M.D. - 1978-1982 - Duke University,
Durham, NC - Medicine
Professional Training:
1982-1985 - Residency, Internal Medicine, Duke University Medical Center, Durham, NC
1985-1989 - Fellowship, Hematology/Oncology, University of PA,
Philadelphia, PA
Postdoctoral Fellowship Experience:
1986-1988 - Laboratory of Dr. Douglas Cines, University of PA, Philadelphia PA
Characterization of anti-endothelial antibodies in patients with
antiphospholipid antibodies.
Certification:
1985 - American Board of Internal Medicine
1987 - Subspecialty of Medical Oncology
1988 - Subspecialty of Hematology
Research - Grant Support:
Active support as principal investigator:
Transfusion Medicine/Clinical Hemostasis Network
1UO1HL72033-01 (National Heart Lung and Blood Institute)
K. McCrae, P.I. (15% effort),
Total award, direct costs $1,270,503
Tropomyosin in the antiangiogenic activity of HKa,
1RO1 HL98274-01
K. McCrae, P.I. (30% effort),
National Heart, Lung and Blood/National Cancer Institutes
Total award, direct costs $1,250,000
Anti-angiogenic activity of cleaved HMW Kininogen,
1RO1 CA083134 (National Cancer Institute)
K. McCrae, P.I., 35% effort,
Total award, direct costs $1,156,705 6/00-5/05
Novel approaches to development and delivery of kininogen and antithrombin derived peptides (from Attenuon L.P.),
K. McCrae, P.I., 15% effort; total award direct costs $300,000 2/00-1/03
Award awaiting approval from CWRU Office of technology transfer
Publications:
1. Ma K, Zhang J.C., Wan K, Hajjar K, McCrae KR. Binding of the anticardiolipin cofactor, b2-glycoprotein I, to endothelial cells is mediated through interactions with annexin II. J. Biol. Chem. 2000; 275(20):15541-15548.
2. Zhang JC, Claffey K, Sakthivel R, Shaw DE, Darzynkiewicz Z, Lu FM, McCrae KR. Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: Partial activity within domain 5. FASEB J. 2000; 14(15):2589-2600.
3. Sakthivel R, Zhang, J.C., Strickland DK, Gåfvels M, McCrae KR. Regulation of the Ligand Binding Activity of the Human Very Low Density Lipoprotein Receptor by Protein Kinase-C Dependent Phosphorylation. J. Biol. Chem. 2001; 276(1): 555-562.
4. McCrae KR, Bussel JB, Mannucci PM, Remuzzi G, Cines DB. Platelets: An update on diagnosis and management of thrombocytopenic disorders. Hematology (Am. Soc. Hematol. Educ. Program 2001: 282-305.
5. Zhang JC, Xiaoping Q, Sakthivel R, Mazar AP, McCrae KR. Inhibition of angiogenesis by two-chain high molecular weight kininogen (HKa) and kininogen-derived peptides. Can. J. Physiol. 2002: 80:85-90.
6. Dowlati A, Robertson K, Cooney M, Petros WP, Stratford M, Jesberger J, Lewin J, Overmoyer B, Makkar V, Stambler B, Taylor A, Waas J, McCrae KR, Remick SC. A Phase I pharmacokinetic study of the novel vascular targeting agent combretastatin A4 phosphate (CA4P) on a single-dose intravenous schedule in patients with advanced cancer. Cancer Research 62:3408-3416, 2002.
7. Zhang JC, Doñate F, Ziats NP, Juarez JC, Mazar AP, Pang YP, McCrae KR. The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin. Proc. Natl. Acad. Sci, U.S.A. 99: 12224-12229, 2002.
8. Brings HA, Wass JK, McCrae KR, Baele HR, Goldstone J. Successful management of life-threatening hemorrhage in a patient with synchronous lupus anticoagulant and factor VIII inhibitor. J. Vascular Surgery 36:853-855, 2002.
9. Juarez JC, Guan X, Shipulina NV, Plunkett ML, Parry GC, Shaw DE, Zhang JC, McCrae KR, Mazar AP, Morgan WT, Doñate F. The histidine-proline rich glycoprotein (HPRG) has potent antiangiogenic and anti-tumor activities mediated through the histidine-proline (H/P) rich domain. Cancer Research 62:5344-5350, 2002.
10. Green H, McCrae KR, Rose PR. Arterial thrombosis in a patient with gynecological cancer. Gyn. Gynecologic Oncology 87:228-230, 2002.
11. Rand JH, Wu XX, Quinn AS, Chen PP, McCrae KR, Bovill EG, Taatjes DJ. Human monoclonal antiphospholipid antibodies disrupt annexin 5 binding to phospholipid bilayers: Evidence from atomic force microscopy, ellipsometry and functional assay. Am. J. Pathol. 163:1193, 2003.
12. Guan X, Juarez JC, Natalya V. Shipulina R, Shaw DE, Morgan WT, McCrae KR, Mazar AP, Doñate F. Histidine-Proline Rich Glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thrombosis and Hemostasis (in press).
13. McCrae KR. Helicobacter Pylori and ITP: More questions than answers. Blood (in press).
14. Waas JK, Singh D, McCrae KR. Response to combination therapy with intravenous anti-D immunoglobulin (WinRho SDF) and intravenous immunoglobulin (IVIg) in a patient with refractory immune thrombocytopenic purpura. (submitted).
15. Zhang J, McCrae KR. Activation of endothelial cells by antiphospholipid/anti-b2 glycoprotein I antibodies requires cross-linking of cell surface annexin II. Blood (submitted).
Books, Monographs, Chapters:
1. McCrae KR, Shattil SJ. Disorders of Platelet Function. In Kelley WN (ed), Textbook of Internal Medicine (4th edition). J.B. Lippincott, New York, NY, 2000. Ch. 239 (pp. 1723-1732).
2. McCrae KR, Feinstein DI, Cines DB. Antiphospholipid Antibodies and the Antiphospholipid Syndrome. In Colman RW, Hirsh J, Marder VJ, Salzman EW (eds), Hemostasis and Thrombosis. Basic Principles and Clinical Practice. 4th edition, 2001, pp 1339-1358.
3. McCrae KR, Cines DB. Drug-induced thrombocytopenia. In Loscalzo J, Schafer AI (eds), Thrombosis and Hemorrhage (3nd ed.), Williams and Wilkins, New York, NY, 2003. (in press).
4. McCrae KR, Sarode R. Acquired bleeding disorders (Chapter 110). In Irwin R, Rippe JM (eds), Irwin and Rippe’s Intensive Care Medicine (5th ed), Lippincott Williams and Wilkins, New York, NY 2002, pp 1219-1231.
5. Downes KA, McCrae KR. Congenital Disorders of Platelet Function. In Provan D (ed), Molecular Hematology, Lippincott, Williams and Wilkins, New York, NY 2004 (in press).
6. McCrae KR, Sadler EJ, Cines DB. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. In Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P (eds), Hematology: Basic Principles and Practice, 4th edition 2004 (in press)
Books Edited:
1. McCrae KR. Thrombocytopenia. Marcel-Dekker, in preparation.
Department of Medicine|
11100 Euclid Avenue| Cleveland, Ohio 44106
