Richard A. Walsh,
M.D.
John H. Hord Professor of Medicine and Chairman, Department
of Medicine, Case Western Reserve University
Physician-in-Chief, University Hospitals of Cleveland
Education
| Institution |
Degree |
Year |
Field |
| Georgetown University |
B.S. |
1968 |
Biology |
| Georgetown Medical School |
M.D. |
1972 |
Medicine |
| Univ. of North Carolina |
Housestaff |
1972-75 |
Internal Medicine |
| Georgetown University |
Fellow |
1975-77 |
Cardiology |
PROFESSIONAL EXPERIENCE
| 1977-1982 |
Assistant Professor of Medicine, University
of Texas Health Science Center |
| 1982-1987 |
Associate Professor of Medicine, University of Texas Health
Science Center |
| 1987-1989 |
Professor of Medicine, University of Texas Health Science
Center |
| 1990-1998 |
Mabel S. Stonehill Professor of Medicine and Director,
Division of Cardiology, University of Cincinnati |
| 1990-1998 |
Professor, Department of Pharmacology and Cell Biophysics |
| 1991-1998 |
Director, Cardiovascular Center, University of Cincinnati |
| 1994-1998 |
Director, NHLBI Specialized Center for Heart Failure,
University of Cincinnati |
| 1998-present |
John H. Hord Professor of Medicine and Chairman, Department
of Medicine, Case Western Reserve University |
| 1998-present |
Physician-in-Chief, University Hospitals of Cleveland,
Cleveland, Ohio |
NATIONAL MEMBERSHIPS AND HONORS
AOA National Medical Honor Society M.D. Magna Cum Laude, Georgetown
University, 1972
NHLBI Cardiovascular, Renal Study Section, 1988-1991; Chairman,
1990-1991
American Heart Association Scientific Publishing Committee,
1998-present
American Heart Association Physiology Pathophysiology Study
Section, Chairman, 1994-1997
American Heart Association National Research Committee, 1995-1998
American Heart Association Council on Circulation Executive
Committee, 1991-present
American Society for Clinical Investigation
Association of American Physicians
Current Editorial Boards: American Journal of Cardiology,
1985-present; American Journal of Physiology, 1991-present;
Circulation Research, 1992-present; American Heart Journal,
1992-present; Circulation, 1993-present;
Editor: Journal of Molecular and Cellular Cardiology, 1999-2002
PUBLICATIONS (selected)
Bowling N, Walsh RA, Song G, Estridge T, Sandusky GE, Fouts
RL, Mintz K, Pickard T, Roden R, Bristow MR, Sabbah HN, Mizrahi
JL, Gromo G, King Gl, Vlahos CJ. Increased protein kinase
C activity and expression of Ca2+-sensitive isoforms in the
failing human heart. Circulation 99(3):384-391,
1999.
Takeishi Y, Bhagwat A, Ball NA, Kirkpatrick DL, Periasamy M,
Walsh RA. Effect of angiotensin converting enzyme inhibition
on protein
kinase C and SR proteins in heart failure.
Am J Physiol 276(45):H53-H62, 1999.
Sato Y, Ferguson DG, Sako H, Dorn II GW, Kadambi VJ, Yatani
A, Hoit B, Walsh RA, Kranias EG. Cardiac-specific
overexpression of mouse cardiac calsequestrin is associated
with depressed cardiovascular function and hypertrophy in transgenic
mice. J Biol Chem 273(43):28470-28477, 1998.
Liggett SB, Wagoner LE, Craft LL, Hornung RW, Hoit BD, McIntosh
TC, Walsh RA. The Ile164 beta2-adrenergic receptor polymorphism adversely effects the outcome of congestive
heart failure. J Clin Invest 102:1534-1539, 1998.
Takeishi Y, Chu G, Kirkpatrick DL, Li Z, Wakasaki H, Kranias
EG, King GL, Walsh RA. In vivo phosphorylation of cardiac
troponin I by protein kinase Cb2 decreases cardiomyocyte
calcium responsiveness and contractility in transgenic mouse
hearts. J Clin Invest 102:72-78, 1998.
Pawloski-Dahm C, Song G, Kirkpatrick DL, Palermo J, Gulick
J, Dorn GW II, Robbins J, Walsh RA. Effects of total replacement
of atrial myosin light chain-2 with the ventricular isoform
in atrial myocytes of transgenic mice. Circulation 97:1508-1513,
1998.
Song G, Campos B, Wagoner LE, Dedman JR, Walsh RA. Altered
cardiac annexin mRNA and protein levels in the left ventricle
of patients with end-stage heart failure. J Mol Cell Cardiol
30:443-451, 1998. Feature Article.
Sakata Y, Hoit BD, Liggett SB, Walsh RA, Dorn GW II.
Decompensation of pressure overload hypertrophy in Gaq overexpressing mice. Circulation 97:1488-1495,
1998.
Walsh RA, Dorn II GW. Growth and hypertrophy of the heart
and blood vessels. In Hurst's the Heart, Ninth Edition,
Alexander, Schlant, and Fuster, ed. New York: McGraw
Hill, Chapter 6, pp. 155-168, 1997.
Hoit BD, Ball N, Walsh RA. Invasive hemodynamics and
force-frequency relations in open- versus closed-chest mice.
Am J Physiol 273:H2528-H2533, 1997.
Paul K, Ball NA, Dorn GW II, Walsh RA. Left ventricular
stretch stimulates angiotensin II-mediated phosphatidylinositol
hydrolysis and protein kinase C e isoform translocation in adult
guinea pig hearts. Circ Res 81:643-650, 1997.
Chu G, Dorn GW II, Luo W, Harrer JM, Kadambi VJ, Walsh RA,
Kranias EG. Monomeric phospholamban overexpression in
gransgenic mouse hearts. Circ Res 81:485-492, 1997.
Wakasaki H, Koya D, Schoen FJ, Hoit BD, Jirousek MR, Ways DK,
Walsh RA, King GL. Targeted overexpression of protein
kinase C b2 isoform in myocardium causes cardiomyopathy.
Proc Nat Acad Sci 94:9320-9325, 1997.
D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP Walsh RA, Liggett
SB, Dorn GW II. Transgenic Gaq overexpression induces
cardiac contractile faillure in mice. Proc Nat Acad Sci
94:8121-8126, 1997.
Hoit BD, Khoury SF, Shao Y, Gabel M, Liggett SB, Walsh RA.
Effects of thyroid hormone on cardiac b-adrenergic responsiveness
in conscious baboons. Circulation 95:592-598, 1997.
Hoit BD, Walsh RA. In vivo echocardiographic assessment of
left ventricular function in transgenic and gene-targeted mice.
Trends Cardiovasc Med 7:129-134, 1997.
Hoit BD, Khan ZU, Pawloski-Dahm CM, Walsh RA. Special
Comunication. In vivo determination of the left ventricular
wall stress-shortening relationship in normal mice. Am
J Physiol 272:H1047-H1052, 1997.
Hoit BD, Pawloski-Dahm CM, Shao Y, Gabel M, Walsh RA.
The effects of a thyroid hormone analog on left ventricular
performance and contractile and calcium cycling proteins in
the baboon. Proc Assoc Am Phys 109(2):136-145, 1997.
Walsh RA. Microtubules and pressure overlod hypertrophy.
Circ Res 80:295-296, 1997.
Khoury, SF, Hoit BD, Dave V, Pawloski-Dahm CM, Shao Y, Gabel
M, Periasamy M, Walsh RA. Effects of thyroid hormone on
left ventricular performance and regulation of contractile and
Ca2+-cycling proteins in the baboon. Circ Res 79:727-735,
1996.
Collins JF, Pawloski-Dahm CM, Davis MG, Ball NA, Dorn II GW,
Walsh RA. The role of the cytoskeleton in left ventricular
pressure overload hypertrophy and failure. J Moll Cell
Cardiol 28:1435-1443, 1996.
Kadambi VJ, Ponniah S, Koss KL, Harrer JM, Dorn II GW, Walsh
RA, Kranias EG. Cardiac-specific overexpression of phospholamban
alters calcium kinetics and resultant cardiomyocyte mechanics
in transgenic mice. J Clin Invest 97:533-539, 1996.
Kiss E, Ball NA, Kranias EG, Walsh RA. Differential changes
in cardiac phospholamban and sarcoplasmic reticular Ca2+-ATPase
protein levels: effects on Ca2+ transport and mechanics
in compensated pressure overload hypertrophy and congestive
heart failure. Circ Res 77:759-764, 1995.
Hoit BD, Khoury SF, Kranias EG, Ball N, Walsh RA. In
vivo echocardiographic detection of enhanced left ventricular
function in gene targeted mice with phospholamban deficiency.
Circ Res 77:632-637, 1995.
Hoit BD, Shao Y, Gabel M, Walsh RA. Left atrial mechanical
and biochemical adaptation to pacing induced heart failure.
Cardiovasc Res 29:469-474, 1995.
Hoit BD, Shao Y, Kinoshita A, Gabel M, Husain A, Walsh RA.
Effects of angiotensin II generated by an angiotensin converting
enzyme-independent pathway on left ventricular performance in
the conscious baboon. J Clin Invest 95:1519-1527, 1995.
Hoit BD, Shao Y, Gabel M, Walsh RA. Disparate effects
of early pressure overload hypertrophy on velocity-dependent
and force-dependent indices of ventricular performance in the
conscious baboon. Circulation 91:1213-1220, 1995.
Dorn GW, Robbins J, Ball N, Walsh RA. Myosin heavy chain
regulation and myocyte contractile depression after LV hypertrophy
in aortic-banded mice. Am J Physiol 267:H400-H405, 1994.
Hoit BD, Shao Y, McMannis K, Gabel M, Walsh RA. Determination
of left atrial volume using sonomicrometry: A cast validation
study. Am J Physiol 264(Heart Circ Physiol 33):H1011-H1016,
1993.
Hoit BD, Kammerer CM, Escobedo LV, VandeBerg JL, Walsh RA.
Correlated expression of atrial myosin heavy chain and regulatory
light chain isoforms. Cardiovasc Res 27:416-422, 1993.
Hoit BD, Shao Y, Tsai LM, Patel R, Gabel M, Walsh RA.
Altered left atrial compliance after atria appendectomy:
Influence on left atrial and ventricular filling. Circ
Res 72:167-175, 1993.
Hoit BD, Shao Y, Gabel M, Walsh RA. Influence of loading
conditions and contractile state on coronary venous flow:
Validation of Doppler velocimetry. Circulation 86:651-659,
1992.
Hoit BD, Walsh RA. Regional atrial distensibility.
Am J Physiol 262(Heart Circ Physiol 31):H1356-H1360, 1992.
Konz KH, Haap M, Hill KE, Burk RF, Walsh RA. Diastolic
dysfunction of perfused rat heart induced by hydrogen peroxide.
Protective effect of selenium. J Mol Cell Cardiol 21:789-795,
1989.
Hixson JE, Henkel RD, Britten ML, Vernier DT, deLemos RA, VandeBerg
JL, Walsh RA. Alpha myosin chain cDNA structure and gene
expression in adult, fetal, and premature baboon myocardium.
J Mol Cell Cardiol 21:1073-1086, 1989.
Henkel RD, VandeBerg JL, Shade RE, Leger JJ, Walsh RA.
Cardiac beta myosin heavy chain diversity in normal and chronically
hypertensive baboons J Clin Invest 83:1487-1493, 1989.
Latham RD, Rubal BJ, Westerhof N, Sipkema P, Virmani R, Rabinowitz
M, Walsh RA. Ventricular/vascular coupling and regional arterial
dynamics in the chronically hypertensive baboon correlation
with cardiovascular structural adaptation. Circ Res 63:798-811,
1988.
