2008

Ramachandra L, Boom WH, Harding CV. Class II MHC antigen processing in phagosomes. Methods Mol Biol. 2008;445:353-377. Abstract (PubMed)

Peloquin CA, Hadad DJ, Molino LP, Palaci M, Boom WH, Dietze R, Johnson JL. Population pharmacokinetics of levofloxacin, gatifloxacin, and moxifloxacin in adults with pulmonary tuberculosis. Antimicrob Agents Chemother. 2008;52:852-857.
Abstract (PubMed)

Anis MM, Fulton SA, Reba SM, Liu Y, Harding CV, Boom WH. Modulation of pulmonary dendritic cell function during mycobacterial infection. Infect Immun. 2008;76:671-677. Abstract (PubMed)

2007

Pennini ME, Liu Y, Yang J, Croniger CM, Boom WH, Harding CV. CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosis 19-kDa lipoprotein. J Immunol. 2007;179:6910-6918. Abstract (PubMed)

Palaci M, Dietze R, Hadad DJ, Ribeiro FK, Peres RL, Vinhas SA, Maciel EL, do Valle Dettoni V, Horter L, Boom WH, Johnson JL, Eisenach KD. Cavitary disease and quantitative sputum bacillary load in cases of pulmonary tuberculosis. J Clin Microbiol. 2007;45:4064-4066. Abstract (PubMed)

Srikantiah P, Walusimbi MN, Kayanja HK, Mayanja-Kizza H, Mugerwa RD, Lin R, Charlebois ED, Boom WH, Whalen CC, Havlir DV. Early virological response of zidovudine/lamivudine/abacavir for patients co-infected with HIV and tuberculosis in Uganda. AIDS. 2007;21:1972-1974. Abstract (PubMed)

Boom WH. New TB vaccines: is there a requirement for CD8 T cells? J Clin Invest. 2007;117:2092-2094. Abstract (PubMed)

Stein CM, Zalwango S, Chiunda AB, Millard C, Leontiev DV, Horvath AL, Cartier KC, Chervenak K, Boom WH, Elston RC, Mugerwa RD, Whalen CC, Iyengar SK. Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Hum Genet. 2007;121:663-673. Abstract (PubMed)

Anis MM, Fulton SA, Reba SM, Harding CV, Boom WH. Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection. Infect Immun. 2007;75:2260-2268. Abstract (PubMed)

Srikantiah P, Lin R, Walusimbi M, Okwera A, Luzze H, Whalen CC, Boom WH, Havlir DV, Charlebois ED. Elevated HIV seroprevalence and risk behavior among Ugandan TB suspects: implications for HIV testing and prevention. Int J Tuberc Lung Dis. 2007;11:168-174. Abstract (PubMed)

2006

Ribeiro-Rodrigues R, Resende Co T, Maciel E, Dietze R, Boom WH, Hirsch C. A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis. Clin Exp Immunol. 2006;144(1):25-34.
Abstract (PubMed)

Johnson JL, Hadad DJ, Boom WH, Daley CL, Peloquin CA, Eisenach KD, Jankus DD, Debanne SM, Charlebois ED, Maciel E, Palaci M, Dietze R. Early and extended early bactericidal activity of levofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. Int J Tuberc Lung Dis 2006;10:605-612.
Abstract (PubMed)

Donald PR. The early bactericidal activity of anti-tuberculosis agents. Int J Tuberc Lung Dis. 2006;10:591.
Abstract (PubMed)

Johnson JL, Ellner JJ. Ch. 36. Tuberculosis and atypical mycobacterial infections. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice, 2nd ed. Philadelphia: Churchill Livingstone, 2006: 394-427.

Pecora ND, Ghering A, Canaday D, Belisle J, Boom WH, Harding CV.  Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and antigen presenting cell function.  J Immunol 2006;177:422-429.
Abstract (PubMed)

Whalen CC, Chiunda A, Zalwango S, Nshuti L, Jones-Lopez E, Okwera A, Hirsch C, Peters P, Boom WH, Mugerwa RD.  Immune correlates of acute Mycobacterium tuberculosis infection in household contacts in Kampala, Uganda. Am J Trop Med Hyg. 2006;75:55-61.
Abstract (PubMed)

Rojas RE, Thomas J, Gehring AJ, Hill P, Belisle J, Harding CV**, Boom WH**.  Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds a5b1 integrin (VLA-5) on CD4+ T Cells and Induces Adhesion to Fibronectin   J. of Immunol. 177:2959-2968, 2006.  (**Joint Senior Authorship)
Abstract (PubMed)

Theus SA, Cave MD, Eisenach KD, Walrath J, Lee H, Mackay W, Whalen C, Silver RF. 2006. Differences in the growth of paired Ugandan isolates of Mycobacterium tuberculosis within human mononuclear phagocytes correlate with epidemiological evidence of strain virulence. Infect. Immun. 2006; 74: 6865-6876.
Abstract (PubMed)

Torres M, Ramachandra L, Rojas RE, Bobadilla K, Thomas J, Canaday DH, Harding CV**, Boom WH**.  Role of phagosomes and MIIC in MHC-II antigen processing of MTB in human macrophages.  Infect. Immun. 74:1621-1630, 2006. (**Joint Senior Authorship)
Abstract (PubMed)

2005

Wallis RS, Johnson JL.  The role of surrogate markers in the clinical evaluation of anti-tuberculous chemotherapy. Curr Med Chem Anti-infective Agents 2005; 4:287-294.

Stein CM, Nshuti L, Chiunda AB, Boom WH, Elston RC, Mugerwa RD, Iyengar SK, Whalen CC. Evidence for a major gene influence on tumor necrosis factor-α expression in tuberculosis: path and segregation analysis.  Hum Hered 2005, 60: 109-118.
Abstract (PubMed)

Wiles S, Ferguson K, Stefanidou M, Young DB, Robertson BD. (2005) Alternative luciferase for monitoring bacterial cells under adverse conditions.  Appl Environ Microbiol. 71:3427-32.
Abstract (PubMed)

Furin JJ, Johnson JL. (2005) Recent advances in the diagnosis and management of tuberculosis. Curr Opin Pulm Med 11(3):189-94.
Abstract (PubMed)

Aung H, Wu M, Johnson JL, Hirsch CS and Toossi Z. Bioactivation of latent transforming growth factor beta1 by Mycobacterium tuberculosis in human mononuclear phagocytes. Scand J Immunol. 2005;61(6):558-65.
Abstract (PubMed)

Hirsch CS, Johnson JL, Okwera A, Kanost RA, Wu M, Peters P, Muhumuza M, McHugh M, Mayanja-Kizza H, Mugerwa RD, Mugyenyi P, Ellner JJ, Toossi Z. (2005) Mechanisms of apoptosis of T-cells in human tuberculosis. J Clin Immunol. 25(4):353-64.
Abstract (PubMed)

Katamba A, Neuhauser D, Smyth K, Adatu FÝ, Katabira E, Whalen CC. (2005) Patients perceived stigma associated with community-based directly observed therapy of tuberculosis in Uganda. East Afr Med J. 82(7):337-42.
Abstract (PubMed)

Blokpoel M, Murphy H, O Toole R, Wiles S, Runn E, Stewart G, Young D, Robertson B. Tetracycline-inducible gene regulation in mycobacteria. Nucleic Acids Research. 2005, 33: e22.
Abstract (PubMed)

Wiles S, Ferguson K, Stefanidou M, Young DB, Robertson BD. Alternative luciferase for monitoring bacterial cells under adverse conditions.  Appl Environ Microbiol. 2005 ;71:3427-32.
Abstract (PubMed)

Rojas RE, Chervenak KA, Thomas J, Morrow J, Nshuti L, Zalwango S, Thiele BA, Whalen CC, Boom WH (2005).  Vdelta2+ gammadelta T cell function in Mycobacterium tuberculosis- and HIV-1-positive patients in the United States and Uganda: application of a whole-blood assay.
. J Inf Dis 192:1806-1814.
Abstract (PubMed)

2004

Fulton SA, Reba SM, Pai RK, Pennini M, Torres M, Harding CV, Boom WH. Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein. Infect Immun. 2004, 72(4):2101-2110.
Abstract (PubMed)

Wallis RS, Kyambadde P, Johnson JL, Horter L, Kittle R, Pohle M, Ducar C, Millard M, Mayanja-Kizza H, Whalen C and Okwera A. A study of the safety, immunology, virology, and microbiology of adjunctive etanercept in HIV-1-associated tuberculosis. AIDS 2004;18:257-264.
Abstract (PubMed)

Elliott AM, Luzze H, Quigley MA, Nakiyingi J, Kyaligonza S, Namujju PB, Ducar C, Ellner JJ, Whitworth JAG, Mugerwa R, Johnson JL, Okwera A. A randomised, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1 associated pleural tuberculosis. J Infect Dis. 2004, 190(5):869-878.
Abstract (PubMed)

Gehring AJ, Dobos KM, Belisle KM, Harding CV**, Boom WH**. Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage MHC-II antigen processing. J Immunol. 2004, 173(4):2660-2668.
Abstract (PubMed)

Islam N, Kanost RA, Teixeira-Johnson L, Hejal R, Aung H, Wilkinson RJ, Hirsch CS, and Toossi Z. The role of cellular activation and tumor necrosis factor (TNF ) in the early expression of Mycobacterium tuberculosis 85B mRNA in human alveolar macrophages. .J Infect Dis. 2004, 190(2):341-351.
Abstract (PubMed)

Johnson JL, Nunn AJ, Fourie PB, Ormerod LP, Mugerwa RD, Chintu C, Mwinga A, Ngwira B, Onyebujoh P, Zumla A. Effect of Mycobacterium vaccae (SRL172) immunotherapy on radiographic healing in tuberculosis. Int J Tuberc Lung Dis. 2004, 11:1348-1354.
Abstract (PubMed)

Pai RK, Pennini ME, Tobian AAR, Canaday DH, Boom WH, Harding CV. Prolonged toll-like receptor signalling by M. tuberculosis and its 19 kDa lipoprotein inhibits IFN-induced regulation of selected genes in macrophages. Infect Immun. 2004, 11:6603-6614.
Abstract (PubMed)

Toossi Z, Mayanja-Kizza H, Kanost A, Edmonds K, McHugh M, and Hirsch C. Protective responses inTuberculosis: Induction of genes for interferon gamma and cytotoxicity by Mycobacterium tuberculosis and during human tuberculosis. Scand J Immunol. 2004, 60(3):299-306.
Abstract (PubMed)

Hanekom WA, Hughes J, Mavinkurve M, Mendillo M, Gelderbloem SJ, Watkins M, Gamieldien H, Sidibana M, Davids V, Mansoor N, Hawkridge A, Haslett PAJ, Ress S, Hussey GD, Kaplan G. Novel application of a whole blood intracellular cytokine detection assay for evaluating specific T cell frequency and function in field studies. J of Immuno Methods 2004;291:185-95.
Abstract (PubMed)

2003

Boom WH, Canaday DH, Fulton SA, Gehring AJ, Rojas RJ, Torres M. Human Immunity to M. tuberculosis: T cell subsets and antigen processing. Tuberculosis, 83:98-106, 2003.
Abstract (PubMed)

Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. J Immunol Methods 2003; 281:129-142.
Abstract (PubMed)

Gehring A, Rojas RE, Canaday DH, Lakey D, Harding CV, Boom WH. The Mycobacterium tuberculosis 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Regulated HLA-DR and Fc R1 on Human Macrophages through Toll-Like Receptor 2. Infect Immun 2003; 71:4487-4497.
Abstract (PubMed)

Guwatudde D, Nakakeeto M, Jones-Lopez EC, Maganda A, Chiunda A, Mugerwa RD, Ellner JJ, Bukenya G, Whalen CC. Tuberculosis in Household Contacts of Infectious Cases in Kampala, Uganda. Am J Epidemiol 2003:158:887-898.
Abstract (PubMed)

Johnson JL, Ssekasanvu E, Okwera A, Mayanja H, Hirsch CS, Nakibali J, Drzayich Jankus D, Eisenach KD, Boom WH, Ellner JJ, Mugerwa RD for the Uganda-Case Western Reserve University Research Collaboration. Randomized trial of adjunctive interleukin-2 in adults with pulmonary tuberculosis. Am J Respir Crit Care Med 2003; 168:185-191.
Abstract (PubMed)

Pai RK, Convery M, Hamilton TA, Boom WH and Harding CV. Inhibition of IFN- -Induced Class II Transactivator Expression by a 19-kDa Lipoprotein from Mycobacterium tuberculosis: A Potential Mechanism for Immune Evasion. J Immunol 2003; 171:175-184.
Abstract (PubMed)

Stein CM, Guwatudde D, Nakakeeto M, Peters P, Elston RC, Tiwari HK, Mugerwa R, Whalen CC. Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis 2003; 187:1679-1685.
Abstract (PubMed)

Tobian AAR, Potter NS, Ramachandra L, Pai RK, Convery M, Boom WH and Harding CV. Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharide. J Immunol 2003; 171:1413-1422.
Abstract (PubMed)

Wallis RS, Vinhas SA, Johnson JL, Ribeiro FC, Palaci M, Peres RL, Sá RT, Dietze R, Chiunda A, Eisenach K, Ellner JJ. Whole blood bactericidal activity during treatment of pulmonary tuberculosis. J Infect Dis 2003; 187:270-278.
Abstract (PubMed)

2002

Canaday DH, Beigi R, Silver RF, Harding CV, Boom WH, Dubyak GR. ATP and control of intracellular growth of mycobacteria by T cells. Infect Immun 2002 Nov; 70 (11):6456-9.
Abstract (PubMed)

Collins KR, Quinones-Mateu ME, Wu M, Luzze H, Johnson JL, Hirsch C, Toossi Z, Arts EJ. Human immunodeficiency virus type 1 (HIV-1) quasispecies at the sites of Mycobacterium tuberculosis infection contribute to systemic HIV-1 heterogeneity. J Virol 2002;76:1697-1706.
Abstract (PubMed)

Fulton SA, Reba SM, Martin TD, Boom WH. Neutrophil mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect Immun 2002 Sep; 70 (9): 5322-7.
Abstract (PubMed)

Manganelli R, Voskuil MI, Schoolnik GK, Dubnau E, Gomez M, Smith I.. Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression. Mol Microbiol. 2002 Jul;45(2):365-74.
Abstract (PubMed)

Nieman S, Rusch-Gerdes S, Joloba ML, Whalen CC, Guwatudde D, Ellner JJ, Eisenach K, Fomukong N, Johnson JL, Mugerwa RD, Okwera A, Schwander SK. Mycobacterium africanum subtype II is associated with two distinct genotypes and is a major cause of human tuberculosis in Kampala, Uganda. J Clin Microbiol 2002;40:3398-3405.
Abstract (PubMed)

Pai RK, Askew D, Boom WH, Harding CV. Regulation of class I MHC expression in APCs: roles of types I, II, and IV class II transactivator. J Immunol 2002 Aug 1; 169 (3):1326-33.
Abstract (PubMed)

Ribeiro-Rodrigues R, Resende Co T, Johnson JL, Ribeiro F, Palaci M, Sá RT, Maciel EL, Lima FEP, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, Hirsch CS. Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance. Clin Diagn Lab Immunol 2002;9:818-823.
Abstract (PubMed)

Rojas RE, Torres M, Fournie JJ, Harding CV, Boom WH. Phosphoantigen presenation by macrophages to mycobacterium tuberculosis - reactive Vgamma9Vdelta2 + T cells: modulation by Chloroquine. Infect Immun 2002; 70 (8): 4019-27.
Abstract (PubMed)

Tristao-Sa R, Ribeiro-Rodrigues R, Teixeira L, Pereira FEL, Dietze R. Intestinal nematodes and pulmonary tuberculosis. Revista da Sociedade Brasileira de Medicina Tropical 2002;35:533-535.

Wallis RS, Johnson JL. Immunotherapy of tuberculosis and other mycobacterial infections. In: Jacobson J, ed. Immunotherapy of Infectious Diseases. Totowa, New Jersey: Human Press, Inc ., 2002: 281-300.

Cheon SH, Kampmann B, Hise AG, Phillips M, Song HY, Landen K, Li Q, Larkin R, Ellner JJ, Silver RF, Hoft DF and Wallis RS. Whole blood bactericidal activity as a potential surrogate marker of immunity after vaccination against tuberculosis. Clin Diagn Lab Immunol 2002 Jul; 9 (4):901-907.
Abstract (PubMed)

Flyer DC, Ramakrishna V, Miller C, Myers H, McDaniel M, Root K, Flournoy C, Engelhard VH, Canaday DH, Marto JA, Ross MM, Hunt DF, Shabanowitz J, White FM. Identification by Mass Spectrometry of CD8+-T-Cell Mycobacterium tuberculosis Epitopes within the RV0341 Gene Product. Infect Immun 2002; 70:2923-2932.
Abstract (PubMed)

Hoft DF, Worku S, Kampmann B, Whalen CS, Ellner JJ, Hirsch CS, Brown RB, Larkin R, Li Q, Hyun J and Silver RF. Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective TB immunity. J Infect Dis 2002; 186:1448-1457.
Abstract (PubMed)

2001

Brill K, Li Q, Scaccia R, Canaday DH, Boom WH, Silver RF. Human natural killer cells mediate killing of intracellular M. tuberculosis H37Rv via perforin-independent mechanisms. Infection and Immunity, 69:1755-1765, 2001.
Abstract (PubMed)

Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH. CD4+ and CD8+ T cells kill intracellular M. tuberculosis by a perforin and FAS/FASL independent mechanism. J. Immunology, 167:2734-2742, 2001.
Abstract (PubMed)

DesJardin LE, Hayes LG, Wayne LG, Sohaskey CD, Eisenach KD. Microaerophilic induction of the alpha crystallin chaperone protein homologue (hspX) mRNA of Mycobacterium tuberculosis. J Bacteriol 2001; 183:5311-5316.
Abstract (PubMed)

Dietze R, Teixeira L, Canedo Rocha LM, Palaci M, Johnson JL, Wells C, Rose L, Eisenach K, Ellner JJ. Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis. Antimicrob Agents Chemother 2001;45:1972-6.
Abstract (PubMed)

Diniz LM, Zandonade E, Dietze R, Pereira FE, Ribeiro-Rodrigues R. Do intestinal nematodes increase the risk for multibacillary leprosy? Am J Trop Med Hyg 2001;65:852-854.
Abstract (PubMed)

Ehrt, S., D. Schnappinger, S. Bekiranov, J. Drenkow, S. Shi, T. Gingeras, T. Gaasterland, G.K. Schoolnik, and C. Nathan. Extensive remodeling of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194: 1123-1139, 2001.
Abstract (PubMed)

Hirsch CS, Johnson JL. Treatment of latent tuberculosis: New U.S. guidelines. Infect Dis Clin Pract 2001; 10(2):93-100.

Hirsch CS, Toossi Z, Johnson JL, Luzze H, Ntambi L, Peters P, McHugh M, Okwera A, Joloba M, Mugyenyi P, Mugerwa RD, Terubuh P, Ellner JJ. Augmentation of Apoptosis and Interferon-g Production at Sites of Active Mycobacterium tuberculosis Infection in Human Tuberculosis. J Infect Dis 2001;183:779-88.
Abstract (PubMed)

Joloba ML, Johnson JL, Namale A, Morrissey A, Assegghai AE, Rüsch-Gerdes S, Mugerwa RD, Ellner JJ, Eisenach KD. Quantitative bacillary response to treatment in Mycobacterium tuberculosis (MTB) and M. africanum infected adults with pulmonary tuberculosis. Int J Tuberc Lung Dis 2001;5:579-82.
Abstract (PubMed)

Kato-Maeda, M., Rhee, J.T., Gingeras, T., Salamon, H., Drenkow, J., Smittipat, N., and Small, P.M. Comparing genomes within the species Mycobacterium tuberculosis. Genome Res. 4: 547-54, 2001.
Abstract (PubMed)

Kato-Maeda, M., Bifani, P.J., Kreiswirth, B., and Small, P.M. The nature and consequences of genetic variability within Mycobacterium tuberculosis. J. Clin. Invest. 107: 533-7, 2001.
Abstract (PubMed)
Lawn SD, Pisell T, Hirsch CS, Wu, M, Butera ST, Toossi Z. Anatomically Compartmentalized HIV Replication in HLA-DR+ Cells and CD14+ Macrophages at the Site of Pleural Tuberculosis Co-infection. J Inf Dis, 184:1127-33, 2001.
Abstract (PubMed)

Luzze H, Elliott AM, Joloba ML, Odida ML, Oweka-Onyee J, Nakiyingi J, Quigley M, Hirsch C, Mugerwa RD, Okwera A, Johnson JL. Evaluation of suspected tuberculous pleurisy: Clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. Int J Tuberc Lung Dis 2001; 5: 746-53.
Abstract (PubMed)

Manganelli, R. M.I. Voskuil, G.K. Schoolnik and I. Smith. The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages. Mol. Microbiol. 41: 423-437, 2001.
Abstract (PubMed)

Mayanja-Kizza H, Waija A, Wu M, Ssengoba A, Peters P, Nalugwa G, Mubiru F, Nassali A, Aung H, Herthoge T, Vanham G, Hirsch CS, Whalen CW, Ellner JJ, and Toossi Z. Activation of Beta-chemokines and CCR-5 and enhanced HIV-1 activity in HIV-infected patients with tuberculosis. J Inf Dis, 183: 1801-4, 2001.
Abstract (PubMed)

Mayanja-Kizza H, Johnson JL, Hirsch CS, Peters P, Surewicz K, Wu M, Nalugwa G, Mubiru F, Luzze H, Waija A, Aung H, Ellner JJ, Whalen CW, and Toossi Z. Macrophage activating cytokines in HIV-1 infected and uninfected subjects with pulmonary tuberculosis. J Inf Dis, 183: 1805-9, 2001.
Abstract (PubMed)

Noss EH, Sellati TJ, Radolf JD, Belisle J, Golenbock DT, Boom WH**, Harding CV**. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19 kD lipoprotein of M. tuberculosis. J of Immunology, 167:910-918, 2001 (**Joint Senior Authorship)
Abstract (PubMed)

Neufert C, Pai RK, Noss EH, Berger M, Boom WH, Harding CV. Mycobacterium tuberculosis 19 kDa lipoprotein promotes neutrophil activation. J. Immunology, 167:1542-1549, 2001.
Abstract (PubMed)
Ramachandra L, Noss EN, Boom WH, Harding CV. Processing of M. tuberculosis antigen 85B involves intra-phagosomal formation of peptide:MHC-II complexes and is inhibited by live bacilli that decrease phagosome maturation. J. Exp. Med., 194:1421-1432, 2001.
Abstract (PubMed)

Sherman, D.R., M.I. Voskuil, R. Liao, M.I. Harrell and G.K. Schoolnik. Regulation of the Mycobacterium tuberculosis hypoxic gene encoding alpha-crystallin. Proc. Natl. Acad. Sci (USA) 98: 7534-9, 2001.
Abstract (PubMed)

Teixeira L, Perkins MD, Johnson JL, Keller RP, Palaci M, Dettoni V, Rocha L, Talbot E, Dietze R. Infection and disease among household contacts of patients with multi-drug resistant tuberculosis. Int J Tuberc Lung Dis 2001; 5: 321-8
Abstract (PubMed)

Toossi Z, Johnson JL, Kanost AR, Wu M, Luzze H, Peters P, Okwera A, Joloba M, Mugyenyi P, Mugerwa RD, Aung H, Ellner JJ, Hirsch CS. Increased replication of Human Immunodeficiency virus-1 (HIV-1) at sites of active M. tuberculosis infection: Potential mechanisms of viral activation. J AIDS 2001; 28: 1-8.
Abstract (PubMed)

Toossi Z, Mayanja-Kizza H, Hirsch CS, Edmonds KL, Spahlinger T, Hom DL, Aung H, Mugyenyi P, Ellner JJ, and Whalen CW. Impact of tuberculosis on Human Immunodeficiency Virus-1 (HIV-1) activity in dually infected patients. Clin Exper Immunol, 123: 233-8, 2001.
Abstract (PubMed)

Wallis RS, Phillips M, Johnson JL, Teixeira L, Canedo Rocha L, Maciel E, Rose L, Wells C, Palaci M, Dietze R, Eisenach K, and Ellner JJ. Inhibition of Isoniazid-Induced Expression of Mycobacterium tuberculosis Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials. Antimicrob Agents Chemother 2001; 45: 1302-4
Abstract (PubMed)

Wilkinson RJ, DesJardin LE, Islam M, Gibson BM, Kanost RA, Wilkinson KA, Poelman D, Eisenach KD, Toossi Z. An increase in expression of a Mycobacterium tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes. Mol Microbiol 2001; 39(3):813-821.
Abstract (PubMed)

Wilson, M.A., M. Voskuil, D. Schnappinger and G.K. Schoolnik. Microarray gene response profiling of Mycobacterium tuberculosis. Methods Mol. Biol. 54: 335-358, 2001.

2000

Hertoghe T, Wajja A, Ntambi L, Okwera A, Aziz MA, Hirsch C, Johnson J, Toossi Z, Mugerwa R, Mugyenyi P, Colebunders R, Ellner J, Vanham G. T cell activation, apoptosis and regulatory cytokine production in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB). Clin Exp Immunol 2000;122: 350-7. (Joint project between TBRU and the Institute of Tropical Medicine - Antwerp, Belgium)
Abstract (PubMed)

Hirsch CS, Johnson, JL. Rifapentine in the treatment and prevention of tuberculosis. Current Treatment Options in Infect Dis 2000;2: 121-4.

Johnson JL, Ellner JJ. Adult tuberculosis overview: African vs. Western perspectives. Curr Opin Pulm Med 2000; 6:180-6.
Abstract (PubMed)

Johnson JL, Kamya RM, Okwera A, Loughlin AM, Nyole S, Hom D, Wallis RS, Hirsch CM, Wolski KW, Foulds J, Mugerwa RD, Ellner JJ for the Uganda-Case Western Reserve Research Collaboration. Randomized controlled trial of Mycobacterim vaccae immunotherapy in non-Human Immunodeficiency Virus-infected Ugandan adults with newly diagnosed pulmonary tuberculosis. J Infect Dis 2000; 181:1304 12.
Abstract (PubMed)

Joloba ML, Johnson JL, Namale A, Morrissey A, Assegghai AE, Mugerwa RD, Ellner JJ, Eisenach KD. Quantitative sputum bacillary load during rifampicin containing short course chemotherapy in human immunodeficiency virus- infected and non-infected adults with pulmonary tuberculosis. Int J Tuberc Lung Dis 2000:4: 526-8.
Abstract (PubMed)

Joloba ML, Whalen CC, Cave DM, Eisenach KD, Johnson JL, Okwera A, Morrissey A, Bajaksouzian S, Feagin J, Mugerwa RD, Ellner JJ, Jacobs MR. Determination of drug susceptibility and DNA fingerprint patterns of clinical isolates of Mycobacterium tuberculosis from Kampala, Uganda. East Afr Med J 2000;77:111-115.
Abstract (PubMed)

Raychaudhuri, S., Stuart, J.M., Liu, X., Small, P.M., and Altman, R. Pattern recognition of genomic features with microarrays: site typing of Mycobacterium tuberculosis strains. Proc. Int. Conf. Intell. Syst. Mol. Biol. 8: 286-95, 2000.
Abstract (PubMed)

Salamon, H., Kato-Maeda, M., Small, P.M., and Gingeras, T. Detection of deleted genomic DNA using a semiautomated computational analysis of GeneChip data. Genome Res. 10: 2044-54, 2000.
Abstract (PubMed)

Wallis RS, Perkins MD, Phillips M, Joloba M, Namale A, Johnson JL, Whalen CC, Teixeira L, Dietze R, Mugerwa R, Eisenach K, Ellner JJ. Predicting the outcome of therapy for pulmonary tuberculosis. Am J Respir Crit Care 2000; 161:1076-80.
Abstract (PubMed)

1999

Brooks JV, Furney SK Orme IM. Metronidazole therapy in mice infected with tuberculosis. Antimicrob Agents Chemother. 1999;43(5):1285-8.
Abstract (PubMed)

DesJardin L, Perkins M, Wolski K, Haun S, Teixeira L, Chen Y, Johnson JL, Ellner JJ, Dietze R, Bates J, Cave MD, Eisenach K. Measurement of sputum Mycobacterium tuberculosis messenger RNA as a surrogate for response to chemotherapy. Am J Respir Crit Care Med 1999;160:203-10.
Abstract (PubMed)

Hellyer T, DesJardin LE, Hehman GL, Cave MD, Eisenach KD. Quantitative analysis of mRNA as a marker for viability of Mycobacterium tuberculosis. J Clin Micro 1999;37(2):290-5.
Abstract (PubMed)

Hellyer T, DesJardin LE, Teixeira L, Perkins MD, Cave MD and Eisenach KD. Detection of viable Mycobacterium tuberculosis by reverse transcription-strand displacement amplification of mRNA. J Clin Micro 1999;37(3); 518-23.
Abstract (PubMed)

Hirsch CS, Toossi Z, Othieno C, Johnson JL, Schwander SK, Robertson S, Wallis RS, Edmonds K, Okwera A, Mugerwa R, Peters P, Ellner JJ. Depressed T-cell interferon-g responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J Infect Dis 1999;180:2069-73.
Abstract (PubMed)

Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Okwera A, Mugerwa R, Mugyenyi P, Ellner JJ. Apoptosis and T-cell hyporesponsiveness in pulmonary tuberculosis. J Infect Dis 1999;179:945-53.
Abstract (PubMed)

Musoke Mudido P, Guwatudde D, Nakakeeto MK, Bukenya GC, Nsamba D, Johnson JL, Mugerwa RD, Ellner JJ, Whalen CC. The effect of bacille Calmette-Guerin vaccination at birth on tuberculin skin test reactivity in Ugandan children. Int J Tuberc Lung Dis 1999;3(10):891-5.
Abstract (PubMed)

Othieno C, Hirsch CS, Hamilton BD, Wilkinson K, Ellner JJ, Toossi, Z. Interaction of Mycobacterium tuberculosis-induced transforming growth factor b1 and interleukin-10. Infect & Immunity 1999;67(11):5730-5.
Abstract (PubMed)

Riska P, Su Y, Bardarov S, Freundlich L, Sarkis G, Hatfull G, Carriere C, Kumar V, Chan J, Jacobs WR Jr. 1999. Rapid film-based determination of antibiotic susceptibilities of Mycobacterium tuberculosis strains by using a luciferase reporter phage and the Bronx Box. J. Clinical Microbiol. 37:1144-49.
Abstract (PubMed)

Wallis RS, Patil S, Cheon SH, Edmonds K, Phillips M, Perkins MD, Joloba M, Namale A, Johnson JL, Teixeira L, Dietze R, Siddiqi S, Mugerwa RD, Eisenach K, Ellner JJ. Drug tolerance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 1999; 43:2600-6.
Abstract (PubMed)

1998

Alland D, Kramnik I, Weisbrod TR, Otsubo L, Miller LP, Jacobs Jr. WR, Bloom BR. Identification of Differentially Expressed mRNA in Prokaryotic Organisms by Customized Amplification Libraries (DECAL): The Effect of Isoniazid on Gene Expression in Mycobacterium tuberculosis. Proc. Nat. Acad. Sci. U.S.A. 1998;22:13227 32.
Abstract (PubMed)

Brooks JV, Orme IM. Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model. Antimicrob Agents Chemother. 1998;42(11):3047-8.
Abstract (PubMed)

DesJardin LE, Chen Y, Perkins MD, Teixeira L, Cave MD and Eisenach KD (1998). Comparative use of competitive PCR and the ABI 7700 for monitoring microbial load in tuberculosis patients during chemotherapy. J. Clin Micro 36:1964-8.
Abstract (PubMed)

Piatek AS, Tyagi S, Pol AC, Telenti A, Miller LP, Kramer FR, Alland D. Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis. Nature Biotech. 1998;16: 359-63.
Abstract (PubMed)

Ssali FN, Kamya MR, Wabwire-Mangen F, Kasasa S, Joloba M, Williams D, Mugerwa RD, Ellner JJ, Johnson JL. A prospective study of community acquired bloodstream infections among febrile adults admitted to Mulago Hospital in Kampala, Uganda. J Acquir Immune Defic Syndr Hum Retrovirol 1998;19: 484-9.
Abstract (PubMed)

Wallis RS, Perkins M, Phillips M, Joloba M, Demchuk B, Namale A, Johnson JL, Williams D, Wolski K, Teixeira L, Dietze R, Mugerwa RD, Eisenach K, Ellner JJ. Induction of the antigen 85 complex of M. tuberculosis in sputum: a determinant of outcome in pulmonary tuberculosis. J Infect Dis 1998;178:1115-21.
Abstract (PubMed)

1997

Carriere C, Riska PF, Zimhonv O, Kriakov J, Bardarov S, Burns J, Chan J, Jacobs Jr., WR. Conditionally replicating luciferase reporter phages: Improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis. J Clin Microbiol. 1997;35: 3232-9.
Abstract (PubMed)

Cooper AM, Callahan JE, and Orme IM. The expression of memory immunity in the lung following secondary exposure to Mycobacterium tuberculosis. Tubercle Lung Dis. 1997;78(1):67-73.
Abstract (PubMed)

Jacobs GG, Johnson JL, Boom WH, Wallis RS, Whalen CC, Ginsberg AM. Tuberculosis vaccines: How close to human testing? Tuberc Lung Dis 1997;78:159-169.
Abstract (PubMed)

Riska PR, Jacobs Jr. WR, Bloom BR, McKitrick, Chan J. Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: Use of p-Nitro-a-Acetylamino-b-Hydroxy Propiophenone. J Clin Microbiol. 1997;35:3225 31.
Abstract (PubMed)

1996

Balasubramanian V, Pavelka Jr. MS, Bardarov SS, Martin J, Weisbrod TR, McAdam RA, Bloom BR, Jacobs Jr. WR. Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. J Bact. 1996;178(1):273-9.
Abstract (PubMed)

DesJardin LE, Perkins MD, Teixeira L, Cave MD, Eisenach KD. Alkaline decontamination of sputum specimens adversely affects stability of mycobacterial mRNA. J Clin Microbiol 1996;34:2435-9.
Abstract (PubMed)

Guleria I, Teitelbaum R, McAdam R, Kalpana G, Jacobs Jr. WR, Bloom BR. Auxotrophic vaccines for tuberculosis. Nature Med. 1996;2(3):1-5.
Abstract (PubMed)

Hellyer TJ, DesJardin LE, Assaf MK, Bates JH, Cave MD, Eisenach KD. Specificity of IS6110-based amplification assays for Mycobacterium tuberculosis complex. J. Clin. Micro. 1996;34:2843-6.
Abstract (PubMed)

Tyagi JS, Das TK, Kinger AK. A M.tuberculosis DNA fragment contains genes encoding cell division proteins ftsX and ftsE, a basic protein and homologues of PemK and Small Protein B. Gene. 1996.
Abstract (PubMed)

Presentations and Abstracts

Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Mugerwa R, Ellner JJ. A role for apoptosis in suppressed T cell responses in patients with tuberculosis in Uganda. Oral presentation at the United States Japan Cooperative Medical Science Program. Thirty second Joint Leprosy/Tuberculosis Conference. Cleveland, Ohio, July 21 23, 1997. Tuberc Lung Dis 1997;78:81.

Kamya RM, Ssali FN, Wabwire Mangen R, Kasasa S, Joloba M, Williams D, Johnson JL. Community acquired bloodstream infections among febrile HIV infected adult patients admitted to Mulago Hospital, Kampala, Uganda. Poster presentation at the Xth International Conference on AIDS and STD in Africa, Abidjan, Ivory Coast, December 7 11, 1997, p. 169, Abstract No. B432.

Ssali FN, Kamya RM, Wabwire Mangen F, Kasasa S, Joloba M, Williams D, Johnson J, Ellner JJ. Mycobacteremia in febrile HIV infected Ugandan patients. Oral presentation at the Xth International Conference on AIDS and STD in Africa, Abidjan, Ivory Coast, December 7 11, 1997, p. 116, Abstract No. A299.

Joloba M, Johnson J, Namale A, Ruesch-Gerdes, Morrissey A, Assegghai A, Nsubuga P, Eisenach K, Mugerwa R, Ellner J. High prevalence of Mycobacterium africanum in HIV-positive tuberculosis adults in Kampala, Uganda. Poster presentation at the Global Congress on Lung Health 29th World Conference of the International Union Against Tuberculosis and Lung Disease. Bangkok, Thailand, November 23-26, 1998. Int J Tuberc Lung Dis 1998;1 (Suppl 2):S206, Abstract 535-PC.

Kamya M, Ssali SN, Wabwire-Mangen F, Joloba M, Mugerwa R, Johnson JL. Community acquired bacteremia and mycobacteremia in febrile adults admitted to Mulago Hospital in Kampala, Uganda. Presented at the XII International Conference on AIDS, Geneva, Switzerland, June 1998. Int Conf AIDS 1998;12:283-4 (abstract no. 22109).

Wallis RS, Perkins M, Phillips M, Joloba M, Demchuk B, Namale A, Johnson J, Williams D, Wolski K, Teixeira L, Dietze R, Mugerwa R, Eisenach K, Ellner J. Induction of M. tuberculosis antigen 85 in sputum: A determinant of outcome in pulmonary tuberculosis. Oral presentation at the United States Japan Cooperative Medical Science Program. Thirty third Joint Leprosy/Tuberculosis Conference. Osaka, Japan, 1998.

Teixeira L, Palaci M, Canedo Rocha L, Johnson JL, Ellner JJ, Rose L, Wells CD, Montgomery AB, Dietze R. Safety and early bactericidal activity of rifalazil in patients with pulmonary tuberculosis. Poster presentation at the Global Congress on Lung Health - 30th World Conference of the International Union Against Tuberculosis and Lung Disease. Madrid, Spain, September 15-18, 1999. Int J Tuberc Lung Dis 3(Suppl 1):S48, Abstract 180-PD.

Teixeira L, Perkins MD, Keller RP, Palaci M, Dettoni VV, Rocha LMC, Talbot E, Johnson JL, Dietze R. Infection and disease among household contacts of patients with multi-drug resistant tuberculosis: A case-control study. Poster presentation at the Global Congress on Lung Health - 30th World Conference of the International Union Against Tuberculosis and Lung Disease. Madrid, Spain, September 15-18, 1999. Int J Tuberc Lung Dis 1999 3(Suppl 1):S33, Abstract 65-PD.

Cheon SH, Hise AG, Phillips M, Silver RF, Li Q, Kampmann B, Hoft DF, and Wallis RS. A Whole Blood Bactericidal Assay for Measurement of Immune Killing of M. tuberculosis. Presented at Tuberculosis: Past, Present, and Future, Amer. Soc. Microbiol., New York, 2000.

Luzze H, Okwera A, Joloba M, Odida M, Nakiyingi J, Mugerwa R, Ellner J, Elliott A, Johnson J. Evaluation of suspected tuberculous pleurisy: Diagnostic yields in HIV-positive and HIV-negative adults. Poster presentation at the Global Congress on Lung Health - 31st World Conference of the International Union Against Tuberculosis and Lung Disease. Florence, Italy, August 30-September 3, 2000. Eur Respir J 2000;13(Suppl 31):148S (Abstract No. P1065)

Eisenach K, DesJardin L, Cave D, Dietze R, Teixeira L, Palaci M, Johnson J, Yun H, Ellner J. Mycobacterial mRNA as a marker for bacterial clearance in TB patients receiving anti-TB therapy. Presented at the Keystone Symposium on Molecular and Cellular Aspects of Tuberculosis Research in the Post Genome Era. Taos, New Mexico, Jan 25-30, 2001.

Eisenach K. Use of surrogate markers of drug efficacy in the clinical evaluation of novel anti-mycobacterial agents. Presented at the Gordon Conference on Tuberculosis Drug Development. New London, New Hampshire, Jun 24-29, 2001.

Eisenach K. Molecular markers during the first 2 months of treatment. Presented at the Global Alliance for TB Drug Development Meeting on Surrogate Markers of Response to TB Treatment. Paris, France, Nov 5-6, 2001.

Hoft, DR, RF Silver, S Worku, B Kampmann, RS Wallis, CS Hirsch, WH Boom, JJ Ellner, and Q Li, "Human BCG vaccination induces immune memory capable of inhibiting intracellular mycobacteria" (Submitted for presentation at the Annual Conference of the American Association of Immunologists, March 2001)

Luzze H, Okwera A, Namale H, Johnson JL, Mugerwa RD, Whalen C, Elliott A. Comparison between the clinical presentation of pleural and pulmonary tuberculosis in HIV-infected Ugandans. Poster presentation at the Global Congress on Lung Health - 32nd World Conference of the International Union Against Tuberculosis and Lung Disease. Paris, France, November 1-4, 2001. Int J Tuberc Lung Dis 2001; 5(11, Suppl 1): S41.

Ribeiro-Rodrigues R, Co Resende T, Ribeiro F, Palaci M, Johnson JL, Sa RT, Cerutti C, Maciel EL, Lima FEP, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, Hirsch CS. Assessment of cytokine levels in sputum from patients with pulmonary tuberculosis as a marker for response to antituberculous chemotherapy. Oral presentation at the United States Japan Cooperative Medical Science Program. Thirty sixth Joint Leprosy/Tuberculosis Conference. New Orleans, USA, 2001.

Wallis, RS, Palaci M, Vinhas S, Ribiero R, Johnson J, Hirsch C, Boom WH, Ellner JJ. A whole blood bactericidal assay for tuberculosis. Submitted for presentation at the Meeting of the American Society for Microbiology 2002.

Johnson JL, Okwera A, Ssekasanvu E, Mayanja H, Hirsch CS, Eisenach KD, Boom WH, Ellner JJ, Mugerwa RD. Adjunctive interleukin 2 in the treatment of HIV-non-infected adults with pulmonary tuberculosis. Poster presentation at the 98th International Conference of the American Thoracic Society. Atlanta, Georgia, May 17-22, 2002. Am J Respir Crit Care Med 2002;165(8):B36.

Boom WH. Human Immune Response to M. Tuberculosis. Oral presentation at the 4th World Congress on TB, Washington, D.C., June 3-5, 2002, p. 10.

Canaday D, Beigi R, Silver RF, Harding CV, Boom WH, Dubyak GR. Role of ATP in T cell killing of M. tuberculosis growth. Poster presentation at the World Congress on Tuberculosis, Washington, D.C., June 3-5, 2002.

Gehring A, Rojas R, Canaday D, Noss E, Lakey D, Harding C, Boom WH. Inhibition of human MHC-II antigen processing by 19 kD lipoprotein of M. tuberculosis. Poster presentation at the World Congress on Tuberculosis, Washington, D.C., June 3-5, 2002.

Niemann S, Rüsch-Gerdes S, Joloba ML, Whalen CC, Guwatudde D, Ellner JJ, Eisenach K, Fomukong N, Johnson JL, Aisu T, Mugerwa RD, Okwera A, Schwander SK. Biochemical and molecular analysis of clinical isolates from patients with pulmonary tuberculosis in Kampala, Uganda. Poster presentation at the 4th World Congress on Tuberculosis. Washington, D.C., June 3-5, 2002, abstract no. 32.

Ssekasanvu E, Johnson JL, Okwera A, Mayanja H, Hirsch CS, Eisenach KD, Boom WH, Ellner JJ, Mugerwa RD. Adjunctive interleukin 2 in the treatment of HIV-non-infected adults with pulmonary tuberculosis. Poster presentation at the 14th Conference of the International Union Against Tuberculosis and Lung Disease (IUATLD) African Region. Durban, South Africa, June 11-14, 2002.

Elliott AM, Luzze H, Quigley MA, Nakiyingi J, Whitworth JAG, Mugerwa R, Ellner JJ, Johnson JL, Okwera A. A randomised, double-blind, placebo controlled trial of the use of prednisolone as an adjunct to anti-tuberculous therapy in HIV-associated pleural tuberculosis in Uganda. Oral presentation at the Global Congress on Lung Health - 33rd World Conference of the International Union Against Tuberculosis and Lung Disease. Montreal, Canada, October 6-10, 2002. Int J Tuberc Lung Dis 2002; 6(10, Suppl 1):S89.

Kucharski LM, Drzayich Jankus D, Foulds J, Whalen CC, Boom WH. Data management of a multi-site international specimen repository. International Society for Biological and Environmental Repositories Annual Meeting, 2004.

Kucharski LM, Wyza M, Drzayich Jankus D, Foulds J, Whalen CC, Boom WH. Consent and confidentiality: Responsible specimen distribution. International Society for Biological and Environmental Repositories Annual Meeting, 2004.

Hirsch CS. Tuberculosis and HIV: Pathogenesis, Host Immune Response and Prospects for an Effective TB Vaccine in HIV-Infected Persons. Presented (oral presentation) as part of Symposium A07: "Issues of Global Importance in Tuberculosis." ALA/ATS International Conference, Orlando, FL, May 2004.

Hirsch C, Rodrigues R, Resende Co T, Detttoni V, Boom WH, Dietze R, Toossi Z. Immune responses in the lung during human tuberculosis: IFN- , chemokines and excess apoptosis. Presented at the 100th International Conference of the American Thoracic Society, Orlando, Florida, May 21-26, 2004, session B84, abstract A462.

Ribeiro-Rodrigues R, Resende Co T, Maciel EL, Dietze R, Boom WH and Hirsch CS. A Role for CD25+CD4+ regulatory cells in the Immune Response during Human Tuberculosis. Presented (oral presentation), ALA/ATS International Conference, Orlando, FL, May 2004.

S Theus S, Cave D, Eisenach K, Walrath J, Mackay W, Whalen C, and Silver R.  Differences in the growth of paired clinical isolates of Mycobacterium tuberculosis within human mononuclear phagoyctes correlate with epidemiological evidence of strain virulence”,(abstract) presented at the 2005 Keystone Conference “Tuberculosis: Integrated Host and Pathogen Biology”, April 2005.

Gler MT, Asonio C, Alcaneses MR, Orillaza RB, Macalintal LE, Raymond L, Quelapio MI, Tupasi T.  Cavitary and drug resistant TB in new cases of pulmonary tuberculosis seen at Makati Medical Center.  (submitted for presentation at the 36th World Congress of the IUATLD, October 21-24, 2005, Paris, France)

Luzze H, Okwera A, Ssekasanvu E, Johnson JL, Mayanja H, Whalen CC, Mugerwa RD. Prevalence of smear-negative pulmonary tuberculosis in Kampala, Uganda.  Poster presentation at the 36th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union). Paris, France, October 18-22, 2005.  Int J Tuberc Lung Dis 2005;9(11, Suppl 1):S97-98.

Ogwang Sam presented a poster  “Comparison of Bactec 12B and 7H10 Media as Markers for Response to Therapy”, at the Union World Conference on Lung Health to be held in Paris, October, 2005.

Julius Muhumuza presented a poster “ Introduction of Rapid Identification of Mycobacterium tuberculosis complex in Bactec 12B vials by PCR into routine practice” at the Union World Conference on Lung Health to be held in Paris, October, 2005.

Kayes Susan et al. presented a poster “Resistance to Anti-tuberculosis Drugs in Patients Attending Mulago Hospital, Kampala” at the annual Burroughs Wellcome Trust Fund annual meeting, South Africa.

Ogwang Sam et a.l presented a poster “Rapid screening of TB cultures for Resistance to rifampicin and Streptomycin using Bacteriophage D29” at the annual Burroughs Wellcome Trust Fund annual meeting, South Africa.

Sam Ogwang  et al. presented a poster “Comparison of rapid tests for screening sputum specimens for rifampicin-resistant tuberculosis” at the annual Burroughs Wellcome Trust Fund annual meeting, South Africa.

Stein CM , Elston RC, Whalen CC (2006). Genetic models for tuberculosis susceptibility.  Presented at the Roadmap MCRCD K12 Annual Meeting, May 4-5, Silver Spring, MD.

Chiunda A “Tuberculous infection in Uganda households”,  Poster presented at:  American Thoraic Society Annual Meeting May 19-24, 2006; San Diego, CA.  .

Gler MTS, Maramba EKS, Quelapio MID, Johnson J, Boom H, Tupasi TE.  Prediction model of bacillary disease among smear-negative PTB cases in a high TB, low HIV prevalence country.  Submitted for presentation at the 37th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union). Paris, France, October 31-November 4, 2006.

Dr. Hirsch also was invited to present these data at a NIH sponsored work-shop on “Regulatory T-cells and  HIV/AIDS” in Cincinnati September7-8 2006..

Dr. Moses Joloba presented the lab’s cost and performance data for its rapid rifampicin-resistance detection studies at a special session of the Stop TB Working Group on New Diagnostics, 1 November 2006, during the 37th Union World Conference on Lung Health in Paris.  His manuscript entitled “Introduction of PCR for Identification of MTB complex in Routine Practice” was published in the November issue of the International Journal of Tuberculosis and Lung Disease.

Sam Ogwang spoke on MDR prevalence, Patrick Orikiriza presented RFLP data, and Francis Mumbowa delivered intriguing data on direct susceptibility testing and the nitrate reductase assay at the annual Wellcome Trust meeting.

Francis Mumbowa presented a poster, “Comparison of Four Rapid Methods for Screening Sputum Specimens for Rifampicin-resistant Tuberculosis” at the 37th Union World Conference on Lung Health in Paris on 4 November 2006.

Francis Mumbowa delivered a talk on using the E-test method for routine rifampicin susceptibility at the Arua scientific conference.

Book Chapters

Johnson JL, Ellner JJ. Ch. 40. Tuberculosis and Atypical Mycobacterial Infections. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, and Practice. Philadelphia: Churchill Livingstone, 1999: 443-473.

Johnson JL, Ellner JJ. Ch. 33. Tuberculosis and Atypical Mycobacterial Infections. In: Guerrant RL, Walker DH, Weller PF, eds. Essentials of Tropical Infectious Diseases. Philadelphia: Churchill Livingstone, 2001: 211-221.

Wallis RS, Johnson JL. Adult tuberculosis in the 21st century: pathogenesis, clinical features, and management. Curr Opin Pulm Med 2001;7:124-32 (invited review)

Fourie PB, Ellner JJ, Johnson JL. Wither Mycobacterium vaccae - encore. Lancet 2002; 360:1032-1033.

Wallis RS, Johnson JL. Ch. 17. Immunotherapy for tuberculosis and other mycobacterial infections. In: Jacobson JM, ed. Immunotherapy for Infectious Diseases. Totowa, New Jersey: Humana Press, Inc., 2002: 281-300.

Boom WH. The acquired immune response. In: At the interface: Strategies for analysis of Mycobacterium tuberculosis interactions with the host. Schlesinger L, editor. Chapter 4: 103-137, 2003.