Lili Liu, Ph.D.
Assistant Professor of Medicine
Education:
M.D. - 1977-81- Nafang Medical University, China. - Medicine
Ph.D. - 1988-92 - School of Pharmacy, Laval University, Quebec, Canada.
Post Graduate Training:
1981-83 - Residency in Medicine, Nafang Medical University, China.
1992-96 - Postdoctoral Fellow and Research Associate, Division of
Hematology/Oncology, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Publications:
1. Spiro T P, Liu L, Gerson S L. New cytotoxic agents for the treatment of metastatic malignant melanoma: temozolomide and related alkylating aagents in combination with guanine analogues to abrogate drug resistance. FORUM Trends in Experimental and Clinical Medicine, 10: 274-285, 2000.
2. Spiro TP, Liu L, Majka S, Haaga J, Willson JK, Gerson SL. Temozolomide: the effect of once-and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase. Clin Cancer Res. 2001 7:2309-17.
3. Taverna P, Liu L, Hwang HS, Hanson AJ, Kinsella TJ, Gerson SL. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. Mutat Res. 2001 May 10;485(4):269-81.
4. Davis BM, Encell LP, Zielske SP, Christians FC, Liu L, Friebert SE, Loeb LA, Gerson SL. Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. Proc Natl Acad Sci U S A. 2001, 98:4950-4.
5. Dowlati A, Haaga J, Remick SC, Spiro TP, Gerson SL, Liu L, Berger SJ, Berger NA, Willson JK. Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clin Cancer Res. 2001, 7:2971-6.
6. Zhou H, Chen WD, Qin X, Lee K, Liu L, Markowitz SD, Gerson SL. MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice. Oncogene. 2001, 20:6009-17.
7. Zhou H, Liu L, Lee K, Gerson SL. Mice transgenic for erbB3 develop lung cancer that is potentiated by methylnitrosourea. Oncogene, 21: 8732-8740, 2002.
8. Liu L, Gerson SL Base Excision Repair as A therapeutic Target in Colon Cancer. Clin. Cancer Res., 8: 2985-2991, 2002.
9. Liu L, Schwartz S, Davis BM, and Gerson SL. Chemotherapy induced O6-Benzylguanine-resistant AGT mutations in mismatch deficient colon cancer . Cancer Res. 62: 3070-3076, 2002.
10. Reese J, Liu L, Gerson SL. Repopulating Defect Of Mismatch Repair-Deficient Hematopoietic Stem Cells. Blood, in press, 2003.
11. Yan, L., Donze JR., and Liu, L. Inactivated MGMT by O6Benzylguaine and BCNU is associated with prolonged G2/M Arrest. Submitted to Mol. Cancer Research, 2003.
12. Liu L, Yan L., Donze JR., Gerson SL. Blockage of abasic site repair enhances antitumor efficacy of BCNU in colon tumor xenografts. Mol. Cancer Ther. 2: 1061-1078, 2003.
13. Yang S, Liu L, Gerson SL and Xu Y. Measurement of anti-cancer agent
methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction.
J Chromatography B, 795:295-307, 2003.
14. Liu L, Gerson SL. The therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway. Curr. Opin. Investig. Drugs, 5: 623-627, 2004.
15. Yan L, Donze JR, Liu L. Inactivated MGMT by O6-Benzylguanine is associated with prolonged G2/M arrest in Cells Treated with BCNU. Submitted to Oncogene, 2004
16. Liu L, NakatsuruY, Gerson SL. A minor population of MMR defective hematopoietic stem cells transplanted into normal mice emerges as lymphoma after exposure to temozolomide. In preparation, 2004.
17. Liu, L., Yan, L., Mahajan,V., Donze, J., and Gerson, S. L. Inhibition of AP site Repair Coupled With Action of Topoisomerase II Poison: A Potential Strategy to Enhance Efficacy of Alkylating Agents. In preparation, 2004.
18. Yan, L., Donze, J., Gerson, S. L. and Liu, L. Gene profiling underlying cellular sensitivity to alkylating therapeutic agents. In preparation, 2004.
19. Liu, L., Aylin O, Donze, J., Reese, J., Gerson, S. L. low topoisomerases I and II protect bone marrow from MX potentiation of TMZ toxicity. In preparation, 2004.
Abstracts:
1. Liu L, Gerson SL. Upregulation of anti-apoptosis genes and decreased G2 arrest contributes to the acquired resistance to BG and BCNU observed in MMR deficient cells harboring Bg-resistance K165 mutant AGT. AACR Annual Meeting, New Orleans LA, 2001, Pg. 645.
2. Liu L, Donze JR, Gerson SL. Methoxamine enhances antitumor efficacy of BCNU in colon tumor xenografts. AACR proc. 2002, Pg. 794.
3. Liu L, Yan L, Gerson SL. Prolonged exposure to MX after TMZ increases cell death mediated by persistent AP site and increased DNA breakage., AACR proc. 2002, Pg. 836.
4. Ozdemir A, Liu L, Reese J, Gerson SL. Selective protection of bone marrow from cytotoxicity of MX combined with TMZ due to low levels of topoisomerases and II. AACR proc. 2002.
5. Ke M, Szabo S, Liu L, Gilliam A, Gerson S, Wood G, Stevens S. Update of the Phase I Clinical Trial of O6 benzylguanine (BG) and carmustine (BCNU) in the treatment of cutaneous T-cell lymphoma. Soc for Investigative Derm, submitted 2002.
6. Ozdemir A, Liu L, Reese J, Gerson S. Low topoisomerase I and II protects bone marrow from MX potentiation of TMZ toxicity. AACR proc. 2002, Pg. 794.
7. Hang Z, Liu L, Keumyoung L, Qin X, Grasso AW, Kung H, Willis JE, Kern HJ, Gerson SL. Mice transgenic for erbB3 develop lung cancer that is potentiated by methylnitrosourea. AACR proc. 2002, Pg. 486.
8. Yan L, Bulgar A, Donze JR and Liu L. Inactivation of AGT involved in extracellular signal pathway to regulate cell proliferation. Proc. AACR 2004.
9. Liu L, Xu Y, Yan L, Donze JR and Gerson, SG Potentiation of chemotherapeutic alkylating agents by targeting abasic lesion in DNA. Proc. AACR 2004.
10. Liu L, Donze JR, Bulgar A and Gerson SL. Apoptotic death induced by TMZ and MX is due to apoptotic signals emanating from mitochondria DNA damage. Proc. AACR 2004.
11. Snell M, Liu L and Gerson SG. Enhanced sensitivity to fludarabine in colon cancer cells co-treated with methoxyamine. Proc. AACR 2004.
12. Verrees M, Liu L and Gerson SG. Interruption of base excision repair selectively enhances Temozolamide and 1,3-bis(2-chloroethyl)-nitrosurea cytotoxicity in treatment of adult human malignant glioma cell lines. Proc. AACR 2004.
