 2002.

Immunology

2001

Ribeiro-Rodrigues R, Co Resende T, Ribeiro F, Palaci M, Johnson JL, Sa RT, Cerutti C, Maciel EL, Lima FEP, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, Hirsch CS. Assessment of cytokine levels in sputum from patients with pulmonary tuberculosis as a marker for response to antituberculous chemotherapy. Oral presentation at the United States Japan Cooperative Medical Science Program. Thirty sixth Joint Leprosy/Tuberculosis Conference. New Orleans, USA, 2001.

Immunology, Mycobacteriology

2001

Luzze H, Okwera A, Namale H, Johnson JL, Mugerwa RD, Whalen C, Elliott A. Comparison between the clinical presentation of pleural and pulmonary tuberculosis in HIV-infected Ugandans. Poster presentation at the Global Congress on Lung Health - 32nd World Conference of the International Union Against Tuberculosis and Lung Disease. Paris, France, November 1-4, 2001. Int J Tuberc Lung Dis 2001; 5(11, Suppl 1): S41.

Clinical TB/HIV

2001

Hoft, DR, RF Silver, S Worku, B Kampmann, RS Wallis, CS Hirsch, WH Boom, JJ Ellner, and Q Li, "Human BCG vaccination induces immune memory capable of inhibiting intracellular mycobacteria" (Submitted for presentation at the Annual Conference of the American Association of Immunologists, March 2001)

Immunology

2001

Eisenach K. Molecular markers during the first 2 months of treatment. Presented at the Global Alliance for TB Drug Development Meeting on Surrogate Markers of Response to TB Treatment. Paris, France, Nov 5-6, 2001.

Mycobacteriology, Clinical TB

2001

Eisenach K. Use of surrogate markers of drug efficacy in the clinical evaluation of novel anti-mycobacterial agents. Presented at the Gordon Conference on Tuberculosis Drug Development. New London, New Hampshire, Jun 24-29, 2001.

Mycobacteriology, Clinical TB

2001

Eisenach K, DesJardin L, Cave D, Dietze R, Teixeira L, Palaci M, Johnson J, Yun H, Ellner J. Mycobacterial mRNA as a marker for bacterial clearance in TB patients receiving anti-TB therapy. Presented at the Keystone Symposium on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era. Taos, New Mexico, Jan 25-30, 2001.

Mycobacteriology

2000

Luzze H, Okwera A, Joloba M, Odida M, Nakiyingi J, Mugerwa R, Ellner J, Elliott A, Johnson J. Evaluation of suspected tuberculous pleurisy: Diagnostic yields in HIV-positive and HIV-negative adults. Poster presentation at the Global Congress on Lung Health - 31st World Conference of the International Union Against Tuberculosis and Lung Disease. Florence, Italy, August 30-September 3, 2000. Eur Respir J 2000;13(Suppl 31):148S (Abstract No. P1065)

Clinical TB/HIV

2000

Cheon SH, Hise AG, Phillips M, Silver RF, Li Q, Kampmann B, Hoft DF, and Wallis RS. A Whole Blood Bactericidal Assay for Measurement of Immune Killing of M. tuberculosis. Presented at Tuberculosis: Past, Present, and Future, Amer. Soc. Microbiol., New York, 2000.

Immunology

1999

Teixeira L, Perkins MD, Keller RP, Palaci M, Dettoni VV, Rocha LMC, Talbot E, Johnson JL, Dietze R. Infection and disease among household contacts of patients with multi-drug resistant tuberculosis: A case-control study. Poster presentation at the Global Congress on Lung Health - 30th World Conference of the International Union Against Tuberculosis and Lung Disease. Madrid, Spain, September 15-18, 1999. Int J Tuberc Lung Dis 1999 3(Suppl 1):S33, Abstract 65-PD.

Clinical TB, Epidemiology

1999

Teixeira L, Palaci M, Canedo Rocha L, Johnson JL, Ellner JJ, Rose L, Wells CD, Montgomery AB, Dietze R. Safety and early bactericidal activity of rifalazil in patients with pulmonary tuberculosis. Poster presentation at the Global Congress on Lung Health - 30th World Conference of the International Union Against Tuberculosis and Lung Disease. Madrid, Spain, September 15-18, 1999. Int J Tuberc Lung Dis 3(Suppl 1):S48, Abstract 180-PD.

Clinical TB

1998

Wallis RS, Perkins M, Phillips M, Joloba M, Demchuk B, Namale A, Johnson J, Williams D, Wolski K, Teixeira L, Dietze R, Mugerwa R, Eisenach K, Ellner J. Induction of M. tuberculosis antigen 85 in sputum: A determinant of outcome in pulmonary tuberculosis. Oral presentation at the United States Japan Cooperative Medical Science Program. Thirty third Joint Leprosy/Tuberculosis Conference. Osaka, Japan, 1998.

Mycobacteriology, Clinical TB/HIV

1998

Kamya M, Ssali SN, Wabwire-Mangen F, Joloba M, Mugerwa R, Johnson JL. Community acquired bacteremia and mycobacteremia in febrile adults admitted to Mulago Hospital in Kampala, Uganda. Presented at the XII International Conference on AIDS, Geneva, Switzerland, June 1998. Int Conf AIDS 1998;12:283-4 (abstract no. 22109).

Clinical TB/HIV

1998

Joloba M, Johnson J, Namale A, Ruesch-Gerdes, Morrissey A, Assegghai A, Nsubuga P, Eisenach K, Mugerwa R, Ellner J. High prevalence of Mycobacterium africanum in HIV-positive tuberculosis adults in Kampala, Uganda. Poster presentation at the Global Congress on Lung Health 29th World Conference of the International Union Against Tuberculosis and Lung Disease. Bangkok, Thailand, November 23-26, 1998. Int J Tuberc Lung Dis 1998;1 (Suppl 2):S206, Abstract 535-PC.

Clinical TB/HIV

1997

Ssali FN, Kamya RM, Wabwire Mangen F, Kasasa S, Joloba M, Williams D, Johnson J, Ellner JJ. Mycobacteremia in febrile HIV infected Ugandan patients. Oral presentation at the Xth International Conference on AIDS and STD in Africa, Abidjan, Ivory Coast, December 7 11, 1997, p. 116, Abstract No. A299.

Clinical TB/HIV

1997

Kamya RM, Ssali FN, Wabwire Mangen R, Kasasa S, Joloba M, Williams D, Johnson JL. Community acquired bloodstream infections among febrile HIV infected adult patients admitted to Mulago Hospital, Kampala, Uganda. Poster presentation at the Xth International Conference on AIDS and STD in Africa, Abidjan, Ivory Coast, December 7 11, 1997, p. 169, Abstract No. B432.

Clinical TB/HIV

1997

Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Mugerwa R, Ellner JJ. A role for apoptosis in suppressed T cell responses in patients with tuberculosis in Uganda. Oral presentation at the United States Japan Cooperative Medical Science Program. Thirty second Joint Leprosy/Tuberculosis Conference. Cleveland, Ohio, July 21 23, 1997. Tuberc Lung Dis 1997;78:81.

Immunology

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Book Chapters

Year

Publication

Areas of Interest

2009

Wallis RS and Johnson JL  Immunotherapy tuberculosis.  In: Schaaf HS, Zumla Z, eds. “Tuberculosis – A Comprehensive Clinical Reference. Elsevier, USA, 2009:718-726

Immunology, Clinical TB

2008 Behar SM, Boom WH. Unconventional T cells. In: Handbook of Tuberculosis: Immunology and Cell Biology (Wiley-VCH,Wenheim, Germany). 2008; 7:157-183.

 

2006

Johnson JL, Ellner JJ. Ch. 36. Tuberculosis and atypical mycobacterial infections. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice, 2nd ed. Philadelphia: Churchill Livingstone, 2006: 394-427.

Clinical TB, Mycobacteriology

2006

Wallis RS, Johnson JL. Surrogate markers to assess clinical efficacy of new antituberculosis drugs. In: Yew WW, Iseman MD, eds. Development of New Antituberculosis Drugs. New York: Nova Science Publishers. Published September 2006)

Immunology, Clinical TB

2003

Boom WH. The acquired immune response. In: At the interface: Strategies for analysis of Mycobacterium tuberculosis interactions with the host. Schlesinger L, editor. Chapter 4: 103-137, 2003.

Immunology

2002

Wallis RS, Johnson JL. Ch. 17. Immunotherapy for tuberculosis and other mycobacterial infections. In: Jacobson JM, ed. Immunotherapy for Infectious Diseases. Totowa, New Jersey: Humana Press, Inc., 2002: 281-300.

Immunology, Clinical TB

2001

Johnson JL, Ellner JJ. Ch. 33. Tuberculosis and Atypical Mycobacterial Infections. In: Guerrant RL, Walker DH, Weller PF, eds. Essentials of Tropical Infectious Diseases. Philadelphia: Churchill Livingstone, 2001: 211-221.

Clinical TB, Mycobacteriology

1999

Johnson JL, Ellner JJ. Ch. 40. Tuberculosis and Atypical Mycobacterial Infections. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, and Practice. Philadelphia: Churchill Livingstone, 1999: 443-473.

Clinical TB, Mycobacteriology